| 628640 | Gzma | granzyme A | ENCODES a protein that exhibits protein homodimerization activity (ortholog); serine-type endopeptidase activity (ortholog); serine-type peptidase activity (ortholog); INVOLVED IN cytotoxic T cell pyroptotic cell death (ortholog); granzyme-mediated programmed cell death signaling pathway (ortholog); positive regulation of apoptotic process (ortholog); PARTICIPATES IN interleukin-12 signaling pathway; ASSOCIATED WITH chronic obstructive pulmonary disease (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN cytolytic granule (ortholog); cytoplasm (ortholog); extracellular space (ortholog); INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-naphthyl isothiocyanate; 3-chloropropane-1,2-diol | 2 | 46473763 | 46485696 | Rat | 149 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 732689 | Gzma | granzyme A | Enables serine-type peptidase activity. Acts upstream of or within response to bacterium. Located in extracellular space and nucleus. Is expressed in thymus primordium. Orthologous to human GZMA (granzyme A). [provided by Alliance of Genome Resources, Apr 2025] | 13 | 113230358 | 113237515 | Mouse | 167 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1348122 | GZMA | granzyme A | Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by in tracellular pathogens. The protein described here is a T cell- and natural killer cell-specific serine protease that may function as a common component necessary for lysis of target cells by cytotoxic T lymphocytes and natural killer cells. [provided by RefSeq, Jul 2008] | 5 | 55102646 | 55110252 | Human | 146 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8907308 | Gzma | granzyme A | ENCODES a protein that exhibits protein homodimerization activity (ortholog); serine-type endopeptidase activity (ortholog); serine-type peptidase activity (ortholog); INVOLVED IN cytotoxic T cell pyroptotic cell death (ortholog); granzyme-mediated programmed cell death signaling pathway (ortholog); positive regulation of apoptotic process (ortholog); PARTICIPATES IN interleukin-12 signaling pathway; ASSOCIATED WITH chronic obstructive pulmonary disease (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN cytolytic granule (ortholog); cytoplasm (ortholog); extracellular space (ortholog) | NW_004955446 | 12560831 | 12568023 | Chinchilla | 19 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11933330 | GZMA | granzyme A | ENCODES a protein that exhibits hydrolase activity (inferred); peptidase activity (inferred); protein homodimerization activity (inferred); INVOLVED IN response to bacterium (ortholog); PARTICIPATES IN interleukin-12 signaling pathway; ASSOCIATED WITH chronic obstructive pulmonary disease (ortholog) ; Experimental Liver Cirrhosis (ortholog); FOUND IN cytolytic granule (inferred); cytoplasm (inferred); extracellular space (inferred) | 5 | 58919129 | 58926620 | Bonobo | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12411288 | GZMA | granzyme A | ENCODES a protein that exhibits hydrolase activity (inferred); peptidase activity (inferred); protein homodimerization activity (inferred); INVOLVED IN response to bacterium (ortholog); PARTICIPATES IN interleukin-12 signaling pathway; ASSOCIATED WITH chronic obstructive pulmonary disease (ortholog) ; Experimental Liver Cirrhosis (ortholog); FOUND IN cytolytic granule (ortholog); extracellular space (ortholog); nucleus (ortholog) | 2 | 42490712 | 42498655 | Dog | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12648389 | Gzma | granzyme A | ENCODES a protein that exhibits hydrolase activity (inferred); peptidase activity (inferred); protein homodimerization activity (inferred); INVOLVED IN response to bacterium (ortholog); PARTICIPATES IN interleukin-12 signaling pathway; ASSOCIATED WITH chronic obstructive pulmonary disease (ortholog) ; Experimental Liver Cirrhosis (ortholog); FOUND IN cytolytic granule (inferred); cytoplasm (inferred); extracellular space (inferred) | NW_004936480 | 12641587 | 12649243 | Squirrel | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625832002 | Gzma | granzyme A | ENCODES a protein that exhibits protein homodimerization activity (ortholog); serine-type endopeptidase activity (ortholog); serine-type peptidase activity (ortholog); INVOLVED IN cytotoxic T cell pyroptotic cell death (ortholog); granzyme-mediated programmed cell death signaling pathway (ortholog); positive regulation of apoptotic process (ortholog); PARTICIPATES IN interleukin-12 signaling pathway; ASSOCIATED WITH chronic obstructive pulmonary disease (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN cytolytic granule (ortholog); cytoplasm (ortholog); extracellular space (ortholog) | | | | Black Rat | 19 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14166239 | GZMA | granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) | ENCODES a protein that exhibits hydrolase activity (inferred); peptidase activity (inferred); protein homodimerization activity (inferred); INVOLVED IN response to bacterium (ortholog); PARTICIPATES IN interleukin-12 signaling pathway; ASSOCIATED WITH chronic obstructive pulmonary disease (ortholog) ; Experimental Liver Cirrhosis (ortholog); FOUND IN cytolytic granule (inferred); cytoplasm (inferred); extracellular space (inferred); INTERACTS WITH ammonia | | | | Pig | 29 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18926750 | Gzma | granzyme A | ENCODES a protein that exhibits protein homodimerization activity (ortholog); INVOLVED IN cytotoxic T cell pyroptotic cell death (ortholog); granzyme-mediated programmed cell death signaling pathway (ortholog); protein maturation (ortholog); PARTICIPATES IN interleukin-12 signaling pathway; ASSOCIAT ED WITH chronic obstructive pulmonary disease (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN cytolytic granule (ortholog); cytoplasm (ortholog); extracellular space (ortholog) | | | | Naked Mole-Rat | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13997672 | GZMA | granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) | ENCODES a protein that exhibits hydrolase activity (inferred); peptidase activity (inferred); serine-type endopeptidase activity (inferred); INVOLVED IN proteolysis (inferred) | | | | Pig | 10 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18532377 | GZMA | granzyme A | ENCODES a protein that exhibits hydrolase activity (inferred); peptidase activity (inferred); protein homodimerization activity (inferred); INVOLVED IN response to bacterium (ortholog); PARTICIPATES IN interleukin-12 signaling pathway; ASSOCIATED WITH chronic obstructive pulmonary disease (ortholog) ; Experimental Liver Cirrhosis (ortholog); FOUND IN cytolytic granule (inferred); cytoplasm (inferred); extracellular space (inferred) | | | | Green Monkey | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155239908 | gzma | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155239907 | gzma.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155235697 | gzma.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 287675912 | XB5962685 [provisional:gzma] | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 287675297 | XB5962685.L [provisional:gzma] | | | | | | African Clawed Frog | | symbol | gene, null |
| 736761 | Atf2 | activating transcription factor 2 | Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; cAMP response element binding activity; and protein dimerization activity. Involved in several processes, including growth plate cartilage development; hindbrain development; and intracellu lar signal transduction. Acts upstream of or within with a positive effect on cellular response to leucine starvation and regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including adipose tissue development; brown fat cell proliferation; and positive regulation of transforming growth factor beta2 production. Located in membrane; nucleus; and site of double-strand break. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and limb. Used to study meconium aspiration syndrome and osteochondrodysplasia. Orthologous to human ATF2 (activating transcription factor 2). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 73646853 | 73723094 | Mouse | 525 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 284188209 | gzmak | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 10399174 | GZMAP1 | granzyme A pseudogene 1 | | 5 | 55073015 | 55096553 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 287555366 | gzmak.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 286163917 | gzmak.S | | | | | | African Clawed Frog | | symbol | gene, null |
