| 1353756 | FOXO4 | forkhead box O4 | This gene encodes a member of the O class of winged helix/forkhead transcription factor family. Proteins encoded by this class are regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving this gene on chromosome X and the h omolog of the Drosophila trithorax gene, encoding a DNA binding protein, located on chromosome 11 is associated with leukemia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010] | X | 71095851 | 71103532 | Human | 205 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1556902 | Foxo4 | forkhead box O4 | Enables sequence-specific DNA binding activity. Acts upstream of or within mitotic G2 DNA damage checkpoint signaling; negative regulation of cell population proliferation; and positive regulation of DNA-templated transcription. Predicted to be located in cytosol and nuclear speck. Predicted to be a ctive in nucleus. Is expressed in several structures, including adipose tissue; central nervous system; early embryo; genitourinary system; and skeletal muscle. Orthologous to human FOXO4 (forkhead box O4). [provided by Alliance of Genome Resources, Jul 2025] | X | 100297855 | 100304479 | Mouse | 260 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1561201 | Foxo4 | forkhead box O4 | ENCODES a protein that exhibits promoter-specific chromatin binding; beta-catenin binding (ortholog); DNA binding (ortholog); INVOLVED IN positive regulation of smooth muscle cell migration; response to nutrient levels; response to water-immersion restraint stress; PARTICIPATES IN phosphatidylinosit ol 3-kinase-Akt signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; ASSOCIATED WITH abnormal placenta junctional zone morphology; increased placenta weight; increased placental labyrinth size; ASSOCIATED WITH alcohol-induced mental disorder; gastric ulcer; paraplegia; FOUND IN cytoplasm (ortholog); cytosol (ortholog); nuclear speck (ortholog); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; acrylamide | X | 70425218 | 70432120 | Rat | 213 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 8810304 | Foxo4 | forkhead box O4 | ENCODES a protein that exhibits beta-catenin binding (ortholog); DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); INVOLVED IN insulin receptor signaling pathway (ortholog); mitotic G2 DNA damage checkpoint signaling (ortholog); negative reg ulation of angiogenesis (ortholog); PARTICIPATES IN phosphatidylinositol 3-kinase-Akt signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; ASSOCIATED WITH alcohol-induced mental disorder (ortholog); gastric ulcer (ortholog); hemangioma (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nuclear speck (ortholog) | NW_004955475 | 10666024 | 10673717 | Chinchilla | 51 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11982737 | FOXO4 | forkhead box O4 | ENCODES a protein that exhibits nucleic acid binding (ortholog); promoter-specific chromatin binding (ortholog); INVOLVED IN mitotic G2 DNA damage checkpoint signaling (ortholog); negative regulation of cell population proliferation (ortholog); positive regulation of DNA-templated transcription (ort holog); PARTICIPATES IN phosphatidylinositol 3-kinase-Akt signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; ASSOCIATED WITH alcohol-induced mental disorder (ortholog); gastric ulcer (ortholog); hemangioma (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nuclear speck (inferred) | X | 60364466 | 60372147 | Bonobo | 63 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12314415 | FOXO4 | forkhead box O4 | ENCODES a protein that exhibits nucleic acid binding (ortholog); promoter-specific chromatin binding (ortholog); INVOLVED IN mitotic G2 DNA damage checkpoint signaling (ortholog); negative regulation of cell population proliferation (ortholog); positive regulation of DNA-templated transcription (ort holog); PARTICIPATES IN phosphatidylinositol 3-kinase-Akt signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; ASSOCIATED WITH alcohol-induced mental disorder (ortholog); gastric ulcer (ortholog); hemangioma (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nuclear speck (inferred) | X | 55469738 | 55477699 | Dog | 61 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12565799 | Foxo4 | forkhead box O4 | ENCODES a protein that exhibits nucleic acid binding (ortholog); promoter-specific chromatin binding (ortholog); INVOLVED IN mitotic G2 DNA damage checkpoint signaling (ortholog); negative regulation of cell population proliferation (ortholog); positive regulation of DNA-templated transcription (ort holog); PARTICIPATES IN phosphatidylinositol 3-kinase-Akt signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; ASSOCIATED WITH alcohol-induced mental disorder (ortholog); gastric ulcer (ortholog); hemangioma (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nuclear speck (inferred) | NW_004936762 | 495271 | 501278 | Squirrel | 62 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625867195 | Foxo4 | forkhead box O4 | ENCODES a protein that exhibits beta-catenin binding (ortholog); DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); INVOLVED IN insulin receptor signaling pathway (ortholog); mitotic G2 DNA damage checkpoint signaling (ortholog); negative reg ulation of angiogenesis (ortholog); PARTICIPATES IN phosphatidylinositol 3-kinase-Akt signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; ASSOCIATED WITH alcohol-induced mental disorder (ortholog); gastric ulcer (ortholog); hemangioma (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nuclear speck (ortholog) | | | | Black Rat | 51 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18695802 | FOXO4 | forkhead box O4 | ENCODES a protein that exhibits nucleic acid binding (ortholog); promoter-specific chromatin binding (ortholog); INVOLVED IN mitotic G2 DNA damage checkpoint signaling (ortholog); negative regulation of cell population proliferation (ortholog); positive regulation of DNA-templated transcription (ort holog); PARTICIPATES IN phosphatidylinositol 3-kinase-Akt signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; ASSOCIATED WITH alcohol-induced mental disorder (ortholog); gastric ulcer (ortholog); hemangioma (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nuclear speck (inferred) | | | | Green Monkey | 63 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13956236 | FOXO4 | forkhead box O4 | ENCODES a protein that exhibits nucleic acid binding (ortholog); promoter-specific chromatin binding (ortholog); INVOLVED IN mitotic G2 DNA damage checkpoint signaling (ortholog); negative regulation of cell population proliferation (ortholog); positive regulation of DNA-templated transcription (ort holog); PARTICIPATES IN phosphatidylinositol 3-kinase-Akt signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; ASSOCIATED WITH alcohol-induced mental disorder (ortholog); gastric ulcer (ortholog); hemangioma (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nuclear speck (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 63 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18909091 | Foxo4 | forkhead box O4 | ENCODES a protein that exhibits beta-catenin binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription factor binding (ortholog); INVOLVED IN insulin receptor signaling pathway (ortholog); mitotic G2 DNA damage checkpoint signa ling (ortholog); negative regulation of angiogenesis (ortholog); PARTICIPATES IN phosphatidylinositol 3-kinase-Akt signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; ASSOCIATED WITH alcohol-induced mental disorder (ortholog); gastric ulcer (ortholog); hemangioma (ortholog); FOUND IN cytosol (ortholog); nuclear speck (ortholog) | | | | Naked Mole-Rat | 57 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155234332 | foxo4 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155234333 | foxo4.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155234347 | foxo4.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405855878 | Foxo4em1Soar | forkhead box O4; CRISPR/Cas9 induced mutant 1, Soar | ASSOCIATED WITH abnormal placenta junctional zone morphology; increased placenta weight; increased placental labyrinth size | | | | Rat | 3 | symbol , description | gene, allele |
| 1321769 | CIC | capicua transcriptional repressor | The protein encoded by this gene is an ortholog of the Drosophila melanogaster capicua gene, and is a member of the high mobility group (HMG)-box superfamily of transcriptional repressors. This protein contains a conserved HMG domain that is involved in DNA binding and nuclear localization, and a co nserved C-terminus. Studies suggest that the N-terminal region of this protein interacts with Atxn1 (GeneID:6310), to form a transcription repressor complex, and in vitro studies suggest that polyglutamine-expansion of ATXN1 may alter the repressor activity of this complex. Mutations in this gene have been associated with olidogdendrogliomas (PMID:21817013). In addition, translocation events resulting in gene fusions of this gene with both DUX4 (GeneID:100288687) and FOXO4 (GeneID:4303) have been associated with round cell sarcomas. There are multiple pseudogenes of this gene found on chromosomes 1, 4, 6, 7, 16, 20, and the Y chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015] | 19 | 42268530 | 42295796 | Human | 168 | description | gene, protein-coding, REVIEWED [RefSeq] |