| 61802 | Gdi2 | GDP dissociation inhibitor 2 | ENCODES a protein that exhibits Rab GDP-dissociation inhibitor activity; small GTPase binding; GTPase activator activity (ortholog); INVOLVED IN vesicle-mediated transport; negative regulation of cilium assembly (ortholog); negative regulation of protein localization to cilium (ortholog); PARTICIPAT ES IN Rab family mediated signaling pathway; ASSOCIATED WITH Down syndrome (ortholog); esophagus squamous cell carcinoma (ortholog); FOUND IN synapse; cytosol (ortholog); Golgi apparatus (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-ethoxyethanol; 2-methoxyethanol | 17 | 71559460 | 71586147 | Rat | 129 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 731527 | Gdi2 | GDP dissociation inhibitor 2 | Contributes to GTPase activator activity. Acts upstream of or within small GTPase-mediated signal transduction. Located in Golgi apparatus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologou s to human GDI2 (GDP dissociation inhibitor 2). [provided by Alliance of Genome Resources, Jul 2025] | 13 | 3588075 | 3616261 | Mouse | 140 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1346683 | GDI2 | GDP dissociation inhibitor 2 | GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from ra b proteins and release GDP from membrane-bound rabs. GDI2 is ubiquitously expressed. The GDI2 gene contains many repetitive elements indicating that it may be prone to inversion/deletion rearrangements. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008] | 10 | 5765223 | 5813434 | Human | 137 | symbol , COSMIC , description , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8878434 | Gdi2 | GDP dissociation inhibitor 2 | ENCODES a protein that exhibits GTPase activator activity (ortholog); Rab GDP-dissociation inhibitor activity (ortholog); small GTPase binding (ortholog); INVOLVED IN negative regulation of cilium assembly (ortholog); negative regulation of protein localization to cilium (ortholog); small GTPase-med iated signal transduction (ortholog); PARTICIPATES IN Rab family mediated signaling pathway; ASSOCIATED WITH Down syndrome (ortholog); esophagus squamous cell carcinoma (ortholog); FOUND IN cytosol (ortholog); Golgi apparatus (ortholog); synapse (ortholog) | NW_004955421 | 22449620 | 22480721 | Chinchilla | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11710251 | GDI2 | GDP dissociation inhibitor 2 | ENCODES a protein that exhibits GTPase activator activity (ortholog); Rab GDP-dissociation inhibitor activity (ortholog); small GTPase binding (ortholog); INVOLVED IN small GTPase-mediated signal transduction (ortholog); vesicle-mediated transport (ortholog); PARTICIPATES IN Rab family mediated sign aling pathway; ASSOCIATED WITH Down syndrome (ortholog); esophagus squamous cell carcinoma (ortholog); FOUND IN synapse (ortholog) | 10 | 5806336 | 5854676 | Bonobo | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12389630 | GDI2 | GDP dissociation inhibitor 2 | ENCODES a protein that exhibits GTPase activator activity (ortholog); Rab GDP-dissociation inhibitor activity (ortholog); small GTPase binding (ortholog); INVOLVED IN negative regulation of cilium assembly (ortholog); negative regulation of protein localization to cilium (ortholog); small GTPase-med iated signal transduction (ortholog); PARTICIPATES IN Rab family mediated signaling pathway; ASSOCIATED WITH Down syndrome (ortholog); esophagus squamous cell carcinoma (ortholog); FOUND IN cytosol (ortholog); synapse (ortholog) | 2 | 30150769 | 30168957 | Dog | 31 | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 12609470 | Gdi2 | GDP dissociation inhibitor 2 | ENCODES a protein that exhibits GTPase activator activity (ortholog); Rab GDP-dissociation inhibitor activity (ortholog); small GTPase binding (ortholog); INVOLVED IN negative regulation of cilium assembly (ortholog); negative regulation of protein localization to cilium (ortholog); small GTPase-med iated signal transduction (ortholog); PARTICIPATES IN Rab family mediated signaling pathway; ASSOCIATED WITH Down syndrome (ortholog); esophagus squamous cell carcinoma (ortholog); FOUND IN cytosol (ortholog); synapse (ortholog) | NW_004936484 | 8748050 | 8775234 | Squirrel | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625835363 | Gdi2 | GDP dissociation inhibitor 2 | ENCODES a protein that exhibits GTPase activator activity (ortholog); Rab GDP-dissociation inhibitor activity (ortholog); small GTPase binding (ortholog); INVOLVED IN negative regulation of cilium assembly (ortholog); negative regulation of protein localization to cilium (ortholog); small GTPase-med iated signal transduction (ortholog); PARTICIPATES IN Rab family mediated signaling pathway; ASSOCIATED WITH Down syndrome (ortholog); esophagus squamous cell carcinoma (ortholog); FOUND IN cytosol (ortholog); Golgi apparatus (ortholog); synapse (ortholog) | | | | Black Rat | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13865626 | GDI2 | GDP dissociation inhibitor 2 | ENCODES a protein that exhibits GTPase activator activity (ortholog); Rab GDP-dissociation inhibitor activity (ortholog); small GTPase binding (ortholog); INVOLVED IN negative regulation of cilium assembly (ortholog); negative regulation of protein localization to cilium (ortholog); small GTPase-med iated signal transduction (ortholog); PARTICIPATES IN Rab family mediated signaling pathway; ASSOCIATED WITH Down syndrome (ortholog); esophagus squamous cell carcinoma (ortholog); FOUND IN synapse (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 34 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18911832 | Gdi2 | GDP dissociation inhibitor 2 | ENCODES a protein that exhibits Rab GDP-dissociation inhibitor activity (ortholog); small GTPase binding (ortholog); INVOLVED IN negative regulation of cilium assembly (ortholog); negative regulation of protein localization to cilium (ortholog); small GTPase-mediated signal transduction (ortholog); PARTICIPATES IN Rab family mediated signaling pathway; ASSOCIATED WITH Down syndrome (ortholog); esophagus squamous cell carcinoma (ortholog); FOUND IN cytosol (ortholog); synapse (ortholog) | | | | Naked Mole-Rat | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18504121 | GDI2 | GDP dissociation inhibitor 2 | ENCODES a protein that exhibits GTPase activator activity (ortholog); Rab GDP-dissociation inhibitor activity (ortholog); small GTPase binding (ortholog); INVOLVED IN small GTPase-mediated signal transduction (ortholog); vesicle-mediated transport (ortholog); PARTICIPATES IN Rab family mediated sign aling pathway; ASSOCIATED WITH Down syndrome (ortholog); esophagus squamous cell carcinoma (ortholog); FOUND IN synapse (ortholog) | | | | Green Monkey | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155233667 | gdi2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155239964 | gdi2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155253373 | gdi2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1583769 | Gdi2-ps1 | GDP dissociation inhibitor 2, pseudogene 1 | | X | 57018159 | 57019480 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 1331946 | Arhgdig | Rho GDP dissociation inhibitor gamma | Enables GDP-dissociation inhibitor activity. Acts upstream of or within blastocyst hatching and regulation of protein localization. Located in membrane. Is expressed in several structures, including central nervous system; epithelium; gonad; trigeminal nerve; and upper jaw molar. Orthologous to huma n ARHGDIG (Rho GDP dissociation inhibitor gamma). [provided by Alliance of Genome Resources, Jul 2025] | 17 | 26418157 | 26420324 | Mouse | 68 | old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1352473 | GDI2P1 | GDP dissociation inhibitor 2 pseudogene 1 | | 7 | 48901756 | 48904003 | Human | | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 3207428 | GDI2P2 | GDP dissociation inhibitor 2 pseudogene 2 | | 1 | 72274535 | 72275148 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |