| 2669 | Gcgr | glucagon receptor | ENCODES a protein that exhibits glucagon receptor activity; peptide hormone binding; INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; exocytosis; PARTICIPATES IN G protein mediated signal ing pathway via Galphas family; glucagon signaling pathway; ASSOCIATED WITH ACTH-independent macronodular adrenal hyperplasia 1 (ortholog); Mahvash disease (ortholog); maturity-onset diabetes of the young type 1 (ortholog); FOUND IN endosome; plasma membrane (ortholog); INTERACTS WITH 1,3,5-trinitro-1,3,5-triazinane; 17alpha-ethynylestradiol; 17beta-estradiol | 10 | 106306803 | 106314970 | Rat | 182 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 69010 | GCGR | glucagon receptor | The protein encoded by this gene is a glucagon receptor that is important in controlling blood glucose levels. Defects in this gene are a cause of non-insulin-dependent diabetes mellitus (NIDDM).[provided by RefSeq, Jan 2010] | 17 | 81804150 | 81814008 | Human | 200 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1332263 | Gcgr | glucagon receptor | Enables glucagon receptor activity. Involved in several processes, including cellular response to glucagon stimulus; glucose homeostasis; and regulation of glycogen metabolic process. Acts upstream of or within cellular response to starvation and positive regulation of gene expression. Is active in plasma membrane. Is expressed in several structures, including brain; foot mesenchyme; gut; liver; and male reproductive gland or organ. Used to study Mahvash Disease. Human ortholog(s) of this gene implicated in Mahvash Disease and type 2 diabetes mellitus. Orthologous to human GCGR (glucagon receptor). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 120420011 | 120429815 | Mouse | 270 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 9027570 | Gcgr | glucagon receptor | ENCODES a protein that exhibits glucagon receptor activity (ortholog); peptide hormone binding (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); adenylate cyclase-modulating G protein-coupled receptor signaling pathway (ortholog); cellular response to glucagon stimulus (ortholog); PARTICIPATES IN G protein mediated signaling pathway via Galphas family; glucagon signaling pathway; ASSOCIATED WITH ACTH-independent macronodular adrenal hyperplasia 1 (ortholog); Mahvash disease (ortholog); maturity-onset diabetes of the young type 1 (ortholog); FOUND IN endosome (ortholog); plasma membrane (ortholog) | NW_004955506 | 1340410 | 1348028 | Chinchilla | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11846774 | GCGR | glucagon receptor | ENCODES a protein that exhibits glucagon receptor activity (ortholog); peptide hormone binding (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); adenylate cyclase-modulating G protein-coupled receptor signaling pathway (ortholog); cellular response to starvation (ortholog); PARTICIPATES IN G protein mediated signaling pathway via Galphas family; glucagon signaling pathway; ASSOCIATED WITH ACTH-independent macronodular adrenal hyperplasia 1 (ortholog); Mahvash disease (ortholog); maturity-onset diabetes of the young type 1 (ortholog); FOUND IN endosome (ortholog) | 17 | 76205023 | 76220171 | Bonobo | 43 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12435104 | GCGR | glucagon receptor | ENCODES a protein that exhibits glucagon receptor activity (ortholog); peptide hormone binding (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); adenylate cyclase-modulating G protein-coupled receptor signaling pathway (ortholog); cellular response to starvation (ortholog); PARTICIPATES IN G protein mediated signaling pathway via Galphas family; glucagon signaling pathway; ASSOCIATED WITH ACTH-independent macronodular adrenal hyperplasia 1 (ortholog); Mahvash disease (ortholog); maturity-onset diabetes of the young type 1 (ortholog); FOUND IN endosome (ortholog) | 9 | 455744 | 463070 | Dog | 38 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12447688 | Gcgr | glucagon receptor | ENCODES a protein that exhibits glucagon receptor activity (ortholog); peptide hormone binding (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); adenylate cyclase-modulating G protein-coupled receptor signaling pathway (ortholog); cellular response to starvation (ortholog); PARTICIPATES IN G protein mediated signaling pathway via Galphas family; glucagon signaling pathway; ASSOCIATED WITH ACTH-independent macronodular adrenal hyperplasia 1 (ortholog); Mahvash disease (ortholog); maturity-onset diabetes of the young type 1 (ortholog); FOUND IN endosome (ortholog) | NW_004936594 | 5347789 | 5351852 | Squirrel | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18929383 | Gcgr | glucagon receptor | ENCODES a protein that exhibits glucagon receptor activity (ortholog); peptide hormone binding (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); adenylate cyclase-modulating G protein-coupled receptor signaling pathway (ortholog); cellular response to starvation (ortholog); PARTICIPATES IN G protein mediated signaling pathway via Galphas family; glucagon signaling pathway; ASSOCIATED WITH ACTH-independent macronodular adrenal hyperplasia 1 (ortholog); Mahvash disease (ortholog); maturity-onset diabetes of the young type 1 (ortholog); FOUND IN endosome (ortholog) | | | | Naked Mole-Rat | 43 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18471836 | GCGR | glucagon receptor | ENCODES a protein that exhibits glucagon receptor activity (ortholog); peptide hormone binding (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); adenylate cyclase-modulating G protein-coupled receptor signaling pathway (ortholog); cellular response to starvation (ortholog); PARTICIPATES IN G protein mediated signaling pathway via Galphas family; glucagon signaling pathway; ASSOCIATED WITH ACTH-independent macronodular adrenal hyperplasia 1 (ortholog); Mahvash disease (ortholog); maturity-onset diabetes of the young type 1 (ortholog); FOUND IN endosome (ortholog) | | | | Green Monkey | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155231224 | gcgr | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625882070 | Gcgr | glucagon receptor | ENCODES a protein that exhibits glucagon receptor activity (ortholog); peptide hormone binding (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); adenylate cyclase-modulating G protein-coupled receptor signaling pathway (ortholog); cellular response to glucagon stimulus (ortholog); PARTICIPATES IN G protein mediated signaling pathway via Galphas family; glucagon signaling pathway; ASSOCIATED WITH ACTH-independent macronodular adrenal hyperplasia 1 (ortholog); Mahvash disease (ortholog); maturity-onset diabetes of the young type 1 (ortholog); FOUND IN endosome (ortholog); plasma membrane (ortholog) | | | | Black Rat | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14186528 | GCGR | glucagon receptor | ENCODES a protein that exhibits glucagon receptor activity; peptide hormone binding (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); adenylate cyclase-modulating G protein-coupled receptor signaling pathway (ortholog); cellular response to starvation (ortholog); PARTICIPATES IN G protein mediated signaling pathway via Galphas family; glucagon signaling pathway; ASSOCIATED WITH ACTH-independent macronodular adrenal hyperplasia 1 (ortholog); Mahvash disease (ortholog); maturity-onset diabetes of the young type 1 (ortholog); FOUND IN endosome (ortholog) | | | | Pig | 44 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155232347 | gcgr.L | | | | | | African Clawed Frog | | symbol | gene, null |