Il4ra Gene Search Result

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4 records found for search term Il4ra

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RGD ID	Symbol	Name	Description	Chr	Start	Stop	Species	Annotations	Match	Type
10798	Il4ra	interleukin 4 receptor, alpha	Predicted to enable interleukin-4 receptor activity. Involved in positive regulation of chemokine production; positive regulation of cold-induced thermogenesis; and positive regulation of macrophage activation. Acts upstream of or within several processes, including defense response to protozoan; ne ... (more) gative regulation of T-helper 1 cell differentiation; and positive regulation of immune effector process. Predicted to be located in centriolar satellite; extracellular space; and nucleoplasm. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including adrenal medulla; early conceptus; hemolymphoid system; medulla oblongata basal plate mantle layer; and reproductive system. Used to study asthma. Human ortholog(s) of this gene implicated in several diseases, including acne; allergic conjunctivitis; multiple sclerosis (multiple); renal tuberculosis; and rheumatoid arthritis. Orthologous to human IL4R (interleukin 4 receptor). [provided by Alliance of Genome Resources, Jul 2025]	7	125151443	125178646	Mouse	377	symbol , PhenoGen	gene, protein-coding, VALIDATED [RefSeq]
2899	Il4r	interleukin 4 receptor	ENCODES a protein that exhibits interleukin-4 receptor activity (ortholog); INVOLVED IN regulation of cell population proliferation; response to estrogen; response to odorant; PARTICIPATES IN interleukin-4 signaling pathway; cytokine mediated signaling pathway; Jak-Stat signaling pathway; ASSOCIATED ... (more) WITH Experimental Autoimmune Myasthenia Gravis; myocardial infarction; Otitis Media with Effusion; FOUND IN extracellular space; plasma membrane (ortholog); receptor complex (ortholog); INTERACTS WITH (+)-pilocarpine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine	1	189545739	189570639	Rat	320	old_gene_symbol	gene, protein-coding, VALIDATED [RefSeq]
735615	IL4R	interleukin 4 receptor	This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein ca ... (more) n be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012]	16	27313756	27364778	Human	336	old_gene_symbol	gene, protein-coding, REVIEWED [RefSeq]
732736	Il13ra1	interleukin 13 receptor, alpha 1	This gene encodes a transmembrane protein that complexes with interleukin 4 receptor alpha (IL4RA) to form a functional receptor for interleukin-13. Signalling through this pathway mediates allergy response and occurs during bronchial asthma. [provided by RefSeq ... (more) , May 2015]	X	35375761	35434915	Mouse	217	description	gene, protein-coding, REVIEWED [RefSeq]