| 708483 | Mark2 | microtubule affinity regulating kinase 2 | ENCODES a protein that exhibits protein serine/threonine kinase activity; tau protein binding; tau-protein kinase activity; INVOLVED IN axon development; establishment or maintenance of cell polarity regulating cell shape; neuron migration; PARTICIPATES IN Notch signaling pathway; ASSOCIATED WITH ad enoid cystic carcinoma (ortholog); autism spectrum disorder (ortholog); autistic disorder (ortholog); FOUND IN glutamatergic synapse; membrane; actin filament (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene | 1 | 213890213 | 213955417 | Rat | 190 | symbol , old_gene_name , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1344457 | MARK2 | microtubule affinity regulating kinase 2 | This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating pro teins. The protein localizes to cell membranes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009] | 11 | 63839110 | 63911020 | Human | 290 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1551063 | Mark2 | MAP/microtubule affinity regulating kinase 2 | Predicted to enable several functions, including ATP binding activity; magnesium ion binding activity; and tau protein binding activity. Predicted to be involved in several processes, including generation of neurons; protein phosphorylation; and regulation of neuron projection development. Located i n basal cortex and nucleus. Is active in glutamatergic synapse and postsynapse. Is expressed in brain; early conceptus; and oocyte. Orthologous to human MARK2 (microtubule affinity regulating kinase 2). [provided by Alliance of Genome Resources, Apr 2025] | 19 | 7252761 | 7319222 | Mouse | 258 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8932970 | Mark2 | microtubule affinity regulating kinase 2 | ENCODES a protein that exhibits ATP binding (ortholog); magnesium ion binding (ortholog); protein serine/threonine kinase activity (ortholog); INVOLVED IN axon development (ortholog); establishment of cell polarity (ortholog); establishment or maintenance of cell polarity regulating cell shape (orth olog); PARTICIPATES IN Notch signaling pathway; ASSOCIATED WITH adenoid cystic carcinoma (ortholog); autism spectrum disorder (ortholog); autistic disorder (ortholog); FOUND IN actin filament (ortholog); basal cortex (ortholog); cytoplasm (ortholog) | NW_004955422 | 21112162 | 21176506 | Chinchilla | 65 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 11717879 | MARK2 | microtubule affinity regulating kinase 2 | ENCODES a protein that exhibits protein serine/threonine kinase activity (ortholog); tau protein binding (ortholog); INVOLVED IN axon development (ortholog); establishment or maintenance of cell polarity regulating cell shape (ortholog); neuron migration (ortholog); PARTICIPATES IN Notch signaling p athway; ASSOCIATED WITH adenoid cystic carcinoma (ortholog); autism spectrum disorder (ortholog); autistic disorder (ortholog); FOUND IN basal cortex (ortholog); glutamatergic synapse (ortholog); nucleus (ortholog) | 11 | 59195852 | 59268391 | Bonobo | 88 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12183384 | MARK2 | microtubule affinity regulating kinase 2 | ENCODES a protein that exhibits protein serine/threonine kinase activity (ortholog); tau protein binding (ortholog); INVOLVED IN axon development (ortholog); establishment or maintenance of cell polarity regulating cell shape (ortholog); neuron migration (ortholog); PARTICIPATES IN Notch signaling p athway; ASSOCIATED WITH adenoid cystic carcinoma (ortholog); autism spectrum disorder (ortholog); autistic disorder (ortholog); FOUND IN basal cortex (ortholog); glutamatergic synapse (ortholog); nucleus (ortholog) | 18 | 53101635 | 53125636 | Dog | 84 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12447118 | Mark2 | microtubule affinity regulating kinase 2 | ENCODES a protein that exhibits protein serine/threonine kinase activity (ortholog); tau protein binding (ortholog); INVOLVED IN axon development (ortholog); establishment or maintenance of cell polarity regulating cell shape (ortholog); neuron migration (ortholog); PARTICIPATES IN Notch signaling p athway; ASSOCIATED WITH adenoid cystic carcinoma (ortholog); autism spectrum disorder (ortholog); autistic disorder (ortholog); FOUND IN basal cortex (ortholog); glutamatergic synapse (ortholog); nucleus (ortholog) | NW_004936599 | 5226603 | 5287677 | Squirrel | 85 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 14267394 | MARK2 | microtubule affinity regulating kinase 2 | ENCODES a protein that exhibits protein serine/threonine kinase activity (ortholog); tau protein binding (ortholog); INVOLVED IN axon development (ortholog); establishment or maintenance of cell polarity regulating cell shape (ortholog); neuron migration (ortholog); PARTICIPATES IN Notch signaling p athway; ASSOCIATED WITH adenoid cystic carcinoma (ortholog); autism spectrum disorder (ortholog); autistic disorder (ortholog); FOUND IN basal cortex (ortholog); glutamatergic synapse (ortholog); nucleus (ortholog) | | | | Pig | 84 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18546853 | MARK2 | microtubule affinity regulating kinase 2 | ENCODES a protein that exhibits protein serine/threonine kinase activity (ortholog); tau protein binding (ortholog); INVOLVED IN axon development (ortholog); establishment or maintenance of cell polarity regulating cell shape (ortholog); neuron migration (ortholog); PARTICIPATES IN Notch signaling p athway; ASSOCIATED WITH adenoid cystic carcinoma (ortholog); autism spectrum disorder (ortholog); autistic disorder (ortholog); FOUND IN basal cortex (ortholog); glutamatergic synapse (ortholog); nucleus (ortholog) | | | | Green Monkey | 87 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18921328 | Mark2 | microtubule affinity regulating kinase 2 | ENCODES a protein that exhibits magnesium ion binding (ortholog); protein serine/threonine kinase activity (ortholog); tau protein binding (ortholog); INVOLVED IN axon development (ortholog); establishment of cell polarity (ortholog); establishment or maintenance of cell polarity regulating cell sha pe (ortholog); PARTICIPATES IN Notch signaling pathway; ASSOCIATED WITH adenoid cystic carcinoma (ortholog); autism spectrum disorder (ortholog); autistic disorder (ortholog); FOUND IN actin filament (ortholog); basal cortex (ortholog); cytosol (ortholog) | | | | Naked Mole-Rat | 81 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 155239421 | mark2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625939172 | Mark2 | microtubule affinity regulating kinase 2 | ENCODES a protein that exhibits ATP binding (ortholog); magnesium ion binding (ortholog); protein serine/threonine kinase activity (ortholog); INVOLVED IN axon development (ortholog); establishment of cell polarity (ortholog); establishment or maintenance of cell polarity regulating cell shape (orth olog); PARTICIPATES IN Notch signaling pathway; ASSOCIATED WITH adenoid cystic carcinoma (ortholog); autism spectrum disorder (ortholog); autistic disorder (ortholog); FOUND IN actin filament (ortholog); basal cortex (ortholog); cytoplasm (ortholog) | | | | Black Rat | 65 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 155241410 | mark2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155233684 | mark2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 5130576 | MARK2P1 | MARK2 pseudogene 1 | | 3 | 9854905 | 9855532 | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 5130575 | MARK2P2 | MARK2 pseudogene 2 | | 3 | 10012384 | 10013133 | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 5130574 | MARK2P3 | MARK2 pseudogene 3 | | 3 | 129334530 | 129335305 | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 5130579 | MARK2P4 | MARK2 pseudogene 4 | | 4 | 176012028 | 176014524 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 5130580 | MARK2P5 | MARK2 pseudogene 5 | | 5 | 15384231 | 15384860 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 5130577 | MARK2P6 | MARK2 pseudogene 6 | | 3 | 128851620 | 128853008 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 5130573 | MARK2P7 | MARK2 pseudogene 7 | | 7 | 36146834 | 36148025 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 5130578 | MARK2P8 | MARK2 pseudogene 8 | | 3 | 128748156 | 128749482 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 5130474 | MARK2P9 | MARK2 pseudogene 9 | INTERACTS WITH aristolochic acid A; arsenite(3-) | 10 | 92418661 | 92419606 | Human | 2 | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, VALIDATED [RefSeq] |
| 5130473 | MARK2P10 | MARK2 pseudogene 10 | | 7 | 96858164 | 96859671 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 5488960 | MARK2P11 | MARK2 pseudogene 11 | INTERACTS WITH sodium arsenite | 5 | 157984644 | 157989984 | Human | 1 | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 5130572 | MARK2P12 | MARK2 pseudogene 12 | | 13 | 73407789 | 73408325 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 6770541 | MARK2P13 | MARK2 pseudogene 13 | | 7 | 36109024 | 36110872 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 7174997 | MARK2P14 | MARK2 pseudogene 14 | | 3 | 11906572 | 11913429 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 7256147 | MARK2P15 | MARK2 pseudogene 15 | | 10 | 83312369 | 83314451 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 7241608 | MARK2P16 | MARK2 pseudogene 16 | | 10 | 89838776 | 89839341 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 8552162 | MARK2P17 | MARK2 pseudogene 17 | | 3 | 128842753 | 128844368 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 16552410 | MARK2P18 | MARK2 pseudogene 18 | | 6 | 669080 | 670307 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 16565666 | MARK2P19 | MARK2 pseudogene 19 | | 3 | 129345410 | 129346129 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 38606438 | MARK2P20 | MARK2 pseudogene 20 | | 3 | 11905181 | 11906306 | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 2298831 | MARK2P21 | MARK2 pseudogene 21 | | 19 | 7004953 | 7006415 | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, pseudo, VALIDATED [RefSeq] |
| 18930610 | LOC101702844 | serine/threonine-protein kinase MARK2-like | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 40912303 | LOC119871452 | serine/threonine-protein kinase MARK2-like | | | | | Dog | | name | gene, pseudo, MODEL [RefSeq] |
| 329870534 | LOC130540554 | serine/threonine-protein kinase MARK2-like | | | | | Bonobo | | name | gene, protein-coding, MODEL [RefSeq] |
| 18932123 | LOC106010479 | serine/threonine-protein kinase MARK2 pseudogene | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 13974028 | LOC110259282 | serine/threonine-protein kinase MARK2 pseudogene | | | | | Pig | | name | gene, pseudo, MODEL [RefSeq] |
| 16565250 | AC025278.2 | MAP/microtubule affinity-regulating kinase (MARK2) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16565849 | AC010200.1 | MAP/microtubule affinity-regulating kinase 2 (MARK2) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16565954 | AL078624.1 | MAP/microtubule affinity-regulating kinase 2 (MARK2) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 1595145 | LOC685303 | similar to Serine/threonine-protein kinase MARK2 (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog) | | | | | Rat | | name | gene, protein-coding |
| 1564986 | 4932415M13Rikl | RIKEN cDNA 4932415M13 gene like | ENCODES a protein that exhibits ATP binding (inferred); kinase activity (inferred); nucleotide binding (inferred) | 9 | 6944600 | 6966705 | Rat | 10 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 2307699 | Gm4513 | predicted gene 4513 | Predicted to be involved in intracellular signal transduction and microtubule cytoskeleton organization. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2025] | 7 | 20326897 | 20332946 | Mouse | 4 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 2307645 | Gm4565 | predicted gene 4565 | ENCODES a protein that exhibits ATP binding (inferred); kinase activity (inferred); nucleotide binding (inferred) | 7 | 22281504 | 22287552 | Mouse | 10 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 7733938 | LOC102549716 | high mobility group protein B1-like | | 17 | 15045186 | 15131044 | Rat | | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 1614181 | Mark1-ps1 | MAP/microtubule affinity regulating kinase 1, pseudogene 1 | | 17 | 54250756 | 54259880 | Mouse | | old_gene_name | gene, pseudo, INFERRED [RefSeq] |
| 7497887 | Mark3-ps1 | microtubule affinity regulating kinase 3, pseudogene 1 | | 1 | 80613227 | 80614794 | Rat | | old_gene_name | gene, ncrna, MODEL [RefSeq] |