F10 (coagulation factor X) - Rat Genome Database

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Gene: F10 (coagulation factor X) Sus scrofa
Analyze
Symbol: F10
Name: coagulation factor X
RGD ID: 14290469
Description: ENCODES a protein that exhibits calcium ion binding (inferred); phospholipid binding (inferred); serine-type endopeptidase activity (inferred); INVOLVED IN blood coagulation (inferred); positive regulation of leukocyte chemotaxis (inferred); positive regulation of TOR signaling (inferred); PARTICIPATES IN acenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; aminocaproic acid pharmacodynamics pathway; ASSOCIATED WITH blood coagulation disease (ortholog); breast cancer (ortholog); factor VII deficiency (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred); membrane (inferred); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: coagulation factor X protein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1178,521,598 - 78,538,258 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11178,521,760 - 78,538,256 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21186,197,298 - 86,215,095 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:19286401   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
F10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1178,521,598 - 78,538,258 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11178,521,760 - 78,538,256 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21186,197,298 - 86,215,095 (-)NCBISscrofa10.2Sscrofa10.2susScr3
F10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3813113,122,799 - 113,149,529 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl13113,122,799 - 113,149,529 (+)EnsemblGRCh38hg38GRCh38
GRCh3713113,777,113 - 113,803,843 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3613112,825,114 - 112,851,844 (+)NCBINCBI36Build 36hg18NCBI36
Build 3413112,825,145 - 112,851,842NCBI
Celera1394,603,103 - 94,629,507 (+)NCBICelera
Cytogenetic Map13q34NCBI
HuRef1394,215,823 - 94,242,228 (+)NCBIHuRef
CHM1_113113,745,235 - 113,771,639 (+)NCBICHM1_1
T2T-CHM13v2.013112,374,457 - 112,401,188 (+)NCBIT2T-CHM13v2.0
F10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39813,087,308 - 13,106,676 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl813,087,308 - 13,106,676 (+)EnsemblGRCm39 Ensembl
GRCm38813,037,308 - 13,056,676 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl813,037,308 - 13,056,676 (+)EnsemblGRCm38mm10GRCm38
MGSCv37813,037,308 - 13,056,216 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36813,037,344 - 13,055,877 (+)NCBIMGSCv36mm8
Celera813,205,092 - 13,223,990 (+)NCBICelera
Cytogenetic Map8A1.1NCBI
cM Map85.73NCBI
F10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81683,170,973 - 83,190,280 (-)NCBIGRCr8
mRatBN7.21676,468,834 - 76,488,141 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1676,468,838 - 76,488,141 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1681,749,382 - 81,768,689 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01685,201,959 - 85,221,266 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01680,451,223 - 80,470,556 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01681,803,169 - 81,822,476 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1681,803,110 - 81,822,716 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01681,288,536 - 81,307,842 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41681,327,237 - 81,346,544 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11681,327,502 - 81,346,809 (-)NCBI
Celera1674,274,866 - 74,294,173 (-)NCBICelera
Cytogenetic Map16q12.5NCBI
F10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955404666,165 - 682,538 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955404666,142 - 682,598 (-)NCBIChiLan1.0ChiLan1.0
F10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v214114,625,296 - 114,651,858 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan113113,310,076 - 113,337,459 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01394,263,202 - 94,289,612 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.113113,332,124 - 113,358,660 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl13113,332,124 - 113,358,660 (+)Ensemblpanpan1.1panPan2
F10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12260,585,563 - 60,597,027 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2260,571,822 - 60,597,024 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2260,297,960 - 60,309,413 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02261,211,249 - 61,222,710 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2261,211,250 - 61,222,699 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12260,709,507 - 60,721,052 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02260,711,813 - 60,723,235 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02260,742,888 - 60,754,688 (+)NCBIUU_Cfam_GSD_1.0
F10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945195,449,719 - 195,476,829 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936472475,333 - 502,377 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936472475,851 - 502,341 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
F10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1391,125,097 - 91,154,000 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl391,124,766 - 91,157,376 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604648,141,434 - 48,190,001 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
F10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624793762,330 - 778,282 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624793762,306 - 777,511 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in F10
447 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium
Low 1 2 1 2 6 2 1
Below cutoff 8 4 1 4 17 1 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000010477   ⟹   ENSSSCP00000010205
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1178,521,598 - 78,538,256 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000068701   ⟹   ENSSSCP00000067174
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1178,521,743 - 78,538,258 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000076561   ⟹   ENSSSCP00000070638
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1178,522,858 - 78,538,256 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000090211   ⟹   ENSSSCP00000073679
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1178,521,743 - 78,537,884 (+)Ensembl
RefSeq Acc Id: NM_001044592   ⟹   NP_001038057
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11178,521,760 - 78,538,256 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001038057 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ABF82361 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSSCP00000010205
  ENSSSCP00000010205.2
  ENSSSCP00000067174.1
  ENSSSCP00000070638.1
  ENSSSCP00000073679.1
  ENSSSCP00035015527.1
  ENSSSCP00060024786.1
  ENSSSCP00065026129.1
Reference Protein Sequences
RefSeq Acc Id: NP_001038057   ⟸   NM_001044592
- Peptide Label: precursor
- UniProtKB: Q19AZ6 (UniProtKB/TrEMBL),   A0A5G2RMA8 (UniProtKB/TrEMBL),   A0A8D0ZEF9 (UniProtKB/TrEMBL),   A0A8D1VIH1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000010205   ⟸   ENSSSCT00000010477
RefSeq Acc Id: ENSSSCP00000067174   ⟸   ENSSSCT00000068701
RefSeq Acc Id: ENSSSCP00000073679   ⟸   ENSSSCT00000090211
RefSeq Acc Id: ENSSSCP00000070638   ⟸   ENSSSCT00000076561
Protein Domains
EGF-like   Gla   Peptidase S1


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000009558 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00035029322 UniProtKB/TrEMBL
  ENSSSCG00060042697 UniProtKB/TrEMBL
  ENSSSCG00065044076 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000010477 ENTREZGENE
  ENSSSCT00000010477.4 UniProtKB/TrEMBL
  ENSSSCT00000068701.2 UniProtKB/TrEMBL
  ENSSSCT00000076561.2 UniProtKB/TrEMBL
  ENSSSCT00000090211.2 UniProtKB/TrEMBL
  ENSSSCT00035038860.1 UniProtKB/TrEMBL
  ENSSSCT00060057923.1 UniProtKB/TrEMBL
  ENSSSCT00065060305.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/TrEMBL
  4.10.740.10 UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
InterPro Coagulation_fac-like_Gla_dom UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/TrEMBL
  GLA-like_dom_SF UniProtKB/TrEMBL
  GLA_domain UniProtKB/TrEMBL
  Pept_S1A_FX UniProtKB/TrEMBL
  Peptidase_S1_PA UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
KEGG Report ssc:733662 UniProtKB/TrEMBL
NCBI Gene F10 ENTREZGENE
PANTHER COAGULATION FACTOR UniProtKB/TrEMBL
  COAGULATION FACTOR X UniProtKB/TrEMBL
Pfam EGF UniProtKB/TrEMBL
  FXa_inhibition UniProtKB/TrEMBL
  Gla UniProtKB/TrEMBL
  Trypsin UniProtKB/TrEMBL
PIRSF Factor_X UniProtKB/TrEMBL
PRINTS CHYMOTRYPSIN UniProtKB/TrEMBL
  GLABLOOD UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/TrEMBL
  EGF_1 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  GLA_1 UniProtKB/TrEMBL
  GLA_2 UniProtKB/TrEMBL
  TRYPSIN_DOM UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
SMART EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  GLA UniProtKB/TrEMBL
  Tryp_SPc UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/TrEMBL
  SSF50494 UniProtKB/TrEMBL
  SSF57630 UniProtKB/TrEMBL
UniProt A0A5G2QR06_PIG UniProtKB/TrEMBL
  A0A5G2R0K3_PIG UniProtKB/TrEMBL
  A0A5G2RMA8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0ZEF9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1VIH1 ENTREZGENE, UniProtKB/TrEMBL
  F1RN41_PIG UniProtKB/TrEMBL
  Q19AZ6 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:111744 ENTREZGENE