| 1305877 | Gns | glucosamine (N-acetyl)-6-sulfatase | ENCODES a protein that exhibits glycosaminoglycan binding; N-acetylglucosamine-6-sulfatase activity; sulfate binding; INVOLVED IN keratan sulfate proteoglycan catabolic process; heparan sulfate proteoglycan catabolic process (ortholog); PARTICIPATES IN glycosaminoglycan degradation pathway; ASSOCIAT ED WITH Desbuquois dysplasia (ortholog); genetic disease (ortholog); mucopolysaccharidosis III (ortholog); FOUND IN azurophil granule (ortholog); lysosome (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; 4,4'-sulfonyldiphenol | 7 | 58774625 | 58808650 | Rat | 122 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1314172 | GNS | glucosamine (N-acetyl)-6-sulfatase | The product of this gene is a lysosomal enzyme found in all cells. It is involved in the catabolism of heparin, heparan sulphate, and keratan sulphate. Deficiency of this enzyme results in the accumulation of undegraded substrate and the lysosomal storage disorder mucopolysaccharidosis type IIID (Sa nfilippo D syndrome). Mucopolysaccharidosis type IIID is the least common of the four subtypes of Sanfilippo syndrome. [provided by RefSeq, Jul 2008] | 12 | 64713449 | 64759406 | Human | 276 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1314173 | Gns | glucosamine (N-acetyl)-6-sulfatase | Enables N-acetylglucosamine-6-sulfatase activity. Involved in heparan sulfate proteoglycan catabolic process. Located in lysosome. Is expressed in several structures, including eye; nervous system; skeleton; and spleen primordium. Used to study mucopolysaccharidosis III. Human ortholog(s) of this ge ne implicated in mucopolysaccharidosis III and mucopolysaccharidosis type IIID. Orthologous to human GNS (glucosamine (N-acetyl)-6-sulfatase). [provided by Alliance of Genome Resources, Jul 2025] | 10 | 121200995 | 121233159 | Mouse | 128 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8983288 | Gns | glucosamine (N-acetyl)-6-sulfatase | ENCODES a protein that exhibits glycosaminoglycan binding (ortholog); N-acetylglucosamine-6-sulfatase activity (ortholog); sulfate binding (ortholog); INVOLVED IN heparan sulfate proteoglycan catabolic process (ortholog); keratan sulfate proteoglycan catabolic process (ortholog); ASSOCIATED WITH Des buquois dysplasia (ortholog); genetic disease (ortholog); mucopolysaccharidosis III (ortholog); FOUND IN azurophil granule (ortholog); lysosome (ortholog) | NW_004955458 | 11471376 | 11500793 | Chinchilla | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12002842 | GNS | glucosamine (N-acetyl)-6-sulfatase | ENCODES a protein that exhibits glycosaminoglycan binding (ortholog); N-acetylglucosamine-6-sulfatase activity (ortholog); sulfate binding (ortholog); INVOLVED IN keratan sulfate proteoglycan catabolic process (ortholog); ASSOCIATED WITH Desbuquois dysplasia (ortholog); genetic disease (ortholog); m ucopolysaccharidosis III (ortholog); FOUND IN azurophil granule (inferred); lysosome (inferred) | 12 | 24164127 | 24209963 | Bonobo | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12305002 | GNS | glucosamine (N-acetyl)-6-sulfatase | ENCODES a protein that exhibits glycosaminoglycan binding (ortholog); N-acetylglucosamine-6-sulfatase activity (ortholog); sulfate binding (ortholog); INVOLVED IN keratan sulfate proteoglycan catabolic process (ortholog); ASSOCIATED WITH Desbuquois dysplasia (ortholog); genetic disease (ortholog); m ucopolysaccharidosis III (ortholog); FOUND IN azurophil granule (inferred); lysosome (inferred) | 10 | 7363628 | 7415618 | Dog | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12730520 | Gns | glucosamine (N-acetyl)-6-sulfatase | ENCODES a protein that exhibits glycosaminoglycan binding (ortholog); N-acetylglucosamine-6-sulfatase activity (ortholog); sulfate binding (ortholog); INVOLVED IN keratan sulfate proteoglycan catabolic process (ortholog); ASSOCIATED WITH Desbuquois dysplasia (ortholog); genetic disease (ortholog); m ucopolysaccharidosis III (ortholog); FOUND IN azurophil granule (inferred); lysosome (inferred) | NW_004936545 | 2974627 | 3010586 | Squirrel | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13923035 | GNS | glucosamine (N-acetyl)-6-sulfatase | ENCODES a protein that exhibits glycosaminoglycan binding (ortholog); N-acetylglucosamine-6-sulfatase activity (ortholog); sulfate binding (ortholog); INVOLVED IN keratan sulfate proteoglycan catabolic process (ortholog); ASSOCIATED WITH Desbuquois dysplasia (ortholog); genetic disease (ortholog); m ucopolysaccharidosis III (ortholog); FOUND IN azurophil granule (inferred); lysosome (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 30 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18456579 | GNS | glucosamine (N-acetyl)-6-sulfatase | ENCODES a protein that exhibits glycosaminoglycan binding (ortholog); N-acetylglucosamine-6-sulfatase activity (ortholog); sulfate binding (ortholog); INVOLVED IN keratan sulfate proteoglycan catabolic process (ortholog); ASSOCIATED WITH Desbuquois dysplasia (ortholog); genetic disease (ortholog); m ucopolysaccharidosis III (ortholog); FOUND IN azurophil granule (inferred); lysosome (inferred) | | | | Green Monkey | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18931984 | Gns | glucosamine (N-acetyl)-6-sulfatase | ENCODES a protein that exhibits glycosaminoglycan binding (ortholog); N-acetylglucosamine-6-sulfatase activity (ortholog); sulfate binding (ortholog); INVOLVED IN keratan sulfate proteoglycan catabolic process (ortholog); ASSOCIATED WITH Desbuquois dysplasia (ortholog); genetic disease (ortholog); m ucopolysaccharidosis III (ortholog); FOUND IN azurophil granule (ortholog) | | | | Naked Mole-Rat | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155241426 | gns | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625994124 | Gns | glucosamine (N-acetyl)-6-sulfatase | ENCODES a protein that exhibits glycosaminoglycan binding (ortholog); N-acetylglucosamine-6-sulfatase activity (ortholog); sulfate binding (ortholog); INVOLVED IN heparan sulfate proteoglycan catabolic process (ortholog); keratan sulfate proteoglycan catabolic process (ortholog); ASSOCIATED WITH Des buquois dysplasia (ortholog); genetic disease (ortholog); mucopolysaccharidosis III (ortholog); FOUND IN azurophil granule (ortholog); lysosome (ortholog) | | | | Black Rat | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155250017 | gns.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155241425 | gns.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1314711 | ANKRD26 | ankyrin repeat domain 26 | This gene encodes a protein containing N-terminal ankyrin repeats which function in protein-protein interactions. Mutations in this gene are associated with autosomal dominant thrombocytopenia-2. Pseudogenes of this gene are found on chromosome 7, 10, 13 and 16. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] | 10 | 26947582 | 27100494 | Human | 167 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 1316352 | ELOVL3 | ELOVL fatty acid elongase 3 | This gene encodes a protein that belongs to the GNS1/SUR4 family. Members of this family play a role in elongation of long chain fatty acids to provide precursors for synthesis of sphingolipids and ceramides. [provided by RefSeq, Jul 2013] | 10 | 102224767 | 102229589 | Human | 166 | description | gene, protein-coding, REVIEWED [RefSeq] |