| 1351449 | FANCB | FA complementation group B | This gene encodes a member of the Fanconi anemia complementation group B. This protein is assembled into a nucleoprotein complex that is involved in the repair of DNA lesions. Mutations in this gene can cause chromosome instability and VACTERL syndrome with hydrocephalus. [provided by RefSeq, Apr 20 16] | X | 14689524 | 14873069 | Human | 345 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1561555 | Fancb | FA complementation group B | INVOLVED IN bone marrow development (ortholog); cellular response to camptothecin (ortholog); cellular response to xenobiotic stimulus (ortholog); ASSOCIATED WITH breast cancer (ortholog); Fanconi anemia (ortholog); Fanconi anemia complementation group A (ortholog); FOUND IN chromatin (ortholog); Fa nconi anaemia nuclear complex (ortholog); INTERACTS WITH 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine | X | 33035387 | 33051993 | Rat | 107 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1618957 | Fancb | Fanconi anemia, complementation group B | Acts upstream of or within several processes, including bone marrow development; cellular response to camptothecin; and regulation of double-strand break repair via homologous recombination. Predicted to be located in chromatin. Predicted to be part of Fanconi anaemia nuclear complex. Is expressed i n cerebral cortex ventricular layer and cortical plate. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group B and head and neck squamous cell carcinoma. Orthologous to human FANCB (FA complementation group B). [provided by Alliance of Genome Resources, Jul 2025] | X | 163763678 | 163780266 | Mouse | 126 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8704578 | Fancb | FA complementation group B | INVOLVED IN bone marrow development (ortholog); cellular response to camptothecin (ortholog); cellular response to xenobiotic stimulus (ortholog); ASSOCIATED WITH breast cancer (ortholog); Fanconi anemia (ortholog); Fanconi anemia complementation group A (ortholog); FOUND IN chromatin (ortholog); Fa nconi anaemia nuclear complex (ortholog) | NW_004955519 | 3337138 | 3364963 | Chinchilla | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11922085 | FANCB | FA complementation group B | INVOLVED IN bone marrow development (ortholog); cellular response to camptothecin (ortholog); cellular response to xenobiotic stimulus (ortholog); ASSOCIATED WITH breast cancer (ortholog); Fanconi anemia (ortholog); Fanconi anemia complementation group A (ortholog); FOUND IN chromatin (inferred); Fa nconi anaemia nuclear complex (inferred) | X | 7470574 | 7500958 | Bonobo | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12405841 | FANCB | FA complementation group B | INVOLVED IN bone marrow development (ortholog); cellular response to camptothecin (ortholog); cellular response to xenobiotic stimulus (ortholog); ASSOCIATED WITH breast cancer (ortholog); Fanconi anemia (ortholog); Fanconi anemia complementation group A (ortholog); FOUND IN chromatin (inferred); Fa nconi anaemia nuclear complex (inferred) | X | 10690826 | 11140838 | Dog | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12728353 | Fancb | FA complementation group B | INVOLVED IN bone marrow development (ortholog); cellular response to camptothecin (ortholog); cellular response to xenobiotic stimulus (ortholog); ASSOCIATED WITH breast cancer (ortholog); Fanconi anemia (ortholog); Fanconi anemia complementation group A (ortholog); FOUND IN chromatin (inferred); Fa nconi anaemia nuclear complex (inferred) | NW_004936470 | 4305220 | 4323456 | Squirrel | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625929508 | Fancb | FA complementation group B | INVOLVED IN bone marrow development (ortholog); cellular response to camptothecin (ortholog); cellular response to xenobiotic stimulus (ortholog); ASSOCIATED WITH breast cancer (ortholog); Fanconi anemia (ortholog); Fanconi anemia complementation group A (ortholog); FOUND IN chromatin (ortholog); Fa nconi anaemia nuclear complex (ortholog) | | | | Black Rat | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13982068 | FANCB | FA complementation group B | INVOLVED IN bone marrow development (ortholog); cellular response to camptothecin (ortholog); cellular response to xenobiotic stimulus (ortholog); ASSOCIATED WITH breast cancer (ortholog); Fanconi anemia (ortholog); Fanconi anemia complementation group A (ortholog); FOUND IN chromatin (inferred); Fa nconi anaemia nuclear complex (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18916062 | Fancb | FA complementation group B | INVOLVED IN bone marrow development (ortholog); cellular response to camptothecin (ortholog); cellular response to xenobiotic stimulus (ortholog); ASSOCIATED WITH breast cancer (ortholog); Fanconi anemia (ortholog); Fanconi anemia complementation group A (ortholog); FOUND IN chromatin (ortholog) | | | | Naked Mole-Rat | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18469367 | FANCB | FA complementation group B | INVOLVED IN bone marrow development (ortholog); cellular response to camptothecin (ortholog); cellular response to xenobiotic stimulus (ortholog); ASSOCIATED WITH breast cancer (ortholog); Fanconi anemia (ortholog); Fanconi anemia complementation group A (ortholog); FOUND IN chromatin (inferred); Fa nconi anaemia nuclear complex (inferred) | | | | Green Monkey | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 736254 | BRCA2 | BRCA2 DNA repair associated | Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The largest exon in both gen es is exon 11, which harbors the most important and frequent mutations in breast cancer patients. The BRCA2 gene was found on chromosome 13q12.3 in human. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq, May 2020] | 13 | 32315077 | 32400268 | Human | 14228 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1322810 | FANCA | FA complementation group A | The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is t he same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group A. Alternative splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are the most common cause of Fanconi anemia. [provided by RefSeq, Jul 2008] | 16 | 89737549 | 89816647 | Human | 1303 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 735813 | FANCC | FA complementation group C | The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is t he same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group C. [provided by RefSeq, Jul 2008] | 9 | 95099054 | 95317709 | Human | 596 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1343234 | FANCD2 | FA complementation group D2 | The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is t he same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group D2. This protein is monoubiquinated in response to DNA damage, resulting in its localization to nuclear foci with other proteins (BRCA1 AND BRCA2) involved in homology-directed DNA repair. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016] | 3 | 10026437 | 10101932 | Human | 507 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1354425 | FANCE | FA complementation group E | The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is t he same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group E. [provided by RefSeq, Jul 2008] | 6 | 35452338 | 35467102 | Human | 280 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1614308 | Fance | Fanconi anemia, complementation group E | This gene encodes the complementation group E subunit of the multimeric Fanconi anemia (FA) nuclear complex composed of proteins encoded by over ten Fanconi anemia complementation (FANC) group genes: FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE , FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The FA complex is necessary for protection against DNA damage. This gene product is required for the nuclear accumulation of FANCC and provides a critical bridge between the FA complex and FANCD2. Defects in the related human gene are a cause of Fanconi anemia, a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. Translation of this protein is initiated at a non-AUG (CUG) start codon, which is inferred from the related human gene and the notion that this protein is functionally indispensable. Multiple transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2009] | 17 | 28532504 | 28545548 | Mouse | 93 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1345063 | FANCF | FA complementation group F | The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is t he same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group F. [provided by RefSeq, Jul 2008] | 11 | 22622533 | 22625823 | Human | 312 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1350702 | FANCG | FA complementation group G | The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is t he same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group G. [provided by RefSeq, Jul 2008] | 9 | 35073839 | 35079942 | Human | 424 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1605380 | FANCI | FA complementation group I | The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is t he same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group I. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] | 15 | 89243979 | 89317259 | Human | 470 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1317358 | FANCM | FA complementation group M | The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is t he same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group M. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015] | 14 | 45135930 | 45200890 | Human | 683 | description | gene, protein-coding, REVIEWED [RefSeq] |
