Lpin1 Gene Search Result

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16 records found for search term Lpin1

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RGD ID	Symbol	Name	Description	Chr	Start	Stop	Species	Annotations	Match	Type
1307646	Lpin1	lipin 1	ENCODES a protein that exhibits histone deacetylase binding (ortholog); peroxisome proliferator activated receptor binding (ortholog); phosphatidate phosphatase activity (ortholog); INVOLVED IN animal organ regeneration; cellular response to insulin stimulus; negative regulation of myelination; PART ... (more) ICIPATES IN mTOR signaling pathway; ASSOCIATED WITH abnormal sciatic nerve morphology; dysmyelination; increased cell proliferation; ASSOCIATED WITH Cachexia; end stage renal disease; Experimental Diabetes Mellitus; FOUND IN cytoplasm (ortholog); cytosol (ortholog); endoplasmic reticulum (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene	6	45039110	45145845	Rat	306	symbol , old_gene_name , PhenoGen	gene, protein-coding, VALIDATED [RefSeq]
1316957	LPIN1	lipin 1	This gene encodes a magnesium-ion-dependent phosphatidic acid phosphohydrolase enzyme that catalyzes the penultimate step in triglyceride synthesis including the dephosphorylation of phosphatidic acid to yield diacylglycerol. Expression of this gene is required for adipocyte differentiation and it a ... (more) lso functions as a nuclear transcriptional coactivator with some peroxisome proliferator-activated receptors to modulate expression of other genes involved in lipid metabolism. Mutations in this gene are associated with metabolic syndrome, type 2 diabetes, acute recurrent rhabdomyolysis, and autosomal recessive acute recurrent myoglobinuria (ARARM). This gene is also a candidate for several human lipodystrophy syndromes. [provided by RefSeq, Mar 2017]	2	11677544	11827409	Human	373	symbol , old_gene_name , COSMIC , Human Proteome Map	gene, protein-coding, REVIEWED [RefSeq]
1316958	Lpin1	lipin 1	Enables several functions, including histone deacetylase binding activity; peroxisome proliferator activated receptor binding activity; and phosphatidate phosphatase activity. Involved in several processes, including mitochondrial fission; positive regulation of metabolic process; and triglyceride m ... (more) etabolic process. Acts upstream of or within several processes, including cellular response to insulin stimulus; regulation of fat cell differentiation; and ruffle organization. Located in endoplasmic reticulum; mitochondrial outer membrane; and nuclear membrane. Part of transcription regulator complex. Is active in endoplasmic reticulum membrane. Is expressed in liver; nervous system; olfactory epithelium; and tooth. Used to study lipodystrophy. Orthologous to human LPIN1 (lipin 1). [provided by Alliance of Genome Resources, Jul 2025]	12	16585670	16697020	Mouse	440	symbol , old_gene_name , PhenoGen , description	gene, protein-coding, VALIDATED [RefSeq]
9067969	Lpin1	lipin 1	ENCODES a protein that exhibits histone deacetylase binding (ortholog); peroxisome proliferator activated receptor binding (ortholog); phosphatidate phosphatase activity (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); animal organ regeneration (ortholog); cellular response to ins ... (more) ulin stimulus (ortholog); PARTICIPATES IN mTOR signaling pathway; ASSOCIATED WITH Acute Recurrent Myoglobinuria, Autosomal Recessive (ortholog); Cachexia (ortholog); end stage renal disease (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); endoplasmic reticulum (ortholog)	NW_004955487	6139188	6207316	Chinchilla	54	symbol , old_gene_name	gene, protein-coding, MODEL [RefSeq]
11976128	LPIN1	lipin 1	ENCODES a protein that exhibits histone deacetylase binding (ortholog); peroxisome proliferator activated receptor binding (ortholog); RNA polymerase II-specific DNA-binding transcription factor binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); animal organ regeneration (or ... (more) tholog); cellular response to insulin stimulus (ortholog); PARTICIPATES IN mTOR signaling pathway; ASSOCIATED WITH Acute Recurrent Myoglobinuria, Autosomal Recessive (ortholog); Cachexia (ortholog); end stage renal disease (ortholog); FOUND IN cytoplasm (ortholog); endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog)	2A	11664727	11815497	Bonobo	54	symbol , old_gene_name	gene, protein-coding, MODEL [RefSeq]
12311729	LPIN1	lipin 1	ENCODES a protein that exhibits histone deacetylase binding (ortholog); peroxisome proliferator activated receptor binding (ortholog); RNA polymerase II-specific DNA-binding transcription factor binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); animal organ regeneration (or ... (more) tholog); cellular response to insulin stimulus (ortholog); PARTICIPATES IN mTOR signaling pathway; ASSOCIATED WITH Acute Recurrent Myoglobinuria, Autosomal Recessive (ortholog); Cachexia (ortholog); end stage renal disease (ortholog); FOUND IN cytoplasm (ortholog); endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog); INTERACTS WITH bisphenol A	17	8348860	8480447	Dog	57	symbol , old_gene_name	gene, protein-coding, MODEL [RefSeq]
12504513	Lpin1	lipin 1	ENCODES a protein that exhibits histone deacetylase binding (ortholog); peroxisome proliferator activated receptor binding (ortholog); RNA polymerase II-specific DNA-binding transcription factor binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); animal organ regeneration (or ... (more) tholog); cellular response to insulin stimulus (ortholog); PARTICIPATES IN mTOR signaling pathway; ASSOCIATED WITH Acute Recurrent Myoglobinuria, Autosomal Recessive (ortholog); Cachexia (ortholog); end stage renal disease (ortholog); FOUND IN cytoplasm (ortholog); endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog)	NW_004936532	7596279	7654139	Squirrel	54	symbol , old_gene_name	gene, protein-coding, MODEL [RefSeq]
18933699	Lpin1	lipin 1	ENCODES a protein that exhibits histone deacetylase binding (ortholog); peroxisome proliferator activated receptor binding (ortholog); RNA polymerase II-specific DNA-binding transcription factor binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); animal organ regeneration (or ... (more) tholog); cellular response to insulin stimulus (ortholog); PARTICIPATES IN mTOR signaling pathway; ASSOCIATED WITH Acute Recurrent Myoglobinuria, Autosomal Recessive (ortholog); Cachexia (ortholog); end stage renal disease (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); endoplasmic reticulum (ortholog)				Naked Mole-Rat	52	symbol , old_gene_name	gene, protein-coding, MODEL [RefSeq]
155231330	lpin1						Tropical Clawed Frog		symbol	gene, null
18506242	LPIN1	lipin 1	ENCODES a protein that exhibits histone deacetylase binding (ortholog); peroxisome proliferator activated receptor binding (ortholog); RNA polymerase II-specific DNA-binding transcription factor binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); animal organ regeneration (or ... (more) tholog); cellular response to insulin stimulus (ortholog); PARTICIPATES IN mTOR signaling pathway; ASSOCIATED WITH Acute Recurrent Myoglobinuria, Autosomal Recessive (ortholog); Cachexia (ortholog); end stage renal disease (ortholog); FOUND IN cytoplasm (ortholog); endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog)				Green Monkey	54	symbol , old_gene_name	gene, protein-coding, MODEL [RefSeq]
626080001	Lpin1	lipin 1	ENCODES a protein that exhibits histone deacetylase binding (ortholog); peroxisome proliferator activated receptor binding (ortholog); phosphatidate phosphatase activity (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); animal organ regeneration (ortholog); cellular response to ins ... (more) ulin stimulus (ortholog); PARTICIPATES IN mTOR signaling pathway; ASSOCIATED WITH Acute Recurrent Myoglobinuria, Autosomal Recessive (ortholog); Cachexia (ortholog); end stage renal disease (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); endoplasmic reticulum (ortholog)				Black Rat	54	symbol , old_gene_name	gene, protein-coding, MODEL [RefSeq]
14293122	LPIN1	lipin 1	ENCODES a protein that exhibits histone deacetylase binding (ortholog); peroxisome proliferator activated receptor binding (ortholog); RNA polymerase II-specific DNA-binding transcription factor binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); animal organ regeneration (or ... (more) tholog); cellular response to insulin stimulus (ortholog); PARTICIPATES IN mTOR signaling pathway; ASSOCIATED WITH Acute Recurrent Myoglobinuria, Autosomal Recessive (ortholog); Cachexia (ortholog); end stage renal disease (ortholog); FOUND IN cytoplasm (ortholog); endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog); INTERACTS WITH copper(II) sulfate; deoxynivalenol; quercetin				Pig	60	symbol , old_gene_name	gene, protein-coding, PROVISIONAL [RefSeq]
155231331	lpin1.L						African Clawed Frog		symbol	gene, null
155243125	lpin1.S						African Clawed Frog		symbol	gene, null
38599153	Lpin1^m1Hubr	lipin 1; ENU induced mutant 1, Hubr	ASSOCIATED WITH abnormal sciatic nerve morphology; dysmyelination; increased cell proliferation				Rat	5	symbol	gene, allele
6484709	Lpin1^em1Mcwi	lipin 1; zinc finger nuclease induced mutant 1, Medical College of Wisconsin	This allele was made by ZFN mutagenesis. The resulting mutation is a 4-bp deletion in exon 3 (del 719-722)				Rat		symbol , old_gene_symbol	gene, allele