| 1310849 | Ipo7 | importin 7 | ENCODES a protein that exhibits histone binding (ortholog); SMAD binding (ortholog); INVOLVED IN innate immune response (ortholog); negative regulation of osteoblast differentiation (ortholog); positive regulation of odontoblast differentiation (ortholog); ASSOCIATED WITH human immunodeficiency viru s infectious disease (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleoplasm (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol | 1 | 173497472 | 173537707 | Rat | 144 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1321989 | IPO7 | importin 7 | The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importi n-beta. Similar to importin-beta, this protein prevents the activation of Ran's GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions. At least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins. [provided by RefSeq, Jul 2008] | 11 | 9384652 | 9448127 | Human | 146 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1321990 | Ipo7 | importin 7 | Enables histone binding activity. Involved in negative regulation of osteoblast differentiation; positive regulation of odontoblast differentiation; and positive regulation of protein localization to nucleus. Acts upstream of or within innate immune response and protein import into nucleus. Located in cytoplasm and nucleus. Orthologous to human IPO7 (importin 7). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 109617522 | 109655816 | Mouse | 159 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 9026698 | Ipo7 | importin 7 | ENCODES a protein that exhibits histone binding (ortholog); SMAD binding (ortholog); INVOLVED IN innate immune response (ortholog); negative regulation of osteoblast differentiation (ortholog); positive regulation of odontoblast differentiation (ortholog); ASSOCIATED WITH human immunodeficiency viru s infectious disease (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleoplasm (ortholog) | NW_004955414 | 25131703 | 25195892 | Chinchilla | 20 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11830017 | IPO7 | importin 7 | ENCODES a protein that exhibits histone binding (ortholog); INVOLVED IN innate immune response (ortholog); negative regulation of osteoblast differentiation (ortholog); positive regulation of odontoblast differentiation (ortholog); ASSOCIATED WITH human immunodeficiency virus infectious disease (ort holog); FOUND IN cytoplasm (inferred); cytosol (inferred); nuclear envelope (inferred) | 11 | 9521055 | 9583638 | Bonobo | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12310746 | IPO7 | importin 7 | ENCODES a protein that exhibits histone binding (inferred); SMAD binding (inferred); small GTPase binding (inferred); INVOLVED IN innate immune response (ortholog); protein import into nucleus (ortholog); ASSOCIATED WITH human immunodeficiency virus infectious disease (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleoplasm (inferred) | 21 | 32692206 | 32748140 | Dog | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12442954 | Ipo7 | importin 7 | ENCODES a protein that exhibits histone binding (inferred); SMAD binding (inferred); small GTPase binding (inferred); INVOLVED IN innate immune response (ortholog); protein import into nucleus (ortholog); ASSOCIATED WITH human immunodeficiency virus infectious disease (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nuclear envelope (inferred) | NW_004936528 | 8683543 | 8739617 | Squirrel | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18931317 | Ipo7 | importin 7 | ENCODES a protein that exhibits histone binding (inferred); SMAD binding (inferred); small GTPase binding (inferred); INVOLVED IN innate immune response (ortholog); protein import into nucleus (ortholog); ASSOCIATED WITH human immunodeficiency virus infectious disease (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nuclear envelope (inferred) | | | | Naked Mole-Rat | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626052921 | Ipo7 | importin 7 | ENCODES a protein that exhibits histone binding (ortholog); SMAD binding (ortholog); INVOLVED IN innate immune response (ortholog); negative regulation of osteoblast differentiation (ortholog); positive regulation of odontoblast differentiation (ortholog); ASSOCIATED WITH human immunodeficiency viru s infectious disease (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleoplasm (ortholog) | | | | Black Rat | 20 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155249495 | ipo7 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18738254 | IPO7 | importin 7 | ENCODES a protein that exhibits histone binding (inferred); SMAD binding (inferred); small GTPase binding (inferred); INVOLVED IN innate immune response (ortholog); protein import into nucleus (ortholog); ASSOCIATED WITH human immunodeficiency virus infectious disease (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nuclear envelope (inferred) | | | | Green Monkey | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14045572 | IPO7 | importin 7 | ENCODES a protein that exhibits histone binding (inferred); SMAD binding (inferred); small GTPase binding (inferred); INVOLVED IN innate immune response (ortholog); protein import into nucleus (ortholog); ASSOCIATED WITH human immunodeficiency virus infectious disease (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleoplasm (inferred) | | | | Pig | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155245257 | ipo7.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155249496 | ipo7.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 2319566 | Ipo7-ps1 | importin 7, pseudogene 1 | | 8 | 47436029 | 47438523 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 1597019 | Ipo7-ps2 | importin 7, pseudogene 2 | | 14 | 29834525 | 29838047 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 5130648 | IPO7P1 | importin 7 pseudogene 1 | | X | 51921664 | 51922499 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 5130650 | IPO7P2 | importin 7 pseudogene 2 | INTERACTS WITH cadmium dichloride | 13 | 24120958 | 24123822 | Human | 1 | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |