| 61828 | Kcnab2 | potassium voltage-gated channel subfamily A regulatory beta subunit 2 | ENCODES a protein that exhibits alcohol dehydrogenase (NADP+) activity; potassium channel regulator activity; protein-containing complex binding; INVOLVED IN myoblast differentiation; regulation of potassium ion transmembrane transport; regulation of protein localization to cell surface; ASSOCIATED WITH chromosome 1p36 deletion syndrome (ortholog); epilepsy (ortholog); genetic disease (ortholog); FOUND IN axon; cytoplasmic side of plasma membrane; cytosol; INTERACTS WITH 1-O-palmitoyl-2-O-(5-oxovaleryl)-sn-glycero-3-phosphocholine; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil | 5 | 168182228 | 168270760 | Rat | 165 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 62119 | Kcnab2 | potassium voltage-gated channel, shaker-related subfamily, beta member 2 | Predicted to enable aldo-keto reductase (NADPH) activity; potassium channel regulator activity; and transmembrane transporter binding activity. Involved in neuromuscular process. Acts upstream of or within hematopoietic progenitor cell differentiation. Located in axon terminus; juxtaparanode region of axon; and postsynaptic density. Is active in axon initial segment. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system; intestine; and sensory organ. Used to study chromosome 1p36 deletion syndrome. Orthologous to human KCNAB2 (potassium voltage-gated channel subfamily A regulatory beta subunit 2). [provided by Alliance of Genome Resources, Apr 2025] | 4 | 152475201 | 152561991 | Mouse | 184 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1354203 | KCNAB2 | potassium voltage-gated channel subfamily A regulatory beta subunit 2 | Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte tran sport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. This member alters functional properties of the KCNA4 gene product. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Dec 2010] | 1 | 5992676 | 6101180 | Human | 251 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8757612 | Kcnab2 | potassium voltage-gated channel subfamily A regulatory beta subunit 2 | ENCODES a protein that exhibits alcohol dehydrogenase (NADP+) activity (ortholog); potassium channel regulator activity (ortholog); protein-containing complex binding (ortholog); INVOLVED IN hematopoietic progenitor cell differentiation (ortholog); myoblast differentiation (ortholog); neuromuscular process (ortholog); ASSOCIATED WITH chromosome 1p36 deletion syndrome (ortholog); epilepsy (ortholog); genetic disease (ortholog); FOUND IN axon (ortholog); axon initial segment (ortholog); axon terminus (ortholog) | NW_004955486 | 6371212 | 6442888 | Chinchilla | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11826240 | KCNAB2 | potassium voltage-gated channel subfamily A regulatory beta subunit 2 | ENCODES a protein that exhibits alcohol dehydrogenase (NADP+) activity (ortholog); protein-containing complex binding (ortholog); transmembrane transporter binding (ortholog); INVOLVED IN hematopoietic progenitor cell differentiation (ortholog); myoblast differentiation (ortholog); neuromuscular pro cess (ortholog); ASSOCIATED WITH chromosome 1p36 deletion syndrome (ortholog); epilepsy (ortholog); genetic disease (ortholog); FOUND IN axon initial segment (ortholog); axon terminus (ortholog); cytoplasmic side of plasma membrane (ortholog) | 1 | 4755412 | 4866424 | Bonobo | 56 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12056752 | KCNAB2 | potassium voltage-gated channel subfamily A regulatory beta subunit 2 | ENCODES a protein that exhibits protein-containing complex binding (ortholog); transmembrane transporter binding (ortholog); INVOLVED IN hematopoietic progenitor cell differentiation (ortholog); myoblast differentiation (ortholog); neuromuscular process (ortholog); ASSOCIATED WITH chromosome 1p36 de letion syndrome (ortholog); epilepsy (ortholog); genetic disease (ortholog); FOUND IN axon initial segment (ortholog); axon terminus (ortholog); cytoplasmic side of plasma membrane (ortholog) | 5 | 59936432 | 60021945 | Dog | 55 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12668890 | Kcnab2 | potassium voltage-gated channel subfamily A regulatory beta subunit 2 | ENCODES a protein that exhibits alcohol dehydrogenase (NADP+) activity (ortholog); protein-containing complex binding (ortholog); transmembrane transporter binding (ortholog); INVOLVED IN hematopoietic progenitor cell differentiation (ortholog); myoblast differentiation (ortholog); neuromuscular pro cess (ortholog); ASSOCIATED WITH chromosome 1p36 deletion syndrome (ortholog); epilepsy (ortholog); genetic disease (ortholog); FOUND IN axon (ortholog); axon initial segment (ortholog); axon terminus (ortholog) | NW_004936623 | 972288 | 987949 | Squirrel | 55 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14045168 | KCNAB2 | potassium voltage-gated channel subfamily A regulatory beta subunit 2 | ENCODES a protein that exhibits protein-containing complex binding (ortholog); transmembrane transporter binding (ortholog); INVOLVED IN hematopoietic progenitor cell differentiation (ortholog); myoblast differentiation (ortholog); neuromuscular process (ortholog); ASSOCIATED WITH chromosome 1p36 de letion syndrome (ortholog); epilepsy (ortholog); genetic disease (ortholog); FOUND IN axon initial segment (ortholog); axon terminus (ortholog); cytoplasmic side of plasma membrane (ortholog) | | | | Pig | 56 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18925388 | Kcnab2 | potassium voltage-gated channel subfamily A regulatory beta subunit 2 | ENCODES a protein that exhibits alcohol dehydrogenase (NADP+) activity (ortholog); protein-containing complex binding (ortholog); transmembrane transporter binding (ortholog); INVOLVED IN hematopoietic progenitor cell differentiation (ortholog); myoblast differentiation (ortholog); neuromuscular pro cess (ortholog); ASSOCIATED WITH chromosome 1p36 deletion syndrome (ortholog); epilepsy (ortholog); genetic disease (ortholog); FOUND IN axon initial segment (ortholog); axon terminus (ortholog); cytoplasmic side of plasma membrane (ortholog) | | | | Naked Mole-Rat | 52 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155239336 | kcnab2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18608467 | KCNAB2 | potassium voltage-gated channel subfamily A regulatory beta subunit 2 | ENCODES a protein that exhibits alcohol dehydrogenase (NADP+) activity (ortholog); protein-containing complex binding (ortholog); transmembrane transporter binding (ortholog); INVOLVED IN hematopoietic progenitor cell differentiation (ortholog); myoblast differentiation (ortholog); neuromuscular pro cess (ortholog); ASSOCIATED WITH chromosome 1p36 deletion syndrome (ortholog); epilepsy (ortholog); genetic disease (ortholog); FOUND IN axon initial segment (ortholog); axon terminus (ortholog); cytoplasmic side of plasma membrane (ortholog) | | | | Green Monkey | 54 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625971350 | Kcnab2 | potassium voltage-gated channel subfamily A regulatory beta subunit 2 | ENCODES a protein that exhibits alcohol dehydrogenase (NADP+) activity (ortholog); potassium channel regulator activity (ortholog); protein-containing complex binding (ortholog); INVOLVED IN hematopoietic progenitor cell differentiation (ortholog); myoblast differentiation (ortholog); neuromuscular process (ortholog); ASSOCIATED WITH chromosome 1p36 deletion syndrome (ortholog); epilepsy (ortholog); genetic disease (ortholog); FOUND IN axon (ortholog); axon initial segment (ortholog); axon terminus (ortholog) | | | | Black Rat | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155250080 | kcnab2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 626186964 | kcnab2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405856006 | kcnab2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405862444 | kcnab2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405864883 | kcnab2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405860644 | kcnab2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 626189074 | kcnab2.S | | | | | | African Clawed Frog | | symbol | gene, null |
