MARK2 (microtubule affinity regulating kinase 2) - Rat Genome Database
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Gene: MARK2 (microtubule affinity regulating kinase 2) Pan paniscus
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Symbol: MARK2
Name: microtubule affinity regulating kinase 2
RGD ID: 11717879
Description: ENCODES a protein that exhibits ATP binding (ortholog); magnesium ion binding (ortholog); protein N-terminus binding (ortholog); INVOLVED IN axon development (ortholog); establishment of cell polarity (ortholog); establishment or maintenance of cell polarity regulating cell shape (ortholog); PARTICIPATES IN Notch signaling pathway; ASSOCIATED WITH adenoid cystic carcinoma (ortholog); high grade glioma (ortholog); Salivary Gland Neoplasms (ortholog); FOUND IN actin filament (ortholog); basal cortex (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: serine/threonine-protein kinase MARK2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11162,546,455 - 62,618,772 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1162,546,455 - 62,618,772 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01159,195,852 - 59,268,391 (+)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
MARK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11162,546,455 - 62,618,772 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1162,546,455 - 62,618,772 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01159,195,852 - 59,268,391 (+)NCBIMhudiblu_PPA_v0panPan3
MARK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1163,838,928 - 63,911,020 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1163,838,928 - 63,911,019 (+)EnsemblGRCh38hg38GRCh38
GRCh381163,838,955 - 63,911,020 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371163,606,582 - 63,678,492 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361163,363,471 - 63,433,633 (+)NCBINCBI36hg18NCBI36
Build 341163,412,650 - 63,433,628NCBI
Celera1160,932,277 - 61,004,686 (+)NCBI
Cytogenetic Map11q13.1NCBI
HuRef1159,934,874 - 60,007,522 (+)NCBIHuRef
CHM1_11163,489,428 - 63,561,505 (+)NCBICHM1_1
Mark2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39197,252,761 - 7,319,225 (-)NCBIGRCm39mm39
GRCm39 Ensembl197,252,761 - 7,319,225 (-)Ensembl
GRCm38197,275,396 - 7,341,860 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl197,275,396 - 7,341,860 (-)EnsemblGRCm38mm10GRCm38
MGSCv37197,349,886 - 7,416,334 (-)NCBIGRCm37mm9NCBIm37
MGSCv36197,343,797 - 7,408,360 (-)NCBImm8
Celera197,047,289 - 7,113,772 (-)NCBICelera
Cytogenetic Map19ANCBI
cM Map195.32NCBI
Mark2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21204,461,029 - 204,526,247 (-)NCBI
Rnor_6.0 Ensembl1222,525,990 - 222,590,220 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01222,525,547 - 222,590,727 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01229,514,726 - 229,578,616 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41209,958,902 - 210,022,099 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11210,117,331 - 210,180,529 (-)NCBI
Celera1201,995,334 - 202,058,517 (-)NCBICelera
Cytogenetic Map1q43NCBI
Mark2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542221,109,940 - 21,176,500 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542221,112,162 - 21,176,506 (-)NCBIChiLan1.0ChiLan1.0
MARK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1853,101,624 - 53,151,561 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11853,101,635 - 53,125,636 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Mark2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365995,226,603 - 5,287,677 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MARK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl28,155,321 - 8,215,706 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.128,153,870 - 8,216,141 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.227,335,901 - 7,364,681 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MARK2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1110,336,690 - 10,410,539 (-)NCBI
ChlSab1.1 Ensembl110,336,639 - 10,409,951 (-)Ensembl
Mark2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476722,346,467 - 22,419,325 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000042423   ⟹   ENSPPAP00000019653
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1162,546,455 - 62,618,772 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000042435   ⟹   ENSPPAP00000019665
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1162,546,455 - 62,618,772 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000042438   ⟹   ENSPPAP00000019668
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1162,546,455 - 62,618,772 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000042467   ⟹   ENSPPAP00000019697
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1162,546,460 - 62,618,772 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000042471   ⟹   ENSPPAP00000019700
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1162,595,964 - 62,618,772 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000042494   ⟹   ENSPPAP00000019720
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1162,602,859 - 62,616,989 (+)Ensembl
RefSeq Acc Id: XM_003828538   ⟹   XP_003828586
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.11162,546,455 - 62,618,772 (+)NCBI
Mhudiblu_PPA_v01159,196,380 - 59,266,967 (+)NCBI
Sequence:
RefSeq Acc Id: XM_003828539   ⟹   XP_003828587
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.11162,595,961 - 62,618,772 (+)NCBI
Mhudiblu_PPA_v01159,245,499 - 59,266,967 (+)NCBI
Sequence:
RefSeq Acc Id: XM_003828540   ⟹   XP_003828588
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.11162,546,455 - 62,618,772 (+)NCBI
Mhudiblu_PPA_v01159,196,365 - 59,266,967 (+)NCBI
Sequence:
RefSeq Acc Id: XM_003828541   ⟹   XP_003828589
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.11162,546,460 - 62,618,772 (+)NCBI
Mhudiblu_PPA_v01159,195,852 - 59,268,391 (+)NCBI
Sequence:
RefSeq Acc Id: XM_003828542   ⟹   XP_003828590
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.11162,546,455 - 62,618,772 (+)NCBI
Mhudiblu_PPA_v01159,196,198 - 59,266,967 (+)NCBI
Sequence:
RefSeq Acc Id: XM_034932844   ⟹   XP_034788735
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v01159,196,401 - 59,268,391 (+)NCBI
RefSeq Acc Id: XM_034932845   ⟹   XP_034788736
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v01159,196,401 - 59,268,391 (+)NCBI
RefSeq Acc Id: XM_034932846   ⟹   XP_034788737
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v01159,196,401 - 59,266,607 (+)NCBI
RefSeq Acc Id: XM_034932847   ⟹   XP_034788738
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v01159,196,401 - 59,268,391 (+)NCBI
RefSeq Acc Id: XM_034932848   ⟹   XP_034788739
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v01159,196,401 - 59,268,391 (+)NCBI
RefSeq Acc Id: XM_034932849   ⟹   XP_034788740
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v01159,196,401 - 59,268,391 (+)NCBI
RefSeq Acc Id: XM_034932850   ⟹   XP_034788741
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v01159,196,401 - 59,266,607 (+)NCBI
Reference Sequences
RefSeq Acc Id: XP_003828590   ⟸   XM_003828542
- Peptide Label: isoform X11
- Sequence:
RefSeq Acc Id: XP_003828586   ⟸   XM_003828538
- Peptide Label: isoform X10
- Sequence:
RefSeq Acc Id: XP_003828588   ⟸   XM_003828540
- Peptide Label: isoform X12
- Sequence:
RefSeq Acc Id: XP_003828589   ⟸   XM_003828541
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_003828587   ⟸   XM_003828539
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_034788738   ⟸   XM_034932847
- Peptide Label: isoform X5
RefSeq Acc Id: XP_034788736   ⟸   XM_034932845
- Peptide Label: isoform X3
RefSeq Acc Id: XP_034788739   ⟸   XM_034932848
- Peptide Label: isoform X6
RefSeq Acc Id: XP_034788740   ⟸   XM_034932849
- Peptide Label: isoform X8
RefSeq Acc Id: XP_034788735   ⟸   XM_034932844
- Peptide Label: isoform X2
RefSeq Acc Id: XP_034788737   ⟸   XM_034932846
- Peptide Label: isoform X4
RefSeq Acc Id: XP_034788741   ⟸   XM_034932850
- Peptide Label: isoform X9
RefSeq Acc Id: ENSPPAP00000019697   ⟸   ENSPPAT00000042467
RefSeq Acc Id: ENSPPAP00000019700   ⟸   ENSPPAT00000042471
RefSeq Acc Id: ENSPPAP00000019720   ⟸   ENSPPAT00000042494
RefSeq Acc Id: ENSPPAP00000019653   ⟸   ENSPPAT00000042423
RefSeq Acc Id: ENSPPAP00000019665   ⟸   ENSPPAT00000042435
RefSeq Acc Id: ENSPPAP00000019668   ⟸   ENSPPAT00000042438
Protein Domains
KA1   Protein kinase   UBA


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000032968 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000019653 ENTREZGENE, UniProtKB/TrEMBL
  ENSPPAP00000019665 ENTREZGENE, UniProtKB/TrEMBL
  ENSPPAP00000019668 ENTREZGENE, UniProtKB/TrEMBL
  ENSPPAP00000019697 ENTREZGENE, UniProtKB/TrEMBL
  ENSPPAP00000019700 UniProtKB/TrEMBL
  ENSPPAP00000019720 UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000042423 UniProtKB/TrEMBL
  ENSPPAT00000042435 UniProtKB/TrEMBL
  ENSPPAT00000042438 UniProtKB/TrEMBL
  ENSPPAT00000042467 UniProtKB/TrEMBL
  ENSPPAT00000042471 UniProtKB/TrEMBL
  ENSPPAT00000042494 UniProtKB/TrEMBL
InterPro KA1/Ssp2_C UniProtKB/TrEMBL
  KA1_dom UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
  UBA UniProtKB/TrEMBL
KEGG Report pps:100980135 UniProtKB/TrEMBL
NCBI Gene MARK2 ENTREZGENE
Pfam KA1 UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
  UBA UniProtKB/TrEMBL
PROSITE KA1 UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
  UBA UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
  UBA UniProtKB/TrEMBL
Superfamily-SCOP SSF103243 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A2R9AQR7_PANPA UniProtKB/TrEMBL
  A0A2R9AR61_PANPA UniProtKB/TrEMBL
  A0A2R9AR77_PANPA UniProtKB/TrEMBL
  A0A2R9AV64_PANPA UniProtKB/TrEMBL
  A0A2R9AV99_PANPA UniProtKB/TrEMBL
  A0A2R9AVB7_PANPA UniProtKB/TrEMBL