GDI2 (GDP dissociation inhibitor 2) - Rat Genome Database

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Pathways
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Gene: GDI2 (GDP dissociation inhibitor 2) Canis lupus familiaris
Analyze
Symbol: GDI2
Name: GDP dissociation inhibitor 2
RGD ID: 12389630
Description: ENCODES a protein that exhibits GTPase activator activity (ortholog); Rab GDP-dissociation inhibitor activity (ortholog); small GTPase binding (ortholog); INVOLVED IN negative regulation of cilium assembly (ortholog); negative regulation of protein localization to cilium (ortholog); small GTPase-mediated signal transduction (ortholog); PARTICIPATES IN Rab family mediated signaling pathway; ASSOCIATED WITH Down syndrome (ortholog); esophagus squamous cell carcinoma (ortholog); genetic disease (ortholog); FOUND IN Golgi apparatus (ortholog); synapse (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: GDI-2; guanosine diphosphate dissociation inhibitor 2; rab GDI beta; rab GDP dissociation inhibitor beta
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
NCBI Annotation Information: Annotation category: suggests misassembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1230,150,769 - 30,168,957 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl230,150,769 - 30,169,110 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha227,170,581 - 27,198,461 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0230,521,228 - 30,549,903 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl230,520,947 - 30,549,902 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1227,617,910 - 27,645,820 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0228,454,277 - 28,482,176 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0229,172,555 - 29,200,474 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA)
Golgi apparatus  (ISO)
membrane  (IEA)
synapse  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:9802909   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
GDI2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1230,150,769 - 30,168,957 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl230,150,769 - 30,169,110 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha227,170,581 - 27,198,461 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0230,521,228 - 30,549,903 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl230,520,947 - 30,549,902 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1227,617,910 - 27,645,820 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0228,454,277 - 28,482,176 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0229,172,555 - 29,200,474 (+)NCBIUU_Cfam_GSD_1.0
GDI2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38105,765,223 - 5,813,434 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl105,765,223 - 5,842,132 (-)EnsemblGRCh38hg38GRCh38
GRCh37105,807,186 - 5,855,397 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36105,847,192 - 5,895,379 (-)NCBINCBI36Build 36hg18NCBI36
Build 34105,847,191 - 5,895,379NCBI
Celera105,737,566 - 5,785,880 (-)NCBICelera
Cytogenetic Map10p15.1NCBI
HuRef105,737,326 - 5,785,616 (-)NCBIHuRef
CHM1_1105,807,126 - 5,855,477 (-)NCBICHM1_1
T2T-CHM13v2.0105,769,012 - 5,817,195 (-)NCBIT2T-CHM13v2.0
Gdi2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39133,588,075 - 3,616,261 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl133,588,063 - 3,617,871 (+)EnsemblGRCm39 Ensembl
GRCm38133,538,075 - 3,566,261 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl133,538,063 - 3,567,871 (+)EnsemblGRCm38mm10GRCm38
MGSCv37133,537,321 - 3,565,507 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36133,537,379 - 3,567,117 (+)NCBIMGSCv36mm8
Celera133,527,746 - 3,555,904 (+)NCBICelera
Cytogenetic Map13A1NCBI
cM Map131.98NCBI
Gdi2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81771,559,460 - 71,586,147 (-)NCBIGRCr8
mRatBN7.21766,649,616 - 66,676,299 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1766,649,619 - 66,676,366 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1770,135,173 - 70,161,857 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01773,963,986 - 73,990,671 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01768,006,986 - 68,033,671 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01770,299,177 - 70,325,864 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1770,299,183 - 70,325,855 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01772,003,428 - 72,030,115 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41777,843,481 - 77,870,171 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11777,854,314 - 77,881,004 (-)NCBI
Celera1766,154,818 - 66,181,499 (-)NCBICelera
Cytogenetic Map17q12.2NCBI
Gdi2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542122,450,402 - 22,480,512 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542122,449,620 - 22,480,721 (-)NCBIChiLan1.0ChiLan1.0
GDI2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2818,318,702 - 18,369,407 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11018,324,025 - 18,372,670 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0105,806,336 - 5,854,676 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1105,790,651 - 5,839,003 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl105,789,496 - 5,839,003 (-)Ensemblpanpan1.1panPan2
Gdi2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934432,582,901 - 32,610,040 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364848,747,984 - 8,779,236 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364848,748,050 - 8,775,234 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GDI2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1065,160,653 - 65,196,447 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11065,160,700 - 65,196,447 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21071,276,439 - 71,312,186 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GDI2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.195,876,245 - 5,923,011 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl95,877,042 - 5,922,968 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605111,178,905 - 11,225,679 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gdi2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624775594,472 - 622,592 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624775594,477 - 622,592 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in GDI2
194 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 22 6 6 6 6 6 12 8 10 6
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000008422   ⟹   ENSCAFP00000007805
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl230,150,769 - 30,169,110 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000066986   ⟹   ENSCAFP00000066376
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl230,150,769 - 30,169,110 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845004468   ⟹   ENSCAFP00845003572
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl230,520,947 - 30,549,902 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845004478   ⟹   ENSCAFP00845003580
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl230,520,958 - 30,549,902 (+)Ensembl
RefSeq Acc Id: NM_001003184   ⟹   NP_001003184
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1230,150,769 - 30,168,957 (+)NCBI
Dog10K_Boxer_Tasha227,170,581 - 27,198,461 (+)NCBI
ROS_Cfam_1.0230,521,228 - 30,549,114 (+)NCBI
UMICH_Zoey_3.1227,617,910 - 27,645,820 (+)NCBI
UNSW_CanFamBas_1.0228,454,277 - 28,482,176 (+)NCBI
UU_Cfam_GSD_1.0229,172,555 - 29,200,474 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038657716   ⟹   XP_038513644
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0230,521,847 - 30,549,903 (+)NCBI
RefSeq Acc Id: XM_038657717   ⟹   XP_038513645
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0230,521,980 - 30,549,903 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001003184   ⟸   NM_001003184
- UniProtKB: O97556 (UniProtKB/Swiss-Prot),   A0A8I3MTF3 (UniProtKB/TrEMBL),   A0A8P0N823 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000066376   ⟸   ENSCAFT00000066986
RefSeq Acc Id: ENSCAFP00000007805   ⟸   ENSCAFT00000008422
RefSeq Acc Id: XP_038513644   ⟸   XM_038657716
- Peptide Label: isoform X1
- UniProtKB: A0A8C0QVU6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038513645   ⟸   XM_038657717
- Peptide Label: isoform X2
- UniProtKB: A0A8C0QVU6 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845003580   ⟸   ENSCAFT00845004478
RefSeq Acc Id: ENSCAFP00845003572   ⟸   ENSCAFT00845004468


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000005223 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030001819 UniProtKB/TrEMBL
  ENSCAFG00040001190 UniProtKB/TrEMBL
  ENSCAFG00845002521 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000008422.5 UniProtKB/TrEMBL
  ENSCAFT00000066986.2 UniProtKB/TrEMBL
  ENSCAFT00030003423.1 UniProtKB/TrEMBL
  ENSCAFT00040002255.1 UniProtKB/TrEMBL
  ENSCAFT00845004468 ENTREZGENE
  ENSCAFT00845004468.1 UniProtKB/TrEMBL
  ENSCAFT00845004478.1 UniProtKB/TrEMBL
Gene3D-CATH 3.50.50.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Guanine Nucleotide Dissociation Inhibitor, domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Guanine Nucleotide Dissociation Inhibitor, domain 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro FAD/NAD-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GDP_dissociation_inhibitor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RabGDI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report cfa:403818 UniProtKB/Swiss-Prot
NCBI Gene GDI2 ENTREZGENE
PANTHER PTHR11787 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAB GDP DISSOCIATION INHIBITOR BETA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam GDI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS RABGDI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RABGDIREP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51905 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8C0PTB7_CANLF UniProtKB/TrEMBL
  A0A8C0QVU6 ENTREZGENE
  A0A8I3MTF3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3N2F9_CANLF UniProtKB/TrEMBL
  A0A8P0N823 ENTREZGENE, UniProtKB/TrEMBL
  GDIB_CANLF UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:41165 ENTREZGENE