| 619890 | Gpr149 | G protein-coupled receptor 149 | ENCODES a protein that exhibits G protein-coupled receptor activity (inferred); INVOLVED IN antral ovarian follicle growth (ortholog); negative regulation of ovulation (ortholog); preantral ovarian follicle growth (ortholog); ASSOCIATED WITH hypertrophic cardiomyopathy (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred); INTERACTS WITH 17alpha-ethynylestradiol; 3,3',4,4',5-pentachlorobiphenyl; 6-propyl-2-thiouracil | 2 | 149059333 | 149130798 | Rat | 42 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1346454 | GPR149 | G protein-coupled receptor 149 | This gene encodes a seven-transmembrane G protein coupled receptor (GPCR) class A family member. Although categorized as a class A GPCR, the encoded protein lacks the first two charged amino acids of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix of class A recep tors which is important for efficient G protein-coupled signal transduction. Mice with a knockout of the orthologous gene are viable and have normal maturation of the ovarian follicle, but show enhanced fertility and ovulation. All GPCRs have a common structural architecture consisting of seven transmembrane alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptor, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. [provided by RefSeq, Jul 2017] | 3 | 154334943 | 154430190 | Human | 43 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1619848 | Gpr149 | G protein-coupled receptor 149 | Predicted to enable G protein-coupled receptor activity and neuropeptide binding activity. Acts upstream of or within antral ovarian follicle growth; negative regulation of ovulation; and preantral ovarian follicle growth. Predicted to be active in neuron projection and plasma membrane. Orthologous to human GPR149 (G protein-coupled receptor 149). [provided by Alliance of Genome Resources, Apr 2025] | 3 | 62436851 | 62512861 | Mouse | 53 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 9002411 | Gpr149 | G protein-coupled receptor 149 | INVOLVED IN antral ovarian follicle growth (ortholog); negative regulation of ovulation (ortholog); preantral ovarian follicle growth (ortholog); ASSOCIATED WITH hypertrophic cardiomyopathy (ortholog) | NW_004955448 | 5682132 | 5749533 | Chinchilla | 4 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11802812 | GPR149 | G protein-coupled receptor 149 | ENCODES a protein that exhibits G protein-coupled receptor activity (inferred); neuropeptide binding (inferred); peptide binding (inferred); INVOLVED IN antral ovarian follicle growth (ortholog); negative regulation of ovulation (ortholog); preantral ovarian follicle growth (ortholog); ASSOCIATED WI TH hypertrophic cardiomyopathy (ortholog); FOUND IN membrane (inferred); neuron projection (inferred); plasma membrane (inferred) | 3 | 151393049 | 151493824 | Bonobo | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12270383 | GPR149 | G protein-coupled receptor 149 | ENCODES a protein that exhibits G protein-coupled receptor activity (inferred); INVOLVED IN antral ovarian follicle growth (ortholog); negative regulation of ovulation (ortholog); preantral ovarian follicle growth (ortholog); ASSOCIATED WITH hypertrophic cardiomyopathy (ortholog); FOUND IN plasma me mbrane (inferred) | 23 | 48470428 | 48535861 | Dog | 13 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12440142 | Gpr149 | G protein-coupled receptor 149 | ENCODES a protein that exhibits G protein-coupled receptor activity (inferred); neuropeptide binding (inferred); peptide binding (inferred); INVOLVED IN antral ovarian follicle growth (ortholog); negative regulation of ovulation (ortholog); preantral ovarian follicle growth (ortholog); ASSOCIATED WI TH hypertrophic cardiomyopathy (ortholog); FOUND IN membrane (inferred); neuron projection (inferred); plasma membrane (inferred) | NW_004936519 | 1997492 | 2070157 | Squirrel | 15 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14143704 | GPR149 | G protein-coupled receptor 149 | ENCODES a protein that exhibits G protein-coupled receptor activity (inferred); INVOLVED IN antral ovarian follicle growth (ortholog); negative regulation of ovulation (ortholog); preantral ovarian follicle growth (ortholog); ASSOCIATED WITH hypertrophic cardiomyopathy (ortholog); FOUND IN plasma me mbrane (inferred) | | | | Pig | 13 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 155238089 | gpr149 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625937185 | Gpr149 | G protein-coupled receptor 149 | INVOLVED IN antral ovarian follicle growth (ortholog); negative regulation of ovulation (ortholog); preantral ovarian follicle growth (ortholog); ASSOCIATED WITH hypertrophic cardiomyopathy (ortholog) | | | | Black Rat | 4 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18733431 | GPR149 | G protein-coupled receptor 149 | ENCODES a protein that exhibits G protein-coupled receptor activity (inferred); neuropeptide binding (inferred); peptide binding (inferred); INVOLVED IN antral ovarian follicle growth (ortholog); negative regulation of ovulation (ortholog); preantral ovarian follicle growth (ortholog); ASSOCIATED WI TH hypertrophic cardiomyopathy (ortholog); FOUND IN membrane (inferred); neuron projection (inferred); plasma membrane (inferred) | | | | Green Monkey | 15 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18935536 | Gpr149 | G protein-coupled receptor 149 | ENCODES a protein that exhibits G protein-coupled receptor activity (inferred); neuropeptide binding (inferred); peptide binding (inferred); INVOLVED IN antral ovarian follicle growth (ortholog); negative regulation of ovulation (ortholog); preantral ovarian follicle growth (ortholog); ASSOCIATED WI TH hypertrophic cardiomyopathy (ortholog); FOUND IN membrane (inferred); neuron projection (inferred); plasma membrane (inferred) | | | | Naked Mole-Rat | 15 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155238088 | gpr149.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155259544 | gpr149.S | | | | | | African Clawed Frog | | symbol | gene, null |
