| 1347027 | HLF | HLF transcription factor, PAR bZIP family member | This gene encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. The encoded protein forms homodimers or heterodimers with other PAR family members and binds sequence-specific promoter elements to activate transcription. Chromosomal transloc ations fusing portions of this gene with the E2A gene cause a subset of childhood B-lineage acute lymphoid leukemias. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] | 17 | 55264960 | 55325187 | Human | 179 | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1582828 | Hlf | HLF transcription factor, PAR bZIP family member | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); sequence-specific DNA binding (ortholog); sequence-specific double-stranded DNA binding (ortholog); INVOLVED IN positive regulation of transcription by RNA polymerase II (ortholog); s keletal muscle cell differentiation (ortholog); ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); prostate cancer (ortholog); stomach cancer (ortholog); FOUND IN nucleoplasm (ortholog); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine | 10 | 75651320 | 75708979 | Rat | 169 | symbol , old_gene_name , PhenoGen , name | gene, protein-coding, VALIDATED [RefSeq] |
| 1614190 | Hlf | hepatic leukemia factor | Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within skeletal muscle cell differentiation. Predicted to be located in nucleoplasm. Predicted to be pa rt of RNA polymerase II transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Orthologous to human HLF (HLF transcription factor, PAR bZIP family member). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 90227361 | 90281745 | Mouse | 196 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8834743 | Hlf | HLF transcription factor, PAR bZIP family member | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); sequence-specific DNA binding (ortholog); sequence-specific double-stranded DNA binding (ortholog); INVOLVED IN positive regulation of transcription by RNA polymerase II (ortholog); s keletal muscle cell differentiation (ortholog); ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); prostate cancer (ortholog); stomach cancer (ortholog); FOUND IN nucleoplasm (ortholog) | NW_004955451 | 7309895 | 7364166 | Chinchilla | 13 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 11987536 | HLF | HLF transcription factor, PAR bZIP family member | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN skeletal muscle cell differentiation (ortholog); ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); prostate cancer (ortholog); stomach cancer (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred) | 17 | 49353790 | 49413676 | Bonobo | 24 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12287664 | HLF | HLF transcription factor, PAR bZIP family member | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN skeletal muscle cell differentiation (ortholog); ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); prostate cancer (ortholog); stomach cancer (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred); INTERACTS WITH bisphenol A | 9 | 30321090 | 30380480 | Dog | 25 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12709956 | Hlf | HLF transcription factor, PAR bZIP family member | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN skeletal muscle cell differentiation (ortholog); ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); prostate cancer (ortholog); stomach cancer (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred) | NW_004936490 | 7273051 | 7324681 | Squirrel | 24 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18908731 | Hlf | HLF transcription factor, PAR bZIP family member | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); sequence-specific DNA binding (ortholog); sequence-specific double-stranded DNA binding (ortholog); INVOLVED IN positive regulation of transcription by RNA polymerase II (ortholog); s keletal muscle cell differentiation (ortholog); ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); prostate cancer (ortholog); stomach cancer (ortholog); FOUND IN nucleoplasm (ortholog) | | | | Naked Mole-Rat | 24 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18593342 | HLF | HLF transcription factor, PAR bZIP family member | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN skeletal muscle cell differentiation (ortholog); ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); prostate cancer (ortholog); stomach cancer (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred) | | | | Green Monkey | 24 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 14134229 | HLF | HLF transcription factor, PAR bZIP family member | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN skeletal muscle cell differentiation (ortholog); ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); prostate cancer (ortholog); stomach cancer (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 25 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 625862747 | Hlf | HLF transcription factor, PAR bZIP family member | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); sequence-specific DNA binding (ortholog); sequence-specific double-stranded DNA binding (ortholog); INVOLVED IN positive regulation of transcription by RNA polymerase II (ortholog); s keletal muscle cell differentiation (ortholog); ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); prostate cancer (ortholog); stomach cancer (ortholog); FOUND IN nucleoplasm (ortholog) | | | | Black Rat | 12 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 155244152 | hlf | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155259163 | hlf.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155244151 | hlf.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 617301382 | HLF-AS1 | HLF antisense RNA 1 | | | | | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, ncrna |
| 68404 | Epas1 | endothelial PAS domain protein 1 | ENCODES a protein that exhibits cobalt ion binding; DNA-binding transcription factor activity; sequence-specific DNA binding; INVOLVED IN cellular response to hypoxia; cellular response to interleukin-1; cellular response to lipopolysaccharide; PARTICIPATES IN hypoxia inducible factor pathway; renal cell carcinoma pathway; ASSOCIATED WITH acute kidney failure; Brain Injuries; bronchopulmonary dysplasia; FOUND IN cytoplasm (ortholog); nuclear speck (ortholog); nucleoplasm (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 1H-benzimidazole | 6 | 13543252 | 13626147 | Rat | 473 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 68594 | EPAS1 | endothelial PAS domain protein 1 | This gene encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. The encoded protein contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways whic h respond to oxygen levels. Mutations in this gene are associated with erythrocytosis familial type 4. [provided by RefSeq, Nov 2009] | 2 | 46297407 | 46386697 | Human | 544 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 68595 | Epas1 | endothelial PAS domain protein 1 | Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein heterodimerization activity. Involved in mRNA transcription by RNA polymerase II; myoblast fate commitment; and positive regul ation of cold-induced thermogenesis. Acts upstream of or within several processes, including multicellular organismal-level iron ion homeostasis; norepinephrine metabolic process; and surfactant homeostasis. Located in cytoplasm and nuclear speck. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and respiratory system. Used to study newborn respiratory distress syndrome. Human ortholog(s) of this gene implicated in familial erythrocytosis 4; lung non-small cell carcinoma; polycythemia; and pulmonary hypertension. Orthologous to human EPAS1 (endothelial PAS domain protein 1). [provided by Alliance of Genome Resources, Jul 2025] | 17 | 87061292 | 87140838 | Mouse | 554 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 6481576 | HLFP1 | HLF pseudogene 1 | | 6 | 132674885 | 132675383 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 16563677 | AC007638.2 | novel transcript, antisense to HLF | | | | | Human | | name | gene, lncrna |
| 1342616 | CFHR3 | complement factor H related 3 | The protein encoded by this gene is a secreted protein, which belongs to the complement factor H-related protein family. It binds to heparin, and may be involved in complement regulation. Mutations in this gene are associated with decreased risk of age-related macular degeneration, and with an incre ased risk of atypical hemolytic-uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] | 1 | 196774840 | 196795407 | Human | 110 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1313477 | LTF | lactotransferrin | This gene is a member of the transferrin family of genes and its protein product is found in the secondary granules of neutrophils. The protein is a major iron-binding protein in milk and body secretions with an antimicrobial activity, making it an important component of the non-specific immune syst em. The protein demonstrates a broad spectrum of properties, including regulation of iron homeostasis, host defense against a broad range of microbial infections, anti-inflammatory activity, regulation of cellular growth and differentiation and protection against cancer development and metastasis. Antimicrobial, antiviral, antifungal and antiparasitic activity has been found for this protein and its peptides. Activity against both DNA and RNA viruses has been found, including activity against SARS-CoV-2, and HIV. [provided by RefSeq, Jul 2021] | 3 | 46435645 | 46485234 | Human | 278 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1345103 | TEF | TEF transcription factor, PAR bZIP family member | This gene encodes a member of the PAR (proline and acidic amino acid-rich) subfamily of basic region/leucine zipper (bZIP) transcription factors. It is expressed in a broad range of cells and tissues in adult animals, however, during embryonic development, TEF expression appears to be restricted to the developing anterior pituitary gland, coincident with the appearance of thyroid-stimulating hormone, beta (TSHB). Indeed, TEF can bind to, and transactivate the TSHB promoter. It shows homology (in the functional domains) with other members of the PAR-bZIP subfamily of transcription factors, which include albumin D box-binding protein (DBP), human hepatic leukemia factor (HLF) and chicken vitellogenin gene-binding protein (VBP); VBP is considered the chicken homologue of TEF. Different members of the subfamily can readily form heterodimers, and share DNA-binding, and transcriptional regulatory properties. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] | 22 | 41367455 | 41399326 | Human | 176 | description | gene, protein-coding, REVIEWED [RefSeq] |
