Mark3 (MAP/microtubule affinity regulating kinase 3) - Rat Genome Database

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Gene: Mark3 (MAP/microtubule affinity regulating kinase 3) Mus musculus
Analyze
Symbol: Mark3
Name: MAP/microtubule affinity regulating kinase 3
RGD ID: 1622386
MGI Page MGI
Description: Predicted to enable protein serine/threonine kinase activity and tau-protein kinase activity. Predicted to be involved in intracellular signal transduction; negative regulation of hippo signaling; and negative regulation of protein localization to nucleus. Predicted to act upstream of or within phosphorylation. Predicted to be located in dendrite. Predicted to be active in cytoplasm and plasma membrane. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system gland; liver; and retina. Human ortholog(s) of this gene implicated in visual impairment and progressive phthisis bulbi. Orthologous to human MARK3 (microtubule affinity regulating kinase 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1600015G02Rik; A430080F22Rik; C-TAK; C-TAK1; ELKL motif kinase 2; EMK-2; Emk2; EMK2/MARK3 serine-threonine protein kinase; ETK-1; ETK1; KIAA4230; MAP/microtubule affinity-regulating kinase 3; MPK-10; MPK10
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912111,540,929 - 111,622,661 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12111,540,957 - 111,622,655 (+)EnsemblGRCm39 Ensembl
GRCm3812111,574,505 - 111,656,227 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12111,574,523 - 111,656,221 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712112,812,721 - 112,894,438 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612112,022,777 - 112,104,031 (+)NCBIMGSCv36mm8
Celera12112,768,826 - 112,852,637 (+)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1261.05NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cell projection  (IEA)
cytoplasm  (IBA,ISO)
dendrite  (ISO)
membrane  (IEA)
plasma membrane  (IBA,ISO)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mouse MP Annotation Import Pipeline RGD automated import pipeline
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1281307   PMID:2466296   PMID:3291115   PMID:8346215   PMID:8889548   PMID:9543386   PMID:10349636   PMID:10512203   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851  
PMID:11741534   PMID:12466851   PMID:12477932   PMID:12520002   PMID:12693553   PMID:14610273   PMID:15226823   PMID:15489334   PMID:15782199   PMID:15840001   PMID:16141072   PMID:16141073  
PMID:16944949   PMID:16959763   PMID:17075132   PMID:17302994   PMID:18227155   PMID:18454193   PMID:18562307   PMID:18799693   PMID:19436707   PMID:20214879   PMID:20733003   PMID:21267068  
PMID:21873635   PMID:22615585   PMID:27866947   PMID:28087714   PMID:28106071   PMID:31636950   PMID:32325033   PMID:32581705   PMID:33792563   PMID:38187761  


Genomics

Comparative Map Data
Mark3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912111,540,929 - 111,622,661 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12111,540,957 - 111,622,655 (+)EnsemblGRCm39 Ensembl
GRCm3812111,574,505 - 111,656,227 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12111,574,523 - 111,656,221 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712112,812,721 - 112,894,438 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612112,022,777 - 112,104,031 (+)NCBIMGSCv36mm8
Celera12112,768,826 - 112,852,637 (+)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1261.05NCBI
MARK3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3814103,385,415 - 103,503,831 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl14103,385,377 - 103,503,831 (+)EnsemblGRCh38hg38GRCh38
GRCh3714103,851,752 - 103,970,168 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3614102,921,524 - 103,039,921 (+)NCBINCBI36Build 36hg18NCBI36
Build 3414102,921,523 - 103,039,917NCBI
Celera1483,905,890 - 84,024,379 (+)NCBICelera
Cytogenetic Map14q32.32-q32.33NCBI
HuRef1484,029,889 - 84,148,541 (+)NCBIHuRef
CHM1_114103,789,889 - 103,908,361 (+)NCBICHM1_1
T2T-CHM13v2.01497,621,350 - 97,739,863 (+)NCBIT2T-CHM13v2.0
Mark3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86136,447,327 - 136,537,409 (+)NCBIGRCr8
mRatBN7.26130,626,612 - 130,716,245 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6130,627,482 - 130,716,647 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6130,794,704 - 130,882,984 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06131,090,690 - 131,178,967 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06130,457,578 - 130,545,967 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06136,040,957 - 136,129,780 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6136,041,777 - 136,129,661 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06144,286,952 - 144,375,010 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46136,348,832 - 136,438,667 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16136,355,018 - 136,444,854 (+)NCBI
Celera6128,183,127 - 128,271,232 (+)NCBICelera
Cytogenetic Map6q32NCBI
Mark3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555382,273,221 - 2,371,154 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555382,273,221 - 2,370,204 (+)NCBIChiLan1.0ChiLan1.0
MARK3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v215104,544,746 - 104,663,152 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan114103,761,598 - 103,879,656 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01484,012,076 - 84,130,136 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.114103,823,900 - 103,941,529 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl14103,823,900 - 103,941,529 (+)Ensemblpanpan1.1panPan2
MARK3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1871,148,263 - 71,269,717 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl871,102,690 - 71,270,399 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha870,659,869 - 70,780,993 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0871,424,060 - 71,545,499 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl871,424,234 - 71,545,424 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1871,113,816 - 71,234,630 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0871,153,195 - 71,274,345 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0871,552,492 - 71,673,590 (+)NCBIUU_Cfam_GSD_1.0
Mark3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244086402,798,889 - 2,904,084 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366211,627,431 - 1,733,047 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366211,627,846 - 1,733,041 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MARK3
(Sus scrofa - pig)		 No map positions available.
MARK3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12481,364,316 - 81,452,115 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2481,364,361 - 81,455,070 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605368,632,588 - 68,747,799 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mark3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247341,362,263 - 1,469,930 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mark3
2501 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:322
Count of miRNA genes:138
Interacting mature miRNAs:149
Transcripts:ENSMUST00000075281, ENSMUST00000084953
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226793Feml10_mfemur length 10, 5 week (mouse)1268346774113363620Mouse
4141610Tailaq1_mtail length adjusted QTL 1 (mouse)Not determined80956708113383533Mouse
4142401Egq10_mearly growth QTL 10 (mouse)Not determined80956708113383533Mouse
4141335W6q10_mweight 6 weeks QTL 10 (mouse)Not determined80956708113383533Mouse
39128213Lwq23_mliver weight QTL 10 (mouse)1280956708113383533Mouse
13524849Ppiq11a_mprepulse inhibition QTL 11a (mouse)1280989143114989143Mouse
13524846Ppiq11_mprepulse inhibition QTL 11 (mouse)1282666396116666396Mouse
1301492Dbsty3_mdiabesity 3 (mouse)Not determined1283532075117532224Mouse
1301879Insq10_minsulin QTL 10 (mouse)Not determined1283532075117532224Mouse
1300883Ath21_matherosclerosis 21 (mouse)Not determined1285961579119961683Mouse
10412156Nociq3_mnociceptive sensitivity inflammatory QTL 3 (mouse)Not determined1286396075114831653Mouse
4142007Chlq17_mcirculating hormone level QTL 17 (mouse)Not determined1288052874120092757Mouse
1300545Lifespan3_mlife span 3 (mouse)Not determined1288052874120092757Mouse
1301308Prdt4_mprion disease incubation time 4 (mouse)Not determined1288308354120092757Mouse
5491194Mobq3_mmultigenic obesity QTL 3 (mouse)Not determined1289664071120092757Mouse
1301836Heal5_mwound healing/regeneration 5 (mouse)Not determined1289939031120092757Mouse
1301922Bbaa6_mB.burgdorferi-associated arthritis 6 (mouse)Not determined1290308268120092757Mouse
10402491Dipa4_mdrug induced psychomotor activation 4 (mouse)Not determined1291222515120092757Mouse
12910532Nrq10a_mnoise-induced hearing loss resistant QTL 10a (mouse)1292750025120092757Mouse
12910533Nrq10_mnoise-induced hearing loss resistant QTL 10 (mouse)1292750025120092757Mouse
1357463Vtbt14_mvertebral trabecular bone trait 14 (mouse)Not determined1292936097120092757Mouse
1300973Abmm_mantibody mediated myocarditis (mouse)Not determined1293264461120092757Mouse
1302177Dps2_mdelta power in slow-wave sleep 2 (mouse)Not determined1294146064120092757Mouse
1302138Im6_mimmunoregulatory 6 (mouse)Not determined1296860337120092757Mouse
1301269Sluc12_msusceptibility to lung cancer 12 (mouse)Not determined1296860337120092757Mouse
10412075Nils1_mneointima lesion size 1 (mouse)Not determined12102024665120092757Mouse
4141297Plyid_mPolymeric IgA dominance (mouse)Not determined109183385115885122Mouse
1558957Igan4_mIgA nephropathy 4 (mouse)Not determined12109750025119024949Mouse

Markers in Region
UniSTS:236952  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3812111,634,227 - 111,634,464UniSTSGRCm38
MGSCv3712112,872,438 - 112,872,675UniSTSGRCm37
Celera12112,829,060 - 112,829,297UniSTS
Cytogenetic Map12F1UniSTS
UniSTS:236957  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3812111,605,028 - 111,605,289UniSTSGRCm38
MGSCv3712112,843,239 - 112,843,500UniSTSGRCm37
Cytogenetic Map12F1UniSTS
Mark3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12F1UniSTS
cM Map12 UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001370744 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001370745 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_021516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_022801 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006515511 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006515512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006515513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006515514 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006515517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006515518 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006515519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011244006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011244007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030246567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030246568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036157203 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036157204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036157205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036157206 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036157207 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036157208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_003949991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC160972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC163357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF240782 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF240783 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH011175 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI850379 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK002654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK040245 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK049500 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK075742 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK083683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK132247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK137671 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK166157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK182780 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK194849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK214464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK217056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK220557 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AV275316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC026445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC066071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA575239 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466549 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CX566304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF410124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L10913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X57244 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000075281   ⟹   ENSMUSP00000074757
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12111,540,957 - 111,622,652 (+)Ensembl
GRCm38.p6 Ensembl12111,574,523 - 111,656,218 (+)Ensembl
RefSeq Acc Id: ENSMUST00000084953   ⟹   ENSMUSP00000082017
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12111,540,961 - 111,622,655 (+)Ensembl
GRCm38.p6 Ensembl12111,574,527 - 111,656,221 (+)Ensembl
RefSeq Acc Id: ENSMUST00000221009
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12111,589,695 - 111,591,535 (+)Ensembl
GRCm38.p6 Ensembl12111,623,261 - 111,625,101 (+)Ensembl
RefSeq Acc Id: ENSMUST00000221390
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12111,570,945 - 111,582,084 (+)Ensembl
GRCm38.p6 Ensembl12111,604,511 - 111,615,650 (+)Ensembl
RefSeq Acc Id: ENSMUST00000221448   ⟹   ENSMUSP00000152377
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12111,541,448 - 111,593,586 (+)Ensembl
GRCm38.p6 Ensembl12111,575,014 - 111,627,152 (+)Ensembl
RefSeq Acc Id: ENSMUST00000221459   ⟹   ENSMUSP00000152483
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12111,541,485 - 111,622,594 (+)Ensembl
GRCm38.p6 Ensembl12111,575,051 - 111,656,160 (+)Ensembl
RefSeq Acc Id: ENSMUST00000221631
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12111,554,584 - 111,594,851 (+)Ensembl
GRCm38.p6 Ensembl12111,588,150 - 111,628,417 (+)Ensembl
RefSeq Acc Id: ENSMUST00000221753   ⟹   ENSMUSP00000152727
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12111,541,485 - 111,622,049 (+)Ensembl
GRCm38.p6 Ensembl12111,575,051 - 111,655,615 (+)Ensembl
RefSeq Acc Id: ENSMUST00000221841
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12111,621,093 - 111,622,128 (+)Ensembl
GRCm38.p6 Ensembl12111,654,659 - 111,655,694 (+)Ensembl
RefSeq Acc Id: ENSMUST00000221923
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12111,590,943 - 111,594,860 (+)Ensembl
GRCm38.p6 Ensembl12111,624,509 - 111,628,426 (+)Ensembl
RefSeq Acc Id: ENSMUST00000222080
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12111,540,970 - 111,622,655 (+)Ensembl
GRCm38.p6 Ensembl12111,574,536 - 111,656,221 (+)Ensembl
RefSeq Acc Id: ENSMUST00000222870   ⟹   ENSMUSP00000152833
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12111,570,945 - 111,593,668 (+)Ensembl
GRCm38.p6 Ensembl12111,604,511 - 111,627,234 (+)Ensembl
RefSeq Acc Id: NM_001370744   ⟹   NP_001357673
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912111,540,955 - 111,622,657 (+)NCBI
GRCm3812111,574,521 - 111,656,223 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001370745   ⟹   NP_001357674
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912111,540,955 - 111,622,657 (+)NCBI
GRCm3812111,574,521 - 111,656,223 (+)NCBI
Sequence:
RefSeq Acc Id: NM_021516   ⟹   NP_067491
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912111,540,944 - 111,622,661 (+)NCBI
GRCm3812111,574,510 - 111,656,227 (+)NCBI
MGSCv3712112,812,721 - 112,894,438 (+)RGD
Celera12112,768,826 - 112,852,637 (+)RGD
cM Map12 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_022801   ⟹   NP_073712
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912111,540,944 - 111,622,661 (+)NCBI
GRCm3812111,574,510 - 111,656,227 (+)NCBI
MGSCv3712112,812,721 - 112,894,438 (+)RGD
Celera12112,768,826 - 112,852,637 (+)RGD
cM Map12 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006515511   ⟹   XP_006515574
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912111,541,367 - 111,622,657 (+)NCBI
GRCm3812111,574,926 - 111,656,223 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006515512   ⟹   XP_006515575
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912111,541,367 - 111,622,657 (+)NCBI
GRCm3812111,574,926 - 111,656,223 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006515513   ⟹   XP_006515576
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912111,541,367 - 111,622,657 (+)NCBI
GRCm3812111,574,926 - 111,656,223 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006515514   ⟹   XP_006515577
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912111,541,367 - 111,622,657 (+)NCBI
GRCm3812111,574,926 - 111,656,223 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006515517   ⟹   XP_006515580
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912111,540,955 - 111,622,250 (+)NCBI
GRCm3812111,574,529 - 111,656,223 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006515518   ⟹   XP_006515581
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912111,540,963 - 111,622,250 (+)NCBI
GRCm3812111,574,529 - 111,656,223 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006515519   ⟹   XP_006515582
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912111,541,367 - 111,622,657 (+)NCBI
GRCm3812111,574,926 - 111,656,223 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011244006   ⟹   XP_011242308
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912111,541,367 - 111,622,657 (+)NCBI
GRCm3812111,574,926 - 111,656,223 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011244007   ⟹   XP_011242309
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912111,541,367 - 111,622,657 (+)NCBI
GRCm3812111,574,926 - 111,656,223 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030246567   ⟹   XP_030102427
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912111,540,955 - 111,622,657 (+)NCBI
GRCm3812111,574,529 - 111,656,223 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030246568   ⟹   XP_030102428
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912111,540,961 - 111,622,250 (+)NCBI
GRCm3812111,574,879 - 111,656,223 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036157203   ⟹   XP_036013096
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912111,541,367 - 111,622,657 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036157204   ⟹   XP_036013097
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912111,540,981 - 111,622,251 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036157205   ⟹   XP_036013098
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912111,540,963 - 111,622,657 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036157206   ⟹   XP_036013099
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912111,541,367 - 111,622,657 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036157207   ⟹   XP_036013100
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912111,540,992 - 111,622,250 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036157208   ⟹   XP_036013101
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912111,541,367 - 111,622,657 (+)NCBI
Sequence:
RefSeq Acc Id: XR_003949991
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912111,540,929 - 111,622,657 (+)NCBI
GRCm3812111,574,505 - 111,656,223 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001357673 (Get FASTA)   NCBI Sequence Viewer  
  NP_001357674 (Get FASTA)   NCBI Sequence Viewer  
  NP_067491 (Get FASTA)   NCBI Sequence Viewer  
  NP_073712 (Get FASTA)   NCBI Sequence Viewer  
  XP_006515574 (Get FASTA)   NCBI Sequence Viewer  
  XP_006515575 (Get FASTA)   NCBI Sequence Viewer  
  XP_006515576 (Get FASTA)   NCBI Sequence Viewer  
  XP_006515577 (Get FASTA)   NCBI Sequence Viewer  
  XP_006515580 (Get FASTA)   NCBI Sequence Viewer  
  XP_006515581 (Get FASTA)   NCBI Sequence Viewer  
  XP_006515582 (Get FASTA)   NCBI Sequence Viewer  
  XP_011242308 (Get FASTA)   NCBI Sequence Viewer  
  XP_011242309 (Get FASTA)   NCBI Sequence Viewer  
  XP_030102427 (Get FASTA)   NCBI Sequence Viewer  
  XP_030102428 (Get FASTA)   NCBI Sequence Viewer  
  XP_036013096 (Get FASTA)   NCBI Sequence Viewer  
  XP_036013097 (Get FASTA)   NCBI Sequence Viewer  
  XP_036013098 (Get FASTA)   NCBI Sequence Viewer  
  XP_036013099 (Get FASTA)   NCBI Sequence Viewer  
  XP_036013100 (Get FASTA)   NCBI Sequence Viewer  
  XP_036013101 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF64455 (Get FASTA)   NCBI Sequence Viewer  
  AAF64456 (Get FASTA)   NCBI Sequence Viewer  
  AAH26445 (Get FASTA)   NCBI Sequence Viewer  
  AAL18865 (Get FASTA)   NCBI Sequence Viewer  
  BAB22261 (Get FASTA)   NCBI Sequence Viewer  
  BAC35922 (Get FASTA)   NCBI Sequence Viewer  
  BAD90540 (Get FASTA)   NCBI Sequence Viewer  
  BAE21056 (Get FASTA)   NCBI Sequence Viewer  
  BAE38602 (Get FASTA)   NCBI Sequence Viewer  
  CAA40520 (Get FASTA)   NCBI Sequence Viewer  
  EDL18623 (Get FASTA)   NCBI Sequence Viewer  
  EDL18624 (Get FASTA)   NCBI Sequence Viewer  
  EDL18625 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000074757
  ENSMUSP00000074757.7
  ENSMUSP00000082017
  ENSMUSP00000082017.6
  ENSMUSP00000152377.2
  ENSMUSP00000152483
  ENSMUSP00000152483.2
  ENSMUSP00000152727
  ENSMUSP00000152727.2
  ENSMUSP00000152833.2
GenBank Protein Q03141 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_067491   ⟸   NM_021516
- Peptide Label: isoform 1
- UniProtKB: Q9JKE5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_073712   ⟸   NM_022801
- Peptide Label: isoform 2
- UniProtKB: Q9JKE5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006515574   ⟸   XM_006515511
- Peptide Label: isoform X1
- UniProtKB: Q9JKE5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006515575   ⟸   XM_006515512
- Peptide Label: isoform X2
- UniProtKB: A0A1Y7VNZ6 (UniProtKB/TrEMBL),   Q9JKE5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006515577   ⟸   XM_006515514
- Peptide Label: isoform X4
- UniProtKB: Q9JKE5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006515576   ⟸   XM_006515513
- Peptide Label: isoform X3
- UniProtKB: Q9JKE5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006515580   ⟸   XM_006515517
- Peptide Label: isoform X6
- UniProtKB: Q9JKE5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006515581   ⟸   XM_006515518
- Peptide Label: isoform X8
- UniProtKB: Q9JKE5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006515582   ⟸   XM_006515519
- Peptide Label: isoform X11
- Sequence:
RefSeq Acc Id: XP_011242308   ⟸   XM_011244006
- Peptide Label: isoform X14
- Sequence:
RefSeq Acc Id: XP_011242309   ⟸   XM_011244007
- Peptide Label: isoform X15
- Sequence:
RefSeq Acc Id: NP_001357673   ⟸   NM_001370744
- Peptide Label: isoform 3
- UniProtKB: Q8R375 (UniProtKB/Swiss-Prot),   Q8C6G9 (UniProtKB/Swiss-Prot),   Q3V1U3 (UniProtKB/Swiss-Prot),   Q3TM40 (UniProtKB/Swiss-Prot),   Q03141 (UniProtKB/Swiss-Prot),   Q9JKE4 (UniProtKB/Swiss-Prot),   Q9JKE5 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001357674   ⟸   NM_001370745
- Peptide Label: isoform 4
RefSeq Acc Id: XP_030102427   ⟸   XM_030246567
- Peptide Label: isoform X7
- UniProtKB: Q9JKE5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_030102428   ⟸   XM_030246568
- Peptide Label: isoform X12
RefSeq Acc Id: ENSMUSP00000152833   ⟸   ENSMUST00000222870
RefSeq Acc Id: ENSMUSP00000082017   ⟸   ENSMUST00000084953
RefSeq Acc Id: ENSMUSP00000074757   ⟸   ENSMUST00000075281
RefSeq Acc Id: ENSMUSP00000152483   ⟸   ENSMUST00000221459
RefSeq Acc Id: ENSMUSP00000152377   ⟸   ENSMUST00000221448
RefSeq Acc Id: ENSMUSP00000152727   ⟸   ENSMUST00000221753
RefSeq Acc Id: XP_036013098   ⟸   XM_036157205
- Peptide Label: isoform X10
- UniProtKB: Q9JKE5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_036013097   ⟸   XM_036157204
- Peptide Label: isoform X9
- UniProtKB: Q9JKE5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_036013100   ⟸   XM_036157207
- Peptide Label: isoform X13
RefSeq Acc Id: XP_036013101   ⟸   XM_036157208
- Peptide Label: isoform X14
RefSeq Acc Id: XP_036013096   ⟸   XM_036157203
- Peptide Label: isoform X5
- UniProtKB: Q9JKE5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_036013099   ⟸   XM_036157206
- Peptide Label: isoform X11
Protein Domains
KA1   Protein kinase   UBA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q03141-F1-model_v2 AlphaFold Q03141 1-753 view protein structure

Promoters
RGD ID:8679338
Promoter ID:EPDNEW_M17700
Type:initiation region
Name:Mark3_1
Description:Mus musculus MAP/microtubule affinity regulating kinase 3 , transcriptvariant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3812111,574,521 - 111,574,581EPDNEW
RGD ID:6822573
Promoter ID:MM_KWN:12834
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:AK048965_2810029C07RIK,   ENSMUST00000007555,   LINCRNA_262,   NM_021516,   NM_022801,   UC007PDJ.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3612112,812,616 - 112,813,462 (-)MPROMDB
RGD ID:6823143
Promoter ID:MM_KWN:12835
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   Brain,   Kidney,   Lung,   MEF_B6
Transcripts:UC007PDM.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3612112,865,681 - 112,866,181 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1341865 AgrOrtholog
Ensembl Genes ENSMUSG00000007411 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000075281 ENTREZGENE
  ENSMUST00000075281.8 UniProtKB/Swiss-Prot
  ENSMUST00000084953 ENTREZGENE
  ENSMUST00000084953.13 UniProtKB/Swiss-Prot
  ENSMUST00000221448.2 UniProtKB/TrEMBL
  ENSMUST00000221459 ENTREZGENE
  ENSMUST00000221459.2 UniProtKB/Swiss-Prot
  ENSMUST00000221753 ENTREZGENE
  ENSMUST00000221753.2 UniProtKB/TrEMBL
  ENSMUST00000222870.2 UniProtKB/TrEMBL
Gene3D-CATH DNA helicase RuvA subunit, C-terminal domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase associated domain 1, KA1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro KA1/Ssp2_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KA1_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MARK1-4_cat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:17169 UniProtKB/Swiss-Prot
MGD MGI:1341865 ENTREZGENE
NCBI Gene 17169 ENTREZGENE
PANTHER MAP/MICROTUBULE AFFINITY-REGULATING KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR24346:SF1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam KA1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mark3 PhenoGen
PROSITE KA1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF103243 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1Y7VJB1_MOUSE UniProtKB/TrEMBL
  A0A1Y7VK86_MOUSE UniProtKB/TrEMBL
  A0A1Y7VNZ6 ENTREZGENE, UniProtKB/TrEMBL
  MARK3_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3TM40 ENTREZGENE
  Q3V1U3 ENTREZGENE
  Q5DTG3_MOUSE UniProtKB/TrEMBL
  Q8C6G9 ENTREZGENE
  Q8R375 ENTREZGENE
  Q9CW99_MOUSE UniProtKB/TrEMBL
  Q9JKE4 ENTREZGENE
  Q9JKE5 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q3TM40 UniProtKB/Swiss-Prot
  Q3V1U3 UniProtKB/Swiss-Prot
  Q8C6G9 UniProtKB/Swiss-Prot
  Q8R375 UniProtKB/Swiss-Prot
  Q9JKE4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-05-26 Mark3  MAP/microtubule affinity regulating kinase 3    MAP/microtubule affinity-regulating kinase 3  Symbol and/or name change 5135510 APPROVED