| 620823 | Lct | lactase | ENCODES a protein that exhibits beta-glucosidase activity; galactosylceramidase activity; glucosylceramidase activity; INVOLVED IN cellobiose catabolic process; glycosylceramide catabolic process; lactose catabolic process; PARTICIPATES IN galactose metabolic pathway; galactosemia pathway; lactose d egradation pathway; ASSOCIATED WITH colitis; diarrhea; Experimental Diabetes Mellitus; FOUND IN brush border; external side of apical plasma membrane (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetylsalicylic acid; aldehydo-D-glucose | 13 | 42334347 | 42376872 | Rat | 148 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1344800 | LCT | lactase | The protein encoded by this gene belongs to the glycosyl hydrolase 1 family of proteins. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme is integral to the plasma membrane and has both phlorizin hydrolase activity and lactase activity. Mutations in t his gene are associated with congenital lactase deficiency. Polymorphisms in this gene are associated with lactase persistence, in which intestinal lactase activity persists at childhood levels into adulthood. [provided by RefSeq, Jan 2016] | 2 | 135787850 | 135837184 | Human | 216 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1551051 | Lct | lactase | Predicted to enable hydrolase activity, hydrolyzing O-glycosyl compounds; protein homodimerization activity; and transferase activity. Predicted to be involved in several processes, including disaccharide catabolic process; glycosylceramide catabolic process; and quercetin catabolic process. Predict ed to be located in brush border and external side of apical plasma membrane. Human ortholog(s) of this gene implicated in congenital lactase deficiency. Orthologous to human LCT (lactase). [provided by Alliance of Genome Resources, Apr 2025] | 1 | 128212493 | 128256055 | Mouse | 150 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 9031116 | Lct | lactase | ENCODES a protein that exhibits beta-glucosidase activity (ortholog); galactosylceramidase activity (ortholog); glucosylceramidase activity (ortholog); INVOLVED IN cellobiose catabolic process (ortholog); glycosylceramide catabolic process (ortholog); lactose catabolic process (ortholog); PARTICIPAT ES IN galactose metabolic pathway; galactosemia pathway; lactose degradation pathway; ASSOCIATED WITH adult respiratory distress syndrome (ortholog); colitis (ortholog); congenital lactase deficiency (ortholog); FOUND IN brush border (ortholog); external side of apical plasma membrane (ortholog) | NW_004955440 | 3148730 | 3197110 | Chinchilla | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11741139 | LCT | lactase | ENCODES a protein that exhibits galactosylceramidase activity (ortholog); glucosylceramidase activity (ortholog); lactase activity (ortholog); INVOLVED IN glycosylceramide catabolic process (ortholog); response to estrogen (ortholog); response to ethanol (ortholog); PARTICIPATES IN galactose metabol ic pathway; galactosemia pathway; lactose degradation pathway; ASSOCIATED WITH adult respiratory distress syndrome (ortholog); colitis (ortholog); congenital lactase deficiency (ortholog); FOUND IN brush border (ortholog) | 2B | 24025383 | 24079779 | Bonobo | 45 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12148607 | LCT | lactase | ENCODES a protein that exhibits galactosylceramidase activity (ortholog); glucosylceramidase activity (ortholog); lactase activity (ortholog); INVOLVED IN glycosylceramide catabolic process (ortholog); response to estrogen (ortholog); response to ethanol (ortholog); PARTICIPATES IN galactose metabol ic pathway; galactosemia pathway; lactose degradation pathway; ASSOCIATED WITH adult respiratory distress syndrome (ortholog); colitis (ortholog); congenital lactase deficiency (ortholog); FOUND IN brush border (ortholog) | 19 | 38571539 | 38620567 | Dog | 49 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12667627 | Lct | lactase | ENCODES a protein that exhibits galactosylceramidase activity (ortholog); glucosylceramidase activity (ortholog); lactase activity (ortholog); INVOLVED IN glycosylceramide catabolic process (ortholog); response to estrogen (ortholog); response to ethanol (ortholog); PARTICIPATES IN galactose metabol ic pathway; galactosemia pathway; lactose degradation pathway; ASSOCIATED WITH adult respiratory distress syndrome (ortholog); colitis (ortholog); congenital lactase deficiency (ortholog); FOUND IN brush border (ortholog) | NW_004936469 | 40064822 | 40108423 | Squirrel | 45 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625952423 | Lct | lactase | ENCODES a protein that exhibits beta-glucosidase activity (ortholog); galactosylceramidase activity (ortholog); glucosylceramidase activity (ortholog); INVOLVED IN cellobiose catabolic process (ortholog); glycosylceramide catabolic process (ortholog); lactose catabolic process (ortholog); PARTICIPAT ES IN galactose metabolic pathway; galactosemia pathway; lactose degradation pathway; ASSOCIATED WITH adult respiratory distress syndrome (ortholog); colitis (ortholog); congenital lactase deficiency (ortholog); FOUND IN brush border (ortholog); external side of apical plasma membrane (ortholog) | | | | Black Rat | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18384906 | LCT | lactase | ENCODES a protein that exhibits galactosylceramidase activity (ortholog); glucosylceramidase activity (ortholog); lactase activity (ortholog); INVOLVED IN glycosylceramide catabolic process (ortholog); response to estrogen (ortholog); response to ethanol (ortholog); PARTICIPATES IN galactose metabol ic pathway; galactosemia pathway; lactose degradation pathway; ASSOCIATED WITH adult respiratory distress syndrome (ortholog); colitis (ortholog); congenital lactase deficiency (ortholog); FOUND IN brush border (ortholog) | | | | Green Monkey | 45 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14016337 | LCT | lactase | ENCODES a protein that exhibits beta-glucosidase activity (inferred); catalytic activity (inferred); hydrolase activity (inferred); INVOLVED IN carbohydrate metabolic process (inferred) | | | | Pig | 12 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18932516 | Lct | lactase | ENCODES a protein that exhibits beta-glucosidase activity (ortholog); galactosylceramidase activity (ortholog); glucosylceramidase activity (ortholog); INVOLVED IN cellobiose catabolic process (ortholog); glycosylceramide catabolic process (ortholog); lactose catabolic process (ortholog); PARTICIPAT ES IN galactose metabolic pathway; galactosemia pathway; lactose degradation pathway; ASSOCIATED WITH adult respiratory distress syndrome (ortholog); colitis (ortholog); congenital lactase deficiency (ortholog); FOUND IN brush border (ortholog); external side of apical plasma membrane (ortholog) | | | | Naked Mole-Rat | 48 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155238720 | lct.2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 14700863 | LCT-AS1 | LCT antisense RNA 1 | ASSOCIATED WITH Hirschsprung's disease; INTERACTS WITH lipopolysaccharide; S-(1,2-dichlorovinyl)-L-cysteine | 2 | 135820191 | 135823087 | Human | 4 | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 155238721 | lct.2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 1305177 | Lctl | lactase-like | ENCODES a protein that exhibits hydrolase activity, hydrolyzing O-glycosyl compounds (inferred); INVOLVED IN lens morphogenesis in camera-type eye (ortholog); ASSOCIATED WITH colorectal cancer (ortholog); FOUND IN brush border (ortholog); endoplasmic reticulum (ortholog); INTERACTS WITH acetamide; b isphenol A; gentamycin | 8 | 73506096 | 73534668 | Rat | 40 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1313050 | Lctl | lactase-like | Predicted to enable hydrolase activity, hydrolyzing O-glycosyl compounds. Involved in lens morphogenesis in camera-type eye. Located in brush border and endoplasmic reticulum. Orthologous to human LCTL (lactase like). [provided by Alliance of Genome Resources, J ul 2025] | 9 | 64024399 | 64045400 | Mouse | 43 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1602287 | LCTL | lactase like | This gene encodes a member of family 1 glycosidases. Glycosidases are enzymes that hydrolyze glycosidic bonds and are classified into families based on primary amino acid sequence. Most members of family 1 have two conserved glutamic acid residues, which are required for enzymatic activity. The mous e ortholog of this protein has been characterized and has a domain structure of an N-terminal signal peptide, glycosidase domain, transmembrane domain, and a short cytoplasmic tail. It lacks one of the conserved glutamic acid residues important for catalysis, and its function remains to be determined (PMID: 12084582). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013] | 15 | 66547532 | 66565998 | Human | 39 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8891083 | Lctl | lactase like | INVOLVED IN lens morphogenesis in camera-type eye (ortholog); ASSOCIATED WITH colorectal cancer (ortholog); FOUND IN brush border (ortholog); endoplasmic reticulum (ortholog) | NW_004955450 | 9127151 | 9139836 | Chinchilla | 4 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11734595 | LCTL | lactase like | ENCODES a protein that exhibits hydrolase activity (inferred); hydrolase activity, acting on glycosyl bonds (inferred); hydrolase activity, hydrolyzing O-glycosyl compounds (inferred); INVOLVED IN carbohydrate metabolic process (inferred); lens morphogenesis in camera-type eye (inferred); visual per ception (inferred); ASSOCIATED WITH colorectal cancer (ortholog); FOUND IN brush border (inferred); endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred) | 15 | 45495650 | 45514096 | Bonobo | 10 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12311316 | LCTL | lactase like | ENCODES a protein that exhibits beta-glucosidase activity (inferred); galactosylceramidase activity (inferred); glucosylceramidase activity (inferred); INVOLVED IN carbohydrate catabolic process (inferred); carbohydrate metabolic process (inferred); lens morphogenesis in camera-type eye (inferred); ASSOCIATED WITH colorectal cancer (ortholog); FOUND IN brush border (inferred); endoplasmic reticulum (inferred) | 30 | 30808356 | 30827504 | Dog | 13 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12545335 | Lctl | lactase like | ENCODES a protein that exhibits beta-glucosidase activity (inferred); galactosylceramidase activity (inferred); glucosylceramidase activity (inferred); INVOLVED IN carbohydrate catabolic process (inferred); carbohydrate metabolic process (inferred); lens morphogenesis in camera-type eye (inferred); ASSOCIATED WITH colorectal cancer (ortholog); FOUND IN brush border (inferred); endoplasmic reticulum (inferred) | NW_004936471 | 26676058 | 26690455 | Squirrel | 13 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155239437 | lctl | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18500116 | LCTL | lactase like | ENCODES a protein that exhibits hydrolase activity (inferred); hydrolase activity, acting on glycosyl bonds (inferred); hydrolase activity, hydrolyzing O-glycosyl compounds (inferred); INVOLVED IN carbohydrate metabolic process (inferred); lens morphogenesis in camera-type eye (inferred); visual per ception (inferred); ASSOCIATED WITH colorectal cancer (ortholog); FOUND IN brush border (inferred); endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred) | | | | Green Monkey | 10 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18902231 | Lctl | lactase like | ENCODES a protein that exhibits beta-glucosidase activity (inferred); galactosylceramidase activity (inferred); glucosylceramidase activity (inferred); INVOLVED IN lens morphogenesis in camera-type eye (ortholog); ASSOCIATED WITH colorectal cancer (ortholog); FOUND IN brush border (ortholog); endopl asmic reticulum (ortholog) | | | | Naked Mole-Rat | 13 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14285786 | LCTL | lactase like | ENCODES a protein that exhibits beta-glucosidase activity (inferred); galactosylceramidase activity (inferred); glucosylceramidase activity (inferred); INVOLVED IN carbohydrate catabolic process (inferred); carbohydrate metabolic process (inferred); lens morphogenesis in camera-type eye (inferred); ASSOCIATED WITH colorectal cancer (ortholog); FOUND IN brush border (inferred); endoplasmic reticulum (inferred) | | | | Pig | 13 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626137958 | Lctl | lactase like | INVOLVED IN lens morphogenesis in camera-type eye (ortholog); ASSOCIATED WITH colorectal cancer (ortholog); FOUND IN brush border (ortholog); endoplasmic reticulum (ortholog) | | | | Black Rat | 4 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155240169 | lctl.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 14242345 | HADHB | hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta | ENCODES a protein that exhibits acetyl-CoA C-acyltransferase activity (ortholog); protein-containing complex binding (ortholog); INVOLVED IN fatty acid beta-oxidation (ortholog); PARTICIPATES IN carnitine palmitoyltransferase I deficiency pathway; ethylmalonic encephalopathy pathway; fatty acid beta degradation pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); Breast Neoplasms (ortholog); Charcot-Marie-Tooth disease (ortholog); FOUND IN mitochondrial fatty acid beta-oxidation multienzyme complex (ortholog) | | | | Pig | 66 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
