| 1349062 | MARCO | macrophage receptor with collagenous structure | The protein encoded by this gene is a member of the class A scavenger receptor family and is part of the innate antimicrobial immune system. The protein may bind both Gram-negative and Gram-positive bacteria via an extracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain. In additio n to short cytoplasmic and transmembrane domains, there is an extracellular spacer domain and a long, extracellular collagenous domain. The protein may form a trimeric molecule by the association of the collagenous domains of three identical polypeptide chains. [provided by RefSeq, Jul 2008] | 2 | 118942194 | 118994660 | Human | 147 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1558468 | Marco | macrophage receptor with collagenous structure | Predicted to enable amyloid-beta binding activity and cargo receptor activity. Predicted to be an extracellular matrix structural constituent conferring tensile strength. Acts upstream of or within apoptotic cell clearance. Predicted to be located in cytoplasm and plasma membrane. Predicted to be pa rt of collagen trimer. Predicted to be active in basement membrane and extracellular space. Is expressed in spleen. Human ortholog(s) of this gene implicated in pulmonary tuberculosis. Orthologous to human MARCO (macrophage receptor with collagenous structure). [provided by Alliance of Genome Resources, Apr 2025] | 1 | 120402267 | 120432753 | Mouse | 159 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1589662 | Marco | macrophage receptor with collagenous structure | ENCODES a protein that exhibits amyloid-beta binding; cargo receptor activity; G protein-coupled receptor binding; INVOLVED IN adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; amyloid-beta clearance; phagocytosis, engulfment; PARTICIPATES IN phagocytosis pathway; ASSOCIATED WITH meningococcal meningitis; Pneumococcal Meningitis; silicosis; FOUND IN cytoplasm; plasma membrane; INTERACTS WITH 17beta-estradiol; acetamide; aflatoxin B1 | 13 | 34169011 | 34210340 | Rat | 131 | symbol , old_gene_name , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 8794413 | Marco | macrophage receptor with collagenous structure | ENCODES a protein that exhibits amyloid-beta binding (ortholog); cargo receptor activity (ortholog); G protein-coupled receptor binding (ortholog); INVOLVED IN adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (ortholog); amyloid-beta clearance (ortholog); apoptotic cell clea rance (ortholog); ASSOCIATED WITH Bacterial Lung Diseases (ortholog); Clostridium Infections (ortholog); COVID-19 (ortholog); FOUND IN cytoplasm (ortholog); plasma membrane (ortholog) | NW_004955459 | 10700645 | 10739222 | Chinchilla | 27 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 11733289 | MARCO | macrophage receptor with collagenous structure | ENCODES a protein that exhibits amyloid-beta binding (ortholog); cargo receptor activity (ortholog); INVOLVED IN adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (ortholog); amyloid-beta clearance (ortholog); apoptotic cell clearance (ortholog); ASSOCIATED WITH Bacterial Lun g Diseases (ortholog); Clostridium Infections (ortholog); COVID-19 (ortholog); FOUND IN cytoplasm (ortholog); plasma membrane (ortholog) | 2B | 5896433 | 5940284 | Bonobo | 30 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12108127 | MARCO | macrophage receptor with collagenous structure | ENCODES a protein that exhibits amyloid-beta binding (ortholog); cargo receptor activity (ortholog); INVOLVED IN adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (ortholog); amyloid-beta clearance (ortholog); apoptotic cell clearance (ortholog); ASSOCIATED WITH Bacterial Lun g Diseases (ortholog); Clostridium Infections (ortholog); COVID-19 (ortholog); FOUND IN cytoplasm (ortholog); plasma membrane (ortholog) | 19 | 30996209 | 31034520 | Dog | 29 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12595668 | Marco | macrophage receptor with collagenous structure | ENCODES a protein that exhibits amyloid-beta binding (ortholog); cargo receptor activity (ortholog); G protein-coupled receptor binding (ortholog); INVOLVED IN adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (ortholog); amyloid-beta clearance (ortholog); apoptotic cell clea rance (ortholog); ASSOCIATED WITH Bacterial Lung Diseases (ortholog); Clostridium Infections (ortholog); COVID-19 (ortholog); FOUND IN cytoplasm (ortholog); plasma membrane (ortholog) | NW_004936469 | 51323746 | 51366551 | Squirrel | 27 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 625861769 | Marco | macrophage receptor with collagenous structure | ENCODES a protein that exhibits amyloid-beta binding (ortholog); cargo receptor activity (ortholog); G protein-coupled receptor binding (ortholog); INVOLVED IN adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (ortholog); amyloid-beta clearance (ortholog); apoptotic cell clea rance (ortholog); ASSOCIATED WITH Bacterial Lung Diseases (ortholog); Clostridium Infections (ortholog); COVID-19 (ortholog); FOUND IN cytoplasm (ortholog); plasma membrane (ortholog) | | | | Black Rat | 27 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 626182297 | marco | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18921987 | Marco | macrophage receptor with collagenous structure | ENCODES a protein that exhibits amyloid-beta binding (ortholog); cargo receptor activity (ortholog); G protein-coupled receptor binding (ortholog); INVOLVED IN adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (ortholog); amyloid-beta clearance (ortholog); apoptotic cell clea rance (ortholog); ASSOCIATED WITH Bacterial Lung Diseases (ortholog); Clostridium Infections (ortholog); COVID-19 (ortholog); FOUND IN cytoplasm (ortholog); plasma membrane (ortholog) | | | | Naked Mole-Rat | 33 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18552290 | MARCO | macrophage receptor with collagenous structure | ENCODES a protein that exhibits amyloid-beta binding (ortholog); cargo receptor activity (ortholog); INVOLVED IN adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (ortholog); amyloid-beta clearance (ortholog); apoptotic cell clearance (ortholog); ASSOCIATED WITH Bacterial Lun g Diseases (ortholog); Clostridium Infections (ortholog); COVID-19 (ortholog); FOUND IN cytoplasm (ortholog); plasma membrane (ortholog) | | | | Green Monkey | 32 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 14087617 | MARCO | macrophage receptor with collagenous structure | ENCODES a protein that exhibits amyloid-beta binding (ortholog); cargo receptor activity (ortholog); INVOLVED IN adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (ortholog); amyloid-beta clearance (ortholog); apoptotic cell clearance (ortholog); ASSOCIATED WITH Bacterial Lun g Diseases (ortholog); Clostridium Infections (ortholog); COVID-19 (ortholog); FOUND IN cytoplasm (ortholog); plasma membrane (ortholog) | | | | Pig | 31 | symbol , old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 616940428 | MARCO-AS1 | MARCO antisense RNA 1 | | | | | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, ncrna |
| 12194023 | MARCOL | MARCO like | ENCODES a protein that exhibits peptidase inhibitor activity (inferred); FOUND IN extracellular region (inferred) | 2 | 42451622 | 42460240 | Dog | 2 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 13208776 | MARCOL | MARCO like | Predicted to be located in endoplasmic reticulum lumen. [provided by Alliance of Genome Resources, Jul 2025] | 5 | 148238525 | 148243580 | Human | 3 | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 15000761 | Marcol | MARCO like | Orthologous to human MARCOL (MARCO like). [provided by Alliance of Genome Resources, Jul 2025] | 18 | 44249330 | 44256212 | Mouse | 2 | symbol , old_gene_name , PhenoGen , name , description | gene, protein-coding, MODEL [RefSeq] |
| 32726428 | MARCOL | MARCO like | | 5 | 143667663 | 143674943 | Bonobo | | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 41001054 | Marcol | MARCO like | INTERACTS WITH Licochalcone B (ortholog); sulforaphane (ortholog) | 18 | 36699606 | 36706063 | Rat | 2 | symbol , old_gene_name , PhenoGen , name | gene, protein-coding, MODEL [RefSeq] |
| 153003059 | MARCOL | MARCO like | | | | | Pig | | symbol , name | gene, protein-coding |
| 625870879 | Marcol | MARCO like | | | | | Black Rat | | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 124926845 | Marcol | MARCO like | | | | | Squirrel | | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18920252 | Marcol | MARCO like | | | | | Naked Mole-Rat | | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 40896183 | MARCOL | MARCO like | | | | | Green Monkey | | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 16562014 | AC013457.1 | novel transcript, antisense to MARCO | | | | | Human | | name | gene, lncrna |