| 1322449 | KDM5B | lysine demethylase 5B | This gene encodes a lysine-specific histone demethylase that belongs to the jumonji/ARID domain-containing family of histone demethylases. The encoded protein is capable of demethylating tri-, di- and monomethylated lysine 4 of histone H3. This protein plays a role in the transcriptional repression or certain tumor suppressor genes and is upregulated in certain cancer cells. This protein may also play a role in genome stability and DNA repair. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016] | 1 | 202724495 | 202808421 | Human | 231 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1557118 | Kdm5b | lysine demethylase 5B | This gene encodes a lysine-specific histone demethylase that belongs to the jumonji/ARID domain-containing family of histone demethylases. The encoded protein is capable of demethylating tri-, di- and monomethylated lysine 4 of histone H3. This protein plays a role in the transcriptional repression or certain tumor suppressor genes and is upregulated in certain cancer cells. This protein may also play a role in genome stability and DNA repair. Homozygous mutant mice display decreased body weight, decreased female fertility, lower uterine weight, and a delay in mammary development. Knockout of this gene has also been associated with embryonic lethality. [provided by RefSeq, Dec 2016] | 1 | 134487916 | 134560621 | Mouse | 194 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 1565602 | Kdm5b | lysine demethylase 5B | ENCODES a protein that exhibits DNA binding (ortholog); histone binding (ortholog); histone H3K4 demethylase activity (ortholog); INVOLVED IN cellular response to fibroblast growth factor stimulus; lens fiber cell differentiation; response to fungicide; PARTICIPATES IN histone modification pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); autosomal recessive intellectual developmental disorder 65 (ortholog); bladder exstrophy-epispadias-cloacal exstrophy complex (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (ortholog); ribonucleoprotein complex (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amitrole | 13 | 48554367 | 48625721 | Rat | 176 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 8709690 | Kdm5b | lysine demethylase 5B | ENCODES a protein that exhibits DNA binding (ortholog); histone binding (ortholog); histone H3K4 demethylase activity (ortholog); INVOLVED IN branching involved in mammary gland duct morphogenesis (ortholog); cellular response to fibroblast growth factor stimulus (ortholog); cellular response to leu kemia inhibitory factor (ortholog); PARTICIPATES IN histone modification pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); autosomal recessive intellectual developmental disorder 65 (ortholog); bladder exstrophy-epispadias-cloacal exstrophy complex (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (ortholog); ribonucleoprotein complex (ortholog) | NW_004955406 | 38755220 | 38823094 | Chinchilla | 54 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12036891 | KDM5B | lysine demethylase 5B | ENCODES a protein that exhibits dioxygenase activity (inferred); DNA binding (inferred); histone binding (inferred); INVOLVED IN branching involved in mammary gland duct morphogenesis (ortholog); cellular response to fibroblast growth factor stimulus (ortholog); cellular response to leukemia inhibit ory factor (ortholog); PARTICIPATES IN histone modification pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); autosomal recessive intellectual developmental disorder 65 (ortholog); bladder exstrophy-epispadias-cloacal exstrophy complex (ortholog); FOUND IN ribonucleoprotein complex (ortholog) | 1 | 178323073 | 178406608 | Bonobo | 72 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12261075 | KDM5B | lysine demethylase 5B | ENCODES a protein that exhibits dioxygenase activity (inferred); DNA binding (inferred); histone binding (inferred); INVOLVED IN branching involved in mammary gland duct morphogenesis (ortholog); cellular response to fibroblast growth factor stimulus (ortholog); cellular response to leukemia inhibit ory factor (ortholog); PARTICIPATES IN histone modification pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); autosomal recessive intellectual developmental disorder 65 (ortholog); bladder exstrophy-epispadias-cloacal exstrophy complex (ortholog); FOUND IN ribonucleoprotein complex (ortholog) | 7 | 336452 | 415568 | Dog | 69 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12637683 | Kdm5b | lysine demethylase 5B | ENCODES a protein that exhibits dioxygenase activity (inferred); DNA binding (inferred); histone binding (inferred); INVOLVED IN branching involved in mammary gland duct morphogenesis (ortholog); cellular response to fibroblast growth factor stimulus (ortholog); cellular response to leukemia inhibit ory factor (ortholog); PARTICIPATES IN histone modification pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); autosomal recessive intellectual developmental disorder 65 (ortholog); bladder exstrophy-epispadias-cloacal exstrophy complex (ortholog); FOUND IN ribonucleoprotein complex (ortholog) | NW_004936567 | 1782056 | 1860861 | Squirrel | 70 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18793764 | KDM5B | lysine demethylase 5B | ENCODES a protein that exhibits dioxygenase activity (inferred); DNA binding (inferred); histone binding (inferred); INVOLVED IN branching involved in mammary gland duct morphogenesis (ortholog); cellular response to fibroblast growth factor stimulus (ortholog); cellular response to leukemia inhibit ory factor (ortholog); PARTICIPATES IN histone modification pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); autosomal recessive intellectual developmental disorder 65 (ortholog); bladder exstrophy-epispadias-cloacal exstrophy complex (ortholog); FOUND IN ribonucleoprotein complex (ortholog) | | | | Green Monkey | 72 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18907085 | Kdm5b | lysine demethylase 5B | ENCODES a protein that exhibits histone binding (ortholog); nucleic acid binding (ortholog); sequence-specific double-stranded DNA binding (ortholog); INVOLVED IN branching involved in mammary gland duct morphogenesis (ortholog); cellular response to fibroblast growth factor stimulus (ortholog); cel lular response to leukemia inhibitory factor (ortholog); PARTICIPATES IN histone modification pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); autosomal recessive intellectual developmental disorder 65 (ortholog); bladder exstrophy-epispadias-cloacal exstrophy complex (ortholog); FOUND IN ribonucleoprotein complex (ortholog) | | | | Naked Mole-Rat | 65 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155239199 | kdm5b | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625874774 | Kdm5b | lysine demethylase 5B | ENCODES a protein that exhibits DNA binding (ortholog); histone binding (ortholog); histone H3K4 demethylase activity (ortholog); INVOLVED IN branching involved in mammary gland duct morphogenesis (ortholog); cellular response to fibroblast growth factor stimulus (ortholog); cellular response to leu kemia inhibitory factor (ortholog); PARTICIPATES IN histone modification pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); autosomal recessive intellectual developmental disorder 65 (ortholog); bladder exstrophy-epispadias-cloacal exstrophy complex (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (ortholog); ribonucleoprotein complex (ortholog) | | | | Black Rat | 54 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14157561 | KDM5B | lysine demethylase 5B | ENCODES a protein that exhibits dioxygenase activity (inferred); DNA binding (inferred); histone binding (inferred); INVOLVED IN branching involved in mammary gland duct morphogenesis (ortholog); cellular response to fibroblast growth factor stimulus (ortholog); cellular response to leukemia inhibit ory factor (ortholog); PARTICIPATES IN histone modification pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); autosomal recessive intellectual developmental disorder 65 (ortholog); bladder exstrophy-epispadias-cloacal exstrophy complex (ortholog); FOUND IN ribonucleoprotein complex (ortholog) | | | | Pig | 71 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 405856715 | kdm5b.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 626173197 | kdm5b.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 626174612 | kdm5b.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405857541 | kdm5b.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405865421 | kdm5b.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405865473 | kdm5b.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 626186362 | kdm5b.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155251778 | kdm5b.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 5687782 | PCAT6 | prostate cancer associated transcript 6 | INTERACTS WITH acrylamide; cadmium dichloride; fipronil | 1 | 202810954 | 202811912 | Human | 10 | old_gene_symbol | gene, ncrna, VALIDATED [RefSeq] |
