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Gene: Marco (macrophage receptor with collagenous structure) Chinchilla lanigera

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Symbol:

Marco

Name:

macrophage receptor with collagenous structure

RGD ID:

8794413

Description:

ENCODES a protein that exhibits amyloid-beta binding (ortholog); cargo receptor activity (ortholog); G protein-coupled receptor binding (ortholog); INVOLVED IN adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (ortholog); amyloid-beta clearance (ortholog); apoptotic cell clearance (ortholog); ASSOCIATED WITH Bacterial Lung Diseases (ortholog); Clostridium Infections (ortholog); COVID-19 (ortholog); FOUND IN cytoplasm (ortholog); plasma membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

macrophage receptor MARCO

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955459	10,698,294 - 10,739,131 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955459	10,700,645 - 10,739,222 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Bacterial Lung Diseases (ISO)

Clostridium Infections (ISO)

COVID-19 (ISO)

cryptococcosis (ISO)

diabetes mellitus (ISO)

hepatocellular carcinoma (ISO)

influenza A (ISO)

meningococcal meningitis (ISO)

Pneumococcal Meningitis (ISO)

pulmonary tuberculosis (ISO)

silicosis (ISO)

Streptococcus pneumonia (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (ISO)

amyloid-beta clearance (ISO)

apoptotic cell clearance (ISO)

endocytosis (ISO)

phagocytosis, engulfment (ISO)

positive regulation of ERK1 and ERK2 cascade (ISO)

receptor-mediated endocytosis (ISO)

Cellular Component

cytoplasm (ISO)

plasma membrane (ISO)

Molecular Function

amyloid-beta binding (ISO)

cargo receptor activity (ISO)

G protein-coupled receptor binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074

Genomics

Comparative Map Data

Marco
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955459	10,698,294 - 10,739,131 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955459	10,700,645 - 10,739,222 (-)	NCBI	ChiLan1.0	ChiLan1.0

MARCO
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	118,942,194 - 118,994,660 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	118,942,194 - 118,994,660 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	119,699,770 - 119,752,236 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	119,416,215 - 119,468,706 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	119,415,974 - 119,468,467	NCBI
Celera	2	113,024,535 - 113,078,253 (+)	NCBI		Celera
Cytogenetic Map	2	q14.2	NCBI
HuRef	2	112,024,650 - 112,076,879 (+)	NCBI		HuRef
CHM1_1	2	119,703,356 - 119,755,847 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	119,375,479 - 119,427,929 (+)	NCBI		T2T-CHM13v2.0

Marco
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	120,402,267 - 120,432,753 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	120,402,267 - 120,432,753 (-)	Ensembl		GRCm39 Ensembl
GRCm38	1	120,474,538 - 120,505,024 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	120,474,538 - 120,505,024 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	122,371,115 - 122,401,661 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	122,302,084 - 122,332,630 (-)	NCBI		MGSCv36	mm8
Celera	1	123,137,568 - 123,168,212 (-)	NCBI		Celera
Cytogenetic Map	1	E2.3	NCBI
cM Map	1	52.71	NCBI

Marco
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	34,169,011 - 34,210,340 (-)	NCBI		GRCr8
mRatBN7.2	13	31,616,278 - 31,648,521 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	31,616,278 - 31,648,521 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	34,183,224 - 34,215,428 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	35,471,075 - 35,503,279 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	32,745,488 - 32,777,692 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	85,115,199 - 85,147,683 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	85,115,201 - 85,135,859 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	84,555,641 - 84,587,281 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	13	31,497,203 - 31,529,354 (-)	NCBI		Celera
Cytogenetic Map	13	q11	NCBI

MARCO
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	13	20,962,321 - 21,006,160 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2B	20,977,294 - 21,021,133 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	5,896,433 - 5,940,284 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	119,475,704 - 119,519,918 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	119,475,677 - 119,520,385 (+)	Ensembl	panpan1.1		panPan2

MARCO
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	19	30,996,209 - 31,034,520 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	19	30,996,347 - 31,034,487 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	19	31,260,569 - 31,305,455 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	19	32,381,105 - 32,426,221 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	19	32,381,113 - 32,419,679 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	19	31,067,312 - 31,112,187 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	19	31,233,786 - 31,278,688 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	19	32,420,649 - 32,465,527 (-)	NCBI		UU_Cfam_GSD_1.0

Marco
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	90,251,204 - 90,294,071 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936469	51,323,746 - 51,366,551 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MARCO
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	24,503,108 - 24,541,283 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	24,502,935 - 24,541,286 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	28,139,421 - 28,177,787 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MARCO
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	11,329,036 - 11,389,428 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	10	11,329,026 - 11,388,999 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666061	11,291,422 - 11,352,136 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Marco
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624732	26,203,219 - 26,236,057 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624732	26,203,345 - 26,236,001 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_013521033	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01048195	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDI01136092	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000005424 ⟹ ENSCLAP00000005328

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955459	10,698,294 - 10,739,131 (-)	Ensembl

Ensembl Acc Id:

ENSCLAT00000005425 ⟹ ENSCLAP00000005329

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955459	10,698,294 - 10,739,131 (-)	Ensembl

RefSeq Acc Id:

XM_013521033 ⟹ XP_013376487

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955459	10,700,645 - 10,739,222 (-)	NCBI

Sequence:

show sequence

ACGAACCACAGCAGTGAAGTGGGAATGAGTGGTTCCCCTTCGGGAACAATTTTGCTGGCTCCAG
GGCTTCGGCCACCTATAAAGCTTAGCAATGGAAAGTAATGTAACCCTCAAAGAGGAAGAGTTCT
TGGGGAGCACTGAAGGAGCAACTTTCGACCAAACCATGATGCCAGTAATGGAGAGCTTCGAAAT
CAATGATTTGAAACCCAGGAAGAAAAATGGGGTGAACTTCATCATGACTACAGTGATCATCATC
TACCTGATTCTGCTCACAGCAGCTGCTGTGCTGCTGGAGTTCCAAGTCCAGGAACTGCAGTGGC
GGCTCCAGATCCTGGAGACATACAACTGCTCCAATGAAACGTTTGCTCTTCCGGAAAAGTCCTT
CTCCTTCCTGCGCTTGGCACATCCAGTGCACAAGGCTCAGAGCGCACTGAGGCTGCAAGACCTA
CAGGCCCAGATCACGGAAGTCCAAGCCAGACAGGAGCACATGTTGCAGCGGGTGGAGGACTTCA
CTCGCAATGCAGAGTTACACGGGATCAAAGGTGAACAAGGCGCCCCAGGTCCAAAGGGAACCGC
CGGTGTGCCTGGAAGGCCAGGCGAGAAGGGAGACAAGGGGGCAGTGGGACCGGCTGGAAGCCCA
GGTCTCCTGGGACTCCAAGGCCCACCAGGCAGGAAGGGAGATCCCGGCCTCCAAGGACCCAAGG
GTGTGCCCGGGGAGCAAGGAGCTGCTGGCATAGCAGGACCTCAAGGGGAGAAAGGCAGCAAAGG
CGACGGAGGTTTCATTGGCCCCAAAGGGGAAACTGGTGCGAAGGGAGATAAAGGGGACCTGGGC
CACCCAGGGAGCAAAGGGAACATGGGCATGAAGGGAGACACAGGGGTCATGGGGCCCCCCGGGC
CCCAGGGGAGCAAAGGTGACTCAGGGAAGCCAGGTCTACCAGGTGTCGCTGGATCTCCTGGAGC
CAAAGGTGATCGAGGACAAGCTGGAGCGCCAGGTGTTCCAGGCCCTCCCGGAGCAGCAGGACCT
TTGGGGCCCAAGGGTGAACGTGGCAGCCCTGGCACGGCTGGAGTAGCAGGAGCACCGGGTAGAC
CTGGGGATCGAGGACCTGAGGGCGTGAAAGGAAGCAAGGGTGATCCAGGAATGCAAGGACAAAA
GGGAACAAAAGGAGAATCAGGAGTCCCAGGATCGGTGGGAGCAAAAGGAGAAAGGGGAATCCCC
GGGCTGGTAGGCTCCCAAGGAGCACCTGGAGCAGTCGGCCAGAAGGGAGACCAAGGAGAGAAAG
GATCTTCTGGGCAGAAAGGAGAAAAGGGAGTGAAAGGAGAAAGAGGTGAAAAAGGCTCATATGC
CTCATCCGTCAGGATCGTCGGCAGTAGTGCTAGAGGCCGGGCTGAAGTTTACTATGAAAACATC
TGGGGGACGATTTGTGATGATGGCTGGGATAACTCTGATGCCACTGTCTTCTGCCGCATGCTGG
GTTACAGCAGGGGAAAAGCACTTGGCTCTTACGGAGGTGGCACTGGGAAGATCTGGCTGGATGA
TGTTGCTTGCCAGGGGTCTGAGTCTACCCTGTGGAGCTGCAACAAGAGCGCCTGGGGATCTCAC
AACTGTGGCCACAGCGAGGATGCCGGCGTGGAGTGCAGCTGATCTCGAAACCCTGAAGTCACCA
CTCTGTCGCCAAGATGGCCTTGGGCTCACACACACGTGGGAAGGAAAGGACTCTGTGAAGGTTC
CCTGGAACTGGCTGAGCAGGTGCTGGAGGTCATTAATAAAAATCAAAGTGCCGCCAGGCAGCAT
CACTG

hide sequence

Protein Sequences


Protein RefSeqs	XP_013376487	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000005328.1
	ENSCLAP00000005329
	ENSCLAP00000005329.1

RefSeq Acc Id:

XP_013376487 ⟸ XM_013521033

- UniProtKB:

A0A8C2UZ97 (UniProtKB/TrEMBL), A0A8C2UU93 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MESNVTLKEEEFLGSTEGATFDQTMMPVMESFEINDLKPRKKNGVNFIMTTVIIIYLILLTAAA
VLLEFQVQELQWRLQILETYNCSNETFALPEKSFSFLRLAHPVHKAQSALRLQDLQAQITEVQA
RQEHMLQRVEDFTRNAELHGIKGEQGAPGPKGTAGVPGRPGEKGDKGAVGPAGSPGLLGLQGPP
GRKGDPGLQGPKGVPGEQGAAGIAGPQGEKGSKGDGGFIGPKGETGAKGDKGDLGHPGSKGNMG
MKGDTGVMGPPGPQGSKGDSGKPGLPGVAGSPGAKGDRGQAGAPGVPGPPGAAGPLGPKGERGS
PGTAGVAGAPGRPGDRGPEGVKGSKGDPGMQGQKGTKGESGVPGSVGAKGERGIPGLVGSQGAP
GAVGQKGDQGEKGSSGQKGEKGVKGERGEKGSYASSVRIVGSSARGRAEVYYENIWGTICDDGW
DNSDATVFCRMLGYSRGKALGSYGGGTGKIWLDDVACQGSESTLWSCNKSAWGSHNCGHSEDAG
VECS

hide sequence

Ensembl Acc Id:

ENSCLAP00000005329 ⟸ ENSCLAT00000005425

Ensembl Acc Id:

ENSCLAP00000005328 ⟸ ENSCLAT00000005424

Protein Domains

SRCR

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000003783	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000005424.1	UniProtKB/TrEMBL
	ENSCLAT00000005425	ENTREZGENE
	ENSCLAT00000005425.1	UniProtKB/TrEMBL
Gene3D-CATH	3.10.250.10	UniProtKB/TrEMBL
InterPro	Collagen	UniProtKB/TrEMBL
	Collagen_Structural_Proteins	UniProtKB/TrEMBL
	Collagen_superfamily	UniProtKB/TrEMBL
	SRCR	UniProtKB/TrEMBL
	SRCR-like_dom	UniProtKB/TrEMBL
	SRCR-like_dom_sf	UniProtKB/TrEMBL
NCBI Gene	Marco	ENTREZGENE
PANTHER	COLLAGEN ALPHA	UniProtKB/TrEMBL
	MACROPHAGE RECEPTOR MARCO	UniProtKB/TrEMBL
	PTHR37456:SF5	UniProtKB/TrEMBL
	SI:CH211-266K2.1	UniProtKB/TrEMBL
Pfam	Collagen	UniProtKB/TrEMBL
	SRCR	UniProtKB/TrEMBL
PRINTS	SPERACTRCPTR	UniProtKB/TrEMBL
PROSITE	SRCR_1	UniProtKB/TrEMBL
	SRCR_2	UniProtKB/TrEMBL
SMART	SM00202	UniProtKB/TrEMBL
Superfamily-SCOP	SSF56487	UniProtKB/TrEMBL
UniProt	A0A8C2UU93	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C2UZ97	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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