| 631397 | Lat2 | linker for activation of T cells family, member 2 | ENCODES a protein that exhibits SH2 domain binding (ortholog); INVOLVED IN B cell activation (ortholog); B cell receptor signaling pathway (ortholog); calcium-mediated signaling (ortholog); ASSOCIATED WITH acute promyelocytic leukemia (ortholog); Disease Progression (ortholog); Experimental Leukemia (ortholog); FOUND IN membrane raft (ortholog); plasma membrane (ortholog); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine | 12 | 27740647 | 27754760 | Rat | 124 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1342914 | LAT2 | linker for activation of T cells family member 2 | This gene is one of the contiguous genes at 7q11.23 commonly deleted in Williams syndrome, a multisystem developmental disorder. This gene consists of at least 14 exons, and its alternative splicing generates 3 transcript variants, all encoding the same protein. [provided by RefSeq, Jul 2008] | 7 | 74210006 | 74229834 | Human | 121 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1617564 | Lat2 | linker for activation of T cells family, member 2 | Predicted to enable SH2 domain binding activity. Predicted to be involved in B cell activation; B cell receptor signaling pathway; and calcium-mediated signaling. Predicted to be located in membrane raft. Predicted to be active in plasma membrane. Is expressed in several structures, including genito urinary system; heart; liver; lung; and spleen. Human ortholog(s) of this gene implicated in Williams-Beuren syndrome. Orthologous to human LAT2 (linker for activation of T cells family member 2). [provided by Alliance of Genome Resources, Jul 2025] | 5 | 134628957 | 134648637 | Mouse | 156 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 9062988 | Lat2 | linker for activation of T cells family member 2 | ENCODES a protein that exhibits SH2 domain binding (ortholog); INVOLVED IN B cell activation (ortholog); B cell receptor signaling pathway (ortholog); calcium-mediated signaling (ortholog); ASSOCIATED WITH acute promyelocytic leukemia (ortholog); Disease Progression (ortholog); Experimental Leukemia (ortholog); FOUND IN membrane raft (ortholog); plasma membrane (ortholog) | NW_004955456 | 13674190 | 13688611 | Chinchilla | 13 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12125951 | LAT2 | linker for activation of T cells family member 2 | ENCODES a protein that exhibits SH2 domain binding (ortholog); INVOLVED IN intracellular signal transduction (ortholog); ASSOCIATED WITH acute promyelocytic leukemia (ortholog); Disease Progression (ortholog); Experimental Leukemia (ortholog); FOUND IN membrane raft (ortholog); plasma membrane (orth olog) | 6 | 6160939 | 6175271 | Dog | 16 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12561473 | Lat2 | linker for activation of T cells family member 2 | ENCODES a protein that exhibits SH2 domain binding (ortholog); INVOLVED IN B cell activation (ortholog); B cell receptor signaling pathway (ortholog); calcium-mediated signaling (ortholog); ASSOCIATED WITH acute promyelocytic leukemia (ortholog); Disease Progression (ortholog); Experimental Leukemia (ortholog); FOUND IN membrane raft (ortholog); plasma membrane (ortholog) | NW_004936543 | 3250956 | 3262668 | Squirrel | 13 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18453790 | LAT2 | linker for activation of T cells family member 2 | ENCODES a protein that exhibits SH2 domain binding (inferred); INVOLVED IN B cell activation (inferred); B cell receptor signaling pathway (inferred); calcium-mediated signaling (inferred); ASSOCIATED WITH acute promyelocytic leukemia (ortholog); Disease Progression (ortholog); Experimental Leukemia (ortholog); FOUND IN membrane raft (inferred); plasma membrane (inferred) | | | | Green Monkey | 18 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626037882 | Lat2 | linker for activation of T cells family member 2 | ENCODES a protein that exhibits SH2 domain binding (ortholog); INVOLVED IN B cell activation (ortholog); B cell receptor signaling pathway (ortholog); calcium-mediated signaling (ortholog); ASSOCIATED WITH acute promyelocytic leukemia (ortholog); Disease Progression (ortholog); Experimental Leukemia (ortholog); FOUND IN membrane raft (ortholog); plasma membrane (ortholog) | | | | Black Rat | 13 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11916450 | LAT2 | linker for activation of T cells family member 2 | ENCODES a protein that exhibits SH2 domain binding (inferred); INVOLVED IN B cell activation (inferred); B cell receptor signaling pathway (inferred); calcium-mediated signaling (inferred); ASSOCIATED WITH acute promyelocytic leukemia (ortholog); Disease Progression (ortholog); Experimental Leukemia (ortholog); FOUND IN membrane raft (inferred); plasma membrane (inferred) | | | | Bonobo | 18 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14200231 | LAT2 | linker for activation of T cells family member 2 | ENCODES a protein that exhibits SH2 domain binding (inferred); INVOLVED IN B cell activation (inferred); B cell receptor signaling pathway (inferred); calcium-mediated signaling (inferred); ASSOCIATED WITH acute promyelocytic leukemia (ortholog); Disease Progression (ortholog); Experimental Leukemia (ortholog); FOUND IN membrane raft (inferred); plasma membrane (inferred) | | | | Pig | 14 | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 18912417 | Lat2 | linker for activation of T cells family member 2 | ENCODES a protein that exhibits SH2 domain binding (ortholog); INVOLVED IN intracellular signal transduction (ortholog); ASSOCIATED WITH acute promyelocytic leukemia (ortholog); Disease Progression (ortholog); Experimental Leukemia (ortholog); FOUND IN membrane raft (ortholog) | | | | Naked Mole-Rat | 15 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 619904 | Slc7a8 | solute carrier family 7 member 8 | ENCODES a protein that exhibits amino acid transmembrane transporter activity (ortholog); antiporter activity (ortholog); glycine transmembrane transporter activity (ortholog); INVOLVED IN amino acid import across plasma membrane (ortholog); amino acid transport (ortholog); glycine transport (orthol og); PARTICIPATES IN amiloride pharmacodynamics pathway; bendroflumethiazide pharmacodynamics pathway; bumetanide pharmacodynamics pathway; ASSOCIATED WITH cataract (ortholog); Dwarfism (ortholog); endometriosis (ortholog); FOUND IN apical plasma membrane (ortholog); basal plasma membrane (ortholog); basolateral plasma membrane (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 15 | 32153016 | 32212715 | Rat | 252 | old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 733687 | Slc7a8 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 8 | Enables L-amino acid transmembrane transporter activity; glycine transmembrane transporter activity; and thyroid hormone transmembrane transporter activity. Involved in carboxylic acid transport and thyroid hormone transport. Acts upstream of or within L-amino acid transport. Located in apical plasm a membrane. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and immune system. Used to study sensorineural hearing loss. Orthologous to human SLC7A8 (solute carrier family 7 member 8). [provided by Alliance of Genome Resources, Jul 2025] | 14 | 54959672 | 55019343 | Mouse | 262 | old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1345085 | SLC7A8 | solute carrier family 7 member 8 | Enables several functions, including neutral L-amino acid transmembrane transporter activity; protein heterodimerization activity; and secondary active transmembrane transporter activity. Involved in L-alanine import across plasma membrane; L-leucine import across plasma membrane; and thyroid hormon e transport. Located in basolateral plasma membrane and microvillus membrane. [provided by Alliance of Genome Resources, Jul 2025] | 14 | 23125295 | 23183660 | Human | 250 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 12386357 | SLC7A8 | solute carrier family 7 member 8 | ENCODES a protein that exhibits amino acid transmembrane transporter activity (inferred); antiporter activity (inferred); glycine transmembrane transporter activity (inferred); INVOLVED IN L-amino acid transport (ortholog); PARTICIPATES IN amiloride pharmacodynamics pathway; bendroflumethiazide phar macodynamics pathway; bumetanide pharmacodynamics pathway; ASSOCIATED WITH cataract (ortholog); Dwarfism (ortholog); endometriosis (ortholog); FOUND IN apical plasma membrane (inferred); basal plasma membrane (inferred); basolateral plasma membrane (inferred) | 8 | 3430208 | 3479985 | Dog | 69 | old_gene_symbol | gene, protein-coding, INFERRED [RefSeq] |
| 14123156 | SLC7A8 | solute carrier family 7 member 8 | ENCODES a protein that exhibits amino acid transmembrane transporter activity (inferred); antiporter activity (inferred); glycine transmembrane transporter activity (inferred); INVOLVED IN L-amino acid transport (ortholog); PARTICIPATES IN amiloride pharmacodynamics pathway; bendroflumethiazide phar macodynamics pathway; bumetanide pharmacodynamics pathway; ASSOCIATED WITH cataract (ortholog); Dwarfism (ortholog); endometriosis (ortholog); FOUND IN apical plasma membrane (inferred); basal plasma membrane (inferred); basolateral plasma membrane (inferred); INTERACTS WITH ammonia; deoxynivalenol | | | | Pig | 71 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 1309193 | Slc7a6 | solute carrier family 7 member 6 | ENCODES a protein that exhibits arginine binding (ortholog); basic amino acid transmembrane transporter activity (ortholog); L-arginine transmembrane transporter activity (ortholog); INVOLVED IN L-arginine transmembrane transport; nitric oxide biosynthetic process; amino acid import across plasma me mbrane (ortholog); PARTICIPATES IN amiloride pharmacodynamics pathway; bendroflumethiazide pharmacodynamics pathway; bumetanide pharmacodynamics pathway; FOUND IN plasma membrane (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; acrylamide | 19 | 50982459 | 51010140 | Rat | 159 | old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1319397 | SLC7A6 | solute carrier family 7 member 6 | Enables L-lysine:L-arginine antiporter activity and arginine binding activity. Involved in L-arginine transmembrane transport; L-leucine transport; and ornithine transport. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025] | 16 | 68264526 | 68301819 | Human | 153 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1553153 | Slc7a6 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 6 | Predicted to enable L-lysine:L-arginine antiporter activity and arginine binding activity. Involved in glycine betaine transport. Predicted to be located in plasma membrane. Is expressed in brain; cumulus oophorus; embryo; gonad; and oocyte. Orthologous to human SLC7A6 (solute carrier family 7 membe r 6). [provided by Alliance of Genome Resources, Jul 2025] | 8 | 106894718 | 106925346 | Mouse | 160 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |