| 1305233 | Havcr2 | hepatitis A virus cellular receptor 2 | ENCODES a protein that exhibits transmembrane signaling receptor activity (ortholog); INVOLVED IN cellular response to lipopolysaccharide (ortholog); defense response to Gram-positive bacterium (ortholog); macrophage activation involved in immune response (ortholog); ASSOCIATED WITH Experimental Art hritis; Experimental Autoimmune Encephalomyelitis; Experimental Autoimmune Neuritis; FOUND IN cell surface; early endosome (ortholog); immunological synapse (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 3,3',4,4',5-pentachlorobiphenyl | 10 | 31383801 | 31415334 | Rat | 155 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1313140 | HAVCR2 | hepatitis A virus cellular receptor 2 | The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance. [provided by RefSeq, Sep 2011] | 5 | 157085832 | 157109044 | Human | 193 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1313141 | Havcr2 | hepatitis A virus cellular receptor 2 | Predicted to enable metal ion binding activity and transmembrane signaling receptor activity. Involved in several processes, including regulation of cytokine production; regulation of defense response; and regulation of leukocyte activation. Located in cell surface; early endosome; and immunological synapse. Is expressed in several structures, including aorta-gonad-mesonephros; gut; liver; lung; and reproductive system. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and renal cell carcinoma. Orthologous to human HAVCR2 (hepatitis A virus cellular receptor 2). [provided by Alliance of Genome Resources, Apr 2025] | 11 | 46345758 | 46372082 | Mouse | 188 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8799895 | Havcr2 | hepatitis A virus cellular receptor 2 | ENCODES a protein that exhibits transmembrane signaling receptor activity (ortholog); INVOLVED IN cellular response to lipopolysaccharide (ortholog); defense response to Gram-positive bacterium (ortholog); macrophage activation involved in immune response (ortholog); ASSOCIATED WITH asthma (ortholog ); cystic fibrosis (ortholog); Eczema (ortholog); FOUND IN cell surface (ortholog); early endosome (ortholog); immunological synapse (ortholog) | NW_004955408 | 11289920 | 11311216 | Chinchilla | 75 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11925070 | HAVCR2 | hepatitis A virus cellular receptor 2 | ENCODES a protein that exhibits transmembrane signaling receptor activity (inferred); INVOLVED IN cellular response to lipopolysaccharide (inferred); defense response to Gram-positive bacterium (inferred); macrophage activation involved in immune response (inferred); ASSOCIATED WITH asthma (ortholog ); cystic fibrosis (ortholog); Eczema (ortholog); FOUND IN cell surface (ortholog) | 5 | 152486125 | 152514004 | Bonobo | 72 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12384915 | HAVCR2 | hepatitis A virus cellular receptor 2 | ENCODES a protein that exhibits transmembrane signaling receptor activity (inferred); INVOLVED IN cellular response to lipopolysaccharide (inferred); defense response to Gram-positive bacterium (inferred); macrophage activation involved in immune response (inferred); ASSOCIATED WITH asthma (ortholog ); cystic fibrosis (ortholog); Eczema (ortholog); FOUND IN cell surface (ortholog) | 4 | 53018990 | 53032035 | Dog | 72 | symbol | gene, protein-coding, INFERRED [RefSeq] |
| 12458280 | Havcr2 | hepatitis A virus cellular receptor 2 | ENCODES a protein that exhibits transmembrane signaling receptor activity (ortholog); INVOLVED IN cellular response to lipopolysaccharide (ortholog); defense response to Gram-positive bacterium (ortholog); macrophage activation involved in immune response (ortholog); ASSOCIATED WITH asthma (ortholog ); cystic fibrosis (ortholog); Eczema (ortholog); FOUND IN cell surface (ortholog); early endosome (ortholog); immunological synapse (ortholog) | NW_004936515 | 6001324 | 6015407 | Squirrel | 75 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18551850 | HAVCR2 | hepatitis A virus cellular receptor 2 | ENCODES a protein that exhibits transmembrane signaling receptor activity (inferred); INVOLVED IN cellular response to lipopolysaccharide (inferred); defense response to Gram-positive bacterium (inferred); macrophage activation involved in immune response (inferred); ASSOCIATED WITH asthma (ortholog ); cystic fibrosis (ortholog); Eczema (ortholog); FOUND IN cell surface (ortholog) | | | | Green Monkey | 72 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14004802 | HAVCR2 | hepatitis A virus cellular receptor 2 | ENCODES a protein that exhibits transmembrane signaling receptor activity (inferred); INVOLVED IN cellular response to lipopolysaccharide (inferred); defense response to Gram-positive bacterium (inferred); macrophage activation involved in immune response (inferred); ASSOCIATED WITH asthma (ortholog ); cystic fibrosis (ortholog); Eczema (ortholog); FOUND IN cell surface (ortholog) | | | | Pig | 72 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626157175 | Havcr2 | hepatitis A virus cellular receptor 2 | ENCODES a protein that exhibits transmembrane signaling receptor activity (ortholog); INVOLVED IN cellular response to lipopolysaccharide (ortholog); defense response to Gram-positive bacterium (ortholog); macrophage activation involved in immune response (ortholog); ASSOCIATED WITH asthma (ortholog ); cystic fibrosis (ortholog); Eczema (ortholog); FOUND IN cell surface (ortholog); early endosome (ortholog); immunological synapse (ortholog) | | | | Black Rat | 75 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18927896 | Havcr2 | hepatitis A virus cellular receptor 2 | ENCODES a protein that exhibits transmembrane signaling receptor activity (ortholog); INVOLVED IN cellular response to lipopolysaccharide (ortholog); defense response to Gram-positive bacterium (ortholog); macrophage activation involved in immune response (ortholog); ASSOCIATED WITH asthma (ortholog ); cystic fibrosis (ortholog); Eczema (ortholog); FOUND IN cell surface (ortholog); early endosome (ortholog); immunological synapse (ortholog) | | | | Naked Mole-Rat | 78 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12143590 | HAVCR1 | hepatitis A virus cellular receptor 1 | INVOLVED IN apoptotic cell clearance (ortholog); phagocytosis, engulfment (ortholog); positive regulation of mast cell activation (ortholog); ASSOCIATED WITH acute kidney failure (ortholog); acute kidney tubular necrosis (ortholog); Albuminuria (ortholog); FOUND IN apical plasma membrane (ortholog); brush border (ortholog); cell surface (ortholog) | 4 | 53012223 | 53066611 | Dog | 75 | ensembl_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |