| 1305914 | Hes7 | hes family bHLH transcription factor 7 | ENCODES a protein that exhibits RNA polymerase II transcription regulatory region sequence-specific DNA binding (ortholog); sequence-specific double-stranded DNA binding (ortholog); INVOLVED IN negative regulation of DNA-templated transcription (ortholog); negative regulation of transcription by RNA polymerase II (ortholog); Notch signaling pathway (ortholog); PARTICIPATES IN Notch signaling pathway; ASSOCIATED WITH Desbuquois dysplasia (ortholog); genetic disease (ortholog); spondylocostal dysostosis (ortholog); FOUND IN nucleus (inferred); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil | 10 | 54322971 | 54327776 | Rat | 77 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1314231 | HES7 | hes family bHLH transcription factor 7 | This gene encodes a member of the hairy and enhancer of split family of bHLH transcription factors. The mouse ortholog of this gene is regulated by Notch signaling. The protein functions as a transcriptional repressor, and is implicated in correct patterning of the axial skeleton. A mutation in this gene has been shown to result in spondylocostal dysostosis. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009] | 17 | 8120592 | 8126634 | Human | 200 | symbol , old_gene_name , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1314232 | Hes7 | hes family bHLH transcription factor 7 | Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of DNA-templated transcription. Acts upstream of or within several processes, including negative regulation of transcription by RNA polymerase II; post-anal tail morphoge nesis; and somitogenesis. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; descending aorta; small intestine; unsegmented mesenchyme; and urinary system. Used to study spondylocostal dysostosis. Human ortholog(s) of this gene implicated in spondylocostal dysostosis 4. Orthologous to human HES7 (hes family bHLH transcription factor 7). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 69009778 | 69014880 | Mouse | 138 | symbol , old_gene_name , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 8833333 | Hes7 | hes family bHLH transcription factor 7 | ENCODES a protein that exhibits RNA polymerase II transcription regulatory region sequence-specific DNA binding (ortholog); sequence-specific double-stranded DNA binding (ortholog); INVOLVED IN negative regulation of DNA-templated transcription (ortholog); negative regulation of transcription by RNA polymerase II (ortholog); Notch signaling pathway (ortholog); PARTICIPATES IN Notch signaling pathway; ASSOCIATED WITH Desbuquois dysplasia (ortholog); genetic disease (ortholog); spondylocostal dysostosis (ortholog) | NW_004955467 | 8837895 | 8841062 | Chinchilla | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12038245 | HES7 | hes family bHLH transcription factor 7 | ENCODES a protein that exhibits RNA polymerase II transcription regulatory region sequence-specific DNA binding (ortholog); sequence-specific double-stranded DNA binding (ortholog); INVOLVED IN negative regulation of DNA-templated transcription (ortholog); negative regulation of transcription by RNA polymerase II (ortholog); Notch signaling pathway (ortholog); PARTICIPATES IN Notch signaling pathway; ASSOCIATED WITH Desbuquois dysplasia (ortholog); genetic disease (ortholog); spondylocostal dysostosis (ortholog) | 17 | 43530919 | 43537999 | Bonobo | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12315095 | HES7 | hes family bHLH transcription factor 7 | ENCODES a protein that exhibits DNA binding (inferred); protein dimerization activity (inferred); RNA polymerase II transcription regulatory region sequence-specific DNA binding (inferred); INVOLVED IN negative regulation of DNA-templated transcription (ortholog); negative regulation of transcriptio n by RNA polymerase II (ortholog); Notch signaling pathway (ortholog); PARTICIPATES IN Notch signaling pathway; ASSOCIATED WITH Spondylocostal Dysostosis, Autosomal Recessive; Desbuquois dysplasia (ortholog); genetic disease (ortholog); FOUND IN nucleus (inferred) | 5 | 32944351 | 32950433 | Dog | 34 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12644332 | Hes7 | hes family bHLH transcription factor 7 | ENCODES a protein that exhibits DNA binding (inferred); protein dimerization activity (inferred); RNA polymerase II transcription regulatory region sequence-specific DNA binding (inferred); INVOLVED IN negative regulation of DNA-templated transcription (ortholog); negative regulation of transcriptio n by RNA polymerase II (ortholog); Notch signaling pathway (ortholog); PARTICIPATES IN Notch signaling pathway; ASSOCIATED WITH Desbuquois dysplasia (ortholog); genetic disease (ortholog); spondylocostal dysostosis (ortholog); FOUND IN nucleus (inferred) | NW_004936595 | 1352621 | 1355177 | Squirrel | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18904917 | Hes7 | hes family bHLH transcription factor 7 | ENCODES a protein that exhibits RNA polymerase II transcription regulatory region sequence-specific DNA binding (ortholog); sequence-specific double-stranded DNA binding (ortholog); INVOLVED IN negative regulation of DNA-templated transcription (ortholog); negative regulation of transcription by RNA polymerase II (ortholog); Notch signaling pathway (ortholog); PARTICIPATES IN Notch signaling pathway; ASSOCIATED WITH Desbuquois dysplasia (ortholog); genetic disease (ortholog); spondylocostal dysostosis (ortholog); FOUND IN nucleus (inferred) | | | | Naked Mole-Rat | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18751740 | HES7 | hes family bHLH transcription factor 7 | ENCODES a protein that exhibits DNA binding (inferred); protein dimerization activity (inferred); RNA polymerase II transcription regulatory region sequence-specific DNA binding (inferred); INVOLVED IN negative regulation of DNA-templated transcription (ortholog); negative regulation of transcriptio n by RNA polymerase II (ortholog); Notch signaling pathway (ortholog); PARTICIPATES IN Notch signaling pathway; ASSOCIATED WITH Desbuquois dysplasia (ortholog); genetic disease (ortholog); spondylocostal dysostosis (ortholog); FOUND IN nucleus (inferred) | | | | Green Monkey | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625909308 | Hes7 | hes family bHLH transcription factor 7 | ENCODES a protein that exhibits RNA polymerase II transcription regulatory region sequence-specific DNA binding (ortholog); sequence-specific double-stranded DNA binding (ortholog); INVOLVED IN negative regulation of DNA-templated transcription (ortholog); negative regulation of transcription by RNA polymerase II (ortholog); Notch signaling pathway (ortholog); PARTICIPATES IN Notch signaling pathway; ASSOCIATED WITH Desbuquois dysplasia (ortholog); genetic disease (ortholog); spondylocostal dysostosis (ortholog) | | | | Black Rat | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14190515 | HES7 | hes family bHLH transcription factor 7 | ENCODES a protein that exhibits DNA binding (inferred); protein dimerization activity (inferred); RNA polymerase II transcription regulatory region sequence-specific DNA binding (inferred); INVOLVED IN negative regulation of DNA-templated transcription (ortholog); negative regulation of transcriptio n by RNA polymerase II (ortholog); Notch signaling pathway (ortholog); PARTICIPATES IN Notch signaling pathway; ASSOCIATED WITH Desbuquois dysplasia (ortholog); genetic disease (ortholog); spondylocostal dysostosis (ortholog); FOUND IN nucleus (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 36 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 288083169 | hes7.1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155241578 | hes7.2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 288083325 | hes7.1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 287814259 | hes7.1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 155237481 | hes7.2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155259165 | hes7.2.S | | | | | | African Clawed Frog | | symbol | gene, null |