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Gene: MXD1 (MAX dimerization protein 1) Homo sapiens
Symbol: MXD1
Name: MAX dimerization protein 1
Description: This gene encodes a member of the MYC/MAX/MAD network of basic helix-loop-helix leucine zipper transcription factors. The MYC/MAX/MAD transcription factors mediate cellular proliferation, differentiation and apoptosis. The encoded protein antagonizes MYC-mediated transcriptional activation of target genes by competing for the binding partner MAX and recruiting repressor complexes containing histone deacetylases. Mutations in this gene may play a role in acute leukemia, and the encoded protein is a potential tumor suppressor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: antagonizer of myc transcriptional activity; bHLHc58; MAD; MAD protein (MAX-binding protein); MAD1; max dimerizer 1; MAX-binding protein; MGC104659
Mus musculus (house mouse) : Mxd1 (MAX dimerization protein 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Mxd1 (max dimerization protein 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mxd1 (MAX dimerization protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : MXD1 (MAX dimerization protein 1)
Canis lupus familiaris (dog) : MXD1 (MAX dimerization protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mxd1 (MAX dimerization protein 1)
Sus scrofa (pig) : MXD1 (MAX dimerization protein 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38269,915,041 - 69,942,945 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37270,142,173 - 70,170,077 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36269,995,707 - 70,023,581 (+)NCBINCBI36hg18NCBI36
Build 34270,053,967 - 70,077,256NCBI
Celera269,993,381 - 70,021,239 (+)NCBI
Cytogenetic Map2p13.3NCBI
HuRef269,878,174 - 69,906,081 (+)NCBIHuRef
CHM1_1270,071,823 - 70,099,727 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on MXD1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1353608
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-10-08
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.