Mmp20 Gene Search Result

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16 records found for search term Mmp20

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RGD ID	Symbol	Name	Description	Chr	Start	Stop	Species	Annotations	Match	Type
1308730	Mmp20	matrix metallopeptidase 20	ENCODES a protein that exhibits metalloendopeptidase activity (ortholog); INVOLVED IN amelogenesis (ortholog); extracellular matrix disassembly (ortholog); protein catabolic process (ortholog); ASSOCIATED WITH amelogenesis imperfecta hypomaturation type 2A2 (ortholog); amelogenesis imperfecta type 1 ... (more) C (ortholog); autosomal dominant intellectual developmental disorder 56 (ortholog); FOUND IN extracellular matrix (inferred); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; acetamide	8	13074279	13114894	Rat	46	symbol , PhenoGen	gene, protein-coding, PROVISIONAL [RefSeq]
1318675	MMP20	matrix metallopeptidase 20	Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secrete ... (more) d as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene degrades amelogenin, the major protein component of dental enamel matrix, and thus thought to play a role in tooth enamel formation. A mutation in this gene, which alters the normal splice pattern and results in premature termination of the encoded protein, has been associated with amelogenesis imperfecta. This gene is part of a cluster of MMP genes located on chromosome 11q22.3. [provided by RefSeq, Aug 2011]	11	102576832	102625332	Human	71	symbol , COSMIC , Human Proteome Map	gene, protein-coding, REVIEWED [RefSeq]
1318676	Mmp20	matrix metallopeptidase 20 (enamelysin)	This gene encodes a member of the matrix metalloproteinase family of zinc-dependent endopeptidases capable of degrading extracellular matrix proteins. This gene is expressed specifically in the ameloblasts and odontoblasts, and the encoded protein is an inactive zymogen that requires proteolytic rem ... (more) oval of a N-terminal propeptide to become enzymatically active. Mice lacking the encoded protein display an amelogenesis imperfecta phenotype. [provided by RefSeq, Oct 2015]	9	7628232	7674969	Mouse	65	symbol , PhenoGen	gene, protein-coding, REVIEWED [RefSeq]
8798615	Mmp20	matrix metallopeptidase 20	ENCODES a protein that exhibits metalloendopeptidase activity (ortholog); INVOLVED IN amelogenesis (ortholog); extracellular matrix disassembly (ortholog); protein catabolic process (ortholog); ASSOCIATED WITH amelogenesis imperfecta hypomaturation type 2A2 (ortholog); amelogenesis imperfecta type 1 ... (more) C (ortholog); autosomal dominant intellectual developmental disorder 56 (ortholog)	NW_004955412	5815450	5869016	Chinchilla	11	symbol	gene, protein-coding, MODEL [RefSeq]
11837402	MMP20	matrix metallopeptidase 20	ENCODES a protein that exhibits endopeptidase activity (inferred); hydrolase activity (inferred); metal ion binding (inferred); INVOLVED IN amelogenesis (ortholog); extracellular matrix disassembly (ortholog); protein catabolic process (ortholog); ASSOCIATED WITH amelogenesis imperfecta hypomaturati ... (more) on type 2A2 (ortholog); amelogenesis imperfecta type 1C (ortholog); autosomal dominant intellectual developmental disorder 56 (ortholog); FOUND IN extracellular matrix (inferred); extracellular region (inferred)	11	97518573	97566881	Bonobo	28	symbol	gene, protein-coding, MODEL [RefSeq]
12292767	MMP20	matrix metallopeptidase 20	ENCODES a protein that exhibits hydrolase activity (inferred); metal ion binding (inferred); metalloendopeptidase activity (inferred); INVOLVED IN amelogenesis (ortholog); extracellular matrix disassembly (ortholog); protein catabolic process (ortholog); ASSOCIATED WITH amelogenesis imperfecta hypom ... (more) aturation type 2A2 (ortholog); amelogenesis imperfecta type 1C (ortholog); autosomal dominant intellectual developmental disorder 56 (ortholog); FOUND IN extracellular matrix (inferred)	5	29106717	29154628	Dog	25	symbol	gene, protein-coding, MODEL [RefSeq]
12727928	Mmp20	matrix metallopeptidase 20	ENCODES a protein that exhibits hydrolase activity (inferred); metal ion binding (inferred); metalloendopeptidase activity (inferred); INVOLVED IN amelogenesis (ortholog); extracellular matrix disassembly (ortholog); protein catabolic process (ortholog); ASSOCIATED WITH amelogenesis imperfecta hypom ... (more) aturation type 2A2 (ortholog); amelogenesis imperfecta type 1C (ortholog); autosomal dominant intellectual developmental disorder 56 (ortholog); FOUND IN extracellular matrix (inferred)	NW_004936551	5310426	5352883	Squirrel	25	symbol	gene, protein-coding, MODEL [RefSeq]
14241858	MMP20	matrix metallopeptidase 20	ENCODES a protein that exhibits hydrolase activity (inferred); metal ion binding (inferred); metalloendopeptidase activity (inferred); INVOLVED IN amelogenesis (ortholog); extracellular matrix disassembly (ortholog); protein catabolic process (ortholog); ASSOCIATED WITH amelogenesis imperfecta hypom ... (more) aturation type 2A2 (ortholog); amelogenesis imperfecta type 1C (ortholog); autosomal dominant intellectual developmental disorder 56 (ortholog); FOUND IN extracellular matrix (inferred)				Pig	25	symbol	gene, protein-coding, PROVISIONAL [RefSeq]
18774249	MMP20	matrix metallopeptidase 20	ENCODES a protein that exhibits endopeptidase activity (inferred); hydrolase activity (inferred); metal ion binding (inferred); INVOLVED IN amelogenesis (ortholog); extracellular matrix disassembly (ortholog); protein catabolic process (ortholog); ASSOCIATED WITH amelogenesis imperfecta hypomaturati ... (more) on type 2A2 (ortholog); amelogenesis imperfecta type 1C (ortholog); autosomal dominant intellectual developmental disorder 56 (ortholog); FOUND IN extracellular matrix (inferred)				Green Monkey	27	symbol	gene, protein-coding, MODEL [RefSeq]
18904439	Mmp20	matrix metallopeptidase 20	ENCODES a protein that exhibits hydrolase activity (inferred); metal ion binding (inferred); metalloendopeptidase activity (inferred); INVOLVED IN amelogenesis (ortholog); extracellular matrix disassembly (ortholog); protein catabolic process (ortholog); ASSOCIATED WITH amelogenesis imperfecta hypom ... (more) aturation type 2A2 (ortholog); amelogenesis imperfecta type 1C (ortholog); autosomal dominant intellectual developmental disorder 56 (ortholog); FOUND IN extracellular matrix (inferred)				Naked Mole-Rat	24	symbol	gene, protein-coding, MODEL [RefSeq]
626055550	Mmp20	matrix metallopeptidase 20	ENCODES a protein that exhibits metalloendopeptidase activity (ortholog); INVOLVED IN amelogenesis (ortholog); extracellular matrix disassembly (ortholog); protein catabolic process (ortholog); ASSOCIATED WITH amelogenesis imperfecta hypomaturation type 2A2 (ortholog); amelogenesis imperfecta type 1 ... (more) C (ortholog); autosomal dominant intellectual developmental disorder 56 (ortholog)				Black Rat	11	symbol	gene, protein-coding, MODEL [RefSeq]
285646038	mmp20						Tropical Clawed Frog		symbol	gene, null
287765328	mmp20.L						African Clawed Frog		symbol	gene, null
38619818	MMP20-AS1	MMP20 antisense RNA 1		11	102641124	102687212	Human		symbol , GTEx , COSMIC , name , Human Proteome Map	gene, ncrna, VALIDATED [RefSeq]
1317990	MMP25	matrix metallopeptidase 25	Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted ... (more) as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred to as MMP20 but has been renamed MMP25. [provided by RefSeq, Jul 2008]	16	3046561	3060726	Human	87	description , old_gene_symbol	gene, protein-coding, REVIEWED [RefSeq]
1317991	Mmp25	matrix metallopeptidase 25	This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded precursor undergoes proteolytic processing to generate a mature, zinc-depen ... (more) dent endopeptidase enzyme. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]	17	23847289	23864006	Mouse	94	old_gene_symbol	gene, protein-coding, REVIEWED [RefSeq]