Fancb (Fanconi anemia, complementation group B) - Rat Genome Database

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Gene: Fancb (Fanconi anemia, complementation group B) Mus musculus
Analyze
Symbol: Fancb
Name: Fanconi anemia, complementation group B
RGD ID: 1618957
MGI Page MGI
Description: Acts upstream of or within several processes, including cellular response to camptothecin; regulation of double-strand break repair via homologous recombination; and replication-born double-strand break repair via sister chromatid exchange. Predicted to be located in nucleus. Predicted to be part of Fanconi anaemia nuclear complex and chromatin. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group B and head and neck squamous cell carcinoma. Orthologous to human FANCB (FA complementation group B).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: BC022692; Fanconi anemia group B protein homolog; MGC31411
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X163,763,678 - 163,780,266 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX163,763,588 - 163,780,268 (+)EnsemblGRCm39 Ensembl
GRCm38X164,980,480 - 164,997,272 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX164,980,592 - 164,997,272 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X161,418,524 - 161,435,204 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X160,324,818 - 160,341,377 (+)NCBIMGSCv36mm8
CeleraX148,182,688 - 148,199,367 (+)NCBICelera
Cytogenetic MapXF5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
2. Mouse MP Annotation Import Pipeline RGD automated import pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Inactivation of the tumor suppressor genes causing the hereditary syndromes predisposing to head and neck cancer via promoter hypermethylation in sporadic head and neck cancers. Smith IM, etal., ORL J Otorhinolaryngol Relat Spec. 2010;72(1):44-50. doi: 10.1159/000292104. Epub 2010 Mar 24.
6. Downregulation of Fanconi anemia genes in sporadic head and neck squamous cell carcinoma. Wreesmann VB, etal., ORL J Otorhinolaryngol Relat Spec. 2007;69(4):218-25. Epub 2007 Apr 4.
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:14610273   PMID:15489334   PMID:16141072   PMID:16141073   PMID:21677750   PMID:21873635  
PMID:23435420   PMID:25520194   PMID:26123487   PMID:26658157   PMID:27760317   PMID:35596251  


Genomics

Comparative Map Data
Fancb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X163,763,678 - 163,780,266 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX163,763,588 - 163,780,268 (+)EnsemblGRCm39 Ensembl
GRCm38X164,980,480 - 164,997,272 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX164,980,592 - 164,997,272 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X161,418,524 - 161,435,204 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X160,324,818 - 160,341,377 (+)NCBIMGSCv36mm8
CeleraX148,182,688 - 148,199,367 (+)NCBICelera
Cytogenetic MapXF5NCBI
FANCB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X14,689,524 - 14,873,069 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 EnsemblX14,690,388 - 14,873,255 (-)EnsemblGRCh38hg38GRCh38
GRCh37X14,861,527 - 14,891,191 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X14,771,450 - 14,801,105 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X14,621,185 - 14,650,848NCBI
CeleraX18,976,913 - 19,006,568 (-)NCBICelera
Cytogenetic MapXp22.2NCBI
HuRefX12,620,535 - 12,649,320 (-)NCBIHuRef
CHM1_1X14,891,941 - 14,921,594 (-)NCBICHM1_1
T2T-CHM13v2.0X14,266,304 - 14,453,760 (-)NCBIT2T-CHM13v2.0
Fancb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X29,403,771 - 29,420,484 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX29,403,771 - 29,420,192 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX30,449,735 - 30,464,253 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0X33,873,385 - 33,887,896 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0X30,074,041 - 30,088,557 (-)NCBIRnor_WKY
Rnor_6.0X31,124,018 - 31,140,790 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX31,124,018 - 31,140,711 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X31,503,522 - 31,520,366 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X50,143,416 - 50,157,928 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX29,762,123 - 29,776,635 (-)NCBICelera
Cytogenetic MapXq14NCBI
Fancb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555193,343,446 - 3,363,814 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555193,337,138 - 3,364,963 (+)NCBIChiLan1.0ChiLan1.0
FANCB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1X16,642,560 - 16,677,341 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X7,470,574 - 7,500,958 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X14,752,929 - 14,785,847 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX14,752,934 - 14,781,817 (-)Ensemblpanpan1.1panPan2
FANCB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X10,690,826 - 11,140,838 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX11,095,200 - 11,141,029 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX10,590,126 - 11,048,772 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X10,643,010 - 11,103,126 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX10,652,282 - 11,109,766 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X10,707,452 - 11,166,364 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X10,698,894 - 11,157,725 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X10,725,702 - 11,185,302 (-)NCBIUU_Cfam_GSD_1.0
Fancb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X4,301,397 - 4,330,134 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364704,305,740 - 4,323,374 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049364704,305,220 - 4,323,456 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FANCB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX11,384,912 - 11,409,057 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X11,386,360 - 11,408,958 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X12,270,926 - 12,362,359 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FANCB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X13,321,304 - 13,352,368 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX13,321,527 - 13,342,478 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605615,154,251 - 15,187,626 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fancb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624944364,563 - 383,098 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624944358,836 - 383,161 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fancb
419 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:164
Count of miRNA genes:61
Interacting mature miRNAs:62
Transcripts:ENSMUST00000057150, ENSMUST00000101082, ENSMUST00000167446
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558900Bw3_mbody weight QTL 3 (mouse)Not determinedX133540040165298595Mouse
10401118Pgia39_mproteoglycan induced arthritis 39 (mouse)Not determinedX144474380169476592Mouse
1302000Pgia25_mproteoglycan induced arthritis 2 (mouse)Not determinedX144474380169476592Mouse
12738421Lfibq17_mliver fibrosis QTL 17 (mouse)X148148453164945064Mouse
1357619Obsty5_mobesity 5 (mouse)Not determinedX160212893164149284Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000057150   ⟹   ENSMUSP00000051402
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX163,763,708 - 163,780,268 (+)Ensembl
GRCm38.p6 EnsemblX164,980,712 - 164,997,272 (+)Ensembl
RefSeq Acc Id: ENSMUST00000167446   ⟹   ENSMUSP00000128141
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX163,763,588 - 163,780,265 (+)Ensembl
GRCm38.p6 EnsemblX164,980,592 - 164,997,269 (+)Ensembl
RefSeq Acc Id: NM_001146081   ⟹   NP_001139553
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X163,763,678 - 163,780,266 (+)NCBI
GRCm38X164,980,592 - 164,997,272 (+)NCBI
MGSCv37X161,418,524 - 161,435,204 (+)RGD
CeleraX148,182,688 - 148,199,367 (+)RGD
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: NM_175027   ⟹   NP_778192
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X163,763,678 - 163,780,266 (+)NCBI
GRCm38X164,980,592 - 164,997,272 (+)NCBI
MGSCv37X161,418,524 - 161,435,204 (+)RGD
CeleraX148,182,688 - 148,199,367 (+)RGD
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: NR_175954
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X163,763,678 - 163,780,266 (+)NCBI
RefSeq Acc Id: XM_006528832   ⟹   XP_006528895
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X163,769,877 - 163,780,260 (+)NCBI
GRCm38X164,986,880 - 164,997,264 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_778192   ⟸   NM_175027
- Peptide Label: isoform 2
- UniProtKB: Q5XJY6 (UniProtKB/Swiss-Prot),   Q3TEX6 (UniProtKB/TrEMBL),   B1AW75 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001139553   ⟸   NM_001146081
- Peptide Label: isoform 1
- UniProtKB: Q5XJY6 (UniProtKB/Swiss-Prot),   Q3TEX6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006528895   ⟸   XM_006528832
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000128141   ⟸   ENSMUST00000167446
RefSeq Acc Id: ENSMUSP00000051402   ⟸   ENSMUST00000057150

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5XJY6-F1-model_v2 AlphaFold Q5XJY6 1-703 view protein structure

Promoters
RGD ID:6845996
Promoter ID:MM_KWN:62704
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000057150,   NM_029730,   OTTMUST00000046620,   OTTMUST00000046621,   OTTMUST00000046623,   OTTMUST00000046624,   OTTMUST00000046625,   OTTMUST00000046626,   OTTMUST00000046627,   OTTMUST00000046697,   UC009UVZ.1,   UC009UWA.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X161,418,051 - 161,418,802 (-)MPROMDB
RGD ID:13681832
Promoter ID:EPDNEW_M25065
Type:initiation region
Name:Fancb_1
Description:Mus musculus Fanconi anemia, complementation group B , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X164,980,682 - 164,980,742EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2448558 AgrOrtholog
Ensembl Genes ENSMUSG00000047757 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000051402 ENTREZGENE
  ENSMUSP00000051402.8 UniProtKB/TrEMBL
  ENSMUSP00000128141 ENTREZGENE
  ENSMUSP00000128141.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000057150 ENTREZGENE
  ENSMUST00000057150.8 UniProtKB/TrEMBL
  ENSMUST00000167446 ENTREZGENE
  ENSMUST00000167446.8 UniProtKB/TrEMBL
InterPro FANCB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:237211 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:2448558 ENTREZGENE
NCBI Gene 237211 ENTREZGENE
PANTHER FANCONI ANEMIA GROUP B PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR28450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fancb PhenoGen
UniProt B1AW75 ENTREZGENE, UniProtKB/TrEMBL
  FANCB_MOUSE UniProtKB/Swiss-Prot
  Q3TEX6 ENTREZGENE, UniProtKB/TrEMBL
  Q497Q5_MOUSE UniProtKB/TrEMBL
  Q5XJY6 ENTREZGENE
  Q8K3C9_MOUSE UniProtKB/TrEMBL