| 2847 | Htr1d | 5-hydroxytryptamine receptor 1D | ENCODES a protein that exhibits G protein-coupled serotonin receptor activity (ortholog); Gi/o-coupled serotonin receptor activity (ortholog); serotonin binding (ortholog); INVOLVED IN regulation of synaptic vesicle exocytosis; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathwa y (ortholog); adenylate cyclase-inhibiting serotonin receptor signaling pathway (ortholog); ASSOCIATED WITH autistic disorder (ortholog); Hypotension (ortholog); obsessive-compulsive disorder (ortholog); FOUND IN glutamatergic synapse; neuronal dense core vesicle; plasma membrane (ortholog); INTERACTS WITH 6-propyl-2-thiouracil; amitriptyline; ammonium chloride | 5 | 153939735 | 153960012 | Rat | 114 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 10747 | Htr1d | 5-hydroxytryptamine (serotonin) receptor 1D | Enables G protein-coupled serotonin receptor activity and serotonin binding activity. Acts upstream of or within response to toxic substance. Predicted to be active in several cellular components, including dendrite; glutamatergic synapse; and neuronal dense core vesicle. Is expressed in several str uctures, including alimentary system; blastocyst; central nervous system; eye; and genitourinary system. Orthologous to human HTR1D (5-hydroxytryptamine receptor 1D). [provided by Alliance of Genome Resources, Apr 2025] | 4 | 136150835 | 136171716 | Mouse | 116 | symbol , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 736440 | HTR1D | 5-hydroxytryptamine receptor 1D | Enables Gi/o-coupled serotonin receptor activity and serotonin receptor activity. Involved in adenylate cyclase-inhibiting serotonin receptor signaling pathway and intestine smooth muscle contraction. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025] | 1 | 23191895 | 23217502 | Human | 116 | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 8896503 | Htr1d | 5-hydroxytryptamine receptor 1D | ENCODES a protein that exhibits G protein-coupled serotonin receptor activity (ortholog); Gi/o-coupled serotonin receptor activity (ortholog); serotonin binding (ortholog); INVOLVED IN adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (ortholog); adenylate cyclase-inhibiting serotonin receptor signaling pathway (ortholog); intestine smooth muscle contraction (ortholog); ASSOCIATED WITH autistic disorder (ortholog); Hypotension (ortholog); obsessive-compulsive disorder (ortholog); FOUND IN glutamatergic synapse (ortholog); neuronal dense core vesicle (ortholog); plasma membrane (ortholog) | NW_004955452 | 3207950 | 3228867 | Chinchilla | 15 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11933967 | HTR1D | 5-hydroxytryptamine receptor 1D | ENCODES a protein that exhibits serotonin binding (ortholog); INVOLVED IN regulation of synaptic vesicle exocytosis (ortholog); response to toxic substance (ortholog); ASSOCIATED WITH autistic disorder (ortholog); Hypotension (ortholog); obsessive-compulsive disorder (ortholog); FOUND IN glutamaterg ic synapse (ortholog); neuronal dense core vesicle (ortholog) | 1 | 22378262 | 22403918 | Bonobo | 36 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12302442 | HTR1D | 5-hydroxytryptamine receptor 1D | ENCODES a protein that exhibits G protein-coupled serotonin receptor activity (ortholog); Gi/o-coupled serotonin receptor activity (ortholog); serotonin binding (ortholog); INVOLVED IN adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (ortholog); intestine smooth muscle contr action (ortholog); regulation of synaptic vesicle exocytosis (ortholog); ASSOCIATED WITH autistic disorder (ortholog); Hypotension (ortholog); obsessive-compulsive disorder (ortholog); FOUND IN glutamatergic synapse (ortholog); neuronal dense core vesicle (ortholog); plasma membrane (ortholog) | 2 | 76198343 | 76200005 | Dog | 36 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12730811 | Htr1d | 5-hydroxytryptamine receptor 1D | ENCODES a protein that exhibits Gi/o-coupled serotonin receptor activity (ortholog); INVOLVED IN adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (ortholog); adenylate cyclase-inhibiting serotonin receptor signaling pathway (ortholog); intestine smooth muscle contraction (or tholog); ASSOCIATED WITH autistic disorder (ortholog); Hypotension (ortholog); obsessive-compulsive disorder (ortholog); FOUND IN glutamatergic synapse (ortholog); neuronal dense core vesicle (ortholog) | NW_004936474 | 8432009 | 8433382 | Squirrel | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14153555 | HTR1D | 5-hydroxytryptamine receptor 1D | ENCODES a protein that exhibits G protein-coupled serotonin receptor activity (ortholog); Gi/o-coupled serotonin receptor activity (ortholog); INVOLVED IN adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (ortholog); intestine smooth muscle contraction (ortholog); regulation of synaptic vesicle exocytosis (ortholog); ASSOCIATED WITH autistic disorder (ortholog); Hypotension (ortholog); obsessive-compulsive disorder (ortholog); FOUND IN glutamatergic synapse (ortholog); neuronal dense core vesicle (ortholog); plasma membrane (ortholog) | | | | Pig | 37 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 626020157 | Htr1d | 5-hydroxytryptamine receptor 1D | ENCODES a protein that exhibits G protein-coupled serotonin receptor activity (ortholog); Gi/o-coupled serotonin receptor activity (ortholog); serotonin binding (ortholog); INVOLVED IN adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (ortholog); adenylate cyclase-inhibiting serotonin receptor signaling pathway (ortholog); intestine smooth muscle contraction (ortholog); ASSOCIATED WITH autistic disorder (ortholog); Hypotension (ortholog); obsessive-compulsive disorder (ortholog); FOUND IN glutamatergic synapse (ortholog); neuronal dense core vesicle (ortholog); plasma membrane (ortholog) | | | | Black Rat | 15 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 288057173 | htr1d | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18908087 | Htr1d | 5-hydroxytryptamine receptor 1D | ENCODES a protein that exhibits Gi/o-coupled serotonin receptor activity (ortholog); INVOLVED IN adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (ortholog); adenylate cyclase-inhibiting serotonin receptor signaling pathway (ortholog); intestine smooth muscle contraction (or tholog); ASSOCIATED WITH autistic disorder (ortholog); Hypotension (ortholog); obsessive-compulsive disorder (ortholog); FOUND IN glutamatergic synapse (ortholog); neuronal dense core vesicle (ortholog) | | | | Naked Mole-Rat | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18576531 | HTR1D | 5-hydroxytryptamine receptor 1D | ENCODES a protein that exhibits serotonin binding (ortholog); INVOLVED IN regulation of synaptic vesicle exocytosis (ortholog); response to toxic substance (ortholog); ASSOCIATED WITH autistic disorder (ortholog); Hypotension (ortholog); obsessive-compulsive disorder (ortholog); FOUND IN glutamaterg ic synapse (ortholog); neuronal dense core vesicle (ortholog) | | | | Green Monkey | 36 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 288083189 | htr1d.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 288057175 | htr1d.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1607548 | Htr1da | 5-hydroxytryptamine (serotonin) receptor 1D alpha | | | | | Mouse | | symbol , PhenoGen | gene, protein-coding |
| 1350130 | HTR1DP1 | 5-hydroxytryptamine receptor 1D pseudogene 1 | INTERACTS WITH cadmium dichloride | 12 | 1152257 | 1153037 | Human | 1 | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 731005 | HTR1B | 5-hydroxytryptamine receptor 1B | The protein encoded by this intronless gene is a G-protein coupled receptor for serotonin (5-hydroxytryptamine). Ligand binding activates second messengers that inhibit the activity of adenylate cyclase and manage the release of serotonin, dopamine, and acetylcholine in the brain. The encoded protei n may be involved in several neuropsychiatric disorders and therefore is often a target of antidepressant and other psychotherapeutic drugs. [provided by RefSeq, Nov 2015] | 6 | 77460924 | 77463491 | Human | 208 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |