| 1342517 | GRHL2 | grainyhead like transcription factor 2 | The protein encoded by this gene is a transcription factor that can act as a homodimer or as a heterodimer with either GRHL1 or GRHL3. Defects in this gene are a cause of non-syndromic sensorineural deafness autosomal dominant type 28 (DFNA28).[provided by RefSeq, Mar 2009] | 8 | 101492439 | 101681200 | Human | 199 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1558066 | Grhl2 | grainyhead like transcription factor 2 | Enables DNA-binding transcription factor activity; chromatin binding activity; and intronic transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including epithelial cell differentiation; neural tube closure; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including embryonic morphogenesis; face development; and lung lobe morphogenesis. Located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 28 and posterior polymorphous corneal dystrophy 4. Orthologous to human GRHL2 (grainyhead like transcription factor 2). [provided by Alliance of Genome Resources, Jul 2025] | 15 | 37233065 | 37363813 | Mouse | 226 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1561191 | Grhl2 | grainyhead-like transcription factor 2 | ENCODES a protein that exhibits chromatin binding (ortholog); chromatin DNA binding (ortholog); DNA-binding transcription activator activity (ortholog); INVOLVED IN anterior neural tube closure (ortholog); bicellular tight junction assembly (ortholog); brain development (ortholog); ASSOCIATED WITH a utosomal dominant nonsyndromic deafness 28 (ortholog); corneal dystrophy (ortholog); ECTODERMAL DYSPLASIA/SHORT STATURE SYNDROME (ortholog); FOUND IN cell-cell junction (ortholog); nucleoplasm (ortholog); nucleus (ortholog); INTERACTS WITH 3-methylfuran; atrazine; bisphenol A | 7 | 70280360 | 70415277 | Rat | 156 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 8912779 | Grhl2 | grainyhead like transcription factor 2 | ENCODES a protein that exhibits chromatin binding (ortholog); chromatin DNA binding (ortholog); DNA-binding transcription activator activity (ortholog); INVOLVED IN anterior neural tube closure (ortholog); bicellular tight junction assembly (ortholog); brain development (ortholog); ASSOCIATED WITH a utosomal dominant nonsyndromic deafness 28 (ortholog); corneal dystrophy (ortholog); ECTODERMAL DYSPLASIA/SHORT STATURE SYNDROME (ortholog); FOUND IN cell-cell junction (ortholog); nucleoplasm (ortholog); nucleus (ortholog) | NW_004955417 | 26401337 | 26533297 | Chinchilla | 60 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11732788 | GRHL2 | grainyhead like transcription factor 2 | ENCODES a protein that exhibits chromatin binding (inferred); chromatin DNA binding (inferred); DNA binding (inferred); INVOLVED IN anterior neural tube closure (ortholog); brain development (ortholog); camera-type eye development (ortholog); ASSOCIATED WITH autosomal dominant nonsyndromic deafness 28 (ortholog); corneal dystrophy (ortholog); ECTODERMAL DYSPLASIA/SHORT STATURE SYNDROME (ortholog); FOUND IN cell-cell junction (inferred); nucleoplasm (inferred); nucleus (inferred) | 8 | 98129147 | 98308120 | Bonobo | 66 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12058139 | GRHL2 | grainyhead like transcription factor 2 | ENCODES a protein that exhibits chromatin binding (inferred); chromatin DNA binding (inferred); DNA binding (inferred); INVOLVED IN anterior neural tube closure (ortholog); brain development (ortholog); camera-type eye development (ortholog); ASSOCIATED WITH autosomal dominant nonsyndromic deafness 28 (ortholog); corneal dystrophy (ortholog); ECTODERMAL DYSPLASIA/SHORT STATURE SYNDROME (ortholog); FOUND IN cell-cell junction (inferred); nucleoplasm (inferred); nucleus (inferred) | 13 | 3204898 | 3362533 | Dog | 65 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12540163 | Grhl2 | grainyhead like transcription factor 2 | ENCODES a protein that exhibits chromatin binding (inferred); chromatin DNA binding (inferred); DNA binding (inferred); INVOLVED IN anterior neural tube closure (ortholog); brain development (ortholog); camera-type eye development (ortholog); ASSOCIATED WITH autosomal dominant nonsyndromic deafness 28 (ortholog); corneal dystrophy (ortholog); ECTODERMAL DYSPLASIA/SHORT STATURE SYNDROME (ortholog); FOUND IN cell-cell junction (inferred); nucleoplasm (inferred); nucleus (inferred) | NW_004936470 | 41856683 | 41961666 | Squirrel | 65 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18921411 | Grhl2 | grainyhead like transcription factor 2 | ENCODES a protein that exhibits chromatin binding (ortholog); chromatin DNA binding (ortholog); DNA-binding transcription activator activity (ortholog); INVOLVED IN anterior neural tube closure (ortholog); bicellular tight junction assembly (ortholog); brain development (ortholog); ASSOCIATED WITH a utosomal dominant nonsyndromic deafness 28 (ortholog); corneal dystrophy (ortholog); ECTODERMAL DYSPLASIA/SHORT STATURE SYNDROME (ortholog); FOUND IN cell-cell junction (ortholog); nucleoplasm (ortholog) | | | | Naked Mole-Rat | 63 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625888306 | Grhl2 | grainyhead like transcription factor 2 | ENCODES a protein that exhibits chromatin binding (ortholog); chromatin DNA binding (ortholog); DNA-binding transcription activator activity (ortholog); INVOLVED IN anterior neural tube closure (ortholog); bicellular tight junction assembly (ortholog); brain development (ortholog); ASSOCIATED WITH a utosomal dominant nonsyndromic deafness 28 (ortholog); corneal dystrophy (ortholog); ECTODERMAL DYSPLASIA/SHORT STATURE SYNDROME (ortholog); FOUND IN cell-cell junction (ortholog); nucleoplasm (ortholog); nucleus (ortholog) | | | | Black Rat | 60 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14157855 | GRHL2 | grainyhead like transcription factor 2 | ENCODES a protein that exhibits chromatin binding (inferred); chromatin DNA binding (inferred); DNA binding (inferred); INVOLVED IN anterior neural tube closure (ortholog); brain development (ortholog); camera-type eye development (ortholog); ASSOCIATED WITH autosomal dominant nonsyndromic deafness 28 (ortholog); corneal dystrophy (ortholog); ECTODERMAL DYSPLASIA/SHORT STATURE SYNDROME (ortholog); FOUND IN cell-cell junction (inferred); nucleoplasm (inferred); nucleus (inferred) | | | | Pig | 66 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18706835 | GRHL2 | grainyhead like transcription factor 2 | ENCODES a protein that exhibits chromatin binding (inferred); chromatin DNA binding (inferred); DNA binding (inferred); INVOLVED IN anterior neural tube closure (ortholog); brain development (ortholog); camera-type eye development (ortholog); ASSOCIATED WITH autosomal dominant nonsyndromic deafness 28 (ortholog); corneal dystrophy (ortholog); ECTODERMAL DYSPLASIA/SHORT STATURE SYNDROME (ortholog); FOUND IN cell-cell junction (inferred); nucleoplasm (inferred); nucleus (inferred) | | | | Green Monkey | 66 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155240554 | grhl2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155235164 | grhl2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155241842 | grhl2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 38608995 | GRHL2-DT | GRHL2 divergent transcript | ASSOCIATED WITH Disease Progression; Stomach Neoplasms | 8 | 101460958 | 101492705 | Human | 2 | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |