FANCM (FA complementation group M)

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Gene: FANCM (FA complementation group M) Homo sapiens

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Symbol:

FANCM

Name:

FA complementation group M

RGD ID:

1317358

HGNC Page

HGNC:23168

Description:

Enables chromatin binding activity. Involved in DNA metabolic process and positive regulation of protein monoubiquitination. Located in chromatin and nucleoplasm. Part of FANCM-MHF complex and Fanconi anaemia nuclear complex. Implicated in primary ovarian insufficiency 15 and spermatogenic failure 28. Biomarker of tongue squamous cell carcinoma.

Type:

protein-coding

RefSeq Status:

REVIEWED

Previously known as:

ATP-dependent RNA helicase FANCM; FAAP250; Fanconi anemia complementation group M; Fanconi anemia group M protein; Fanconi anemia, complementation group M; fanconi anemia-associated polypeptide of 250 kDa; KIAA1596; MGC176453; POF15; protein Hef ortholog; SPGF28

RGD Orthologs

Mouse

Rat

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Mus musculus (house mouse):	Fancm (Fanconi anemia, complementation group M)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):	Fancm (FA complementation group M)	HGNC	Ensembl, NCBI, OrthoMCL, Panther, Treefam
Chinchilla lanigera (long-tailed chinchilla):	Fancm (FA complementation group M)	NCBI	Ortholog
Pan paniscus (bonobo/pygmy chimpanzee):	FANCM (FA complementation group M)	NCBI	Ortholog
Canis lupus familiaris (dog):	FANCM (FA complementation group M)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Fancm (FA complementation group M)	NCBI	Ortholog
Sus scrofa (pig):	FANCM (FA complementation group M)	HGNC	EggNOG, Ensembl, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Chlorocebus sabaeus (green monkey):	FANCM (FA complementation group M)	NCBI	Ortholog
Heterocephalus glaber (naked mole-rat):	Fancm (FA complementation group M)	NCBI	Ortholog
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Fancm (FA complementation group M)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Fancm (Fanconi anemia, complementation group M)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	fancm (FA complementation group M)	Alliance	DIOPT (OrthoFinder\|PhylomeDB\|SonicParanoid\|ZFIN)
Saccharomyces cerevisiae (baker's yeast):	MPH1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Fancm	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	fancm	Alliance	DIOPT (Ensembl Compara\|OrthoFinder)
Xenopus laevis (African clawed frog):	fancm.L	Alliance	DIOPT (Xenbase)

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	45,135,930 - 45,200,890 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	14	45,135,930 - 45,200,890 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	14	45,605,133 - 45,670,093 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	44,674,886 - 44,739,840 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	14	25,466,389 - 25,531,345 (+)	NCBI		Celera
Cytogenetic Map	14	q21.2	NCBI
HuRef	14	25,716,007 - 25,780,814 (+)	NCBI		HuRef
CHM1_1	14	45,543,284 - 45,608,236 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	14	39,327,942 - 39,392,898 (+)	NCBI		T2T-CHM13v2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar