| 1307556 | Fech | ferrochelatase | ENCODES a protein that exhibits ferrochelatase activity; heme binding (ortholog); identical protein binding (ortholog); INVOLVED IN cellular response to dexamethasone stimulus; heme biosynthetic process; response to arsenic-containing substance; PARTICIPATES IN acute intermittent porphyria pathway; erythropoietic porphyria pathway; heme biosynthetic pathway; ASSOCIATED WITH Hepatic Porphyrias; bile duct disease (ortholog); colon adenocarcinoma (ortholog); FOUND IN mitochondrial inner membrane (ortholog); mitochondrial matrix (ortholog); mitochondrial membrane (ortholog); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 18 | 60215325 | 60248525 | Rat | 269 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1316819 | FECH | ferrochelatase | The protein encoded by this gene is localized to the mitochondrion, where it catalyzes the insertion of the ferrous form of iron into protoporphyrin IX in the heme synthesis pathway. Mutations in this gene are associated with erythropoietic protoporphyria. Two transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene is found on chromosome 3.[provided by RefSeq, May 2010] | 18 | 57544377 | 57586702 | Human | 332 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1316820 | Fech | ferrochelatase | Enables several functions, including ferrochelatase activity; heme binding activity; and iron-responsive element binding activity. Involved in heme A biosynthetic process; heme B biosynthetic process; and heme O biosynthetic process. Acts upstream of or within several processes, including multicellu lar organismal-level iron ion homeostasis; regulation of protein metabolic process; and very-low-density lipoprotein particle assembly. Located in mitochondrial inner membrane. Is active in mitochondrial matrix. Is expressed in several structures, including choroid plexus; heart; integumental system; liver and biliary system; and respiratory system. Used to study erythropoietic protoporphyria. Human ortholog(s) of this gene implicated in cutaneous porphyria and erythropoietic protoporphyria. Orthologous to human FECH (ferrochelatase). [provided by Alliance of Genome Resources, Apr 2025] | 18 | 64589613 | 64622169 | Mouse | 322 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8935149 | Fech | ferrochelatase | ENCODES a protein that exhibits ferrochelatase activity (ortholog); heme binding (ortholog); identical protein binding (ortholog); INVOLVED IN cellular response to dexamethasone stimulus (ortholog); cholesterol metabolic process (ortholog); detection of UV (ortholog); PARTICIPATES IN acute intermitt ent porphyria pathway; erythropoietic porphyria pathway; heme biosynthetic pathway; ASSOCIATED WITH bile duct disease (ortholog); colon adenocarcinoma (ortholog); cutaneous porphyria (ortholog); FOUND IN mitochondrial inner membrane (ortholog); mitochondrial matrix (ortholog); mitochondrial membrane (ortholog) | NW_004955402 | 41902868 | 41938099 | Chinchilla | 73 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11990425 | FECH | ferrochelatase | ENCODES a protein that exhibits ferrochelatase activity (ortholog); INVOLVED IN cellular response to dexamethasone stimulus (ortholog); cholesterol metabolic process (ortholog); detection of UV (ortholog); PARTICIPATES IN acute intermittent porphyria pathway; erythropoietic porphyria pathway; heme b iosynthetic pathway; ASSOCIATED WITH bile duct disease (ortholog); colon adenocarcinoma (ortholog); cutaneous porphyria (ortholog); FOUND IN mitochondrial inner membrane (inferred); mitochondrial matrix (inferred); mitochondrial membrane (inferred) | 18 | 50934520 | 50977132 | Bonobo | 87 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12250249 | FECH | ferrochelatase | ENCODES a protein that exhibits ferrochelatase activity (ortholog); INVOLVED IN cellular response to dexamethasone stimulus (ortholog); cholesterol metabolic process (ortholog); detection of UV (ortholog); PARTICIPATES IN acute intermittent porphyria pathway; erythropoietic porphyria pathway; heme b iosynthetic pathway; ASSOCIATED WITH bile duct disease (ortholog); colon adenocarcinoma (ortholog); cutaneous porphyria (ortholog); FOUND IN mitochondrion (ortholog) | 1 | 18352184 | 18384251 | Dog | 86 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12670420 | Fech | ferrochelatase | ENCODES a protein that exhibits ferrochelatase activity (ortholog); INVOLVED IN cellular response to dexamethasone stimulus (ortholog); cholesterol metabolic process (ortholog); detection of UV (ortholog); PARTICIPATES IN acute intermittent porphyria pathway; erythropoietic porphyria pathway; heme b iosynthetic pathway; ASSOCIATED WITH bile duct disease (ortholog); colon adenocarcinoma (ortholog); cutaneous porphyria (ortholog); FOUND IN mitochondrial inner membrane (inferred); mitochondrial matrix (inferred); mitochondrial membrane (inferred) | NW_004936497 | 6755626 | 6788568 | Squirrel | 86 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14377151 | FeCH | | | | | | Fly | | symbol | gene, null |
| 18781631 | FECH | ferrochelatase | ENCODES a protein that exhibits ferrochelatase activity (ortholog); INVOLVED IN cellular response to dexamethasone stimulus (ortholog); cholesterol metabolic process (ortholog); detection of UV (ortholog); PARTICIPATES IN acute intermittent porphyria pathway; erythropoietic porphyria pathway; heme b iosynthetic pathway; ASSOCIATED WITH bile duct disease (ortholog); colon adenocarcinoma (ortholog); cutaneous porphyria (ortholog); FOUND IN mitochondrial inner membrane (inferred); mitochondrial matrix (inferred); mitochondrial membrane (inferred) | | | | Green Monkey | 87 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18930857 | Fech | ferrochelatase | ENCODES a protein that exhibits ferrochelatase activity (ortholog); heme binding (ortholog); identical protein binding (ortholog); INVOLVED IN cellular response to dexamethasone stimulus (ortholog); cholesterol metabolic process (ortholog); detection of UV (ortholog); PARTICIPATES IN acute intermitt ent porphyria pathway; erythropoietic porphyria pathway; heme biosynthetic pathway; ASSOCIATED WITH bile duct disease (ortholog); colon adenocarcinoma (ortholog); cutaneous porphyria (ortholog); FOUND IN mitochondrial matrix (ortholog); mitochondrial membrane (ortholog) | | | | Naked Mole-Rat | 80 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 625908155 | Fech | ferrochelatase | ENCODES a protein that exhibits ferrochelatase activity (ortholog); heme binding (ortholog); identical protein binding (ortholog); INVOLVED IN cellular response to dexamethasone stimulus (ortholog); cholesterol metabolic process (ortholog); detection of UV (ortholog); PARTICIPATES IN acute intermitt ent porphyria pathway; erythropoietic porphyria pathway; heme biosynthetic pathway; ASSOCIATED WITH bile duct disease (ortholog); colon adenocarcinoma (ortholog); cutaneous porphyria (ortholog); FOUND IN mitochondrial inner membrane (ortholog); mitochondrial matrix (ortholog); mitochondrial membrane (ortholog) | | | | Black Rat | 73 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14172332 | FECH | ferrochelatase | ENCODES a protein that exhibits ferrochelatase activity (ortholog); INVOLVED IN cellular response to dexamethasone stimulus (ortholog); cholesterol metabolic process (ortholog); detection of UV (ortholog); PARTICIPATES IN acute intermittent porphyria pathway; erythropoietic porphyria pathway; heme b iosynthetic pathway; ASSOCIATED WITH bile duct disease (ortholog); colon adenocarcinoma (ortholog); cutaneous porphyria (ortholog); FOUND IN mitochondrion (ortholog) | | | | Pig | 86 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 155241847 | fech | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155242314 | fech.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155256485 | fech.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 12092695 | ATP8B1 | ATPase phospholipid transporting 8B1 | ENCODES a protein that exhibits phosphatidylserine flippase activity (ortholog); INVOLVED IN bile acid metabolic process (ortholog); ASSOCIATED WITH benign recurrent intrahepatic cholestasis 1 (ortholog); genetic disease (ortholog); intrahepatic cholestasis (ortholog); FOUND IN brush border membrane (ortholog) | 1 | 18156664 | 18279131 | Dog | 70 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 1342832 | FECHP1 | ferrochelatase pseudogene 1 | | 3 | 34872581 | 34875228 | Human | | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 1350091 | MAFK | MAF bZIP transcription factor K | The developmentally regulated expression of the globin genes depends on upstream regulatory elements termed locus control regions (LCRs). LCRs are associated with powerful enhancer activity that is mediated by the transcription factor NFE2 (nuclear factor erythroid-2). NFE2 recognition sites are als o present in the gene promoters of 2 heme biosynthetic enzymes, porphobilinogen deaminase (PBGD; MIM 609806) and ferrochelatase (FECH; MIM 612386). NFE2 DNA-binding activity consists of a heterodimer containing an 18-kD Maf protein (MafF, MafG (MIM 602020), or MafK) and p45 (MIM 601490). Both subunits are members of the activator protein-1 superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160). Maf homodimers suppress transcription at NFE2 sites.[supplied by OMIM, Nov 2008] | 7 | 1530702 | 1543043 | Human | 194 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 732401 | MYH9 | myosin heavy chain 9 | This gene encodes a conventional non-muscle myosin; this protein should not be confused with the unconventional myosin-9a or 9b (MYO9A or MYO9B). The encoded protein is a myosin IIA heavy chain that contains an IQ domain and a myosin head-like domain which is involved in several important functions, including cytokinesis, cell motility and maintenance of cell shape. Defects in this gene have been associated with non-syndromic sensorineural deafness autosomal dominant type 17, Epstein syndrome, Alport syndrome with macrothrombocytopenia, Sebastian syndrome, Fechtner syndrome and macrothrombocytopenia with progressive sensorineural deafness. [provided by RefSeq, Dec 2011] | 22 | 36281280 | 36387967 | Human | 666 | description | gene, protein-coding, REVIEWED [RefSeq] |