| 1348695 | EHD2 | EH domain containing 2 | This gene encodes a member of the EH domain-containing protein family. These proteins are characterized by a C-terminal EF-hand domain, a nucleotide-binding consensus site at the N terminus and a bipartite nuclear localization signal. The encoded protein interacts with the actin cytoskeleton through an N-terminal domain and also binds to an EH domain-binding protein through the C-terminal EH domain. This interaction appears to connect clathrin-dependent endocytosis to actin, suggesting that this gene product participates in the endocytic pathway. [provided by RefSeq, Jul 2008] | 19 | 47713422 | 47743134 | Human | 169 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1557952 | Ehd2 | EH-domain containing 2 | Enables identical protein binding activity and protein domain specific binding activity. Involved in several processes, including plasma membrane tubulation; positive regulation of endocytic recycling; and positive regulation of myoblast fusion. Acts upstream of or within cortical actin cytoskeleton organization and endocytosis. Located in caveola; cytosol; and perinuclear region of cytoplasm. Is expressed in several structures, including brown fat; neural tube; and vascular element. Orthologous to human EHD2 (EH domain containing 2). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 15680883 | 15701402 | Mouse | 172 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1560856 | Ehd2 | EH-domain containing 2 | ENCODES a protein that exhibits identical protein binding (ortholog); protein domain specific binding (ortholog); INVOLVED IN cortical actin cytoskeleton organization (ortholog); endocytic recycling (ortholog); endocytosis (ortholog); PARTICIPATES IN endocytosis pathway; FOUND IN caveola (ortholog); cytosol (ortholog); membrane (ortholog); INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 2,3,7,8-tetrachlorodibenzodioxine; 3',5'-cyclic AMP | 1 | 85767757 | 85786974 | Rat | 182 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 8833157 | Ehd2 | EH domain containing 2 | ENCODES a protein that exhibits identical protein binding (ortholog); protein domain specific binding (ortholog); INVOLVED IN cortical actin cytoskeleton organization (ortholog); endocytic recycling (ortholog); endocytosis (ortholog); FOUND IN caveola (ortholog); cytosol (ortholog); membrane (orthol og) | NW_004955574 | 1490877 | 1503651 | Chinchilla | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11927011 | EHD2 | EH domain containing 2 | ENCODES a protein that exhibits ATP binding (inferred); cadherin binding (inferred); calcium ion binding (inferred); INVOLVED IN cortical actin cytoskeleton organization (ortholog); endocytosis (ortholog); FOUND IN caveola (inferred); cytoplasm (inferred); cytosol (inferred) | 19 | 44707747 | 44737370 | Bonobo | 40 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12386925 | EHD2 | EH domain containing 2 | ENCODES a protein that exhibits ATP binding (inferred); calcium ion binding (inferred); GTP binding (inferred); INVOLVED IN cortical actin cytoskeleton organization (ortholog); endocytosis (ortholog); FOUND IN caveola (inferred); cytoplasm (inferred); cytosol (inferred) | 1 | 108317471 | 108336032 | Dog | 38 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12614235 | Ehd2 | EH domain containing 2 | ENCODES a protein that exhibits identical protein binding (ortholog); protein domain specific binding (ortholog); INVOLVED IN cortical actin cytoskeleton organization (ortholog); endocytosis (ortholog); plasma membrane tubulation (ortholog); FOUND IN caveola (ortholog); cytosol (ortholog); membrane (ortholog) | NW_004936664 | 1316621 | 1331678 | Squirrel | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626113909 | Ehd2 | EH domain containing 2 | ENCODES a protein that exhibits identical protein binding (ortholog); protein domain specific binding (ortholog); INVOLVED IN cortical actin cytoskeleton organization (ortholog); endocytic recycling (ortholog); endocytosis (ortholog); FOUND IN caveola (ortholog); cytosol (ortholog); membrane (orthol og) | | | | Black Rat | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155257848 | ehd2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18392568 | EHD2 | EH domain containing 2 | ENCODES a protein that exhibits ATP binding (inferred); cadherin binding (inferred); calcium ion binding (inferred); INVOLVED IN cortical actin cytoskeleton organization (ortholog); endocytosis (ortholog); FOUND IN caveola (inferred); cytoplasm (inferred); cytosol (inferred) | | | | Green Monkey | 40 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14035752 | EHD2 | EH domain containing 2 | ENCODES a protein that exhibits ATP binding (inferred); calcium ion binding (inferred); GTP binding (inferred); INVOLVED IN cortical actin cytoskeleton organization (ortholog); endocytosis (ortholog); FOUND IN caveola (inferred); cytoplasm (inferred); cytosol (inferred) | | | | Pig | 38 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18907488 | Ehd2 | EH domain containing 2 | ENCODES a protein that exhibits identical protein binding (ortholog); protein domain specific binding (ortholog); INVOLVED IN cortical actin cytoskeleton organization (ortholog); endocytosis (ortholog); plasma membrane tubulation (ortholog); FOUND IN caveola (ortholog); cytosol (ortholog); membrane (ortholog) | | | | Naked Mole-Rat | 35 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155259210 | ehd2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155252252 | ehd2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 621762 | Ehd3 | EH-domain containing 3 | ENCODES a protein that exhibits ATP binding (inferred); calcium ion binding (inferred); GTP binding (inferred); INVOLVED IN cilium assembly (ortholog); early endosome to Golgi transport (ortholog); endocytic recycling (ortholog); PARTICIPATES IN endocytosis pathway; ASSOCIATED WITH acute myeloid leu kemia (ortholog); hepatocellular carcinoma (ortholog); FOUND IN ciliary pocket membrane (ortholog); ciliary transition zone (ortholog); cilium (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-methoxyethanol; 3,7-dihydropurine-6-thione | 6 | 27392709 | 27417445 | Rat | 179 | old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1553109 | Ehd3 | EH-domain containing 3 | Predicted to enable calcium ion binding activity; lipid binding activity; and purine ribonucleoside triphosphate binding activity. Involved in cilium assembly; positive regulation of voltage-gated calcium channel activity; and regulation of heart contraction. Acts upstream of or within protein local ization to plasma membrane and regulation of cardiac muscle cell membrane potential. Located in endocytic vesicle and perinuclear region of cytoplasm. Is expressed in several structures, including adrenal gland; central nervous system; heart; otic capsule; and turbinate bone primordium. Orthologous to human EHD3 (EH domain containing 3). [provided by Alliance of Genome Resources, Apr 2025] | 17 | 74111836 | 74139088 | Mouse | 197 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |