| 1303236 | Esrrg | estrogen-related receptor gamma | ENCODES a protein that exhibits AF-2 domain binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); estrogen response element binding (ortholog); INVOLVED IN positive regulation of cold-induced thermogenesis (ortholog); positive regulation of DNA-temp lated transcription (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH Fetal Growth Retardation (ortholog); primary ovarian insufficiency (ortholog); FOUND IN nucleus (inferred); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 13 | 101699043 | 102316877 | Rat | 223 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1349366 | ESRRG | estrogen related receptor gamma | This gene encodes a member of the estrogen receptor-related receptor (ESRR) family, which belongs to the nuclear hormone receptor superfamily. All members of the ESRR family share an almost identical DNA binding domain, which is composed of two C4-type zinc finger motifs. The ESRR members are orphan nuclear receptors; they bind to the estrogen response element and steroidogenic factor 1 response element, and activate genes controlled by both response elements in the absence of any ligands. The ESRR family is closely related to the estrogen receptor (ER) family. They share target genes, co-regulators and promoters, and by targeting the same set of genes, the ESRRs seem to interfere with the ER-mediated estrogen response in various ways. It has been reported that the family member encoded by this gene functions as a transcriptional activator of DNA cytosine-5-methyltransferases 1 (Dnmt1) expression by direct binding to its response elements in the DNMT1 promoters, modulates cell proliferation and estrogen signaling in breast cancer, and negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation and bone formation. Multiple alternatively spliced transcript variants have been identified, which mainly differ at the 5' end and some of which encode protein isoforms differing in the N-terminal region. [provided by RefSeq, Aug 2011] | 1 | 216503246 | 217137702 | Human | 222 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1551381 | Esrrg | estrogen-related receptor gamma | Enables DNA-binding transcription activator activity, RNA polymerase II-specific and estrogen response element binding activity. Involved in positive regulation of cold-induced thermogenesis and positive regulation of transcription by RNA polymerase II. Predicted to be active in chromatin and nucleu s. Is expressed in several structures, including central nervous system; genitourinary system; gut; heart; and sensory organ. Orthologous to human ESRRG (estrogen related receptor gamma). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 187340707 | 187947082 | Mouse | 242 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8740345 | Esrrg | estrogen related receptor gamma | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); estrogen response element binding (ortholog); identical protein binding (ortholog); INVOLVED IN positive regulation of cold-induced thermogenesis (ortholog); positive regulation of DN A-templated transcription (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH Fetal Growth Retardation (ortholog); primary ovarian insufficiency (ortholog) | NW_004955406 | 1260240 | 1784652 | Chinchilla | 20 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11798215 | ESRRG | estrogen related receptor gamma | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN DNA-templated transcription (inferred); nuclear receptor-mediated steroid hormone signaling pathway (inferred); positive regulation of cold-induced thermogenesis (inferred); ASSOCIATED WITH Fetal Growth Retardation (or tholog); primary ovarian insufficiency (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred) | 1 | 192074260 | 192667610 | Bonobo | 37 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12075025 | ESRRG | estrogen related receptor gamma | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN DNA-templated transcription (inferred); nuclear receptor-mediated steroid hormone signaling pathway (inferred); positive regulation of cold-induced thermogenesis (inferred); ASSOCIATED WITH Fetal Growth Retardation (or tholog); primary ovarian insufficiency (ortholog); FOUND IN nucleus (inferred) | 38 | 11825055 | 12439143 | Dog | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12526934 | Esrrg | estrogen related receptor gamma | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN DNA-templated transcription (inferred); nuclear receptor-mediated steroid hormone signaling pathway (inferred); positive regulation of cold-induced thermogenesis (inferred); ASSOCIATED WITH Fetal Growth Retardation (or tholog); primary ovarian insufficiency (ortholog); FOUND IN nucleus (inferred) | NW_004936628 | 1635161 | 2058198 | Squirrel | 37 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155241803 | esrrg | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18906710 | Esrrg | estrogen related receptor gamma | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); estrogen response element binding (ortholog); identical protein binding (ortholog); INVOLVED IN positive regulation of cold-induced thermogenesis (ortholog); positive regulation of DN A-templated transcription (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH Fetal Growth Retardation (ortholog); primary ovarian insufficiency (ortholog); FOUND IN nucleus (inferred) | | | | Naked Mole-Rat | 37 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18394220 | ESRRG | estrogen related receptor gamma | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN DNA-templated transcription (inferred); nuclear receptor-mediated steroid hormone signaling pathway (inferred); positive regulation of cold-induced thermogenesis (inferred); ASSOCIATED WITH Fetal Growth Retardation (or tholog); primary ovarian insufficiency (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred) | | | | Green Monkey | 37 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13856772 | ESRRG | estrogen related receptor gamma | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN DNA-templated transcription (inferred); nuclear receptor-mediated steroid hormone signaling pathway (inferred); positive regulation of cold-induced thermogenesis (inferred); ASSOCIATED WITH Fetal Growth Retardation (or tholog); primary ovarian insufficiency (ortholog); FOUND IN nucleus (inferred) | | | | Pig | 42 | symbol , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 626002777 | Esrrg | estrogen related receptor gamma | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); estrogen response element binding (ortholog); identical protein binding (ortholog); INVOLVED IN positive regulation of cold-induced thermogenesis (ortholog); positive regulation of DN A-templated transcription (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH Fetal Growth Retardation (ortholog); primary ovarian insufficiency (ortholog) | | | | Black Rat | 20 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155253338 | esrrg.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155241802 | esrrg.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 288057306 | esrrgr | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 288083354 | esrrgr.L | | | | | | African Clawed Frog | | symbol | gene, null |
