| 70927 | Mgst1 | microsomal glutathione S-transferase 1 | ENCODES a protein that exhibits glutathione binding; glutathione transferase activity; identical protein binding; INVOLVED IN Leydig cell differentiation; response to lipopolysaccharide; response to xenobiotic stimulus; PARTICIPATES IN glutathione metabolic pathway; phase I biotransformation pathway via cytochrome P450; ASSOCIATED WITH chronic obstructive pulmonary disease (ortholog); COVID-19 (ortholog); neurodegenerative disease (ortholog); FOUND IN apical part of cell; endoplasmic reticulum; endoplasmic reticulum membrane; INTERACTS WITH (+)-schisandrin B; (-)-epigallocatechin 3-gallate; (S)-amphetamine | 4 | 172760930 | 172776157 | Rat | 354 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 734278 | Mgst1 | microsomal glutathione S-transferase 1 | Enables glutathione transferase activity. Acts upstream of or within glutathione metabolic process. Located in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; brain; respiratory system; sensory organ; and urinary system. Orthologous to human MGST1 ='font-weight:700;'>MGST1 (microsomal glutathione S-transferase 1). [provided by Alliance of Genome Resources, Jul 2025] | 6 | 138117525 | 138133753 | Mouse | 360 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 737343 | MGST1 | microsomal glutathione S-transferase 1 | The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress. Several transcript variants, some non-protein coding and some protein coding, have been found for this gene. [provided by RefSeq, May 2012] | 12 | 16347115 | 16593331 | Human | 350 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8883708 | Mgst1 | microsomal glutathione S-transferase 1 | ENCODES a protein that exhibits glutathione binding (ortholog); glutathione peroxidase activity (ortholog); glutathione transferase activity (ortholog); INVOLVED IN cellular response to lipid hydroperoxide (ortholog); glutathione metabolic process (ortholog); glutathione transport (ortholog); ASSOCI ATED WITH chronic obstructive pulmonary disease (ortholog); COVID-19 (ortholog); neurodegenerative disease (ortholog); FOUND IN apical part of cell (ortholog); endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog) | NW_004955413 | 12989935 | 13005203 | Chinchilla | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11730035 | MGST1 | microsomal glutathione S-transferase 1 | ENCODES a protein that exhibits glutathione binding (ortholog); glutathione transferase activity (ortholog); identical protein binding (ortholog); INVOLVED IN glutathione metabolic process (ortholog); Leydig cell differentiation (ortholog); response to lipopolysaccharide (ortholog); ASSOCIATED WITH chronic obstructive pulmonary disease (ortholog); COVID-19 (ortholog); neurodegenerative disease (ortholog); FOUND IN apical part of cell (ortholog); endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog) | 12 | 16347737 | 16383776 | Bonobo | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12203958 | MGST1 | microsomal glutathione S-transferase 1 | ENCODES a protein that exhibits glutathione binding (ortholog); glutathione transferase activity (ortholog); identical protein binding (ortholog); INVOLVED IN glutathione metabolic process (ortholog); Leydig cell differentiation (ortholog); response to lipopolysaccharide (ortholog); ASSOCIATED WITH chronic obstructive pulmonary disease (ortholog); COVID-19 (ortholog); neurodegenerative disease (ortholog); FOUND IN apical part of cell (ortholog); endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog); INTERACTS WITH clofibrate; phenobarbital | 27 | 30370588 | 30391898 | Dog | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12488709 | Mgst1 | microsomal glutathione S-transferase 1 | ENCODES a protein that exhibits glutathione binding (ortholog); glutathione transferase activity (ortholog); identical protein binding (ortholog); INVOLVED IN glutathione metabolic process (ortholog); Leydig cell differentiation (ortholog); response to lipopolysaccharide (ortholog); ASSOCIATED WITH chronic obstructive pulmonary disease (ortholog); COVID-19 (ortholog); neurodegenerative disease (ortholog); FOUND IN apical part of cell (ortholog); endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog) | NW_004936587 | 1270030 | 1287130 | Squirrel | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155240563 | mgst1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625903824 | Mgst1 | microsomal glutathione S-transferase 1 | ENCODES a protein that exhibits glutathione binding (ortholog); glutathione peroxidase activity (ortholog); glutathione transferase activity (ortholog); INVOLVED IN cellular response to lipid hydroperoxide (ortholog); glutathione metabolic process (ortholog); glutathione transport (ortholog); ASSOCI ATED WITH chronic obstructive pulmonary disease (ortholog); COVID-19 (ortholog); neurodegenerative disease (ortholog); FOUND IN apical part of cell (ortholog); endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog) | | | | Black Rat | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18907264 | Mgst1 | microsomal glutathione S-transferase 1 | ENCODES a protein that exhibits glutathione binding (ortholog); glutathione peroxidase activity (ortholog); glutathione transferase activity (ortholog); INVOLVED IN cellular response to lipid hydroperoxide (ortholog); glutathione metabolic process (ortholog); glutathione transport (ortholog); ASSOCI ATED WITH chronic obstructive pulmonary disease (ortholog); COVID-19 (ortholog); neurodegenerative disease (ortholog); FOUND IN apical part of cell (ortholog); endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog) | | | | Naked Mole-Rat | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14013617 | MGST1 | microsomal glutathione S-transferase 1 | ENCODES a protein that exhibits glutathione binding (ortholog); glutathione transferase activity (ortholog); identical protein binding (ortholog); INVOLVED IN glutathione metabolic process (ortholog); Leydig cell differentiation (ortholog); response to lipopolysaccharide (ortholog); ASSOCIATED WITH chronic obstructive pulmonary disease (ortholog); COVID-19 (ortholog); neurodegenerative disease (ortholog); FOUND IN apical part of cell (ortholog); endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 32 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18576379 | MGST1 | microsomal glutathione S-transferase 1 | ENCODES a protein that exhibits glutathione binding (ortholog); glutathione transferase activity (ortholog); identical protein binding (ortholog); INVOLVED IN glutathione metabolic process (ortholog); Leydig cell differentiation (ortholog); response to lipopolysaccharide (ortholog); ASSOCIATED WITH chronic obstructive pulmonary disease (ortholog); COVID-19 (ortholog); neurodegenerative disease (ortholog); FOUND IN apical part of cell (ortholog); endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog) | | | | Green Monkey | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155254225 | mgst1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 69032 | PTGES | prostaglandin E synthase | The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induc ed apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses. [provided by RefSeq, Jul 2008] | 9 | 129738349 | 129753042 | Human | 373 | old_gene_name , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |