| 61850 | F10 | coagulation factor X | ENCODES a protein that exhibits phospholipid binding (ortholog); serine-type endopeptidase activity (ortholog); INVOLVED IN positive regulation of TOR signaling (ortholog); proteolysis (ortholog); zymogen activation (ortholog); PARTICIPATES IN coagulation cascade pathway; acenocoumarol pharmacodynam ics pathway; alteplase pharmacodynamics pathway; ASSOCIATED WITH hyperhomocysteinemia; Peritoneal Fibrosis; blood coagulation disease (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 17beta-estradiol 3-benzoate | 16 | 83170973 | 83190280 | Rat | 225 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 62142 | F10 | coagulation factor X | This gene encodes factor X, a component of both the intrinsic and extrinsic blood coagulation pathways. The encoded protein is a zymogen that undergoes further processing in a vitamin K-dependent manner to generate mature factor X, a heterodimer comprised of disulfide-linked heavy and light chains. The mature factor X is proteolytically activated either by factor IXa (intrinsic pathway) or factor VIIa (extrinsic pathway) to form factor Xa serine endopeptidase. Activated factor Xa catalyzes the conversion of prothrombin to thrombin. A complete lack of the encoded protein is fatal to mice. A severe deficiency of the encoded protein in mice causes age-dependent iron deposition and cardiac fibrosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015] | 8 | 13087308 | 13106676 | Mouse | 238 | symbol , PhenoGen , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1342967 | F10 | coagulation factor X | This gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides. [provided by RefSeq, Aug 2015] | 13 | 113122799 | 113149529 | Human | 313 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8825740 | F10 | coagulation factor X | ENCODES a protein that exhibits phospholipid binding (ortholog); serine-type endopeptidase activity (ortholog); INVOLVED IN positive regulation of TOR signaling (ortholog); proteolysis (ortholog); zymogen activation (ortholog); PARTICIPATES IN acenocoumarol pharmacodynamics pathway; alteplase pharma codynamics pathway; aminocaproic acid pharmacodynamics pathway; ASSOCIATED WITH blood coagulation disease (ortholog); breast cancer (ortholog); factor X deficiency (ortholog); FOUND IN serine-type endopeptidase complex (ortholog) | NW_004955404 | 666142 | 682598 | Chinchilla | 40 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11746137 | F10 | coagulation factor X | ENCODES a protein that exhibits calcium ion binding (inferred); hydrolase activity (inferred); peptidase activity (inferred); INVOLVED IN zymogen activation (ortholog); PARTICIPATES IN acenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; aminocaproic acid pharmacodynamics path way; ASSOCIATED WITH blood coagulation disease (ortholog); breast cancer (ortholog); factor X deficiency (ortholog); FOUND IN serine-type endopeptidase complex (ortholog) | 13 | 94263202 | 94289612 | Bonobo | 56 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12327496 | F10 | coagulation factor X | ENCODES a protein that exhibits calcium ion binding (inferred); hydrolase activity (inferred); peptidase activity (inferred); INVOLVED IN zymogen activation (ortholog); PARTICIPATES IN acenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; aminocaproic acid pharmacodynamics path way; ASSOCIATED WITH blood coagulation disease (ortholog); breast cancer (ortholog); factor X deficiency (ortholog); FOUND IN serine-type endopeptidase complex (ortholog) | 22 | 60585563 | 60597027 | Dog | 57 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12579940 | F10 | coagulation factor X | ENCODES a protein that exhibits calcium ion binding (inferred); hydrolase activity (inferred); peptidase activity (inferred); INVOLVED IN zymogen activation (ortholog); PARTICIPATES IN acenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; aminocaproic acid pharmacodynamics path way; ASSOCIATED WITH blood coagulation disease (ortholog); breast cancer (ortholog); factor X deficiency (ortholog); FOUND IN serine-type endopeptidase complex (ortholog) | NW_004936472 | 475851 | 502341 | Squirrel | 55 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14290469 | F10 | coagulation factor X | ENCODES a protein that exhibits calcium ion binding (inferred); hydrolase activity (inferred); peptidase activity (inferred); INVOLVED IN zymogen activation (ortholog); PARTICIPATES IN acenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; aminocaproic acid pharmacodynamics path way; ASSOCIATED WITH blood coagulation disease (ortholog); breast cancer (ortholog); factor X deficiency (ortholog); FOUND IN serine-type endopeptidase complex (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 58 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18633634 | F10 | coagulation factor X | ENCODES a protein that exhibits calcium ion binding (inferred); hydrolase activity (inferred); peptidase activity (inferred); INVOLVED IN zymogen activation (ortholog); PARTICIPATES IN acenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; aminocaproic acid pharmacodynamics path way; ASSOCIATED WITH blood coagulation disease (ortholog); breast cancer (ortholog); factor X deficiency (ortholog); FOUND IN serine-type endopeptidase complex (ortholog) | | | | Green Monkey | 56 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18933243 | F10 | coagulation factor X | ENCODES a protein that exhibits phospholipid binding (ortholog); INVOLVED IN positive regulation of TOR signaling (ortholog); zymogen activation (ortholog); PARTICIPATES IN acenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; aminocaproic acid pharmacodynamics pathway; ASSOCIA TED WITH blood coagulation disease (ortholog); breast cancer (ortholog); factor X deficiency (ortholog); FOUND IN serine-type endopeptidase complex (ortholog) | | | | Naked Mole-Rat | 54 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155254717 | f10 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625865185 | F10 | coagulation factor X | ENCODES a protein that exhibits phospholipid binding (ortholog); serine-type endopeptidase activity (ortholog); INVOLVED IN positive regulation of TOR signaling (ortholog); proteolysis (ortholog); zymogen activation (ortholog); PARTICIPATES IN acenocoumarol pharmacodynamics pathway; alteplase pharma codynamics pathway; aminocaproic acid pharmacodynamics pathway; ASSOCIATED WITH blood coagulation disease (ortholog); breast cancer (ortholog); factor X deficiency (ortholog); FOUND IN serine-type endopeptidase complex (ortholog) | | | | Black Rat | 40 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155255102 | f10.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 9588724 | F10-AS1 | F10 antisense RNA 1 | | 13 | 113128155 | 113130046 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 38669908 | F10-AS2 | F10 antisense RNA 2 | | 13 | 113150212 | 113153986 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, protein-coding, MODEL [RefSeq] |
| 1578783 | F10m1Mcwi | coagulation factor X; mutation 1, Medical College of Wisconsin | mutation generated by ENU (N-ethyl-N-nitrourea); V453G mutation is generated from the codon change GTC/GGC | | | | Rat | | symbol , old_gene_symbol | gene, allele |
| 1579886 | F10m2Mcwi | coagulation factor X; mutation 2, Medical College of Wisconsin | mutation generated by ENU (N-ethyl-N-nitrourea); C388Stop mutation is generated from the codon change TGC/TGA | | | | Rat | | symbol , old_gene_symbol | gene, allele |
| 1318939 | FAM110A | family with sequence similarity 110 member A | Involved in mitotic spindle organization. Located in cytosol; microtubule cytoskeleton; and nucleus. [provided by Alliance of Genome Resources, Jul 2025] | 20 | 833715 | 846277 | Human | 82 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1601857 | PCID2 | PCI domain containing 2 | This gene encodes a component of the TREX-2 complex (transcription and export complex 2), which regulates mRNA export from the nucleus. This protein regulates expression of Mad2 mitotic arrest deficient-like 1, a cell division checkpoint protein. This protein also interacts with and stabilizes Brca2 (breast cancer 2) protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016] | 13 | 113165002 | 113208669 | Human | 85 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 14368264 | F10B5.2 | | | | | | Roundworm | | symbol | gene, null |
| 14378459 | F10B5.8 | | | | | | Roundworm | | symbol | gene, null |
| 14372612 | F10C2.3 | | | | | | Roundworm | | symbol | gene, null |
| 14378468 | F10C2.4 | | | | | | Roundworm | | symbol | gene, null |
| 14378471 | F10C2.5 | | | | | | Roundworm | | symbol | gene, null |
| 14372317 | F10D2.8 | | | | | | Roundworm | | symbol | gene, null |
| 14378478 | F10D7.2 | | | | | | Roundworm | | symbol | gene, null |
| 14377008 | F10D7.3 | | | | | | Roundworm | | symbol | gene, null |
| 14378481 | F10D7.5 | | | | | | Roundworm | | symbol | gene, null |
| 14378483 | F10E7.5 | | | | | | Roundworm | | symbol | gene, null |
| 14373316 | F10E7.9 | | | | | | Roundworm | | symbol | gene, null |
| 14373593 | F10E9.4 | | | | | | Roundworm | | symbol | gene, null |
| 14378486 | F10E9.5 | | | | | | Roundworm | | symbol | gene, null |
| 25825058 | F10G7.5 | | | | | | Roundworm | | symbol | gene, null |
| 14378490 | F10G8.1 | | | | | | Roundworm | | symbol | gene, null |
| 14378491 | F10G8.8 | | | | | | Roundworm | | symbol | gene, null |
| 14373148 | F10G8.9 | | | | | | Roundworm | | symbol | gene, null |
| 25825310 | F10D11.6 | | | | | | Roundworm | | symbol | gene, null |
| 14374173 | F10E7.11 | | | | | | Roundworm | | symbol | gene, null |
| 14370688 | F10E9.11 | | | | | | Roundworm | | symbol | gene, null |
| 14378487 | F10G7.10 | | | | | | Roundworm | | symbol | gene, null |
| 12052181 | F7 | coagulation factor VII | ENCODES a protein that exhibits endopeptidase activity (ortholog); signaling receptor binding (ortholog); INVOLVED IN animal organ regeneration (ortholog); blood coagulation (ortholog); circadian rhythm (ortholog); PARTICIPATES IN acenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pa thway; aminocaproic acid pharmacodynamics pathway; ASSOCIATED WITH factor VII deficiency; acquired angioedema (ortholog); Acute Liver Failure (ortholog); FOUND IN extracellular space (ortholog); membrane (ortholog); protein-containing complex (ortholog) | 22 | 60572459 | 60582743 | Dog | 162 | ensembl_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 5687098 | Ighv7-1 | immunoglobulin heavy variable 7-1 | Predicted to enable antigen binding activity. Predicted to be involved in immunoglobulin mediated immune response. Orthologous to several human genes including IGHV3-72 (immunoglobulin heavy variable 3-72) and IGHV3OR15-7 (immunoglobulin heavy variable 3/OR15-7 (pseudogene)). [provided by Alliance o f Genome Resources, Jul 2025] | 12 | 113860028 | 113860566 | Mouse | 16 | old_gene_symbol | gene, pseudo, VALIDATED [RefSeq] |