| 619883 | Mark3 | microtubule affinity regulating kinase 3 | ENCODES a protein that exhibits protein phosphatase binding (ortholog); protein serine/threonine kinase activity (ortholog); tau-protein kinase activity (ortholog); INVOLVED IN negative regulation of hippo signaling (ortholog); negative regulation of protein localization to nucleus (ortholog); prote in phosphorylation (ortholog); ASSOCIATED WITH visual impairment and progressive phthisis bulbi (ortholog); FOUND IN cytoplasm (ortholog); dendrite (ortholog); plasma membrane (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene | 6 | 136447327 | 136537409 | Rat | 140 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1353156 | MARK3 | microtubule affinity regulating kinase 3 | The protein encoded by this gene is activated by phosphorylation and in turn is involved in the phosphorylation of tau proteins MAP2 and MAP4. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] | 14 | 103385415 | 103503831 | Human | 159 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1622386 | Mark3 | MAP/microtubule affinity regulating kinase 3 | Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in several processes, including negative regulation of hippo signaling; negative regulation of protein localization to nucleus; and peptidyl-serine autophosphorylation. Predicted to be located in dendrite. Predict ed to be active in cytoplasm and plasma membrane. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system gland; liver; and retina. Human ortholog(s) of this gene implicated in visual impairment and progressive phthisis bulbi. Orthologous to human MARK3 (microtubule affinity regulating kinase 3). [provided by Alliance of Genome Resources, Apr 2025] | 12 | 111540929 | 111622661 | Mouse | 142 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8929249 | Mark3 | microtubule affinity regulating kinase 3 | ENCODES a protein that exhibits protein phosphatase binding (ortholog); protein serine/threonine kinase activity (ortholog); tau-protein kinase activity (ortholog); INVOLVED IN negative regulation of hippo signaling (ortholog); negative regulation of protein localization to nucleus (ortholog); prote in phosphorylation (ortholog); ASSOCIATED WITH visual impairment and progressive phthisis bulbi (ortholog); FOUND IN cytoplasm (ortholog); dendrite (ortholog); plasma membrane (ortholog) | NW_004955538 | 2273221 | 2370204 | Chinchilla | 36 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11688638 | MARK3 | microtubule affinity regulating kinase 3 | ENCODES a protein that exhibits ATP binding (inferred); kinase activity (inferred); metal ion binding (inferred); INVOLVED IN protein phosphorylation (ortholog); ASSOCIATED WITH visual impairment and progressive phthisis bulbi (ortholog); FOUND IN cell projection (inferred); cytoplasm (inferred); de ndrite (inferred) | 14 | 84012076 | 84130136 | Bonobo | 61 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12312579 | MARK3 | microtubule affinity regulating kinase 3 | ENCODES a protein that exhibits ATP binding (inferred); kinase activity (inferred); nucleotide binding (inferred); INVOLVED IN protein phosphorylation (ortholog); ASSOCIATED WITH visual impairment and progressive phthisis bulbi (ortholog); FOUND IN cell projection (inferred); cytoplasm (inferred); d endrite (inferred) | 8 | 71148263 | 71269717 | Dog | 56 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12616898 | Mark3 | microtubule affinity regulating kinase 3 | ENCODES a protein that exhibits ATP binding (inferred); kinase activity (inferred); nucleotide binding (inferred); INVOLVED IN protein phosphorylation (ortholog); ASSOCIATED WITH visual impairment and progressive phthisis bulbi (ortholog); FOUND IN cytoplasm (inferred); dendrite (inferred); plasma m embrane (inferred) | NW_004936621 | 1627846 | 1733041 | Squirrel | 57 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18556868 | MARK3 | microtubule affinity regulating kinase 3 | ENCODES a protein that exhibits ATP binding (inferred); kinase activity (inferred); nucleotide binding (inferred); INVOLVED IN protein phosphorylation (ortholog); ASSOCIATED WITH visual impairment and progressive phthisis bulbi (ortholog); FOUND IN cytoplasm (inferred); dendrite (inferred); plasma m embrane (inferred) | | | | Green Monkey | 56 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155233963 | mark3 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625995190 | Mark3 | microtubule affinity regulating kinase 3 | ENCODES a protein that exhibits protein phosphatase binding (ortholog); protein serine/threonine kinase activity (ortholog); tau-protein kinase activity (ortholog); INVOLVED IN negative regulation of hippo signaling (ortholog); negative regulation of protein localization to nucleus (ortholog); prote in phosphorylation (ortholog); ASSOCIATED WITH visual impairment and progressive phthisis bulbi (ortholog); FOUND IN cytoplasm (ortholog); dendrite (ortholog); plasma membrane (ortholog) | | | | Black Rat | 36 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14076540 | MARK3 | microtubule affinity regulating kinase 3 | ENCODES a protein that exhibits ATP binding (inferred); kinase activity (inferred); metal ion binding (inferred); INVOLVED IN protein phosphorylation (ortholog); ASSOCIATED WITH visual impairment and progressive phthisis bulbi (ortholog); FOUND IN cell projection (inferred); cytoplasm (inferred); de ndrite (inferred) | | | | Pig | 58 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18932431 | Mark3 | microtubule affinity regulating kinase 3 | ENCODES a protein that exhibits protein phosphatase binding (ortholog); INVOLVED IN negative regulation of hippo signaling (ortholog); negative regulation of protein localization to nucleus (ortholog); protein phosphorylation (ortholog); ASSOCIATED WITH visual impairment and progressive phthisis bul bi (ortholog); FOUND IN cell projection (inferred); cytoplasm (inferred); dendrite (inferred) | | | | Naked Mole-Rat | 53 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155233962 | mark3.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405857933 | mark3.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405857950 | mark3.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 626188459 | mark3.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405865647 | mark3.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405859922 | mark3.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 7497887 | Mark3-ps1 | microtubule affinity regulating kinase 3, pseudogene 1 | | 1 | 80613227 | 80614794 | Rat | | symbol , PhenoGen | gene, ncrna, MODEL [RefSeq] |
| 8552023 | MARK3P1 | microtubule affinity regulating kinase 3 pseudogene 1 | | 12 | 46681991 | 46682734 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 8552134 | MARK3P2 | microtubule affinity regulating kinase 3 pseudogene 2 | | 3 | 12857314 | 12858686 | Human | | symbol , GTEx , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 8551958 | MARK3P3 | microtubule affinity regulating kinase 3 pseudogene 3 | | 3 | 128847693 | 128849411 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 12321818 | EIF5 | eukaryotic translation initiation factor 5 | ENCODES a protein that exhibits eukaryotic initiation factor eIF2 binding (ortholog); translation initiation factor activity (ortholog); INVOLVED IN activation of GTPase activity (ortholog); formation of translation preinitiation complex (ortholog); PARTICIPATES IN translation initiation pathway; AS SOCIATED WITH schizophrenia (ortholog); FOUND IN nucleus (ortholog) | 8 | 71102628 | 71111971 | Dog | 46 | ensembl_gene_symbol | gene, protein-coding, MODEL [RefSeq] |