| 1316283 | LILRB3 | leukocyte immunoglobulin like receptor B3 | This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane doma in, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] | 19 | 54216278 | 54223007 | Human | 112 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1566307 | Lilrb3 | leukocyte immunoglobulin like receptor B3 | INVOLVED IN cell surface receptor signaling pathway (inferred); ASSOCIATED WITH COVID-19 (ortholog); hepatocellular carcinoma (ortholog); FOUND IN plasma membrane (inferred); INTERACTS WITH 17beta-estradiol (ortholog); 2-palmitoylglycerol (ortholog); 3,3',4,4',5-pentachlorobiphenyl (ortholog) | 1 | 79001483 | 79011054 | Rat | 21 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1603957 | LILRA6 | leukocyte immunoglobulin like receptor A6 | Predicted to enable inhibitory MHC class I receptor activity. Predicted to be involved in cytokine-mediated signaling pathway and immune response-regulating signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, J ul 2025] | 19 | 54236590 | 54242790 | Human | 61 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 70895 | Lilrb2 | leukocyte immunoglobulin like receptor B2 | PARTICIPATES IN B cell receptor signaling pathway; FOUND IN plasma membrane (inferred); INTERACTS WITH bisphenol A; dioxygen | 1 | 74242200 | 74250051 | Rat | 9 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 14233011 | LOC100624191 | leukocyte immunoglobulin-like receptor subfamily A member 6 | INVOLVED IN cell surface receptor signaling pathway (inferred); FOUND IN plasma membrane (inferred) | | | | Pig | 6 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 11857246 | LOC100980151 | leukocyte immunoglobulin-like receptor subfamily A member 3 | ENCODES a protein that exhibits inhibitory MHC class I receptor activity (inferred); INVOLVED IN adaptive immune response (inferred); cytokine-mediated signaling pathway (inferred); immune response-regulating signaling pathway (inferred); FOUND IN cell surface (inferred); plasma membrane (inferred) | 19 | 51247496 | 51251980 | Bonobo | 18 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 11803214 | LOC100991256 | leukocyte immunoglobulin-like receptor subfamily B member 3 | ENCODES a protein that exhibits amyloid-beta binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN B cell homeostasis (ortholog); B cell mediated immunity (ortholog); cytokine-mediated signaling pathway (ortholog); FOUND IN plasma membrane (inferred) | 19 | 51148567 | 51154764 | Bonobo | 25 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 18915601 | LOC101722653 | leukocyte immunoglobulin-like receptor subfamily A member 6 | ENCODES a protein that exhibits inhibitory MHC class I receptor activity (inferred); INVOLVED IN cytokine-mediated signaling pathway (inferred); immune response-regulating signaling pathway (inferred); FOUND IN plasma membrane (inferred) | | | | Naked Mole-Rat | 5 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 12358694 | LOC484306 | leukocyte immunoglobulin-like receptor subfamily B member 3 | ENCODES a protein that exhibits apolipoprotein binding (ortholog); fibronectin binding (ortholog); protein phosphatase binding (ortholog); INVOLVED IN Fc receptor mediated inhibitory signaling pathway (ortholog); interleukin-10-mediated signaling pathway (ortholog); mast cell activation (ortholog); FOUND IN cell surface (ortholog) | 1 | 102779562 | 102786924 | Dog | 49 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 12323238 | LOC611446 | leukocyte immunoglobulin-like receptor subfamily A member 6 | ENCODES a protein that exhibits amyloid-beta binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN B cell homeostasis (ortholog); B cell mediated immunity (ortholog); cytokine-mediated signaling pathway (ortholog); FOUND IN plasma membrane (inferred) | 1 | 102955916 | 102978669 | Dog | 24 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 1307219 | Pira2 | paired-Ig-like receptor A2 | INVOLVED IN cell communication (inferred); cell surface receptor signaling pathway (inferred); ASSOCIATED WITH lung disease (ortholog); FOUND IN plasma membrane (inferred); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine | 1 | 74283713 | 74338208 | Rat | 54 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1620100 | Pirb | paired Ig-like receptor B | Enables amyloid-beta binding activity and protein homodimerization activity. Involved in learning or memory; negative regulation of protein metabolic process; and regulation of synaptic plasticity. Acts upstream of or within several processes, including B cell homeostasis; B cell mediated immunity; and myeloid dendritic cell differentiation. Predicted to be located in cytoplasm; external side of plasma membrane; and extracellular space. Predicted to be active in plasma membrane. Is expressed in cerebral cortex; cerebral cortex subventricular zone; cerebral cortex ventricular layer; and ganglionic eminence. Orthologous to several human genes including LILRA4 (leukocyte immunoglobulin like receptor A4); LILRB1 (leukocyte immunoglobulin like receptor B1); and LILRB5 (leukocyte immunoglobulin like receptor B5). [provided by Alliance of Genome Resources, Apr 2025] | 7 | 3715504 | 3723381 | Mouse | 141 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 38613913 | LOC102725035 | leukocyte immunoglobulin-like receptor subfamily B member 3 | INVOLVED IN cell surface receptor signaling pathway (inferred) | | | | Human | 1 | ensembl_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 38660420 | LOC107987462 | leukocyte immunoglobulin-like receptor subfamily B member 3 | ENCODES a protein that exhibits amyloid-beta binding; INVOLVED IN negative regulation of osteoclast differentiation; FOUND IN plasma membrane (inferred); secretory granule membrane (inferred) | | | | Human | 18 | ensembl_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 1589827 | Pirb | paired Ig-like receptor B | ENCODES a protein that exhibits amyloid-beta binding; protein homodimerization activity (ortholog); INVOLVED IN B cell homeostasis (ortholog); B cell mediated immunity (ortholog); cytokine-mediated signaling pathway (ortholog); FOUND IN plasma membrane (inferred); INTERACTS WITH 17beta-estradiol; 17 beta-estradiol 3-benzoate; amphetamine | 1 | 74414556 | 74433015 | Rat | 106 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |