| 620072 | Elp1 | elongator acetyltransferase complex subunit 1 | ENCODES a protein that exhibits ATP binding; protein kinase activity; INVOLVED IN I-kappaB phosphorylation; tRNA wobble uridine modification (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); Charcot-Marie-Tooth disease (ortholog); Gaucher's disease (ortholog); FOUND IN cytoplasm (ortholog); c ytosol (ortholog); elongator holoenzyme complex (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene | 5 | 76248545 | 76300985 | Rat | 143 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 734035 | ELP1 | elongator acetyltransferase complex subunit 1 | The protein encoded by this gene is a scaffold protein and a regulator for three different kinases involved in proinflammatory signaling. The encoded protein can bind NF-kappa-B-inducing kinase and I-kappa-B kinases through separate domains and assemble them into an active kinase complex. Mutations in this gene have been associated with familial dysautonomia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016] | 9 | 108867517 | 108934124 | Human | 598 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 734036 | Elp1 | elongator complex protein 1 | Predicted to enable ATP binding activity; protein kinase activity; and tRNA binding activity. Involved in tRNA wobble uridine modification. Located in cytoplasm. Is expressed in several structures, including brain; genitourinary system; liver; lung; and spleen. Used to study Riley-Day syndrome and h emophagocytic lymphohistiocytosis. Human ortholog(s) of this gene implicated in Riley-Day syndrome; asthma; kyphosis; medulloblastoma; and scoliosis. Orthologous to human ELP1 (elongator acetyltransferase complex subunit 1). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 56746547 | 56802565 | Mouse | 285 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 8892359 | Elp1 | elongator acetyltransferase complex subunit 1 | ENCODES a protein that exhibits ATP binding (ortholog); protein kinase activity (ortholog); INVOLVED IN I-kappaB phosphorylation (ortholog); tRNA wobble uridine modification (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); Charcot-Marie-Tooth disease (ortholog); Gaucher's disease (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); elongator holoenzyme complex (ortholog) | NW_004955419 | 18035197 | 18097681 | Chinchilla | 32 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 11668347 | ELP1 | elongator acetyltransferase complex subunit 1 | ENCODES a protein that exhibits ATP binding (ortholog); protein kinase activity (ortholog); INVOLVED IN I-kappaB phosphorylation (ortholog); ASSOCIATED WITH asthma (ortholog); Breast Neoplasms (ortholog); Charcot-Marie-Tooth disease (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); elon gator holoenzyme complex (inferred) | 9 | 80020131 | 80085076 | Bonobo | 40 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 12088032 | ELP1 | elongator acetyltransferase complex subunit 1 | ENCODES a protein that exhibits ATP binding (ortholog); protein kinase activity (ortholog); INVOLVED IN I-kappaB phosphorylation (ortholog); ASSOCIATED WITH asthma (ortholog); Breast Neoplasms (ortholog); Charcot-Marie-Tooth disease (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); elon gator holoenzyme complex (inferred) | 11 | 64035667 | 64094402 | Dog | 40 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 12704700 | Elp1 | elongator acetyltransferase complex subunit 1 | ENCODES a protein that exhibits ATP binding (ortholog); protein kinase activity (ortholog); INVOLVED IN I-kappaB phosphorylation (ortholog); ASSOCIATED WITH asthma (ortholog); Breast Neoplasms (ortholog); Charcot-Marie-Tooth disease (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); elon gator holoenzyme complex (inferred) | NW_004936559 | 3924185 | 3981907 | Squirrel | 40 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 18903306 | Elp1 | elongator acetyltransferase complex subunit 1 | ENCODES a protein that exhibits ATP binding (ortholog); protein kinase activity (ortholog); INVOLVED IN I-kappaB phosphorylation (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); Charcot-Marie-Tooth disease (ortholog); Gaucher's disease (ortholog); FOUND IN nucleoplasm (ortholog) | | | | Naked Mole-Rat | 36 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 13986494 | ELP1 | elongator acetyltransferase complex subunit 1 | ENCODES a protein that exhibits ATP binding (ortholog); protein kinase activity (ortholog); INVOLVED IN I-kappaB phosphorylation (ortholog); ASSOCIATED WITH asthma (ortholog); Breast Neoplasms (ortholog); Charcot-Marie-Tooth disease (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); elon gator holoenzyme complex (inferred) | | | | Pig | 39 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 18516282 | ELP1 | elongator acetyltransferase complex subunit 1 | ENCODES a protein that exhibits ATP binding (ortholog); protein kinase activity (ortholog); INVOLVED IN I-kappaB phosphorylation (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); Charcot-Marie-Tooth disease (ortholog); Gaucher's disease (ortholog); FOUND IN cytoplasm (inferred); cytosol (infe rred); elongator holoenzyme complex (inferred) | | | | Green Monkey | 40 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |