| 1304754 | Hcls1 | hematopoietic cell specific Lyn substrate 1 | ENCODES a protein that exhibits protein kinase binding (ortholog); protein-containing complex binding (ortholog); RNA polymerase II-specific DNA-binding transcription factor binding (ortholog); INVOLVED IN actin filament organization (ortholog); cellular response to cytokine stimulus (ortholog); ery throcyte differentiation (ortholog); ASSOCIATED WITH rheumatoid arthritis (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleus (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; alpha-Zearalanol | 11 | 77322873 | 77346333 | Rat | 143 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1312380 | HCLS1 | hematopoietic cell-specific Lyn substrate 1 | Enables RNA polymerase II-specific DNA-binding transcription factor binding activity; protein kinase binding activity; and signaling adaptor activity. Involved in several processes, including granulocyte colony-stimulating factor signaling pathway; positive regulation of phosphatidylinositol 3-kinas e/protein kinase B signal transduction; and positive regulation of protein import into nucleus. Located in cytosol; nucleus; and plasma membrane. Part of transcription regulator complex. [provided by Alliance of Genome Resources, Jul 2025] | 3 | 121631399 | 121660903 | Human | 129 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1312381 | Hcls1 | hematopoietic cell specific Lyn substrate 1 | Enables SH3 domain binding activity. Involved in several processes, including erythrocyte differentiation; positive regulation of myeloid leukocyte differentiation; and regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in thymus primordium. Orthologous to human HCLS1 (hematopoietic cell-specific Lyn substrate 1). [provided by Alliance of Genome Resources, Jul 2025] | 16 | 36755345 | 36783576 | Mouse | 159 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 9059074 | Hcls1 | hematopoietic cell-specific Lyn substrate 1 | ENCODES a protein that exhibits protein kinase binding (ortholog); protein-containing complex binding (ortholog); RNA polymerase II-specific DNA-binding transcription factor binding (ortholog); INVOLVED IN actin filament organization (ortholog); cellular response to cytokine stimulus (ortholog); ery throcyte differentiation (ortholog); ASSOCIATED WITH rheumatoid arthritis (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleus (ortholog) | NW_004955427 | 20999934 | 21020401 | Chinchilla | 44 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11970726 | HCLS1 | hematopoietic cell-specific Lyn substrate 1 | ENCODES a protein that exhibits actin filament binding (inferred); protein kinase binding (inferred); protein-containing complex binding (inferred); INVOLVED IN actin filament organization (inferred); cell migration (inferred); cellular response to cytokine stimulus (inferred); ASSOCIATED WITH rheum atoid arthritis (ortholog); FOUND IN actin filament (inferred); cortical actin cytoskeleton (inferred); cytoplasm (inferred) | 3 | 118733505 | 118763177 | Bonobo | 52 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12296368 | HCLS1 | hematopoietic cell-specific Lyn substrate 1 | ENCODES a protein that exhibits protein kinase binding (inferred); protein-containing complex binding (inferred); RNA polymerase II-specific DNA-binding transcription factor binding (inferred); INVOLVED IN actin filament organization (inferred); cellular response to cytokine stimulus (inferred); ery throcyte differentiation (inferred); ASSOCIATED WITH rheumatoid arthritis (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); mitochondrion (inferred) | 33 | 24901023 | 24925710 | Dog | 52 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12701588 | Hcls1 | hematopoietic cell-specific Lyn substrate 1 | ENCODES a protein that exhibits actin filament binding (inferred); protein kinase binding (inferred); protein-containing complex binding (inferred); INVOLVED IN actin filament organization (inferred); cell migration (inferred); cellular response to cytokine stimulus (inferred); ASSOCIATED WITH rheum atoid arthritis (ortholog); FOUND IN actin filament (inferred); cortical actin cytoskeleton (inferred); cytoplasm (inferred) | NW_004936536 | 8065489 | 8084777 | Squirrel | 52 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14099053 | HCLS1 | hematopoietic cell-specific Lyn substrate 1 | ENCODES a protein that exhibits protein kinase binding (inferred); protein-containing complex binding (inferred); RNA polymerase II-specific DNA-binding transcription factor binding (inferred); INVOLVED IN actin filament organization (inferred); cellular response to cytokine stimulus (inferred); ery throcyte differentiation (inferred); ASSOCIATED WITH rheumatoid arthritis (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); mitochondrion (inferred) | | | | Pig | 52 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18368285 | HCLS1 | hematopoietic cell-specific Lyn substrate 1 | ENCODES a protein that exhibits actin filament binding (inferred); protein kinase binding (inferred); protein-containing complex binding (inferred); INVOLVED IN actin filament organization (inferred); cell migration (inferred); cellular response to cytokine stimulus (inferred); ASSOCIATED WITH rheum atoid arthritis (ortholog); FOUND IN actin filament (inferred); cortical actin cytoskeleton (inferred); cytoplasm (inferred) | | | | Green Monkey | 52 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18911955 | Hcls1 | hematopoietic cell-specific Lyn substrate 1 | ENCODES a protein that exhibits actin filament binding (inferred); protein kinase binding (inferred); protein-containing complex binding (inferred); INVOLVED IN actin filament organization (inferred); cell migration (inferred); cellular response to cytokine stimulus (inferred); ASSOCIATED WITH rheum atoid arthritis (ortholog); FOUND IN actin filament (inferred); cortical actin cytoskeleton (inferred); cytoplasm (inferred) | | | | Naked Mole-Rat | 52 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155232592 | hcls1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626134867 | Hcls1 | hematopoietic cell-specific Lyn substrate 1 | ENCODES a protein that exhibits protein kinase binding (ortholog); protein-containing complex binding (ortholog); RNA polymerase II-specific DNA-binding transcription factor binding (ortholog); INVOLVED IN actin filament organization (ortholog); cellular response to cytokine stimulus (ortholog); ery throcyte differentiation (ortholog); ASSOCIATED WITH rheumatoid arthritis (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleus (ortholog) | | | | Black Rat | 44 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155237031 | hcls1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155245672 | hcls1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1620872 | Hax1 | HCLS1 associated X-1 | Predicted to enable interleukin-1 binding activity; protein domain specific binding activity; and signaling adaptor activity. Predicted to be involved in several processes, including granulocyte colony-stimulating factor signaling pathway; positive regulation of macromolecule metabolic process; and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to act upstream of or within cell surface receptor signaling pathway. Located in several cellular components, including lamellipodium; mitochondrial matrix; and sarcoplasmic reticulum. Is expressed in coelomic epithelium of testis; ovary; and testis mesenchyme. Human ortholog(s) of this gene implicated in severe congenital neutropenia 3. Orthologous to human HAX1 (HCLS1 associated protein X-1). [provided by Alliance of Genome Resources, Apr 2025] | 3 | 89902753 | 89906023 | Mouse | 205 | old_gene_name , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1311331 | Hs1bp3 | HCLS1 binding protein 3 | ENCODES a protein that exhibits phosphatidylinositol binding (inferred); INVOLVED IN regulation of apoptotic process (ortholog); FOUND IN endoplasmic reticulum (ortholog); mitochondrion (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil | 6 | 36911864 | 36942126 | Rat | 62 | old_gene_name , name | gene, protein-coding, VALIDATED [RefSeq] |
| 1553147 | Hs1bp3 | HCLS1 binding protein 3 | Predicted to enable phosphatidylinositol binding activity. Predicted to be involved in regulation of apoptotic process. Predicted to act upstream of or within T cell differentiation and cell surface receptor signaling pathway. Predicted to be located in endoplasmic reticulum and mitochondrion. Ortho logous to human HS1BP3 (HCLS1 binding protein 3). [provided by Alliance of Genome Resources, Jul 2025] | 12 | 8363389 | 8393824 | Mouse | 66 | old_gene_name , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1602467 | HS1BP3 | HCLS1 binding protein 3 | The protein encoded by this gene shares similarity with mouse Hs1bp3, an Hcls1/Hs1-interacting protein that may be involved in lymphocyte activation. [provided by RefSeq, Jul 2008] | 2 | 20553861 | 20651098 | Human | 58 | old_gene_name , name , description | gene, protein-coding, REVIEWED [RefSeq] |
| 8984008 | Hs1bp3 | HCLS1 binding protein 3 | INVOLVED IN regulation of apoptotic process (ortholog); FOUND IN endoplasmic reticulum (ortholog); mitochondrion (ortholog) | NW_004955469 | 3105897 | 3133918 | Chinchilla | 6 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 11995857 | HS1BP3 | HCLS1 binding protein 3 | ENCODES a protein that exhibits phosphatidylinositol binding (inferred); INVOLVED IN regulation of apoptotic process (inferred); FOUND IN endoplasmic reticulum (inferred); mitochondrion (inferred) | 2A | 20464789 | 20636827 | Bonobo | 7 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12189686 | HS1BP3 | HCLS1 binding protein 3 | ENCODES a protein that exhibits phosphatidylinositol binding (inferred); INVOLVED IN regulation of apoptotic process (inferred); FOUND IN endoplasmic reticulum (inferred); mitochondrion (inferred) | 17 | 15577552 | 15610141 | Dog | 7 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12531555 | Hs1bp3 | HCLS1 binding protein 3 | ENCODES a protein that exhibits phosphatidylinositol binding (inferred); INVOLVED IN regulation of apoptotic process (inferred); FOUND IN endoplasmic reticulum (inferred); mitochondrion (inferred) | NW_004936493 | 10830956 | 10859315 | Squirrel | 7 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 14065106 | HS1BP3 | HCLS1 binding protein 3 | ENCODES a protein that exhibits phosphatidylinositol binding (inferred); INVOLVED IN regulation of apoptotic process (inferred); FOUND IN endoplasmic reticulum (inferred); mitochondrion (inferred) | | | | Pig | 7 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18362523 | HS1BP3 | HCLS1 binding protein 3 | ENCODES a protein that exhibits phosphatidylinositol binding (inferred); INVOLVED IN regulation of apoptotic process (inferred); FOUND IN endoplasmic reticulum (inferred); mitochondrion (inferred) | | | | Green Monkey | 7 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18900024 | Hs1bp3 | HCLS1 binding protein 3 | ENCODES a protein that exhibits phosphatidylinositol binding (inferred); INVOLVED IN regulation of apoptotic process (ortholog); FOUND IN endoplasmic reticulum (ortholog); mitochondrion (ortholog) | | | | Naked Mole-Rat | 7 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 625908195 | Hs1bp3 | HCLS1 binding protein 3 | INVOLVED IN regulation of apoptotic process (ortholog); FOUND IN endoplasmic reticulum (ortholog); mitochondrion (ortholog) | | | | Black Rat | 6 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 727960 | Hax1 | HCLS1 associated protein X-1 | ENCODES a protein that exhibits protein domain specific binding; interleukin-1 binding (ortholog); signaling adaptor activity (ortholog); INVOLVED IN cellular response to cytokine stimulus (ortholog); granulocyte colony-stimulating factor signaling pathway (ortholog); mitochondrion organization (ort holog); ASSOCIATED WITH genetic disease (ortholog); hereditary sensory neuropathy type 4 (ortholog); neutropenia (ortholog); FOUND IN apical plasma membrane; clathrin-coated vesicle; sarcoplasmic reticulum; INTERACTS WITH 3-chloropropane-1,2-diol; bisphenol A; cadmium dichloride | 2 | 177731918 | 177735670 | Rat | 162 | old_gene_name , name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1607073 | HAX1 | HCLS1 associated protein X-1 | The protein encoded by this gene is known to associate with hematopoietic cell-specific Lyn substrate 1, a substrate of Src family tyrosine kinases. It also interacts with the product of the polycystic kidney disease 2 gene, mutations in which are associated with autosomal-dominant polycystic kidney disease, and with the F-actin-binding protein, cortactin. It was earlier thought that this gene product is mainly localized in the mitochondria, however, recent studies indicate it to be localized in the cell body. Mutations in this gene result in autosomal recessive severe congenital neutropenia, also known as Kostmann disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] | 1 | 154272629 | 154275875 | Human | 211 | old_gene_name , name | gene, protein-coding, REVIEWED [RefSeq] |
| 8707790 | Hax1 | HCLS1 associated protein X-1 | ENCODES a protein that exhibits interleukin-1 binding (ortholog); protein domain specific binding (ortholog); signaling adaptor activity (ortholog); INVOLVED IN cellular response to cytokine stimulus (ortholog); granulocyte colony-stimulating factor signaling pathway (ortholog); mitochondrion organi zation (ortholog); ASSOCIATED WITH genetic disease (ortholog); hereditary sensory neuropathy type 4 (ortholog); neutropenia (ortholog); FOUND IN actin cytoskeleton (ortholog); apical plasma membrane (ortholog); clathrin-coated vesicle (ortholog) | NW_004955545 | 816789 | 819667 | Chinchilla | 55 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 11882942 | HAX1 | HCLS1 associated protein X-1 | ENCODES a protein that exhibits protein domain specific binding (ortholog); INVOLVED IN mitochondrion organization (ortholog); ASSOCIATED WITH genetic disease (ortholog); hereditary sensory neuropathy type 4 (ortholog); neutropenia (ortholog); FOUND IN apical plasma membrane (ortholog); clathrin-coa ted vesicle (ortholog); cytoplasm (ortholog) | 1 | 129627564 | 129630920 | Bonobo | 63 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12259989 | HAX1 | HCLS1 associated protein X-1 | ENCODES a protein that exhibits interleukin-1 binding (ortholog); protein domain specific binding (ortholog); INVOLVED IN cellular response to cytokine stimulus (ortholog); mitochondrion organization (ortholog); positive regulation of granulocyte differentiation (ortholog); ASSOCIATED WITH genetic d isease (ortholog); hereditary sensory neuropathy type 4 (ortholog); neutropenia (ortholog); FOUND IN actin cytoskeleton (ortholog); apical plasma membrane (ortholog); clathrin-coated vesicle (ortholog) | 7 | 42969711 | 42972783 | Dog | 60 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12505577 | Hax1 | HCLS1 associated protein X-1 | ENCODES a protein that exhibits protein domain specific binding (ortholog); INVOLVED IN mitochondrion organization (ortholog); ASSOCIATED WITH genetic disease (ortholog); hereditary sensory neuropathy type 4 (ortholog); neutropenia (ortholog); FOUND IN apical plasma membrane (ortholog); clathrin-coa ted vesicle (ortholog) | NW_004936580 | 3961433 | 3964322 | Squirrel | 64 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 14075328 | HAX1 | HCLS1 associated protein X-1 | ENCODES a protein that exhibits protein domain specific binding (ortholog); INVOLVED IN mitochondrion organization (ortholog); ASSOCIATED WITH genetic disease (ortholog); hereditary sensory neuropathy type 4 (ortholog); neutropenia (ortholog); FOUND IN apical plasma membrane (ortholog); clathrin-coa ted vesicle (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 46 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18384188 | HAX1 | HCLS1 associated protein X-1 | ENCODES a protein that exhibits protein domain specific binding (ortholog); INVOLVED IN mitochondrion organization (ortholog); ASSOCIATED WITH genetic disease (ortholog); hereditary sensory neuropathy type 4 (ortholog); neutropenia (ortholog); FOUND IN apical plasma membrane (ortholog); clathrin-coa ted vesicle (ortholog) | | | | Green Monkey | 64 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18902268 | Hax1 | HCLS1 associated protein X-1 | ENCODES a protein that exhibits interleukin-1 binding (ortholog); protein domain specific binding (ortholog); signaling adaptor activity (ortholog); INVOLVED IN cellular response to cytokine stimulus (ortholog); granulocyte colony-stimulating factor signaling pathway (ortholog); mitochondrion organi zation (ortholog); ASSOCIATED WITH genetic disease (ortholog); hereditary sensory neuropathy type 4 (ortholog); neutropenia (ortholog); FOUND IN apical plasma membrane (ortholog); clathrin-coated vesicle (ortholog); cytoplasm (ortholog) | | | | Naked Mole-Rat | 60 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 626105736 | Hax1 | HCLS1 associated protein X-1 | ENCODES a protein that exhibits interleukin-1 binding (ortholog); protein domain specific binding (ortholog); signaling adaptor activity (ortholog); INVOLVED IN cellular response to cytokine stimulus (ortholog); granulocyte colony-stimulating factor signaling pathway (ortholog); mitochondrion organi zation (ortholog); ASSOCIATED WITH genetic disease (ortholog); hereditary sensory neuropathy type 4 (ortholog); neutropenia (ortholog); FOUND IN actin cytoskeleton (ortholog); apical plasma membrane (ortholog); clathrin-coated vesicle (ortholog) | | | | Black Rat | 55 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 13320042 | LOC111093595 | HCLS1-binding protein 3-like | | 32 | 30457839 | 30458670 | Dog | | old_gene_name , name | gene, pseudo, MODEL [RefSeq] |
| 12176523 | LOC100685968 | HCLS1-associated protein X-1-like | | 5 | 36398580 | 36399623 | Dog | | old_gene_name , name | gene, pseudo, MODEL [RefSeq] |
| 12013212 | LOC100979176 | HCLS1-associated protein X-1-like | | X | 137220463 | 137221498 | Bonobo | | name | gene, pseudo, MODEL [RefSeq] |
| 13171279 | LOC110598387 | HCLS1-associated protein X-1-like | | NW_004936535 | 2534597 | 2535277 | Squirrel | | old_gene_name , name | gene, pseudo, MODEL [RefSeq] |
| 626071467 | LOC116883189 | HCLS1-associated protein X-1-like | | | | | Black Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 625931068 | LOC116903794 | HCLS1-associated protein X-1-like | | | | | Black Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 625990480 | LOC116908202 | HCLS1-associated protein X-1-like | | | | | Black Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 626075364 | LOC116910251 | HCLS1-associated protein X-1-like | | | | | Black Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 626022540 | LOC116913896 | HCLS1-associated protein X-1-like | | | | | Black Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 18395119 | LOC103232711 | HCLS1-associated protein X-1 pseudogene | | | | | Green Monkey | | old_gene_name , name | gene, pseudo, MODEL [RefSeq] |
| 2318687 | Hax1-ps1 | HCLS1 associated protein X-1, pseudogene 1 | | 17 | 55066085 | 55066966 | Rat | | old_gene_name , name | gene, pseudo, MODEL [RefSeq] |
| 2319448 | Hax1-ps2 | HCLS1 associated protein X-1, pseudogene 2 | | 10 | 31829121 | 31830369 | Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 2323955 | Hax1-ps3 | HCLS1 associated protein X-1, pseudogene 3 | | 15 | 84948551 | 84949375 | Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 2318121 | Hax1-ps4 | HCLS1 associated protein X-1, pseudogene 4 | | 4 | 164935121 | 164936318 | Rat | | old_gene_name , name | gene, pseudo, MODEL [RefSeq] |
| 1595952 | Hax1-ps5 | HCLS1 associated protein X-1, pseudogene 5 | | 8 | 80577734 | 80578778 | Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 2323822 | Hax1-ps6 | HCLS1 associated protein X-1, pseudogene 6 | | 4 | 164852278 | 164866275 | Rat | | old_gene_name , name | gene, pseudo, MODEL [RefSeq] |