Hes7 (hes family bHLH transcription factor 7)

Gene: Hes7 (hes family bHLH transcription factor 7) Chinchilla lanigera

Analyze

Symbol:

Hes7

Name:

hes family bHLH transcription factor 7

RGD ID:

8833333

Description:

ENCODES a protein that exhibits RNA polymerase II transcription regulatory region sequence-specific DNA binding (ortholog); sequence-specific double-stranded DNA binding (ortholog); INVOLVED IN negative regulation of DNA-templated transcription (ortholog); negative regulation of transcription by RNA polymerase II (ortholog); Notch signaling pathway (ortholog); PARTICIPATES IN Notch signaling pathway; ASSOCIATED WITH common variable immunodeficiency (ortholog); cone-rod dystrophy 6 (ortholog); craniosynostosis (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

hairy and enhancer of split 7; transcription factor HES-7

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955467	8,837,886 - 8,841,739 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955467	8,837,895 - 8,841,062 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

common variable immunodeficiency (ISO)

cone-rod dystrophy 6 (ISO)

craniosynostosis (ISO)

Diamond-Blackfan anemia (ISO)

Dwarfism (ISO)

dyskeratosis congenita (ISO)

genetic disease (ISO)

hypophosphatemia (ISO)

intellectual disability (ISO)

Li-Fraumeni syndrome (ISO)

microcephaly (ISO)

mitral valve insufficiency (ISO)

osteochondrodysplasia (ISO)

scoliosis (ISO)

spondylocostal dysostosis (ISO)

spondylocostal dysostosis 2 (ISO)

spondylocostal dysostosis 4 (ISO)

Spondylocostal Dysostosis, Autosomal Recessive (ISO)

Sprengel Deformity (ISO)

very long chain acyl-CoA dehydrogenase deficiency (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of DNA-templated transcription (ISO)

negative regulation of transcription by RNA polymerase II (ISO)

Notch signaling pathway (ISO)

post-anal tail morphogenesis (ISO)

rhythmic process (ISO)

skeletal system development (ISO)

somitogenesis (ISO)

Molecular Function

protein binding (ISO)

RNA polymerase II transcription regulatory region sequence-specific DNA binding (ISO)

sequence-specific double-stranded DNA binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

Notch signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Hes7
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955467	8,837,886 - 8,841,739 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955467	8,837,895 - 8,841,062 (+)	NCBI	ChiLan1.0	ChiLan1.0

HES7
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	8,120,592 - 8,126,634 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	8,120,592 - 8,124,106 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	8,023,910 - 8,027,424 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	7,965,024 - 7,968,127 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	17	7,965,613 - 7,968,127	NCBI
Celera	17	8,051,536 - 8,055,038 (-)	NCBI		Celera
Cytogenetic Map	17	p13.1	NCBI
HuRef	17	7,918,810 - 7,922,312 (-)	NCBI		HuRef
CHM1_1	17	8,032,430 - 8,035,932 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	17	8,025,967 - 8,032,000 (-)	NCBI		T2T-CHM13v2.0

Hes7
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	69,009,778 - 69,014,880 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	69,011,230 - 69,014,881 (+)	Ensembl		GRCm39 Ensembl
GRCm38	11	69,118,906 - 69,124,054 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	69,120,404 - 69,124,055 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	68,933,955 - 68,936,761 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	68,936,648 - 68,939,454 (+)	NCBI		MGSCv36	mm8
Celera	11	76,063,996 - 76,066,802 (+)	NCBI		Celera
Cytogenetic Map	11	B3	NCBI
cM Map	11	42.38	NCBI

Hes7
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	54,322,971 - 54,327,776 (+)	NCBI		GRCr8
mRatBN7.2	10	53,824,124 - 53,828,934 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	53,825,574 - 53,828,097 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	58,485,921 - 58,490,147 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	57,974,520 - 57,978,746 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	53,482,684 - 53,486,910 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	55,704,485 - 55,710,523 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	55,707,164 - 55,709,687 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	55,447,857 - 55,453,578 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	55,879,891 - 55,882,414 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	55,893,497 - 55,895,968 (+)	NCBI
Celera	10	52,991,107 - 52,993,630 (+)	NCBI		Celera
Cytogenetic Map	10	q24	NCBI

HES7
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	65,627,074 - 65,632,353 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	70,436,476 - 70,441,751 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	43,530,919 - 43,537,999 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	48,266,123 - 48,269,274 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

HES7
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	32,944,351 - 32,950,433 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	32,944,037 - 32,947,591 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	33,080,600 - 33,086,052 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	33,047,237 - 33,052,693 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	33,046,923 - 33,050,780 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	33,014,161 - 33,019,612 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	32,969,959 - 32,975,406 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	33,149,996 - 33,155,451 (-)	NCBI		UU_Cfam_GSD_1.0

Hes7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	47,878,435 - 47,883,516 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936595	1,352,621 - 1,356,113 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936595	1,352,621 - 1,355,177 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HES7
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	53,333,907 - 53,337,575 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	53,334,350 - 53,339,336 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	12	55,804,486 - 55,813,950 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

HES7
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	7,502,976 - 7,509,506 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	7,503,932 - 7,506,448 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666059	13,896,047 - 13,901,673 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Hes7
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624786	10,692,329 - 10,695,132 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624786	10,692,329 - 10,699,346 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005399434	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01051475	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDJ01193638	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000011418 ⟹ ENSCLAP00000011281

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955467	8,837,886 - 8,841,739 (+)	Ensembl

RefSeq Acc Id:

XM_005399434 ⟹ XP_005399491

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955467	8,837,895 - 8,841,062 (+)	NCBI

Sequence:

show sequence

AGCAATGGTCACCCGAGATAGAGCTGAGAATAGGGACGGCCCCAAGATGCTGAAGCCGCTAGTG
GAGAAGCGGCGCCGGGACCGCATCAACCGCAGCCTGGAAGAGCTACGGCTGCTGCTGCTGGAGC
GGACCCGGGACCAGAACCTCCGGAACCCGAAGTTGGAGAAAGCAGAGATACTGGAGTTCGCCGT
GGGCTACTTGAGGGAGCGAAGCCGGGTGGAGCCCCCGGGGGTTCCCCGGTCCCCAGTCCAGGAC
GCCGAGGCGCTCGCCAGCTGCTACTTGTCCGGCTTCCGCGAATGCCTGCTCCGCTTGGCAGCCT
TCGCGCACGACGCCAGCCCGGCCGCCCGCGCCCAGCTCTTCTCCGCGCTGCACGGCTACCTGCG
CCCCAAACCGCCTCGGCCGGAGCCCGTAGATCCGAGGCCCCCAATGTCGCGTCCACCGCTGGAC
CCCGCCACACCAGCTCTTGGCCCCGCGCTGCACCAGGGCCCCCCTAGCCCGCGCTGCGCTTGGT
CCCCATCCCTCTGCTCCCCTAGCGCCTGGGATTCTGGCGCGCCGGCGCCCCTCACCGGACTGCT
GCCGCCGCCGCCGCCGCCTTACAGACAAGACGGGGCTCCCAAGGCCCCGCCGCTCCCGCCGCCC
GCTTTCTGGAGACCTTGGCCCTGAGCTCAGGGGGGATGGGGGCGGGAGCGGGGGCTGGGAGTGG
GGTAGAGACTCCAGCCCGAGGGCAGCAGAGGGATCCGGGCGTCCGGGCGAGGTGTTGGGGAGGG
CAGCGGGGCGCGGGGGCTCAGCGCGTGGGTGAGATGTGGTCTATATTAGAGTATCTATATAAAT
ATATATTCCCTGATTCCTGTCCCTTTTCCCCGACCCCCTCCACCCTGCTTCTAGGATTGTACCC
TCTGCTCCAGCTCAGTCCTAGTCCTTTCCCAAGTCCCTAGTGCATGGAATAAAGTGGTTATTAA
ATCCCCGTGTGTCCCGGAGCCAGGGCCCTGCCTTTATCTCGGCGTCCACGCCCACTTTCCCTTC
CTTTCTGTCTTCTACCCGTAGTCCTGCTCTCCATGGCCCAAGTCCCAGGGCAAACAGGTAAGTA
AAGAGAGCAGAGCAGAGACTAAGGTTAGGTCTGAAACCAAGTGGGAAGCGCAGAGATAGGGTAG
GGGAAAAGAGATGGGCCTTTAAGAAAAGCCAGGTAAAAAGGAAAGAAAGGAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005399491	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000011281
	ENSCLAP00000011281.1

RefSeq Acc Id:

XP_005399491 ⟸ XM_005399434

- UniProtKB:

A0A8C2YNB6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MVTRDRAENRDGPKMLKPLVEKRRRDRINRSLEELRLLLLERTRDQNLRNPKLEKAEILEFAVG
YLRERSRVEPPGVPRSPVQDAEALASCYLSGFRECLLRLAAFAHDASPAARAQLFSALHGYLRP
KPPRPEPVDPRPPMSRPPLDPATPALGPALHQGPPSPRCAWSPSLCSPSAWDSGAPAPLTGLLP
PPPPPYRQDGAPKAPPLPPPAFWRPWP

hide sequence

RefSeq Acc Id:

ENSCLAP00000011281 ⟸ ENSCLAT00000011418

Protein Domains

bHLH Orange

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000007782	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000011418	ENTREZGENE
	ENSCLAT00000011418.1	UniProtKB/TrEMBL
Gene3D-CATH	4.10.280.10	UniProtKB/TrEMBL
InterPro	bHLH_dom	UniProtKB/TrEMBL
	HLH_DNA-bd_sf	UniProtKB/TrEMBL
	Orange_dom	UniProtKB/TrEMBL
NCBI Gene	Hes7	ENTREZGENE
PANTHER	BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED	UniProtKB/TrEMBL
	PTHR10985:SF84	UniProtKB/TrEMBL
Pfam	HLH	UniProtKB/TrEMBL
PROSITE	BHLH	UniProtKB/TrEMBL
	ORANGE	UniProtKB/TrEMBL
SMART	HLH	UniProtKB/TrEMBL
Superfamily-SCOP	SSF47459	UniProtKB/TrEMBL
UniProt	A0A8C2YNB6	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-08-25	Hes7	hes family bHLH transcription factor 7		hairy and enhancer of split 7 (Drosophila)	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIA

Imported Disease Annotations - OMIM

RGD Manual Annotations

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIA

Imported Disease Annotations - OMIM

RGD Manual Annotations