| 1557490 | Mknk1 | MAP kinase-interacting serine/threonine kinase 1 | This gene encodes a serine-threonine protein kinase that is activated by extracellular signal-regulated kinase or p38 mitogen-activated protein kinases, and it may function in cytokine and environmental stress responses. This kinase is required for phosphorylation of eukaryotic translation initiatio n factor 4E but it is not required for cell growth during development. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Oct 2013] | 4 | 115695140 | 115736453 | Mouse | 134 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 1559603 | Mknk1 | MAPK interacting serine/threonine kinase 1 | ENCODES a protein that exhibits protein serine/threonine kinase activity; ATP binding (ortholog); INVOLVED IN peptidyl-serine phosphorylation; regulation of translational initiation; extrinsic apoptotic signaling pathway in absence of ligand (ortholog); PARTICIPATES IN the extracellular signal-regul ated Raf/Mek/Erk signaling pathway; cyclooxygenase mediated pathway of arachidonic acid metabolism; p38 MAPK signaling pathway; ASSOCIATED WITH substance-related disorder (ortholog); FOUND IN nucleoplasm (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil | 5 | 134554881 | 134594392 | Rat | 135 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1605115 | MKNK1 | MAPK interacting serine/threonine kinase 1 | This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction wit h the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2012] | 1 | 46557407 | 46604268 | Human | 138 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8900909 | Mknk1 | MAPK interacting serine/threonine kinase 1 | ENCODES a protein that exhibits ATP binding (ortholog); protein serine/threonine kinase activity (ortholog); INVOLVED IN extrinsic apoptotic signaling pathway in absence of ligand (ortholog); intracellular signal transduction (ortholog); peptidyl-serine phosphorylation (ortholog); PARTICIPATES IN cy clooxygenase mediated pathway of arachidonic acid metabolism; p38 MAPK signaling pathway; the extracellular signal-regulated Raf/Mek/Erk signaling pathway; ASSOCIATED WITH substance-related disorder (ortholog); FOUND IN nucleoplasm (ortholog) | NW_004955464 | 11697946 | 11750258 | Chinchilla | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11776107 | MKNK1 | MAPK interacting serine/threonine kinase 1 | ENCODES a protein that exhibits protein serine/threonine kinase activity (ortholog); INVOLVED IN extrinsic apoptotic signaling pathway in absence of ligand (ortholog); intracellular signal transduction (ortholog); peptidyl-serine phosphorylation (ortholog); PARTICIPATES IN cyclooxygenase mediated pa thway of arachidonic acid metabolism; p38 MAPK signaling pathway; the extracellular signal-regulated Raf/Mek/Erk signaling pathway; ASSOCIATED WITH substance-related disorder (ortholog); FOUND IN nucleoplasm (inferred) | 1 | 45859888 | 45906840 | Bonobo | 36 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12401649 | MKNK1 | MAPK interacting serine/threonine kinase 1 | ENCODES a protein that exhibits protein serine/threonine kinase activity (ortholog); INVOLVED IN extrinsic apoptotic signaling pathway in absence of ligand (ortholog); peptidyl-serine phosphorylation (ortholog); protein phosphorylation (ortholog); PARTICIPATES IN cyclooxygenase mediated pathway of a rachidonic acid metabolism; p38 MAPK signaling pathway; the extracellular signal-regulated Raf/Mek/Erk signaling pathway; ASSOCIATED WITH substance-related disorder (ortholog); FOUND IN nucleoplasm (inferred) | 15 | 13857495 | 13898709 | Dog | 40 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12484385 | Mknk1 | MAPK interacting serine/threonine kinase 1 | ENCODES a protein that exhibits ATP binding (ortholog); protein serine/threonine kinase activity (ortholog); INVOLVED IN extrinsic apoptotic signaling pathway in absence of ligand (ortholog); intracellular signal transduction (ortholog); peptidyl-serine phosphorylation (ortholog); PARTICIPATES IN cy clooxygenase mediated pathway of arachidonic acid metabolism; p38 MAPK signaling pathway; the extracellular signal-regulated Raf/Mek/Erk signaling pathway; ASSOCIATED WITH substance-related disorder (ortholog); FOUND IN nucleoplasm (ortholog) | NW_004936474 | 27568325 | 27611315 | Squirrel | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14061560 | MKNK1 | MAPK interacting serine/threonine kinase 1 | ENCODES a protein that exhibits protein serine/threonine kinase activity (ortholog); INVOLVED IN extrinsic apoptotic signaling pathway in absence of ligand (ortholog); peptidyl-serine phosphorylation (ortholog); protein phosphorylation (ortholog); PARTICIPATES IN cyclooxygenase mediated pathway of a rachidonic acid metabolism; p38 MAPK signaling pathway; the extracellular signal-regulated Raf/Mek/Erk signaling pathway; ASSOCIATED WITH substance-related disorder (ortholog); FOUND IN nucleoplasm (inferred) | | | | Pig | 40 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18534020 | MKNK1 | MAPK interacting serine/threonine kinase 1 | ENCODES a protein that exhibits protein serine/threonine kinase activity (ortholog); INVOLVED IN extrinsic apoptotic signaling pathway in absence of ligand (ortholog); intracellular signal transduction (ortholog); peptidyl-serine phosphorylation (ortholog); PARTICIPATES IN cyclooxygenase mediated pa thway of arachidonic acid metabolism; p38 MAPK signaling pathway; the extracellular signal-regulated Raf/Mek/Erk signaling pathway; ASSOCIATED WITH substance-related disorder (ortholog); FOUND IN nucleoplasm (inferred) | | | | Green Monkey | 36 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18915594 | Mknk1 | MAPK interacting serine/threonine kinase 1 | ENCODES a protein that exhibits protein serine/threonine kinase activity (ortholog); INVOLVED IN extrinsic apoptotic signaling pathway in absence of ligand (ortholog); intracellular signal transduction (ortholog); peptidyl-serine phosphorylation (ortholog); PARTICIPATES IN cyclooxygenase mediated pa thway of arachidonic acid metabolism; p38 MAPK signaling pathway; the extracellular signal-regulated Raf/Mek/Erk signaling pathway; ASSOCIATED WITH substance-related disorder (ortholog); FOUND IN nucleoplasm (ortholog) | | | | Naked Mole-Rat | 36 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155241680 | mknk1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625981761 | Mknk1 | MAPK interacting serine/threonine kinase 1 | ENCODES a protein that exhibits ATP binding (ortholog); protein serine/threonine kinase activity (ortholog); INVOLVED IN extrinsic apoptotic signaling pathway in absence of ligand (ortholog); intracellular signal transduction (ortholog); peptidyl-serine phosphorylation (ortholog); PARTICIPATES IN cy clooxygenase mediated pathway of arachidonic acid metabolism; p38 MAPK signaling pathway; the extracellular signal-regulated Raf/Mek/Erk signaling pathway; ASSOCIATED WITH substance-related disorder (ortholog); FOUND IN nucleoplasm (ortholog) | | | | Black Rat | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155241681 | mknk1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 596934370 | mknk1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 596936127 | mknk1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 596934251 | mknk1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 596933533 | mknk1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155253543 | mknk1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 6767228 | MKNK1-AS1 | MKNK1 antisense RNA 1 | INTERACTS WITH Aflatoxin B2 alpha; bisphenol A; bisphenol F | 1 | 46538696 | 46570255 | Human | 8 | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
