| 1305813 | Fbxl7 | F-box and leucine-rich repeat protein 7 | INVOLVED IN G2/M transition of mitotic cell cycle (ortholog); mitotic cell cycle (ortholog); protein polyubiquitination (ortholog); FOUND IN centrosome (ortholog); SCF ubiquitin ligase complex (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 2-methoxyethanol | 2 | 78870236 | 79239697 | Rat | 116 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1314074 | FBXL7 | F-box and leucine rich repeat protein 7 | This gene encodes a member of the F-box protein family which is characterized by a 42-48 amino acid motif, the F-box, which binds to the S-phase kinase-associated protein 1 (Skp1) protein. The F-box proteins constitute one of the four subunits of E3 ubiquitin protein ligases called SCFs (SKP1-Cul1-F -box), which play a role in phosphorylation-dependent ubiquitination of proteins. The F-box proteins are divided into 3 subfamilies based on the other domain in the protein: F-box proteins that also have a WD-40 domain (Fbws subfamily), F-box proteins that also have leucine-rich repeats (Fbls subfamily) and F-box proteins that contain other motifs or lack known protein-interaction domains (Fbxs subfamily). The protein encoded by this gene belongs to the Fbls subfamily. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013] | 5 | 15500180 | 15939793 | Human | 120 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1620364 | Fbxl7 | F-box and leucine-rich repeat protein 7 | Involved in G2/M transition of mitotic cell cycle; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; and protein polyubiquitination. Located in centrosome. Part of SCF ubiquitin ligase complex. Orthologous to human FBXL7 (F-box and leucine rich repeat protein 7). [provided by Alliance of Genome Resources, Jul 2025] | 15 | 26540540 | 26895650 | Mouse | 110 | symbol , PhenoGen , description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 8898049 | Fbxl7 | F-box and leucine rich repeat protein 7 | INVOLVED IN G2/M transition of mitotic cell cycle (ortholog); mitotic cell cycle (ortholog); protein polyubiquitination (ortholog); FOUND IN centrosome (ortholog); SCF ubiquitin ligase complex (ortholog) | NW_004955426 | 4659787 | 5044074 | Chinchilla | 16 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11723664 | FBXL7 | F-box and leucine rich repeat protein 7 | INVOLVED IN cell division (inferred); G2/M transition of mitotic cell cycle (inferred); mitotic cell cycle (inferred); FOUND IN centrosome (inferred); SCF ubiquitin ligase complex (inferred) | 5 | 15804479 | 16237326 | Bonobo | 18 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12123348 | FBXL7 | F-box and leucine rich repeat protein 7 | INVOLVED IN cell division (inferred); G2/M transition of mitotic cell cycle (inferred); mitotic cell cycle (inferred); FOUND IN centrosome (inferred); SCF ubiquitin ligase complex (inferred) | 4 | 87348187 | 87637517 | Dog | 18 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12525157 | Fbxl7 | F-box and leucine rich repeat protein 7 | INVOLVED IN cell division (inferred); G2/M transition of mitotic cell cycle (inferred); mitotic cell cycle (inferred); FOUND IN centrosome (inferred); SCF ubiquitin ligase complex (inferred) | NW_004936665 | 605225 | 973735 | Squirrel | 18 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18934008 | Fbxl7 | F-box and leucine rich repeat protein 7 | INVOLVED IN G2/M transition of mitotic cell cycle (ortholog); mitotic cell cycle (ortholog); protein ubiquitination (ortholog); FOUND IN centrosome (inferred); SCF ubiquitin ligase complex (inferred) | | | | Naked Mole-Rat | 14 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 20867352 | FBXL7 | F-box and leucine rich repeat protein 7 | INVOLVED IN cell division (inferred); G2/M transition of mitotic cell cycle (inferred); mitotic cell cycle (inferred); FOUND IN centrosome (inferred); SCF ubiquitin ligase complex (inferred) | | | | Green Monkey | 14 | symbol | gene, protein-coding |
| 625909619 | Fbxl7 | F-box and leucine rich repeat protein 7 | INVOLVED IN G2/M transition of mitotic cell cycle (ortholog); mitotic cell cycle (ortholog); protein polyubiquitination (ortholog); FOUND IN centrosome (ortholog); SCF ubiquitin ligase complex (ortholog) | | | | Black Rat | 16 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14376991 | Fbxl7 | | | | | | Fly | | symbol | gene, null |
| 18679589 | FBXL7 | F-box and leucine rich repeat protein 7 | INVOLVED IN G2/M transition of mitotic cell cycle (ortholog); mitotic cell cycle (ortholog); protein polyubiquitination (ortholog); FOUND IN centrosome (ortholog); SCF ubiquitin ligase complex (ortholog) | | | | Green Monkey | 16 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155251744 | fbxl7 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 14273464 | FBXL7 | F-box and leucine rich repeat protein 7 | INVOLVED IN cell division (inferred); G2/M transition of mitotic cell cycle (inferred); mitotic cell cycle (inferred); FOUND IN centrosome (inferred); SCF ubiquitin ligase complex (inferred) | | | | Pig | 18 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155255812 | fbxl7.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155248703 | fbxl7.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1352891 | FBXL18 | F-box and leucine rich repeat protein 18 | The protein encoded by this gene is a member of a family of proteins that contain an approximately 40-amino acid F-box motif. This motif is important for interaction with SKP1 and for targeting some proteins for degradation. The encoded protein has been shown to control the cellular level of FBXL7 tyle='font-weight:700;'>FBXL7, a protein that induces mitotic arrest, by targeting it for polyubiquitylation and proteasomal degradation. Members of the F-box protein family, such as FBXL18, are characterized by an approximately 40-amino acid F-box motif. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains. [provided by RefSeq, Mar 2016] | 7 | 5454425 | 5513809 | Human | 55 | description | gene, protein-coding, REVIEWED [RefSeq] |
