| 621881 | Idh3b | isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta | ENCODES a protein that exhibits enzyme activator activity (ortholog); INVOLVED IN tricarboxylic acid cycle (ortholog); PARTICIPATES IN citric acid cycle pathway; fumaric aciduria pathway; mitochondrial complex II deficiency pathway; ASSOCIATED WITH Disease Progression (ortholog); fundus dystrophy (o rtholog); optic atrophy (ortholog); FOUND IN isocitrate dehydrogenase complex (NAD+) (ortholog); mitochondrion (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride; bisphenol A | 3 | 137934971 | 137940275 | Rat | 123 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1349945 | IDH3B | isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta | Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent is ocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the beta subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Sep 2016] | 20 | 2658395 | 2664216 | Human | 242 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1550265 | Idh3b | isocitrate dehydrogenase 3 (NAD+) beta | Predicted to enable NAD binding activity; magnesium ion binding activity; and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be involved in isocitrate metabolic process and tricarboxylic acid cycle. Located in mitochondrion. Part of isocitrate deh ydrogenase complex (NAD+). Is expressed in several structures, including alimentary system; integumental system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in retinitis pigmentosa 46. Orthologous to human IDH3B (isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta). [provided by Alliance of Genome Resources, Apr 2025] | 2 | 130121229 | 130126371 | Mouse | 133 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8998908 | Idh3b | isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta | ENCODES a protein that exhibits enzyme activator activity (ortholog); INVOLVED IN tricarboxylic acid cycle (ortholog); PARTICIPATES IN citric acid cycle pathway; fumaric aciduria pathway; mitochondrial complex II deficiency pathway; ASSOCIATED WITH Disease Progression (ortholog); fundus dystrophy (o rtholog); optic atrophy (ortholog); FOUND IN isocitrate dehydrogenase complex (NAD+) (ortholog); mitochondrion (ortholog) | NW_004955415 | 13642804 | 13649023 | Chinchilla | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11890891 | IDH3B | isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta | ENCODES a protein that exhibits enzyme activator activity (ortholog); INVOLVED IN isocitrate metabolic process (inferred); tricarboxylic acid cycle (inferred); PARTICIPATES IN citric acid cycle pathway; fumaric aciduria pathway; mitochondrial complex II deficiency pathway; ASSOCIATED WITH Disease Pr ogression (ortholog); fundus dystrophy (ortholog); optic atrophy (ortholog); FOUND IN isocitrate dehydrogenase complex (NAD+) (inferred); mitochondrion (inferred) | 20 | 2766598 | 2772571 | Bonobo | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12201338 | IDH3B | isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta | ENCODES a protein that exhibits enzyme activator activity (ortholog); INVOLVED IN tricarboxylic acid cycle (inferred); PARTICIPATES IN citric acid cycle pathway; fumaric aciduria pathway; mitochondrial complex II deficiency pathway; ASSOCIATED WITH Disease Progression (ortholog); fundus dystrophy (o rtholog); optic atrophy (ortholog); FOUND IN isocitrate dehydrogenase complex (NAD+) (ortholog) | 24 | 18556437 | 18561399 | Dog | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12582302 | Idh3b | isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta | ENCODES a protein that exhibits enzyme activator activity (ortholog); INVOLVED IN isocitrate metabolic process (inferred); tricarboxylic acid cycle (inferred); PARTICIPATES IN citric acid cycle pathway; fumaric aciduria pathway; mitochondrial complex II deficiency pathway; ASSOCIATED WITH Disease Pr ogression (ortholog); fundus dystrophy (ortholog); optic atrophy (ortholog); FOUND IN isocitrate dehydrogenase complex (NAD+) (inferred); mitochondrion (inferred) | NW_004936485 | 16033287 | 16038097 | Squirrel | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18909260 | Idh3b | isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta | ENCODES a protein that exhibits enzyme activator activity (ortholog); INVOLVED IN isocitrate metabolic process (inferred); tricarboxylic acid cycle (inferred); PARTICIPATES IN citric acid cycle pathway; fumaric aciduria pathway; mitochondrial complex II deficiency pathway; ASSOCIATED WITH Disease Pr ogression (ortholog); fundus dystrophy (ortholog); optic atrophy (ortholog); FOUND IN isocitrate dehydrogenase complex (NAD+) (ortholog) | | | | Naked Mole-Rat | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18550478 | IDH3B | isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta | ENCODES a protein that exhibits enzyme activator activity (ortholog); INVOLVED IN isocitrate metabolic process (inferred); tricarboxylic acid cycle (inferred); PARTICIPATES IN citric acid cycle pathway; fumaric aciduria pathway; mitochondrial complex II deficiency pathway; ASSOCIATED WITH Disease Pr ogression (ortholog); fundus dystrophy (ortholog); optic atrophy (ortholog); FOUND IN isocitrate dehydrogenase complex (NAD+) (inferred); mitochondrion (inferred) | | | | Green Monkey | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14377519 | Idh3b | | | | | | Fly | | symbol | gene, null |
| 13928301 | IDH3B | isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta | ENCODES a protein that exhibits enzyme activator activity; INVOLVED IN tricarboxylic acid cycle (inferred); PARTICIPATES IN citric acid cycle pathway; fumaric aciduria pathway; mitochondrial complex II deficiency pathway; ASSOCIATED WITH Disease Progression (ortholog); fundus dystrophy (ortholog); o ptic atrophy (ortholog); FOUND IN isocitrate dehydrogenase complex (NAD+) (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 32 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 155256988 | idh3b | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155244610 | idh3b.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 149735948 | IDH3B-DT | IDH3B divergent transcript | | 20 | 2664274 | 2669453 | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 16554056 | IDH3B-DT | IDH3B divergent transcript | | | | | Human | | symbol , COSMIC , name , Human Proteome Map | gene, lncrna |
| 1587369 | Idh3b-ps1 | isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta, pseudogene 1 | | 7 | 97190508 | 97191643 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |