| 1353608 | MXD1 | MAX dimerization protein 1 | This gene encodes a member of the MYC/MAX/MAD network of basic helix-loop-helix leucine zipper transcription factors. The MYC/MAX/MAD transcription factors mediate cellular proliferation, differentiation and apoptosis. The encoded protein antagonizes MYC-mediated transcriptional activation of target genes by competing for the binding partner MAX and recruiting repressor complexes containing histone deacetylases. Mutations in this gene may play a role in acute leukemia, and the encoded protein is a potential tumor suppressor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011] | 2 | 69915109 | 69942945 | Human | 206 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1557837 | Mxd1 | MAX dimerization protein 1 | Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in several c ellular components, including chromatin; mitochondrion; and nucleoplasm. Predicted to be part of Mad-Max complex. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system; integumental system; and sensory organ. Orthologous to human MXD1 (MAX dimerization protein 1). [provided by Alliance of Genome Resources, Jul 2025] | 6 | 86624026 | 86646099 | Mouse | 211 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1564525 | Mxd1 | max dimerization protein 1 | ENCODES a protein that exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); RNA polymerase II cis-regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH all ergic contact dermatitis (ortholog); Cocaine-Related Disorders (ortholog); FOUND IN chromatin (ortholog); nucleus (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; amphetamine; atrazine | 4 | 120654731 | 120678972 | Rat | 208 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 8859414 | Mxd1 | MAX dimerization protein 1 | ENCODES a protein that exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); RNA polymerase II cis-regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH all ergic contact dermatitis (ortholog); Cocaine-Related Disorders (ortholog); FOUND IN chromatin (ortholog); nucleus (ortholog) | NW_004955424 | 15209609 | 15235396 | Chinchilla | 9 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11981687 | MXD1 | MAX dimerization protein 1 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); DNA-binding transcription repressor activity, RNA polymerase II-specific (inferred); INVOLVED IN DNA-templated transcription (inferred); negative regulation of tr anscription by RNA polymerase II (inferred); regulation of transcription by RNA polymerase II (inferred); ASSOCIATED WITH allergic contact dermatitis (ortholog); Cocaine-Related Disorders (ortholog); FOUND IN chromatin (inferred); nucleus (inferred) | 2A | 69957798 | 70002615 | Bonobo | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12376896 | MXD1 | MAX dimerization protein 1 | ENCODES a protein that exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); INVOLVED IN DNA-templated transcription (inferred); negative regulation of transcription by RNA polymerase II (inferred); ASSOCIATED WITH allergic contact dermatitis (ortholog); Cocai ne-Related Disorders (ortholog); FOUND IN chromatin (ortholog) | 10 | 68550232 | 68572950 | Dog | 14 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12450416 | Mxd1 | MAX dimerization protein 1 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); DNA-binding transcription repressor activity, RNA polymerase II-specific (inferred); INVOLVED IN DNA-templated transcription (inferred); negative regulation of tr anscription by RNA polymerase II (inferred); regulation of transcription by RNA polymerase II (inferred); ASSOCIATED WITH allergic contact dermatitis (ortholog); Cocaine-Related Disorders (ortholog); FOUND IN chromatin (inferred); nucleus (inferred) | NW_004936491 | 14127581 | 14152118 | Squirrel | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18932026 | Mxd1 | MAX dimerization protein 1 | ENCODES a protein that exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); INVOLVED IN DNA-templated transcription (inferred); negative regulation of transcription by RNA polymerase II (inferred); regulation of transcription by RNA polymerase II (inferred); ASSOCIATED WITH allergic contact dermatitis (ortholog); Cocaine-Related Disorders (ortholog); FOUND IN chromatin (ortholog) | | | | Naked Mole-Rat | 14 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155237230 | mxd1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626094832 | Mxd1 | MAX dimerization protein 1 | ENCODES a protein that exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); RNA polymerase II cis-regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH all ergic contact dermatitis (ortholog); Cocaine-Related Disorders (ortholog); FOUND IN chromatin (ortholog); nucleus (ortholog) | | | | Black Rat | 9 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18430557 | MXD1 | MAX dimerization protein 1 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); DNA-binding transcription repressor activity, RNA polymerase II-specific (inferred); INVOLVED IN DNA-templated transcription (inferred); negative regulation of tr anscription by RNA polymerase II (inferred); regulation of transcription by RNA polymerase II (inferred); ASSOCIATED WITH allergic contact dermatitis (ortholog); Cocaine-Related Disorders (ortholog); FOUND IN chromatin (inferred); nucleus (inferred) | | | | Green Monkey | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14238106 | MXD1 | MAX dimerization protein 1 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription repressor activity, RNA polymerase II-specific (inferred); protein dimerization activity (inferred); INVOLVED IN DNA-templated transcription (inferred); negative regulation of transcription by RNA polymerase II (inferr ed); ASSOCIATED WITH allergic contact dermatitis (ortholog); Cocaine-Related Disorders (ortholog); FOUND IN chromatin (inferred); nucleus (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 18 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155237707 | mxd1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155242088 | mxd1.S | | | | | | African Clawed Frog | | symbol | gene, null |