| 621018 | Mta1 | metastasis associated 1 | ENCODES a protein that exhibits enzyme binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding (ortholog); RNA polymerase II-specific DNA-binding transcription factor binding (ortholog); INVOLVED IN female pregnancy; secretory granule organization; chromatin remodeling (orthol og); PARTICIPATES IN CHD family mediated chromatin remodeling pathway; ASSOCIATED WITH endometriosis (ortholog); Lymphatic Metastasis (ortholog); Parkinson's disease (ortholog); FOUND IN endoplasmic reticulum; Golgi apparatus; nucleus; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2-methoxyethanol | 6 | 137999845 | 138038696 | Rat | 222 | symbol , old_gene_name , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 731516 | MTA1 | metastasis associated 1 | This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many no rmal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011] | 14 | 105419827 | 105470729 | Human | 202 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 735614 | Mta1 | metastasis associated 1 | Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and transcription coactivator activity. Involved in several processes, including circadian regulation of gene expression; entrainment of circadian clock by photoperiod; and locomotor rhythm. Located in cytoplasm a nd nucleus. Part of NuRD complex. Is expressed in several structures, including brain; early conceptus; eye; genitourinary system; and mandibular process mesenchyme. Orthologous to human MTA1 (metastasis associated 1). [provided by Alliance of Genome Resources, Jul 2025] | 12 | 113061830 | 113100826 | Mouse | 223 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 9015580 | Mta1 | metastasis associated 1 | ENCODES a protein that exhibits enzyme binding (ortholog); RNA polymerase II cis-regulatory region sequence-specific DNA binding (ortholog); RNA polymerase II-specific DNA-binding transcription factor binding (ortholog); INVOLVED IN chromatin remodeling (ortholog); circadian regulation of gene expre ssion (ortholog); double-strand break repair (ortholog); PARTICIPATES IN CHD family mediated chromatin remodeling pathway; ASSOCIATED WITH endometriosis (ortholog); Lymphatic Metastasis (ortholog); Parkinson's disease (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); endoplasmic reticulum (ortholog) | NW_004955538 | 3630383 | 3671005 | Chinchilla | 68 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 11892317 | MTA1 | metastasis associated 1 | ENCODES a protein that exhibits enzyme binding (ortholog); RNA polymerase II cis-regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN circadian regulation of gene expression (ortholog); entrainment of circadian clock by photoperiod (ortholog); female pregnancy (ortholog); PARTICIP ATES IN CHD family mediated chromatin remodeling pathway; ASSOCIATED WITH endometriosis (ortholog); Lymphatic Metastasis (ortholog); Parkinson's disease (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); endoplasmic reticulum (ortholog) | 14 | 86058412 | 86111736 | Bonobo | 71 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12285773 | MTA1 | metastasis associated 1 | ENCODES a protein that exhibits enzyme binding (ortholog); INVOLVED IN circadian regulation of gene expression (ortholog); entrainment of circadian clock by photoperiod (ortholog); female pregnancy (ortholog); PARTICIPATES IN CHD family mediated chromatin remodeling pathway; ASSOCIATED WITH endometr iosis (ortholog); Lymphatic Metastasis (ortholog); Parkinson's disease (ortholog); FOUND IN endoplasmic reticulum (ortholog); Golgi apparatus (ortholog) | 8 | 72752894 | 72772236 | Dog | 76 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12625668 | Mta1 | metastasis associated 1 | ENCODES a protein that exhibits enzyme binding (ortholog); INVOLVED IN circadian regulation of gene expression (ortholog); entrainment of circadian clock by photoperiod (ortholog); female pregnancy (ortholog); PARTICIPATES IN CHD family mediated chromatin remodeling pathway; ASSOCIATED WITH endometr iosis (ortholog); Lymphatic Metastasis (ortholog); Parkinson's disease (ortholog); FOUND IN endoplasmic reticulum (ortholog); Golgi apparatus (ortholog) | NW_004936621 | 117785 | 140917 | Squirrel | 76 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 14205465 | MTA1 | metastasis associated 1 | ENCODES a protein that exhibits enzyme binding (ortholog); INVOLVED IN circadian regulation of gene expression (ortholog); entrainment of circadian clock by photoperiod (ortholog); female pregnancy (ortholog); PARTICIPATES IN CHD family mediated chromatin remodeling pathway; ASSOCIATED WITH endometr iosis (ortholog); Lymphatic Metastasis (ortholog); Parkinson's disease (ortholog); FOUND IN endoplasmic reticulum (ortholog); Golgi apparatus (ortholog) | | | | Pig | 76 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 20866570 | MTA1 | metastasis associated 1 | | | | | Green Monkey | | symbol | gene, protein-coding |
| 155246962 | mta1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625982369 | Mta1 | metastasis associated 1 | ENCODES a protein that exhibits enzyme binding (ortholog); RNA polymerase II cis-regulatory region sequence-specific DNA binding (ortholog); RNA polymerase II-specific DNA-binding transcription factor binding (ortholog); INVOLVED IN chromatin remodeling (ortholog); circadian regulation of gene expre ssion (ortholog); double-strand break repair (ortholog); PARTICIPATES IN CHD family mediated chromatin remodeling pathway; ASSOCIATED WITH endometriosis (ortholog); Lymphatic Metastasis (ortholog); Parkinson's disease (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); endoplasmic reticulum (ortholog) | | | | Black Rat | 68 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18764228 | MTA1 | metastasis associated 1 | ENCODES a protein that exhibits enzyme binding (ortholog); INVOLVED IN circadian regulation of gene expression (ortholog); entrainment of circadian clock by photoperiod (ortholog); female pregnancy (ortholog); PARTICIPATES IN CHD family mediated chromatin remodeling pathway; ASSOCIATED WITH endometr iosis (ortholog); Lymphatic Metastasis (ortholog); Parkinson's disease (ortholog); FOUND IN endoplasmic reticulum (ortholog); Golgi apparatus (ortholog) | | | | Green Monkey | 75 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 628359204 | mta1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405862271 | mta1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405861188 | mta1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405861162 | mta1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405856632 | mta1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155246961 | mta1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 16559319 | MTA1-DT | MTA1 divergent transcript | INTERACTS WITH okadaic acid | 14 | 105417581 | 105419739 | Human | 1 | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 14385405 | MTA1-like | | | | | | Fly | | symbol | gene, null |
| 18930293 | LOC101721757 | metastasis-associated protein MTA1 | ENCODES a protein that exhibits chromatin binding (inferred); DNA binding (inferred); histone deacetylase binding (inferred); INVOLVED IN double-strand break repair (inferred); negative regulation of transcription by RNA polymerase II (inferred); positive regulation of DNA-templated transcription (i nferred); FOUND IN nucleoplasm (inferred); nucleus (inferred); NuRD complex (inferred) | | | | Naked Mole-Rat | 17 | name , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 1315536 | Mta2 | metastasis-associated gene family, member 2 | Enables histone deacetylase activity and transcription coregulator activity. Involved in negative regulation of DNA-templated transcription. Acts upstream of or within genomic imprinting; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polym erase II. Located in nucleus. Part of NuRD complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; limb; and retina. Used to study systemic lupus erythematosus. Orthologous to human MTA2 (metastasis associated 1 family member 2). [provided by Alliance of Genome Resources, Jul 2025] | 19 | 8919239 | 8929659 | Mouse | 170 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 16561252 | AL928654.2 | novel transcript, antisense to MTA1 | | | | | Human | | name | gene, lncrna |
| 1315535 | MTA2 | metastasis associated 1 family member 2 | This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family th at encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis. [provided by RefSeq, May 2011] | 11 | 62593214 | 62601865 | Human | 134 | old_gene_name , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1316833 | BLOC1S1 | biogenesis of lysosomal organelles complex 1 subunit 1 | BLOC1S1 is a component of the ubiquitously expressed BLOC1 multisubunit protein complex. BLOC1 is required for normal biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules (Starcevic and Dell'Angelica, 2004 [PubMed 15102850]).[supplie d by OMIM, Mar 2008] | 12 | 55716046 | 55719703 | Human | 102 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
