Hes7 (hes family bHLH transcription factor 7) - Rat Genome Database
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Gene: Hes7 (hes family bHLH transcription factor 7) Mus musculus
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Symbol: Hes7
Name: hes family bHLH transcription factor 7
RGD ID: 1314232
MGI Page MGI
Description: Is expressed in several structures, including central nervous system; retina; small intestine; unsegmented mesenchyme; and urinary system. Human ortholog(s) of this gene implicated in spondylocostal dysostosis. Orthologous to human HES7 (hes family bHLH transcription factor 7); PARTICIPATES IN Notch signaling pathway; INTERACTS WITH fluoxetine; lithium chloride; potassium dichromate.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: bHLH factor Hes7; bHLHb3; bHLHb37; hairy and enhancer of split 7; hairy and enhancer of split 7 (Drosophila); mHes7; transcription factor HES-7
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391169,009,783 - 69,014,880 (+)NCBIGRCm39mm39
GRCm39 Ensembl1169,011,230 - 69,014,881 (+)Ensembl
GRCm381169,118,906 - 69,124,054 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1169,120,404 - 69,124,055 (+)EnsemblGRCm38mm10GRCm38
MGSCv371168,933,955 - 68,936,761 (+)NCBIGRCm37mm9NCBIm37
MGSCv361168,936,648 - 68,939,454 (+)NCBImm8
Celera1176,063,996 - 76,066,802 (+)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1142.38NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11260262   PMID:11641270   PMID:12466851   PMID:12477932   PMID:12617809   PMID:12670869   PMID:12783854   PMID:14672936  
PMID:14681479   PMID:15170214   PMID:15170697   PMID:15511637   PMID:15731404   PMID:15821257   PMID:15902259   PMID:16000382   PMID:16127714   PMID:16141072   PMID:16141073   PMID:16342160  
PMID:16412699   PMID:16516838   PMID:16602821   PMID:16840533   PMID:17611704   PMID:17681139   PMID:17937396   PMID:17983837   PMID:18045842   PMID:18157121   PMID:18234727   PMID:18287559  
PMID:18477475   PMID:18557763   PMID:18579680   PMID:18708576   PMID:18775957   PMID:19161597   PMID:19306043   PMID:19440349   PMID:19590010   PMID:19666558   PMID:19779553   PMID:19795512  
PMID:19853565   PMID:19882724   PMID:19956724   PMID:20003319   PMID:20059953   PMID:20335362   PMID:20346937   PMID:21203428   PMID:21267068   PMID:21300886   PMID:21368122   PMID:21632822  
PMID:21750544   PMID:21795391   PMID:21799763   PMID:21873635   PMID:22326607   PMID:22484060   PMID:23219549   PMID:23326414   PMID:23465881   PMID:23671110   PMID:24151332   PMID:24165510  
PMID:24952961   PMID:25248974   PMID:25733872   PMID:25813538   PMID:26496195   PMID:26718008   PMID:26728556   PMID:26811377   PMID:27144312   PMID:27894818   PMID:28893950   PMID:29437832  
PMID:29474908   PMID:29895619   PMID:31235634   PMID:31320326   PMID:31899345   PMID:32943519  


Genomics

Comparative Map Data
Hes7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391169,009,783 - 69,014,880 (+)NCBIGRCm39mm39
GRCm39 Ensembl1169,011,230 - 69,014,881 (+)Ensembl
GRCm381169,118,906 - 69,124,054 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1169,120,404 - 69,124,055 (+)EnsemblGRCm38mm10GRCm38
MGSCv371168,933,955 - 68,936,761 (+)NCBIGRCm37mm9NCBIm37
MGSCv361168,936,648 - 68,939,454 (+)NCBImm8
Celera1176,063,996 - 76,066,802 (+)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1142.38NCBI
HES7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl178,120,592 - 8,124,106 (-)EnsemblGRCh38hg38GRCh38
GRCh38178,120,590 - 8,126,032 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37178,023,910 - 8,027,424 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36177,965,024 - 7,968,127 (-)NCBINCBI36hg18NCBI36
Build 34177,965,613 - 7,968,127NCBI
Celera178,051,536 - 8,055,038 (-)NCBI
Cytogenetic Map17p13.1NCBI
HuRef177,918,810 - 7,922,312 (-)NCBIHuRef
CHM1_1178,032,430 - 8,035,932 (-)NCBICHM1_1
Hes7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21053,824,124 - 53,828,350 (+)NCBI
Rnor_6.0 Ensembl1055,707,164 - 55,709,687 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01055,704,485 - 55,710,523 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01055,447,857 - 55,453,578 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41055,879,891 - 55,882,414 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11055,893,497 - 55,895,968 (+)NCBI
Celera1052,991,107 - 52,993,630 (+)NCBICelera
Cytogenetic Map10q24NCBI
Hes7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554678,837,886 - 8,841,739 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554678,837,895 - 8,841,062 (+)NCBIChiLan1.0ChiLan1.0
HES7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11748,266,123 - 48,269,274 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01743,530,919 - 43,537,999 (+)NCBIMhudiblu_PPA_v0panPan3
HES7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl532,944,037 - 32,947,591 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1532,944,351 - 32,950,433 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Hes7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365951,352,621 - 1,355,177 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HES7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1253,334,901 - 53,337,376 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11253,334,350 - 53,339,336 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21255,804,486 - 55,813,950 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HES7
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1167,502,976 - 7,509,506 (-)NCBI
ChlSab1.1 Ensembl167,503,932 - 7,506,448 (-)Ensembl
Hes7
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462478610,692,329 - 10,699,346 (-)NCBI

Position Markers
Hes7  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381169,122,159 - 69,122,942UniSTSGRCm38
MGSCv371168,935,661 - 68,936,444UniSTSGRCm37
Celera1176,065,702 - 76,066,485UniSTS
Cytogenetic Map11B3UniSTS
cM Map1137.0UniSTS
Hes7  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11B3UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11330000072800000Mouse
13208559Wght10_mweight 10 (mouse)11400000089000000Mouse
13208558Lgth12_mbody length 12 (mouse)11400000095000000Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11693027789128908Mouse
1559002Lmrq4_mLeishmania major resistance QTL 4 (mouse)Not determined111231863769794121Mouse
1357859Lvrq7_mliver weight QTL 7 (mouse)Not determined1112318637118131898Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112318637118131898Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1917420497007000Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112185736495990405Mouse
1357782Char8_mP. chabaudi malaria resistance QTL 8 (mouse)Not determined113568778969794161Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113600000085000000Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113639175083590530Mouse
1301788Lbw8_mlupus NZB x NZW 8 (mouse)Not determined113661246070618665Mouse
1301896Tria1_mT-cell receptor induced activation 1 (mouse)Not determined113672273870723028Mouse
4141853Skmw17_mskeletal muscle weight 17 (mouse)Not determined113719011571190238Mouse
10766457Nwa3_mNew Zealand White autoimmunity 3 (mouse)113812528972125383Mouse
11532698Sluc36a_msusceptibility to lung cancer 36a (mouse)114236579176365904Mouse
11532699Sluc36b_msusceptibility to lung cancer 36b (mouse)114236579176365904Mouse
4142300Ctrq3_mC. trachomatis resistance QTL 3 (mouse)Not determined114473921176963931Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44739211113167183Mouse
4141000Nidd3_mnon-insulin-dependent diabetes mellitus 3 (mouse)Not determined4515120179151308Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114527504680087498Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114581775489927907Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114629434180294436Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114642858180428696Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115018736584187585Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115260355986603559Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115349976287499911Mouse
4141830Pregq1_mpregnancy QTL 1 (mouse)Not determined115423592683842826Mouse
4141875Etax9_methanol induced ataxia 9 (mouse)Not determined5539415972319101Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156973201114267131Mouse
1300664Etohcta9_methanol conditioned taste aversion 9 (mouse)Not determined115786383491863932Mouse
10053682Eae45_mexperimental allergic encephalomyelitis susceptibility 45 (mouse)Not determined115859972974863932Mouse
1300924Ity2_mimmunity to S. typhimurium 2 (mouse)Not determined15861720487804412Mouse
4141982Skts-fp2_mskin tumor susceptibility in FVB and PWK 2 (mouse)Not determined5882844085175703Mouse
11532697Sluc36_msusceptibility to lung cancer 36 (mouse)115936579169591873Mouse
1301987Pid3_mprior incubation determinant 3 (mouse)Not determined116179599488808902Mouse
1301319Dautb4_mdopamine uptake transporter binding 4 (mouse)Not determined116226517996265327Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162700000109500000Mouse
1301999Lmr15_mleishmaniasis resistance 15 (mouse)Not determined116342858181939647Mouse
10044004Stzid3_mstreptozotocin induced diabetes susceptibility 3 (mouse)Not determined116342858194173092Mouse
11039501Ltpr6a_mLeishmania tropica response 6a (mouse)116493951098939647Mouse
11039502Ltpr6b_mLeishmania tropica response 6b (mouse)116493951098939647Mouse
11039515Ltpr6_mLeishmania tropica response 6 (mouse)116493951098939647Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166842594100842826Mouse
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166842594100842826Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66842594100842826Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166842594100842826Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166842594100842826Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166842594100842826Mouse
4142316Ity2b_mimmunity to S. typhimurium 2b (mouse)Not determined116718736579923086Mouse
27226783Tibl5_mtibia length 5, 5 week (mouse)1168300000102000000Mouse
36049778Ars6_mantibody response to SARS-CoV 6, day 15, IgM (mouse)116910000072600000Mouse
36049779Ars7_mantibody response to SARS-CoV 7, day 29, IgG1 (mouse)116910000072600000Mouse
36049784Ars8_mantibody response to SARS-CoV 8, day 29, IgG2a+IgG2c (mouse)116910000072600000Mouse
36049785Ars9_mantibody response to SARS-CoV 9, day 29, IgM (mouse)116910000072600000Mouse
36049786Ars10_mantibody response to SARS-CoV 10, 4 days post-rechallenge, IgG2a+IgG2c (mouse)116910000072600000Mouse
36049787Ars11_mantibody response to SARS-CoV 11, 4 days post-rechallenge, IgM (mouse)116910000072600000Mouse
36049788Ars1_mantibody response to SARS-CoV 1, day 7, IgG1 (mouse)116910000072600000Mouse
36049789Ars2_mantibody response to SARS-CoV 2, day 7, IgG2a+IgG2c (mouse)116910000072600000Mouse
36049790Ars3_mantibody response to SARS-CoV 3, day 7, IgG2b (mouse)116910000072600000Mouse
36049791Ars4_mantibody response to SARS-CoV 4, day 7, IgG3 (mouse)116910000072600000Mouse
36049792Ars5_mantibody response to SARS-CoV 5, day 7, IgM (mouse)116910000072600000Mouse
35673314Ari2_mantibody response to influenza 2, day 10, IgG3 (mouse)116910000072600000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:293
Count of miRNA genes:239
Interacting mature miRNAs:249
Transcripts:ENSMUST00000024543
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000024543   ⟹   ENSMUSP00000024543
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1169,120,404 - 69,124,055 (+)Ensembl
RefSeq Acc Id: NM_033041   ⟹   NP_149030
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391169,011,279 - 69,014,085 (+)NCBI
GRCm381169,120,453 - 69,123,259 (+)NCBI
MGSCv371168,933,955 - 68,936,761 (+)RGD
Celera1176,063,996 - 76,066,802 (+)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006534556   ⟹   XP_006534619
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391169,009,783 - 69,014,880 (+)NCBI
GRCm381169,118,906 - 69,124,054 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_149030   ⟸   NM_033041
- UniProtKB: Q8BKT2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006534619   ⟸   XM_006534556
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000024543   ⟸   ENSMUST00000024543
Protein Domains
bHLH   Orange


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2135679 AgrOrtholog
Ensembl Genes ENSMUSG00000023781 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000024543 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000024543 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.280.10 UniProtKB/Swiss-Prot
InterPro bHLH_dom UniProtKB/Swiss-Prot
  HES-7 UniProtKB/Swiss-Prot
  HLH_DNA-bd_sf UniProtKB/Swiss-Prot
  Orange_dom UniProtKB/Swiss-Prot
KEGG Report mmu:84653 UniProtKB/Swiss-Prot
MGD MGI:2135679 ENTREZGENE
NCBI Gene 84653 ENTREZGENE
PANTHER PTHR10985:SF84 UniProtKB/Swiss-Prot
Pfam HLH UniProtKB/Swiss-Prot
PhenoGen Hes7 PhenoGen
PROSITE BHLH UniProtKB/Swiss-Prot
  ORANGE UniProtKB/Swiss-Prot
SMART HLH UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47459 UniProtKB/Swiss-Prot
UniProt HES7_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A3KPD3 UniProtKB/Swiss-Prot
  Q99JA6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-10-31 Hes7  hes family bHLH transcription factor 7    hairy and enhancer of split 7 (Drosophila)  Symbol and/or name change 5135510 APPROVED