| 1559851 | Hexim1 | HEXIM P-TEFb complex subunit 1 | ENCODES a protein that exhibits 7SK snRNA binding (ortholog); cyclin-dependent protein serine/threonine kinase inhibitor activity (ortholog); identical protein binding (ortholog); INVOLVED IN activation of innate immune response (ortholog); heart development (ortholog); negative regulation of DNA-te mplated transcription (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); hereditary breast ovarian cancer syndrome (ortholog); FOUND IN 7SK snRNP (ortholog); cytoplasm (ortholog); nucleoplasm (ortholog); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine | 10 | 88562889 | 88565001 | Rat | 142 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1606576 | HEXIM1 | HEXIM P-TEFb complex subunit 1 | Expression of this gene is induced by hexamethylene-bis-acetamide in vascular smooth muscle cells. This gene has no introns. [provided by RefSeq, Jul 2008] | 17 | 45148475 | 45152099 | Human | 148 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1614974 | Hexim1 | hexamethylene bis-acetamide inducible 1 | Predicted to enable several functions, including 7SK snRNA binding activity; P-TEFb complex binding activity; and cyclin-dependent protein serine/threonine kinase inhibitor activity. Acts upstream of or within heart development and negative regulation of DNA-templated transcription. Located in nucle us. Is expressed in several structures, including branchial arch; embryo mesenchyme; heart and pericardium; hindgut dorsal mesentery; and sensory organ. Orthologous to human HEXIM1 (HEXIM P-TEFb complex subunit 1). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 103007151 | 103010551 | Mouse | 173 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 11835328 | HEXIM1 | HEXIM P-TEFb complex subunit 1 | ENCODES a protein that exhibits 7SK snRNA binding (inferred); cyclin-dependent protein serine/threonine kinase inhibitor activity (inferred); identical protein binding (inferred); INVOLVED IN heart development (ortholog); negative regulation of DNA-templated transcription (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); hereditary breast ovarian cancer syndrome (ortholog); FOUND IN 7SK snRNP (inferred); cytoplasm (inferred); nucleoplasm (inferred) | 17 | 12175544 | 12180077 | Bonobo | 47 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12238372 | HEXIM1 | HEXIM P-TEFb complex subunit 1 | ENCODES a protein that exhibits 7SK snRNA binding (ortholog); identical protein binding (ortholog); P-TEFb complex binding (ortholog); INVOLVED IN activation of innate immune response (ortholog); heart development (ortholog); negative regulation of DNA-templated transcription (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); hereditary breast ovarian cancer syndrome (ortholog); FOUND IN 7SK snRNP (ortholog); nucleoplasm (ortholog) | 9 | 18384811 | 18387981 | Dog | 37 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12550053 | Hexim1 | HEXIM P-TEFb complex subunit 1 | ENCODES a protein that exhibits 7SK snRNA binding (inferred); cyclin-dependent protein serine/threonine kinase inhibitor activity (inferred); identical protein binding (inferred); INVOLVED IN heart development (ortholog); negative regulation of DNA-templated transcription (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); hereditary breast ovarian cancer syndrome (ortholog); FOUND IN 7SK snRNP (inferred); cytoplasm (inferred); nucleoplasm (inferred) | NW_004936541 | 1458474 | 1463039 | Squirrel | 47 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14134160 | HEXIM1 | HEXIM P-TEFb complex subunit 1 | ENCODES a protein that exhibits 7SK snRNA binding (inferred); cyclin-dependent protein serine/threonine kinase inhibitor activity (inferred); identical protein binding (inferred); INVOLVED IN heart development (ortholog); negative regulation of DNA-templated transcription (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); hereditary breast ovarian cancer syndrome (ortholog); FOUND IN 7SK snRNP (inferred); cytoplasm (inferred); nucleoplasm (inferred) | | | | Pig | 47 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 19260178 | HEXIM1 | HEXIM P-TEFb complex subunit 1 | | | | | Dog | | symbol | gene, protein-coding |
| 18774054 | HEXIM1 | HEXIM P-TEFb complex subunit 1 | ENCODES a protein that exhibits 7SK snRNA binding (inferred); cyclin-dependent protein serine/threonine kinase inhibitor activity (inferred); identical protein binding (inferred); INVOLVED IN heart development (ortholog); negative regulation of DNA-templated transcription (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); hereditary breast ovarian cancer syndrome (ortholog); FOUND IN 7SK snRNP (inferred); cytoplasm (inferred); nucleoplasm (inferred) | | | | Green Monkey | 47 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18919225 | Hexim1 | HEXIM P-TEFb complex subunit 1 | ENCODES a protein that exhibits identical protein binding (ortholog); P-TEFb complex binding (ortholog); protein kinase inhibitor activity (ortholog); INVOLVED IN activation of innate immune response (ortholog); heart development (ortholog); negative regulation of DNA-templated transcription (orthol og); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); hereditary breast ovarian cancer syndrome (ortholog); FOUND IN 7SK snRNP (ortholog) | | | | Naked Mole-Rat | 40 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 152178025 | HEXIM1 | HEXIM P-TEFb complex subunit 1 | | | | | Naked Mole-Rat | | symbol | gene, protein-coding |
| 155237761 | hexim1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155237760 | hexim1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155231916 | hexim1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 38630134 | HEXIM2-AS1 | HEXIM2 antisense RNA 1 | | 17 | 45149662 | 45161538 | Human | | old_gene_name | gene, ncrna, VALIDATED [RefSeq] |
| 1601726 | HEXIM2 | HEXIM P-TEFb complex subunit 2 | This gene encodes a member of the HEXIM family of proteins. This protein is a component of the 7SK small nuclear ribonucleoprotein. This protein has been found to negatively regulate the kinase activity of the cyclin-dependent kinase P-TEFb, which phosphorylates multiple target proteins to promote t ranscriptional elongation. This gene is located approximately 7 kb downstream from related family member HEXIM1 on chromosome 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015] | 17 | 45160174 | 45170040 | Human | 89 | description | gene, protein-coding, REVIEWED [RefSeq] |