| 631350 | Neurog3 | neurogenin 3 | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific; double-stranded DNA binding; chromatin DNA binding (ortholog); INVOLVED IN forebrain development; hindbrain development; positive regulation of cell differentiation; PARTICIPATES IN maturity-ons et diabetes of the young pathway; ASSOCIATED WITH congenital malabsorptive diarrhea 4 (ortholog); Experimental Diabetes Mellitus (ortholog); genetic disease (ortholog); FOUND IN nucleus (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3H-1,2-dithiole-3-thione; ammonium chloride | 20 | 30622533 | 30624015 | Rat | 94 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1344822 | NEUROG3 | neurogenin 3 | The protein encoded by this gene is a basic helix-loop-helix (bHLH) transcription factor involved in neurogenesis. The encoded protein likely acts as a heterodimer with another bHLH protein. Defects in this gene are a cause of congenital malabsorptive diarrhea 4 (DIAR4).[provided by RefSeq, May 2010 ] | 10 | 69571485 | 69573422 | Human | 148 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1552201 | Neurog3 | neurogenin 3 | Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin DNA binding activity. Involved in positive regulation of DNA-templated transcription and transdifferentiation. Acts upstream of or within epithelial cell differentiation; positive regulation of transcription by RNA polymerase II; and regulation of dendrite morphogenesis. Located in nucleus. Is expressed in several structures, including central nervous system; early conceptus; eye; genitourinary system; and gut. Human ortholog(s) of this gene implicated in congenital malabsorptive diarrhea 4; glucose intolerance; and type 2 diabetes mellitus. Orthologous to human NEUROG3 (neurogenin 3). [provided by Alliance of Genome Resources, Jul 2025] | 10 | 61968869 | 61970542 | Mouse | 160 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 9016817 | Neurog3 | neurogenin 3 | ENCODES a protein that exhibits chromatin DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription factor activity (ortholog); INVOLVED IN enteroendocrine cell differentiation (ortholog); epithelial cell differentiation (o rtholog); forebrain development (ortholog); ASSOCIATED WITH congenital malabsorptive diarrhea 4 (ortholog); Experimental Diabetes Mellitus (ortholog); genetic disease (ortholog); FOUND IN nucleus (ortholog) | NW_004955437 | 21577896 | 21578546 | Chinchilla | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11820080 | NEUROG3 | neurogenin 3 | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); double-stranded DNA binding (ortholog); INVOLVED IN epithelial cell differentiation (ortholog); forebrain development (ortholog); hindbrain development (ortholog); ASSOCIATED WITH con genital malabsorptive diarrhea 4 (ortholog); Experimental Diabetes Mellitus (ortholog); genetic disease (ortholog); FOUND IN nucleus (inferred) | 10 | 66039739 | 66041804 | Bonobo | 43 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12275576 | NEUROG3 | neurogenin 3 | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); double-stranded DNA binding (ortholog); INVOLVED IN epithelial cell differentiation (ortholog); forebrain development (ortholog); hindbrain development (ortholog); ASSOCIATED WITH con genital malabsorptive diarrhea 4 (ortholog); Experimental Diabetes Mellitus (ortholog); genetic disease (ortholog); FOUND IN nucleus (inferred) | 4 | 20654824 | 20657816 | Dog | 41 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12673428 | Neurog3 | neurogenin 3 | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); double-stranded DNA binding (ortholog); INVOLVED IN epithelial cell differentiation (ortholog); forebrain development (ortholog); hindbrain development (ortholog); ASSOCIATED WITH con genital malabsorptive diarrhea 4 (ortholog); Experimental Diabetes Mellitus (ortholog); genetic disease (ortholog); FOUND IN nucleus (inferred) | NW_004936521 | 8932998 | 8933645 | Squirrel | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155250922 | neurog3 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18908377 | Neurog3 | neurogenin 3 | ENCODES a protein that exhibits chromatin DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); INVOLVED IN enteroendocrine cell differentiation (ortholog); epi thelial cell differentiation (ortholog); forebrain development (ortholog); ASSOCIATED WITH congenital malabsorptive diarrhea 4 (ortholog); Experimental Diabetes Mellitus (ortholog); genetic disease (ortholog); FOUND IN nucleus (inferred) | | | | Naked Mole-Rat | 40 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14267496 | NEUROG3 | neurogenin 3 | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); double-stranded DNA binding (ortholog); INVOLVED IN epithelial cell differentiation (ortholog); forebrain development (ortholog); hindbrain development (ortholog); ASSOCIATED WITH con genital malabsorptive diarrhea 4 (ortholog); Experimental Diabetes Mellitus (ortholog); genetic disease (ortholog); FOUND IN nucleus (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625951506 | Neurog3 | neurogenin 3 | ENCODES a protein that exhibits chromatin DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription factor activity (ortholog); INVOLVED IN enteroendocrine cell differentiation (ortholog); epithelial cell differentiation (o rtholog); forebrain development (ortholog); ASSOCIATED WITH congenital malabsorptive diarrhea 4 (ortholog); Experimental Diabetes Mellitus (ortholog); genetic disease (ortholog); FOUND IN nucleus (ortholog) | | | | Black Rat | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18381080 | NEUROG3 | neurogenin 3 | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); double-stranded DNA binding (ortholog); INVOLVED IN epithelial cell differentiation (ortholog); forebrain development (ortholog); hindbrain development (ortholog); ASSOCIATED WITH con genital malabsorptive diarrhea 4 (ortholog); Experimental Diabetes Mellitus (ortholog); genetic disease (ortholog); FOUND IN nucleus (inferred) | | | | Green Monkey | 43 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155252031 | neurog3.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155250923 | neurog3.S | | | | | | African Clawed Frog | | symbol | gene, null |