IPO7 (importin 7) - Rat Genome Database

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Gene: IPO7 (importin 7) Homo sapiens
Analyze
Symbol: IPO7
Name: importin 7
RGD ID: 1321989
HGNC Page HGNC:9852
Description: Enables SMAD binding activity. Predicted to be involved in several processes, including negative regulation of osteoblast differentiation; positive regulation of odontoblast differentiation; and protein import into nucleus. Predicted to act upstream of or within innate immune response. Located in cytosol and nucleoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: FLJ14581; Imp7; importin-7; MGC138673; RAN-binding protein 7; RANBP7
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: IPO7P1   IPO7P2  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38119,384,652 - 9,448,127 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl119,384,652 - 9,448,127 (+)EnsemblGRCh38hg38GRCh38
GRCh37119,406,199 - 9,469,674 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36119,362,780 - 9,423,651 (+)NCBINCBI36Build 36hg18NCBI36
Build 34119,362,779 - 9,423,651NCBI
Celera119,527,846 - 9,591,349 (+)NCBICelera
Cytogenetic Map11p15.4NCBI
HuRef119,077,758 - 9,141,170 (+)NCBIHuRef
CHM1_1119,405,091 - 9,468,610 (+)NCBICHM1_1
T2T-CHM13v2.0119,469,789 - 9,533,256 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP)
1-nitropyrene  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-methylcholine  (EXP)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (EXP)
6-propyl-2-thiouracil  (ISO)
aflatoxin B1  (EXP,ISO)
aflatoxin M1  (EXP)
amitrole  (ISO)
aristolochic acid A  (EXP)
Aroclor 1254  (ISO)
arsenite(3-)  (EXP)
benzo[a]pyrene  (EXP)
benzo[a]pyrene diol epoxide I  (EXP)
benzo[e]pyrene  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol B  (EXP)
bisphenol F  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (EXP)
cannabidiol  (EXP)
CGP 52608  (EXP)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP)
Cuprizon  (EXP)
dexamethasone  (EXP)
dicrotophos  (EXP)
diethylstilbestrol  (EXP)
enzyme inhibitor  (EXP)
ethanol  (ISO)
fluoranthene  (ISO)
flutamide  (ISO)
fulvestrant  (EXP)
gentamycin  (ISO)
hydrogen peroxide  (EXP)
indole-3-methanol  (ISO)
indometacin  (EXP)
ivermectin  (EXP)
ketoconazole  (EXP)
menadione  (EXP)
methapyrilene  (EXP)
methimazole  (ISO)
methyl methanesulfonate  (EXP)
nefazodone  (ISO)
nimesulide  (ISO)
paracetamol  (EXP)
paraquat  (ISO)
piroxicam  (EXP)
prostaglandin A1  (ISO)
resveratrol  (EXP)
SB 431542  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP)
sulfadimethoxine  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
tolcapone  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
valproic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IBA,IDA,IEA)
membrane  (HDA)
nuclear envelope  (IBA,IEA)
nuclear pore  (TAS)
nucleoplasm  (IDA)
nucleus  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:9214382   PMID:9687515   PMID:10209022   PMID:10228156   PMID:10944119   PMID:11024021   PMID:11682607   PMID:12080050   PMID:12477932   PMID:12665801   PMID:12853482  
PMID:15282309   PMID:15489334   PMID:15592455   PMID:15964792   PMID:16196087   PMID:16344560   PMID:16704975   PMID:17020411   PMID:17110338   PMID:17314511   PMID:17360709   PMID:17491008  
PMID:17848547   PMID:18003734   PMID:18029348   PMID:18519565   PMID:18781797   PMID:19193229   PMID:19435463   PMID:19609347   PMID:19615732   PMID:19788888   PMID:19946888   PMID:20085707  
PMID:20467437   PMID:20473970   PMID:20719241   PMID:21081503   PMID:21139048   PMID:21319273   PMID:21419860   PMID:21825151   PMID:21873635   PMID:21890473   PMID:21906983   PMID:21963094  
PMID:21987572   PMID:22053931   PMID:22174317   PMID:22268729   PMID:22284678   PMID:22509482   PMID:22586326   PMID:22863883   PMID:22939629   PMID:23000965   PMID:23067392   PMID:23125841  
PMID:23181366   PMID:23349634   PMID:23414517   PMID:23439083   PMID:23667531   PMID:23956138   PMID:24100013   PMID:24457600   PMID:24586428   PMID:24711643   PMID:24798327   PMID:25324306  
PMID:25693804   PMID:25737280   PMID:25754235   PMID:25852190   PMID:25921289   PMID:25959826   PMID:25963833   PMID:26085085   PMID:26186194   PMID:26344197   PMID:26439863   PMID:26496610  
PMID:26549023   PMID:26618866   PMID:26638075   PMID:26760575   PMID:26777405   PMID:26831064   PMID:26839216   PMID:26878725   PMID:26972000   PMID:27025967   PMID:27377895   PMID:27381982  
PMID:27432908   PMID:27512140   PMID:27528606   PMID:27634302   PMID:27684187   PMID:27703004   PMID:27880917   PMID:28330616   PMID:28378594   PMID:28514442   PMID:28515276   PMID:28675297  
PMID:28685749   PMID:28712289   PMID:28883622   PMID:29053956   PMID:29117863   PMID:29180619   PMID:29229926   PMID:29331416   PMID:29357390   PMID:29378950   PMID:29395067   PMID:29467282  
PMID:29478914   PMID:29490077   PMID:29507755   PMID:29509190   PMID:29511261   PMID:29568061   PMID:29777862   PMID:29791485   PMID:29991511   PMID:30021884   PMID:30352685   PMID:30455355  
PMID:30585266   PMID:30619736   PMID:30711629   PMID:30809309   PMID:30833792   PMID:30948266   PMID:31073040   PMID:31091453   PMID:31177093   PMID:31182584   PMID:31319097   PMID:31470122  
PMID:31501420   PMID:31505435   PMID:31519766   PMID:31586073   PMID:31678930   PMID:31685992   PMID:31732153   PMID:31871319   PMID:31980649   PMID:31995728   PMID:32129710   PMID:32416067  
PMID:32552912   PMID:32683582   PMID:32707033   PMID:32738194   PMID:32807901   PMID:32941674   PMID:33005030   PMID:33060197   PMID:33239621   PMID:33397691   PMID:33482249   PMID:33545068  
PMID:33658012   PMID:33742100   PMID:33957083   PMID:33961781   PMID:34079125   PMID:34373451   PMID:34709727   PMID:34917906   PMID:35044719   PMID:35227662   PMID:35241646   PMID:35271311  
PMID:35338135   PMID:35439318   PMID:35446349   PMID:35546148   PMID:35562734   PMID:35563538   PMID:35588577   PMID:35776542   PMID:35831314   PMID:35842443   PMID:35906200   PMID:35915257  
PMID:35944360   PMID:35973513   PMID:36042349   PMID:36089195   PMID:36114006   PMID:36168627   PMID:36180527   PMID:36215168   PMID:36244648   PMID:36261009   PMID:36282215   PMID:36376293  
PMID:36526897   PMID:36574265   PMID:36597993   PMID:36604567   PMID:36634849   PMID:36690276   PMID:36964488   PMID:37689310   PMID:37827155   PMID:38113892  


Genomics

Comparative Map Data
IPO7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38119,384,652 - 9,448,127 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl119,384,652 - 9,448,127 (+)EnsemblGRCh38hg38GRCh38
GRCh37119,406,199 - 9,469,674 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36119,362,780 - 9,423,651 (+)NCBINCBI36Build 36hg18NCBI36
Build 34119,362,779 - 9,423,651NCBI
Celera119,527,846 - 9,591,349 (+)NCBICelera
Cytogenetic Map11p15.4NCBI
HuRef119,077,758 - 9,141,170 (+)NCBIHuRef
CHM1_1119,405,091 - 9,468,610 (+)NCBICHM1_1
T2T-CHM13v2.0119,469,789 - 9,533,256 (+)NCBIT2T-CHM13v2.0
Ipo7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397109,617,522 - 109,655,816 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7109,617,481 - 109,655,816 (+)EnsemblGRCm39 Ensembl
GRCm387110,018,315 - 110,056,609 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7110,018,274 - 110,056,609 (+)EnsemblGRCm38mm10GRCm38
MGSCv377117,161,939 - 117,198,628 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367109,809,602 - 109,846,291 (+)NCBIMGSCv36mm8
Celera7109,992,202 - 110,028,891 (+)NCBICelera
Cytogenetic Map7E3NCBI
cM Map757.7NCBI
Ipo7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81173,497,472 - 173,537,707 (+)NCBIGRCr8
mRatBN7.21164,062,702 - 164,102,938 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1164,062,702 - 164,102,938 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1172,398,957 - 172,439,194 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01179,584,959 - 179,625,195 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01172,267,135 - 172,307,393 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01174,655,939 - 174,696,173 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1174,655,939 - 174,696,173 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01181,641,921 - 181,696,091 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41167,658,312 - 167,698,113 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11167,768,982 - 167,808,323 (+)NCBI
Celera1161,960,661 - 162,000,936 (+)NCBICelera
Cytogenetic Map1q33NCBI
Ipo7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541425,131,821 - 25,195,961 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541425,131,703 - 25,195,892 (+)NCBIChiLan1.0ChiLan1.0
IPO7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2911,827,388 - 11,889,994 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11111,785,980 - 11,848,626 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0119,521,055 - 9,583,638 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1119,256,060 - 9,318,610 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl119,256,060 - 9,318,333 (+)Ensemblpanpan1.1panPan2
IPO7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12132,692,206 - 32,748,140 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2132,691,933 - 32,746,124 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2132,259,943 - 32,315,887 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02133,570,892 - 33,626,829 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2133,570,873 - 33,626,610 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12132,834,650 - 32,890,535 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02133,001,050 - 33,056,915 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02133,294,796 - 33,350,686 (+)NCBIUU_Cfam_GSD_1.0
Ipo7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494752,650,515 - 52,705,688 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365288,680,976 - 8,739,892 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365288,683,543 - 8,739,617 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IPO7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9111,662 - 163,104 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19111,657 - 163,137 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2912,448 - 49,237 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IPO7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1155,360,645 - 55,422,470 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl155,362,694 - 55,422,427 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038153,046,986 - 153,110,405 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ipo7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247661,519,937 - 1,594,018 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247661,519,946 - 1,594,014 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in IPO7
28 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 11p15.5-13(chr11:202758-31726224)x3 copy number gain See cases [RCV000053613] Chr11:202758..31726224 [GRCh38]
Chr11:202758..31747772 [GRCh37]
Chr11:192758..31704348 [NCBI36]
Chr11:11p15.5-13		 pathogenic
GRCh38/hg38 11p15.5-15.1(chr11:446754-18904742)x3 copy number gain See cases [RCV000133997] Chr11:446754..18904742 [GRCh38]
Chr11:446754..18926289 [GRCh37]
Chr11:436754..18882865 [NCBI36]
Chr11:11p15.5-15.1		 pathogenic
GRCh38/hg38 11p15.4(chr11:9166889-9494694)x3 copy number gain See cases [RCV000139156] Chr11:9166889..9494694 [GRCh38]
Chr11:9188436..9516241 [GRCh37]
Chr11:9145012..9472817 [NCBI36]
Chr11:11p15.4		 uncertain significance
GRCh38/hg38 11p15.5-15.4(chr11:61793-10727969)x3 copy number gain See cases [RCV000139987] Chr11:61793..10727969 [GRCh38]
Chr11:61793..10749516 [GRCh37]
Chr11:51793..10706092 [NCBI36]
Chr11:11p15.5-15.4		 pathogenic
GRCh38/hg38 11p15.4(chr11:7995676-10437205)x3 copy number gain See cases [RCV000143490] Chr11:7995676..10437205 [GRCh38]
Chr11:8017223..10458752 [GRCh37]
Chr11:7973799..10415328 [NCBI36]
Chr11:11p15.4		 uncertain significance
GRCh37/hg19 11p15.5-12(chr11:230615-37698540)x3 copy number gain See cases [RCV000511561] Chr11:230615..37698540 [GRCh37]
Chr11:11p15.5-12		 pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470) copy number gain See cases [RCV000511729] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)x3 copy number gain See cases [RCV000510881] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11p15.5-15.3(chr11:193146-12643136) copy number gain Silver-Russell syndrome 1 [RCV000767567] Chr11:193146..12643136 [GRCh37]
Chr11:11p15.5-15.3		 pathogenic
NM_006391.3(IPO7):c.1790A>G (p.Asp597Gly) single nucleotide variant Inborn genetic diseases [RCV003259279] Chr11:9430912 [GRCh38]
Chr11:9452459 [GRCh37]
Chr11:11p15.4		 uncertain significance
GRCh37/hg19 11p15.5-14.3(chr11:230615-25584362)x3 copy number gain See cases [RCV000512225] Chr11:230615..25584362 [GRCh37]
Chr11:11p15.5-14.3		 pathogenic
GRCh37/hg19 11p15.5-13(chr11:230615-31995219)x3 copy number gain See cases [RCV000512477] Chr11:230615..31995219 [GRCh37]
Chr11:11p15.5-13		 pathogenic
GRCh37/hg19 11p15.5-15.4(chr11:230615-9704511)x3 copy number gain not provided [RCV000683369] Chr11:230615..9704511 [GRCh37]
Chr11:11p15.5-15.4		 pathogenic
GRCh37/hg19 11p15.5-15.1(chr11:230615-17099213)x3 copy number gain not provided [RCV000683372] Chr11:230615..17099213 [GRCh37]
Chr11:11p15.5-15.1		 pathogenic
GRCh37/hg19 11p15.5-q25(chr11:198510-134934063)x3 copy number gain not provided [RCV000737348] Chr11:198510..134934063 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11p15.5-q25(chr11:70864-134938470)x3 copy number gain not provided [RCV000749874] Chr11:70864..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11p15.5-13(chr11:235934-33826995)x3 copy number gain not provided [RCV001006372] Chr11:235934..33826995 [GRCh37]
Chr11:11p15.5-13		 pathogenic
GRCh37/hg19 11p15.5-14.2(chr11:230615-26881146)x3 copy number gain See cases [RCV002286351] Chr11:230615..26881146 [GRCh37]
Chr11:11p15.5-14.2		 pathogenic
NM_006391.3(IPO7):c.2477A>G (p.Asp826Gly) single nucleotide variant Inborn genetic diseases [RCV002733021] Chr11:9437962 [GRCh38]
Chr11:9459509 [GRCh37]
Chr11:11p15.4		 uncertain significance
NM_006391.3(IPO7):c.1264C>G (p.Pro422Ala) single nucleotide variant Inborn genetic diseases [RCV002688452] Chr11:9425191 [GRCh38]
Chr11:9446738 [GRCh37]
Chr11:11p15.4		 uncertain significance
NM_006391.3(IPO7):c.1088C>G (p.Ala363Gly) single nucleotide variant Inborn genetic diseases [RCV002905040] Chr11:9423823 [GRCh38]
Chr11:9445370 [GRCh37]
Chr11:11p15.4		 uncertain significance
NM_006391.3(IPO7):c.1861G>A (p.Val621Ile) single nucleotide variant Inborn genetic diseases [RCV002728277] Chr11:9430983 [GRCh38]
Chr11:9452530 [GRCh37]
Chr11:11p15.4		 uncertain significance
NM_006391.3(IPO7):c.2935G>A (p.Ala979Thr) single nucleotide variant Inborn genetic diseases [RCV002946999] Chr11:9442113 [GRCh38]
Chr11:9463660 [GRCh37]
Chr11:11p15.4		 uncertain significance
NM_006391.3(IPO7):c.286G>T (p.Val96Leu) single nucleotide variant Inborn genetic diseases [RCV002863947] Chr11:9408605 [GRCh38]
Chr11:9430152 [GRCh37]
Chr11:11p15.4		 uncertain significance
NM_006391.3(IPO7):c.406T>A (p.Tyr136Asn) single nucleotide variant Inborn genetic diseases [RCV002781849] Chr11:9410013 [GRCh38]
Chr11:9431560 [GRCh37]
Chr11:11p15.4		 uncertain significance
NM_006391.3(IPO7):c.2011A>T (p.Met671Leu) single nucleotide variant Inborn genetic diseases [RCV002888208] Chr11:9433783 [GRCh38]
Chr11:9455330 [GRCh37]
Chr11:11p15.4		 uncertain significance
NM_006391.3(IPO7):c.2786A>T (p.Asp929Val) single nucleotide variant Inborn genetic diseases [RCV002950335] Chr11:9440545 [GRCh38]
Chr11:9462092 [GRCh37]
Chr11:11p15.4		 uncertain significance
NM_006391.3(IPO7):c.1517T>C (p.Ile506Thr) single nucleotide variant Inborn genetic diseases [RCV002789707] Chr11:9429122 [GRCh38]
Chr11:9450669 [GRCh37]
Chr11:11p15.4		 uncertain significance
NM_006391.3(IPO7):c.2580G>C (p.Gln860His) single nucleotide variant Inborn genetic diseases [RCV002641478] Chr11:9438170 [GRCh38]
Chr11:9459717 [GRCh37]
Chr11:11p15.4		 uncertain significance
NM_006391.3(IPO7):c.799A>G (p.Ile267Val) single nucleotide variant Inborn genetic diseases [RCV002939750] Chr11:9420483 [GRCh38]
Chr11:9442030 [GRCh37]
Chr11:11p15.4		 uncertain significance
NM_006391.3(IPO7):c.2357C>G (p.Ala786Gly) single nucleotide variant Inborn genetic diseases [RCV002963522] Chr11:9437842 [GRCh38]
Chr11:9459389 [GRCh37]
Chr11:11p15.4		 uncertain significance
NM_006391.3(IPO7):c.2182G>A (p.Gly728Arg) single nucleotide variant Inborn genetic diseases [RCV002896809] Chr11:9436280 [GRCh38]
Chr11:9457827 [GRCh37]
Chr11:11p15.4		 uncertain significance
NM_006391.3(IPO7):c.2413C>T (p.Arg805Cys) single nucleotide variant Inborn genetic diseases [RCV002920369] Chr11:9437898 [GRCh38]
Chr11:9459445 [GRCh37]
Chr11:11p15.4		 uncertain significance
NM_006391.3(IPO7):c.677C>G (p.Thr226Arg) single nucleotide variant Inborn genetic diseases [RCV002944396] Chr11:9417099 [GRCh38]
Chr11:9438646 [GRCh37]
Chr11:11p15.4		 uncertain significance
NM_006391.3(IPO7):c.2947G>C (p.Gly983Arg) single nucleotide variant Inborn genetic diseases [RCV003279279] Chr11:9442125 [GRCh38]
Chr11:9463672 [GRCh37]
Chr11:11p15.4		 uncertain significance
NM_006391.3(IPO7):c.1876A>G (p.Lys626Glu) single nucleotide variant Inborn genetic diseases [RCV003200713] Chr11:9430998 [GRCh38]
Chr11:9452545 [GRCh37]
Chr11:11p15.4		 uncertain significance
NM_006391.3(IPO7):c.2408A>G (p.Asn803Ser) single nucleotide variant Inborn genetic diseases [RCV003190809] Chr11:9437893 [GRCh38]
Chr11:9459440 [GRCh37]
Chr11:11p15.4		 uncertain significance
NM_006391.3(IPO7):c.1721C>T (p.Thr574Ile) single nucleotide variant Inborn genetic diseases [RCV003346040] Chr11:9429803 [GRCh38]
Chr11:9451350 [GRCh37]
Chr11:11p15.4		 uncertain significance
NM_006391.3(IPO7):c.1397G>A (p.Ser466Asn) single nucleotide variant Inborn genetic diseases [RCV003367228] Chr11:9428601 [GRCh38]
Chr11:9450148 [GRCh37]
Chr11:11p15.4		 uncertain significance
NM_006391.3(IPO7):c.189G>A (p.Met63Ile) single nucleotide variant Inborn genetic diseases [RCV003350366] Chr11:9408508 [GRCh38]
Chr11:9430055 [GRCh37]
Chr11:11p15.4		 uncertain significance
NM_006391.3(IPO7):c.218C>T (p.Thr73Ile) single nucleotide variant Inborn genetic diseases [RCV003383326] Chr11:9408537 [GRCh38]
Chr11:9430084 [GRCh37]
Chr11:11p15.4		 uncertain significance
NM_006391.3(IPO7):c.1399A>G (p.Ser467Gly) single nucleotide variant Inborn genetic diseases [RCV003351048] Chr11:9428603 [GRCh38]
Chr11:9450150 [GRCh37]
Chr11:11p15.4		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1899
Count of miRNA genes:1020
Interacting mature miRNAs:1178
Transcripts:ENST00000379719, ENST00000527431, ENST00000528833, ENST00000530037, ENST00000531235, ENST00000533233, ENST00000533680
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
IB3562  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37119,468,212 - 9,468,369UniSTSGRCh37
Build 36119,424,788 - 9,424,945RGDNCBI36
Celera119,589,887 - 9,590,044RGD
Cytogenetic Map11p15.4UniSTS
HuRef119,139,708 - 9,139,865UniSTS
GeneMap99-GB4 RH Map1145.36UniSTS
Whitehead-RH Map1143.7UniSTS
RH69452  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37119,468,032 - 9,468,204UniSTSGRCh37
Build 36119,424,608 - 9,424,780RGDNCBI36
Celera119,589,707 - 9,589,879RGD
Cytogenetic Map11p15.4UniSTS
HuRef119,139,528 - 9,139,700UniSTS
RH40012  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371324,695,287 - 24,695,472UniSTSGRCh37
GRCh37119,467,467 - 9,467,653UniSTSGRCh37
Build 36119,424,043 - 9,424,229RGDNCBI36
Celera119,589,142 - 9,589,328RGD
Celera135,757,509 - 5,757,694UniSTS
Cytogenetic Map13q12.12UniSTS
Cytogenetic Map11p15.4UniSTS
HuRef119,138,963 - 9,139,149UniSTS
HuRef135,507,150 - 5,507,335UniSTS
SHGC-82116  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37119,445,544 - 9,445,885UniSTSGRCh37
Build 36119,402,120 - 9,402,461RGDNCBI36
Celera119,567,247 - 9,567,588RGD
Cytogenetic Map11p15.4UniSTS
HuRef119,117,222 - 9,117,563UniSTS
TNG Radiation Hybrid Map114506.0UniSTS
GDB:451541  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371324,695,869 - 24,696,092UniSTSGRCh37
GRCh37119,466,853 - 9,467,074UniSTSGRCh37
Build 36119,423,429 - 9,423,650RGDNCBI36
Celera119,588,529 - 9,588,749RGD
Celera135,758,091 - 5,758,314UniSTS
Cytogenetic Map13q12.12UniSTS
Cytogenetic Map11p15.4UniSTS
HuRef119,138,350 - 9,138,570UniSTS
HuRef135,507,732 - 5,507,955UniSTS
SHGC-31060  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37119,469,496 - 9,469,620UniSTSGRCh37
Build 36119,426,072 - 9,426,196RGDNCBI36
Celera119,591,171 - 9,591,295RGD
Cytogenetic Map11p15.4UniSTS
HuRef119,140,992 - 9,141,116UniSTS
TNG Radiation Hybrid Map114525.0UniSTS
Stanford-G3 RH Map11298.0UniSTS
GeneMap99-GB4 RH Map1145.29UniSTS
Whitehead-RH Map1145.9UniSTS
NCBI RH Map1126.6UniSTS
GeneMap99-G3 RH Map11298.0UniSTS
SHGC-36072  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37119,468,822 - 9,468,922UniSTSGRCh37
Build 36119,425,398 - 9,425,498RGDNCBI36
Celera119,590,497 - 9,590,597RGD
Cytogenetic Map11p15.4UniSTS
HuRef119,140,318 - 9,140,418UniSTS
GeneMap99-G3 RH Map11298.0UniSTS
MARC_17859-17860:1025012152:3  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37119,467,084 - 9,467,545UniSTSGRCh37
Build 36119,423,660 - 9,424,121RGDNCBI36
Celera119,588,759 - 9,589,220RGD
HuRef119,138,580 - 9,139,041UniSTS
G27408  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11p15.4UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2426 2170 1607 513 1273 354 4356 2066 3477 398 1408 1611 175 1 1203 2787 6 2
Low 13 817 119 111 674 111 1 131 257 21 52 2 1 1
Below cutoff 4 4

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_006391 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC055845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC132192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF098799 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ295844 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK027487 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK027892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK074908 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK312885 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL117596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL137335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC114929 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM980653 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX342418 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA780921 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000379719   ⟹   ENSP00000369042
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl119,384,652 - 9,448,127 (+)Ensembl
RefSeq Acc Id: ENST00000527431   ⟹   ENSP00000435235
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl119,384,653 - 9,414,353 (+)Ensembl
RefSeq Acc Id: ENST00000528833
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl119,410,069 - 9,414,591 (+)Ensembl
RefSeq Acc Id: ENST00000530037
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl119,423,786 - 9,425,324 (+)Ensembl
RefSeq Acc Id: ENST00000531235
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl119,420,279 - 9,420,669 (+)Ensembl
RefSeq Acc Id: ENST00000533233   ⟹   ENSP00000433313
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl119,384,652 - 9,410,032 (+)Ensembl
RefSeq Acc Id: ENST00000533680
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl119,402,734 - 9,403,540 (+)Ensembl
RefSeq Acc Id: ENST00000630083   ⟹   ENSP00000486575
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl119,384,764 - 9,392,308 (+)Ensembl
RefSeq Acc Id: NM_006391   ⟹   NP_006382
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38119,384,652 - 9,448,127 (+)NCBI
GRCh37119,406,169 - 9,469,674 (+)ENTREZGENE
Build 36119,362,780 - 9,423,651 (+)NCBI Archive
HuRef119,077,758 - 9,141,170 (+)ENTREZGENE
CHM1_1119,405,091 - 9,468,610 (+)NCBI
T2T-CHM13v2.0119,469,789 - 9,533,256 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_006382   ⟸   NM_006391
- UniProtKB: Q9H177 (UniProtKB/Swiss-Prot),   Q1RMF7 (UniProtKB/Swiss-Prot),   B2R786 (UniProtKB/Swiss-Prot),   A6NNM5 (UniProtKB/Swiss-Prot),   Q9NTE3 (UniProtKB/Swiss-Prot),   O95373 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000433313   ⟸   ENST00000533233
RefSeq Acc Id: ENSP00000369042   ⟸   ENST00000379719
RefSeq Acc Id: ENSP00000486575   ⟸   ENST00000630083
RefSeq Acc Id: ENSP00000435235   ⟸   ENST00000527431
Protein Domains
Importin N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O95373-F1-model_v2 AlphaFold O95373 1-1038 view protein structure

Promoters
RGD ID:6789016
Promoter ID:HG_KWN:12295
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_006391
Position:
Human AssemblyChrPosition (strand)Source
Build 36119,362,569 - 9,363,069 (+)MPROMDB
RGD ID:7219611
Promoter ID:EPDNEW_H15552
Type:initiation region
Name:IPO7_1
Description:importin 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38119,384,652 - 9,384,712EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:9852 AgrOrtholog
COSMIC IPO7 COSMIC
Ensembl Genes ENSG00000205339 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000379719 ENTREZGENE
  ENST00000379719.8 UniProtKB/Swiss-Prot
  ENST00000527431.1 UniProtKB/TrEMBL
  ENST00000533233.1 UniProtKB/TrEMBL
  ENST00000630083.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000205339 GTEx
HGNC ID HGNC:9852 ENTREZGENE
Human Proteome Map IPO7 Human Proteome Map
InterPro ARM-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Importin-beta_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  XPO2_central UniProtKB/Swiss-Prot
KEGG Report hsa:10527 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 10527 ENTREZGENE
OMIM 605586 OMIM
PANTHER IMPORTIN-7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IMPORTIN-7, 8, 11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Cse1 UniProtKB/Swiss-Prot
  IBN_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA34213 PharmGKB
PROSITE IMPORTIN_B_NT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART IBN_N UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48371 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6NNM5 ENTREZGENE
  B2R786 ENTREZGENE
  B3KNG9_HUMAN UniProtKB/TrEMBL
  E9PLB2_HUMAN UniProtKB/TrEMBL
  E9PLJ0_HUMAN UniProtKB/TrEMBL
  IPO7_HUMAN UniProtKB/Swiss-Prot
  L8E8A9_HUMAN UniProtKB/TrEMBL
  O95373 ENTREZGENE
  Q1RMF7 ENTREZGENE
  Q9H177 ENTREZGENE
  Q9NTE3 ENTREZGENE
UniProt Secondary A6NNM5 UniProtKB/Swiss-Prot
  B2R786 UniProtKB/Swiss-Prot
  Q1RMF7 UniProtKB/Swiss-Prot
  Q9H177 UniProtKB/Swiss-Prot
  Q9NTE3 UniProtKB/Swiss-Prot