Gzma (granzyme A) - Rat Genome Database

Name: Gzma
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Gzma (granzyme A) Chinchilla lanigera

Analyze

Symbol:

Gzma

Name:

granzyme A

RGD ID:

8907308

Description:

ENCODES a protein that exhibits protein homodimerization activity (ortholog); serine-type endopeptidase activity (ortholog); serine-type peptidase activity (ortholog); INVOLVED IN cytotoxic T cell pyroptotic process (ortholog); granzyme-mediated programmed cell death signaling pathway (ortholog); positive regulation of apoptotic process (ortholog); PARTICIPATES IN interleukin-12 signaling pathway; ASSOCIATED WITH chronic obstructive pulmonary disease (ortholog); Experimental Liver Cirrhosis (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (ortholog); extracellular space (ortholog); nucleus (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GZMA (granzyme A)	NCBI	Ortholog
Mus musculus (house mouse):	Gzma (granzyme A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Gzma (granzyme A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GZMA (granzyme A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GZMA (granzyme A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Gzma (granzyme A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	GZMA (granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3))	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	GZMA (granzyme A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Gzma (granzyme A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955446	12,560,658 - 12,568,053 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955446	12,560,831 - 12,568,023 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

chronic obstructive pulmonary disease (ISO)

Experimental Liver Cirrhosis (ISO)

genetic disease (ISO)

Neurodevelopmental Disorders (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cytotoxic T cell pyroptotic process (ISO)

granzyme-mediated programmed cell death signaling pathway (ISO)

positive regulation of apoptotic process (ISO)

protein maturation (ISO)

proteolysis involved in protein catabolic process (ISO)

pyroptosis (ISO)

response to bacterium (ISO)

Cellular Component

cytoplasm (ISO)

extracellular space (ISO)

nucleus (ISO)

Molecular Function

protein binding (ISO)

protein homodimerization activity (ISO)

serine-type endopeptidase activity (ISO)

serine-type peptidase activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

interleukin-12 signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Gzma
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955446	12,560,658 - 12,568,053 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955446	12,560,831 - 12,568,023 (-)	NCBI	ChiLan1.0	ChiLan1.0

GZMA
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	55,102,646 - 55,110,252 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	55,102,646 - 55,110,252 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	54,398,474 - 54,406,080 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	54,434,230 - 54,441,818 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	54,434,229 - 54,441,818	NCBI
Celera	5	51,351,660 - 51,358,967 (+)	NCBI		Celera
Cytogenetic Map	5	q11.2	NCBI
HuRef	5	51,372,038 - 51,379,264 (+)	NCBI		HuRef
CHM1_1	5	54,401,713 - 54,409,574 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	5	55,930,246 - 55,937,579 (+)	NCBI		T2T-CHM13v2.0

Gzma
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	113,230,358 - 113,237,515 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	113,230,359 - 113,237,515 (-)	Ensembl		GRCm39 Ensembl
GRCm38	13	113,093,824 - 113,100,981 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	113,093,825 - 113,100,981 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	113,884,035 - 113,891,189 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	13	114,214,703 - 114,221,857 (-)	NCBI		MGSCv36	mm8
Celera	13	117,414,494 - 117,421,678 (-)	NCBI		Celera
Cytogenetic Map	13	D2.2	NCBI
cM Map	13	63.93	NCBI

Gzma
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	46,473,763 - 46,485,696 (-)	NCBI		GRCr8
mRatBN7.2	2	44,740,569 - 44,752,502 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	44,740,569 - 44,752,493 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	51,849,991 - 51,861,867 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	49,908,348 - 49,920,224 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	44,783,785 - 44,795,643 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	44,968,846 - 44,981,436 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	44,968,765 - 44,981,458 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	64,004,695 - 64,017,285 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	44,488,295 - 44,500,128 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	44,416,527 - 44,428,361 (-)	NCBI
Celera	2	40,513,802 - 40,525,612 (-)	NCBI		Celera
Cytogenetic Map	2	q14	NCBI

GZMA
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	58,830,039 - 58,837,338 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	56,983,664 - 56,990,990 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	58,919,129 - 58,926,620 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	60,540,988 - 60,548,274 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	60,540,988 - 60,548,506 (-)	Ensembl	panpan1.1		panPan2

GZMA
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	42,490,712 - 42,498,655 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	42,490,069 - 42,498,464 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	39,536,721 - 39,544,284 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	42,950,252 - 42,957,426 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	42,949,874 - 42,957,230 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	40,020,302 - 40,027,904 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	40,830,532 - 40,838,091 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	41,653,466 - 41,660,635 (+)	NCBI		UU_Cfam_GSD_1.0

Gzma
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	203,705,039 - 203,712,759 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936480	12,641,433 - 12,649,324 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936480	12,641,587 - 12,649,243 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GZMA
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	16	34,282,120 - 34,290,477 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	16	34,282,160 - 34,290,422 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	16	36,385,694 - 36,393,956 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GZMA
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	4	51,340,329 - 51,347,569 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	4	51,340,356 - 51,348,249 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666049	209,615 - 216,838 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gzma
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624759	4,177,857 - 4,185,324 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624759	4,177,857 - 4,185,325 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005392711	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01040238	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDJ01174665	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000007113 ⟹ ENSCLAP00000007001

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955446	12,560,658 - 12,568,053 (-)	Ensembl

RefSeq Acc Id:

XM_005392711 ⟹ XP_005392768

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955446	12,560,831 - 12,568,023 (-)	NCBI

Sequence:

show sequence

TGACTTTCCTTCTGATTGATGTGGGAACACCAGCCACAATGAGGAACTCCTATGCACTGCTGGC
ATCTTCTCTCTCGATTGTCATTTTTCTTCTACTAATTCCTGAAGATGCCTGTGTAAGAATTATT
GGGGGACATGAAGTGACTCCTCATTCAAGACCCTACATGGTCCTACTAAAATTTGACCAAACAA
AAATCTGTGCTGGTGCTTTGATTGCACAAAATTGGGTATTGACTGCAGCCCACTGTGACCTGAA
AAAAAAGGCCCAGGTCATTCTTGGGGCTCACTCAATAACCGCAAATGAACCAGAAAAACAGATA
ATATCAGTTAAGAAGGAGTTTCCTCATCCATGCTTTGACCTGGACACAGGTGAAAATGATCTTA
AACTTCTTCAGCTAAACAAAATGGCAAAAATTAACAAAAATGTAGCTATCCTTCAACTACCTAA
CAATGGGGATGACGTGAAACCAGGAACTATATGTCATGTTGCAGGGTGGGGGATGACCAGCAAT
AATTCACCTCTGTCTGATGTTCTAAGAGAAGTCAATGTCACCACCATAGATAGAAAAATCTGCA
ATAATGCAGAACACTACAATTTTAATCCTGTGATTGGACTCAATATGATTTGTGCCGGAAGCCC
TCGTGGTGGGAAAGACTCATGCCATGGAGATTCTGGAAGCCCTTTGCGGTGTGGAGGTGTTTTC
CGAGGCATCACTTCCTTTGGCCATCCAGGGAAATGTGGAGTCCCTCAAGCACCTGGTGTCTATA
CGCGTCTCTCAAAAAAATACATTCACTGGATAGATAAGGTTATGAAGGAGACAGTTTAGATAAC
TGTATTTTATTTCATTTGTTGTCAAGTCAATCTTATCACAAATAAAATCAATCTGTATTGCTGT
A

hide sequence

Protein Sequences


Protein RefSeqs	XP_005392768	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000007001
	ENSCLAP00000007001.1

RefSeq Acc Id:

XP_005392768 ⟸ XM_005392711

- UniProtKB:

A0A8C2V2Z8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MRNSYALLASSLSIVIFLLLIPEDACVRIIGGHEVTPHSRPYMVLLKFDQTKICAGALIAQNWV
LTAAHCDLKKKAQVILGAHSITANEPEKQIISVKKEFPHPCFDLDTGENDLKLLQLNKMAKINK
NVAILQLPNNGDDVKPGTICHVAGWGMTSNNSPLSDVLREVNVTTIDRKICNNAEHYNFNPVIG
LNMICAGSPRGGKDSCHGDSGSPLRCGGVFRGITSFGHPGKCGVPQAPGVYTRLSKKYIHWIDK
VMKETV

hide sequence

RefSeq Acc Id:

ENSCLAP00000007001 ⟸ ENSCLAT00000007113

Protein Domains

Peptidase S1

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000004932	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000007113	ENTREZGENE
	ENSCLAT00000007113.1	UniProtKB/TrEMBL
Gene3D-CATH	2.40.10.10	UniProtKB/TrEMBL
InterPro	Peptidase_S1_PA	UniProtKB/TrEMBL
	Peptidase_S1_PA_chymotrypsin	UniProtKB/TrEMBL
	Peptidase_S1A	UniProtKB/TrEMBL
	Trypsin_dom	UniProtKB/TrEMBL
	TRYPSIN_HIS	UniProtKB/TrEMBL
NCBI Gene	Gzma	ENTREZGENE
PANTHER	GRANZYME A	UniProtKB/TrEMBL
	KALLIKREIN-RELATED	UniProtKB/TrEMBL
Pfam	Trypsin	UniProtKB/TrEMBL
PRINTS	CHYMOTRYPSIN	UniProtKB/TrEMBL
PROSITE	TRYPSIN_DOM	UniProtKB/TrEMBL
	TRYPSIN_HIS	UniProtKB/TrEMBL
SMART	Tryp_SPc	UniProtKB/TrEMBL
Superfamily-SCOP	SSF50494	UniProtKB/TrEMBL
UniProt	A0A8C2V2Z8	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-16	Gzma	granzyme A		granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - PID (archival)